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Study examines care received by patients with knee osteoarthritis

A new study published in Arthritis & Rheumatology found that only a minority of patients with knee osteoarthritis used non-surgical care such as physical therapy and knee injections. The study suggests that surgery may be more commonly substituted for conservative care in regions with high rates of knee replacements.

SourceWiley·JournalArthritis & Rheumatology·DateJun 9, 2021

Birth weight is associated with osteoporosis risk later in life

Research from the UK Biobank and the Genetic Factors for Osteoporosis consortium found that heavier birth weight is associated with a higher risk of bone fracture and osteoporosis. The study suggests that genes affecting birth weight may also influence an individual's risk of developing osteoporosis as they age.

SourceWiley·JournalJournal of Bone and Mineral Research·DateJun 9, 2021

Speech droplets drive transmission of SARS-CoV-2

Researchers found that intermediate-sized respiratory droplets emitted while speaking can carry significant amounts of virus and remain suspended in air for minutes. These 'speech droplets' pose a considerable risk of SARS-CoV-2 transmission, particularly in enclosed spaces without proper ventilation.

SourceWiley·JournalJournal of Internal Medicine·DateJun 9, 2021

DNA circuits

Scientists have created a molecular switching circuit made of DNA that can change the shape of soft matter based on pH levels. The DNA switches react differently with their surroundings, allowing for potential applications in soft robotics and logical function networks.

SourceWiley·JournalAngewandte Chemie International Edition·DateJun 2, 2021

Cancer treatments may accelerate cellular aging

New research suggests that anti-cancer therapies can hasten cellular aging, leading to increased inflammation and fatigue in patients with head and neck cancer. Epigenetic changes associated with these treatments may contribute to age-related conditions.

SourceWiley·JournalCancer·DateMay 24, 2021

What are the effects of inappropriate prescriptions in older adults?

A study published in British Journal of Clinical Pharmacology found that potentially inappropriate prescribing is associated with functional decline, falls and hospital admissions. Decision support tools can help reduce medication-related harm, but comprehensive assessment of medication use during care transitions is crucial.

SourceWiley·JournalBritish Journal of Clinical Pharmacology·DateMay 19, 2021

Study points to potential treatment for citrus disease

A new study suggests that hexanoic acid could be a suitable substitute for chemical protection in citrus cultivation, addressing concerns about the impact of old-school defenses on food safety. Researchers believe this fatty acid may help protect against diseases like canker, which causes brownish lesions on leaves and fruit.

SourceWiley·JournalJournal of Applied Microbiology·DateMay 19, 2021

Music may benefit older adults with cognitive impairment

An analysis of nine studies found that active music-making can provide significant cognitive benefits to older adults with mild cognitive impairment or dementia. Music-based interventions have the potential to support millions of older adults in their emotional, social, and well-being needs.

SourceWiley·JournalJournal of the American Geriatrics Society·DateMay 19, 2021

Study reveals high levels of contaminants in killer whales

A study published in Environmental Toxicology and Chemistry reveals high levels of contaminants in killer whales near Norway, affecting their tissues and offspring. The findings also highlight the persistence and mobility of chemicals in marine ecosystems.

SourceWiley·JournalEnvironmental Toxicology and Chemistry·DateMay 19, 2021

A hairpin to fight cancer

Researchers have developed a bicyclic peptide that binds to and inhibits the oncogenic protein beta-catenin, which is associated with certain types of tumor. The peptide's unique hairpin shape and cyclic nature mimic natural protein structures, making it an attractive starting point for developing new antitumor drugs.

SourceWiley·JournalAngewandte Chemie International Edition·DateMay 12, 2021

Protected by nanobrushes

Researchers developed nanosized cargo packages that can deliver water-soluble proteins into cancer cells while keeping them intact. The 'nanobrushes' use polymer strands with antibodies on the outside and protected proteins within.

SourceWiley·JournalAngewandte Chemie International Edition·DateMay 6, 2021

Can Twitter help improve dental education?

Studies found Twitter's real-time Q&A sessions and semi-anonymous interactions can benefit students' engagement and confidence. However, barriers to Twitter's use in dental education include privacy concerns and professionalism issues.

SourceWiley·JournalJournal of Dental Education·DateMay 5, 2021

Which medications are most toxic to the liver?

A recent study analyzing 156,570 hospitalized patients found that anti-infective agents, cancer medications, and nonsteroidal anti-inflammatory drugs were the most toxic to the liver. Voriconazole, an antifungal medication, was associated with the highest incidence of drug-induced liver injury.

SourceWiley·JournalBritish Journal of Clinical Pharmacology·DateMay 5, 2021

Light pollution at night affects the calls of migratory birds

Research published in Ibis found that call rates of migratory birds were significantly higher in urban areas compared to villages, indicating a impact of artificial light on bird migration. The study suggests that improved management of urban lighting is necessary to mitigate this effect.

SourceWiley·JournalIbis·DateMay 5, 2021

How accurate are virtual assessments of cognitive function?

A study analyzed 121 published studies on virtual and in-person cognitive assessments for diagnosing dementia or mild cognitive impairment. The analysis found good reliability and accuracy of virtual assessments for diagnosing dementia, but identified barriers to implementing cognitive assessments for older adults.

SourceWiley·JournalJournal of the American Geriatrics Society·DateMay 5, 2021

Now available with a negative charge too

Researchers have introduced a new anionic organoborane compound, borafluorene, which is a system of three carbon rings joined at the edges with a boron atom. The team used carbenes to stabilize the elusive anions and demonstrated their potential as chemical building blocks.

SourceWiley·JournalAngewandte Chemie International Edition·DateMay 5, 2021

Do bacteria in the mouth affect risk of developing rheumatoid arthritis?

Researchers discovered a possible link between oral microbes and rheumatoid arthritis, finding similar bacterial compositions in patients' mouths as those at risk of developing the disease. The study suggests that potentially pro-inflammatory bacteria, such as Prevotella and Veillonella, may play a role in the disease

SourceWiley·JournalArthritis & Rheumatology·DateMay 5, 2021

Strong and flexible cofactors

Scientists have created a cube-shaped iron-sulfur cluster that can support a multiple bond between iron and nitrogen, a structural motif involved in biological nitrogen fixation. The discovery shows the cluster's ability to accommodate an unusual bond without distorting its structure.

SourceWiley·JournalAngewandte Chemie International Edition·DateMay 3, 2021

CO2 catalysis made more accessible

Researchers have discovered a new aerogel electrocatalyst formed from inexpensive metal alloys, enabling highly efficient electrochemical conversion of carbon dioxide. The process achieves an efficiency of 93% with minimal byproducts.

SourceWiley·JournalAngewandte Chemie International Edition·DateApr 30, 2021

Do school shootings have a copycat effect?

An analysis of US school shootings between 1990 and 2017 found that following a shooting, the risk of additional incidents in the same and neighboring states increases significantly. The study suggests that media coverage can minimize the risk of provoking further shootings by finding a balance between reporting on these events.

SourceWiley·JournalContemporary Economic Policy·DateApr 21, 2021

Music improves older adults' sleep quality

Listening to music before bed significantly improves sleep quality among older adults. Longer listening periods yield the most effective results. Music therapy is an easy-to-administer strategy that may become a first-line treatment option.

SourceWiley·JournalJournal of the American Geriatrics Society·DateApr 21, 2021

New insights on inflammation in COVID-19

A new study in Arthritis & Rheumatology identifies specific blood markers to distinguish excessive COVID-19 inflammation from cytokine storm syndromes. This finding has significant implications for treating critically ill patients with COVID-19.

SourceWiley·JournalArthritis & Rheumatology·DateApr 21, 2021

New analysis addresses fear of cancer recurrence

A new analysis published in Psycho-Oncology found that fear of cancer recurrence leads to increased use of healthcare resources by cancer survivors. Implementing existing effective interventions for fear of cancer recurrence may improve both mental health and reduce unnecessary healthcare usage.

SourceWiley·JournalPsycho-Oncology·DateApr 21, 2021

The fastest one wins

A team at the Indian Institute of Science developed a catalytic version of the Fischer indole synthesis that primarily produces one enantiomer. The reaction involves a dynamic kinetic resolution mechanism with a chiral catalyst, resulting in moderate yields and good to excellent enantiomeric selectivity.

SourceWiley·JournalAngewandte Chemie International Edition·DateApr 8, 2021

How has the COVID-19 pandemic impacted peoples' interactions with nature?

The COVID-19 pandemic has changed people's interactions with nature in both positive and negative ways, providing valuable knowledge about these interactions. The article highlights the potential long-term consequences of this shift and recommends further research to establish actions that can positively impact humans and nature.

SourceWiley·JournalPeople and Nature·DateApr 7, 2021