Researchers have identified ultra-fast gas flows through atomic-scale apertures in 2D membranes, confirming a century-old equation of fluid dynamics. The study's findings hold promise for applications in water and gas purification, air quality monitoring, and energy harvesting.
Researchers Gustavo D. Aguirre, Jean Bennett, and Albert M. Maguire receive $1 million prize for developing FDA-approved gene therapy for Leber congenital amaurosis, a genetic disease causing visual impairments. Their work has enabled routine treatment of the condition, restoring vision in children and adults.
Researchers identify NAD+ capping as a key regulator of RNA stability in plants, allowing them to dynamically respond to environmental cues and stress. This process is similar to what has been found in mammalian cells, with implications for understanding plant development and response to hormone signals.
A study published in Science Immunology reveals that the activity of IL-33, an immune signaling molecule, depends on which cell type releases it. This discovery opens up a new direction for understanding its involvement in various health conditions such as obesity, inflammatory bowel disease, and asthma.
A study found that mobile devices expose Americans to a much greater variety of news, contrary to the conventional wisdom about segregated news bubbles. This exposure can help reduce the effects of misinformation and promote democratic discourse.
An international team led by George Hajishengallis showed that training the innate immune system with β-glucan can inspire neutrophils to target tumors. The study found that trained immunity can be transferred through bone marrow transplants, leading to improved tumor-fighting ability.
A study led by George Hajishengallis found that targeting the DEL-1 molecule could be an effective way to treat inflammatory and autoimmune conditions. The researchers discovered that DEL-1 promotes the generation and immunosuppressive activity of regulatory T cells, which are crucial in maintaining health.
A study of Maine's Swan's Island reveals declines in five species of mussels, barnacles, and snails over two decades, with young mussels experiencing the sharpest decline. The researchers attribute these changes to climate-driven ocean acidification and warming, which affect shellfish ability to thicken their shells.
Researchers at the University of Pennsylvania have created a new type of quasiparticle called helical topological exciton-polaritons, which have a defined spin locked to their direction of motion. This achievement opens up possibilities for using them to transmit information or perform computations at unprecedented speeds.
In a new study, researchers have identified the molecular mechanism behind two key proteins that influence plant form and timing of developmental transitions. The study reveals an antagonistic relationship between Terminal Flower 1 (TLF1) and Flowering Locus T (FT) proteins, which promote branch formation and flowering, respectively.
The Penn Center for Multi-Scale Molecular Mapping of the Female Reproductive System will create a comprehensive resource for women's health by documenting the molecular characteristics of individual cells in the female reproductive system.
Researchers found that providing text message reminders and redesigning the summons form improved court appearance rates by 21% and 13%, respectively. The interventions avoided at least 30,000 arrest warrants and resulted in about 20,000 fully dismissed cases.
A team of researchers developed an innovative approach to identify and evaluate candidate molecules that can image and track the progression of Parkinson's disease. They screened millions of compounds using a high-throughput computational method, identifying two promising candidates with extremely high binding affinity to alpha-synuclein.
A study of search and rescue dogs found that dogs at the disaster site lived a similar length of time as those in a control group, with no discernable difference in cause of death. The most common cause of death was age-related conditions such as arthritis and cancer.
A study by University of Pennsylvania researchers describes an effective gene therapy for Krabbe disease in dogs, which has shown promising results with no significant symptoms after four years. The treatment approach, using the AAV9 vector, has also been found to positively affect both central and peripheral nervous systems.
Scientists link the end of the Green Sahara to a previously unknown megadrought in Southeast Asia, which lasted over 1,000 years and shifted human settlement patterns. The study provides new insights into the impact of climate change on societal adaptations and upheavals.
According to the study published in the Proceedings of the National Academy of Sciences, rocks on Earth are, on average, cube-shaped due to fragmentation processes. The researchers' findings suggest that this shape is statistically average and applies not only to Earth but also around the solar system.
A web-based database, Archaeal Proteome Project (ArcPP), collects and makes available datasets to further research on archaea, a domain of microorganisms. The platform provides easily accessible data and expertise for analyzing proteomics studies, yielding significant new insights into archaeal biology.
Researchers at the University of Pennsylvania used a glowing dye to illuminate cancerous tissue during surgery, which helped identify spread to lymph nodes. The technique could improve outcomes in breast cancer patients undergoing breast-conserving surgery.
A new study reveals that ancient fish species Tanyrhinichthys mcallisteri, dating back 300 million years, exhibits features similar to modern sturgeons despite divergent evolutionary paths. The findings indicate multiple instances of convergent evolution, highlighting the adaptability of fish in response to environmental conditions.
A study by University of Pennsylvania researchers found that different types of networks share a similar underlying structure that allows them to convey large amounts of information efficiently. The balance between community and heterogeneous structures is key to creating information-rich but easy-to-interpret networks.
Researchers found that parasite infection was strongly associated with the overall composition of the microbiome, which could accurately predict a person's country and lifestyle. The study also discovered that the presence of four soil-transmitted gut parasites tended to co-occur at a higher rate than chance.
Researchers identified an enzyme, p38α kinase, as crucial for metastasis, which is the primary cause of cancer deaths. By blocking this enzyme using an inhibitor, they successfully reduced melanoma's spread to the lungs and prolonged survival time.
Researchers identified a novel strategy to address underlying causes of LAD1 patients' symptoms by mimicking the efferocytosis process, which was absent in these individuals. The study found that small-molecule compounds that stimulate this process alleviated signs of inflammation and promoted bone regeneration in animal models.
Researchers at the University of Pennsylvania have developed a system that can manipulate and detect orbital angular momentum, or OAM, of light on small semiconductor chips. This breakthrough enables the transmission of multiple distinct OAM modes, potentially shattering the bandwidth bottleneck in optical communications.
A team from the University of Pennsylvania and Georgia Tech discovered that cavity-causing bacteria, Streptococcus mutans, are encased in a protective community of other microbes forming a unique spatial organization. This structure is crucial to how they cause tooth decay and can be used to target the pathogenic core of dental biofilms.
The human brain balances complexity and accuracy when processing patterns, with errors playing a crucial role in learning and cognition. The new model suggests that the brain constantly strives to represent things in simple terms, with participants showing quicker responses to sequences generated by modular networks.
Researchers have developed a metal-air scavenger that provides power by breaking chemical bonds in metal surfaces, outperforming batteries and harvesters. The technology has 10 times more power density than the best energy harvesters and 13 times more energy density than lithium-ion batteries.
Researchers create tiny aircraft made from 'nanocardboard' that can levitate and carry payloads ten times heavier than themselves in the Martian atmosphere. The design uses a temperature differential to generate thrust, enabling the flyers to potentially serve as atmospheric probes on Mars, Pluto, and other planets.
A new study has identified a molecular pathway responsible for the progression and spread of triple-negative breast cancer (TNBC). By blocking the signaling pathway, researchers found that tumors grew and spread more slowly. The findings suggest that patients with low ELF5 protein levels should be given interferon-gamma signaling-block...
Researchers created a laboratory model of three types of brain cells to study HIV's impact on the central nervous system. The model revealed that HIV infection can take a toll on the brain, causing inflammation and damage. Antiretroviral therapy (ART) can reduce inflammation by around 70%, but also triggers its own unique response.
A new feathered dinosaur species, Dineobellator notohesperus, has been discovered in New Mexico, providing insights into the paleo-biodiversity of the American Southwest. The species, a member of the dromaeosaurid group, had feathers, flexible arms and hands, and a unique tail with a stiffened base.
Scientists have identified a crucial protein called SKP1 that drives a key transition step in male meiosis, the process resulting in sperm production. Without this protein, meiosis cannot proceed, and defects can occur, leading to male infertility, pregnancy loss, or birth defects.
Researchers used super-resolution imaging and a computational algorithm to study how bacteria multiply and grow into dense biofilms. They found that growth patterns are analogous to urbanization, with individual bacteria forming 'cities' that merge and expand over time.
Using DES data, researchers found more than 300 trans-Neptunian objects, including 245 discoveries made by DES. The method developed by Pedro Bernardinelli can also be used to search for TNOs in upcoming astronomy surveys.
New research challenges traditional models of community ecology, suggesting that mutualism is compatible with stable communities. The balance of mutualism with other types of interactions plays a determinative role in community dynamics and stability.
Researchers at the University of Pennsylvania have developed an affordable oral therapy to help broken bones heal faster in people with diabetes. The therapy, grown in plants, uses a protein called insulin-like growth factor-1 (IGF-1) to stimulate bone-building cells and promote bone regeneration.
A new publication in Nature Communications presents a unifying model that explains diverse interactions between decision strategy and the environment, highlighting the similarity of their features. The findings shed light on the tight-knit forces that link changes in strategic action to environmental change, and vice versa.
Scientists have created a protein drug composed of angiotensin converting enzyme-2 (ACE2) and its product angiotensin (1-7) that can be taken orally to treat pulmonary arterial hypertension. The drug has shown promise in animal models, reducing pulmonary artery pressure and improving cardiac function.
Scientists have uncovered a crucial role of mucosal antibodies, specifically IgT, in regulating the microbiome and defending against pathogens in fish. By manipulating the immune system of rainbow trout, researchers found that IgT plays two paradoxical roles: reducing bad microbes while promoting beneficial bacteria.
African charcoal production supports nomadic lifestyles, while its large-scale use contributes to deforestation. Despite efforts to regulate, charcoal remains a significant source of energy worldwide, with millions of metric tons produced annually.
A new study by University of Pennsylvania researchers found that people, smokers and non-smokers alike, were often inaccurate in their answers to questions about smoking's health effects. However, when participants discussed their ideas with others, especially in a networked setting, they became more accurate in their assessments.
A team of researchers at the University of Pennsylvania found that when particles are wet and dry, thin solid bridges formed between larger clumps increase aggregates' stability. The size of particles plays a crucial role in determining how strongly they stick together.
Researchers discovered that activating a mosquito's immune system can prevent the transmission of disease-causing parasites like Dirofilaria immitis and Brugia malayi. By boosting the immune response, mosquitoes can block parasite development, potentially stopping diseases like canine heartworm and human lymphatic filariasis.
A new study from University of Pennsylvania sociologist Wendy Roth found that DIY DNA tests do not lead to a greater belief in racial essentialism. However, those who understand more about genetics going in become more skeptical, while those with less understanding believe in essentialism more strongly.
Researchers at the University of Pennsylvania have discovered a way to synthesize organic 'Legos' that can be easily connected to make new materials. The new method uses electricity to create thin films of 2D sheets stacked in multiple layers, resulting in lightweight and heat-tolerant materials with enhanced properties.
Toxoplasma gondii injects proteins into host macrophages, altering their behavior and suppressing the immune response. This manipulation leads to the creation of M2 macrophages, which reduce inflammation and allow the parasite to evade elimination by T cells.
Researchers have created kirigami structures that can support 14,000 times their own weight without adhesives or fasteners. The tilted triangle design is strongest when flaps are undamaged and untapped, and its unique geometry allows for horizontal compression within the center of the design.
Research from University of Pennsylvania and Georgetown suggests drug-associated mortality is double the initially reported number. Drug use decreased life expectancy after age 15 by 1.4 years for men and 0.7 years for women, with West Virginia and other states experiencing high rates.
Researchers found that young children who exhibit less fear and desire for social connection are at risk of developing callous-unemotional traits, which can lead to antisocial behavior. These traits are characterized by a lack of empathy and sensitivity to others' emotions.