Wolfram Syndrome is a progressive degenerative disease characterized by diabetes, psychiatric symptoms, loss of vision, deafness, and incontinence. Yale researchers have discovered a potential treatment involving two existing drugs that restore calcium signaling and improve cell functions.
A DNA twist separates double helix into a single strand, regulating placental growth and development. The sixth base of DNA, N6-methyladenine, stabilizes this structure, controlling cell fate.
Researchers at Yale University have discovered a novel approach to finding biological signals in ancient fossils, providing insights into major evolutionary questions. The study has already revealed valuable information about the soft shells that encased early dinosaur eggs and identified an ancient creature known as the Tully Monster.
A new study by Yale University researchers found that a nurse-delivered strategy to prevent falls among older adults reduced the rate of first adjudicated serious fall injury by nearly 10%. The approach also produced significant reductions in self-reported injuries, highlighting its potential in reducing fall-related harm.
A Yale, Baylor study reveals new cell types in lungs affected by Idiopathic Pulmonary Fibrosis (IPF), revealing how cells change in response to the disease. The findings deepen understanding of IPF and could improve treatment of it and other fibrotic lung diseases.
A Yale University study found that teens delaying driver licensure are missing critical safety training, including nighttime driving restrictions and passenger limits. This can lead to a higher risk of crashes and fatalities among vulnerable populations.
Researchers found an immune system cell called interleukin-6 (IL-6) triggers inflammation in times of stress, worsening health problems such as diabetes and autoimmune disease. Blocking IL-6 production protects stressed mice from inflammation and alleviates symptoms of depression.
A Yale Cancer Center study confirms the effectiveness of combining chemotherapy and trastuzumab in treating aggressive uterine serous carcinoma, a rare form of endometrial cancer. The treatment significantly improves progression-free survival, with no increase in toxicity.
Researchers blocked a 'jamming signal' that prevents interleukin-18 from reaching tumors, significantly reducing their growth in mice with cancer. The treatment, developed by Yale scientists, uses a synthetic version of IL-18 that can overcome the blocking protein and increase anti-tumor responses.
Yale researchers identified four approved drugs that can suppress HIV reactivation and reduce damaging immune responses. These drugs, including ruxolitinib and mycophenolic acid, show promise as a complement to antiretroviral therapy in treating HIV infection.
Researchers found that thorns in citrus plants arise from stem cells, which undergo a programmed arrest to create the sharp pointy end. This discovery may lead to safer fruit harvesting and more fruitful orchards.
Researchers propose PANDAS, a type of pediatric autoimmune neuropsychiatric disorder, as a possible cause of sudden childhood OCD cases. The study identifies antibodies binding to interneurons in the brain as a key factor contributing to the disorder.
Researchers at Yale University have made a breakthrough in treating Rett Syndrome, a devastating genetic disorder affecting 1 in 10,000 girls. The experimental cancer drug JQ1 has been shown to extend the life of mice with Rett Syndrome by approximately 50%.
Researchers found evidence of continental growth starting as early as 4.4 billion years ago, indicating that tectonic plate movement began more than a billion years earlier than previously believed. This discovery challenges our understanding of Earth's geological history and suggests a complex process involving the recycling of crust.
A new study reveals that supermassive black holes experience a surge in activity as galaxies within galaxy clusters stop forming stars. The intense pressure allows for a final feast of gas clouds and stars before shutting off normal feeding, suggesting an intricate interplay between black hole behavior and star formation.
Yale researchers have identified a neural home of the feeling of stress in the brain, revealing a network of connections from the hippocampus to the dorsal lateral frontal cortex. This discovery may help develop targeted therapies for anxiety and other mental health disorders.
A recent Yale University study found that bullying is a common precursor to suicide among LGBTQ youth, with death records of LGBTQ youths being about five times more likely to mention bullying than non-LGBTQ peers. The study suggests that additional steps are needed to protect these young people against the threat of bullying.
A genome-wide analysis has identified 19 new genetic risk factors for problematic alcohol use and confirmed 10 previously known factors. The study also found shared genetic associations with psychiatric disorders such as depression and anxiety.
Researchers have developed a new imaging tool that detects widespread synaptic loss throughout the brain in early stages of Alzheimer's disease. This breakthrough enables scientists to identify areas of specific damage and monitor disease progression.
Researchers at Yale University have discovered a molecular explanation for how HIV hides in immune system cells, allowing it to remain dormant and re-emerge. By understanding this process, scientists may develop new ways to control HIV infection.
A study by Yale researchers found that only 21% of emergency department clinicians indicated readiness to offer buprenorphine to patients with opioid use disorder. Barriers included lack of formal training, time limitations, and perceptions that initiating therapy falls outside the scope of emergency medicine.
A study by Yale psychologists and economists found that people tend to misremember being more generous than they actually were when asked about past behavior. This faulty recall helps individuals maintain a positive self-image and can reduce the need for motivated reasoning.
Yale researchers developed a new approach to track COVID-19's spread by leveraging real-time population flow data, demonstrating its effectiveness in forecasting the outbreak and identifying high-risk areas. The model accurately predicted subsequent COVID-19 infections across China and corroborated official case counts.
A new study led by Yale Cancer Center researchers shows that immunotherapy prior to surgery can increase the rate of complete eradication of high-risk HER2-negative breast cancer from the breast and lymph nodes. The treatment combination of durvalumab, a checkpoint inhibitor, with chemotherapy resulted in a higher pCR rate compared to ...
A Yale-led study found that a cancer therapy drug can slow T cell infiltration and reverse damage in kidney tissue damaged by lupus. The findings suggest the therapy might be beneficial for patients with lupus nephritis.
A new study by Yale University researchers found that genetic variations can trigger functional changes in the brain before birth, during early childhood, and later in life. The study analyzed DNA and RNA data from 176 tissue samples across various developmental stages, revealing age-specific effects of genetic variants on brain function.
Researchers find that warmer, more humid environments can slow viral transmission through airborne particles. The ideal relative humidity for indoor environments is between 40-60%. Maintaining moderate humidity levels could be an ally in slowing rates of viral transmission.
Yale researchers identified a critical molecule in prefrontal cortex circuits that enables working memory. Activating this receptor may offer potential treatments for neurocognitive disorders like schizophrenia and Alzheimer's disease.
A Yale University study found that robots expressing vulnerability improve human-to-human communication, leading to more positive group experiences. Humans on teams with vulnerable robots spent twice as much time talking to each other and reported enjoying the experience more.
Researchers at Yale University found that mice exposed to stress in the womb and after birth experience lifelong immune system deficiencies, making them more susceptible to bacterial infections and tumors. Early-life exposure to glucocorticoids permanently alters immune responses, rewiring the body to respond differently.
Yale scientists have discovered the molecular mechanisms that trigger metabolic imbalance between glucose production and energy utilization in the liver. They found that a protein called INSP3R1 regulates both gluconeogenesis and fat oxidation in response to glucagon, providing new insights into glucagon biology.
A new study from Yale University reveals that third-hand smoke can travel into indoor spaces through human contact, exposing non-smokers to hazardous chemicals. The research found that even in well-ventilated areas like movie theaters, people can carry and release third-hand smoke contaminants, posing health risks.
A new Yale study suggests that consuming low-calorie sweeteners with carbohydrates impairs metabolism. The research challenges the 'uncoupling hypothesis' and instead finds that sucralose can cause problematic metabolic responses when paired with carbs.
A Yale-led team of researchers discovered that the transverse arch in the human foot, not previously studied, is responsible for nearly half of the foot's stiffness. This finding challenges conventional thinking about the human foot's structure and evolution.
Researchers at Yale University found a unique brain signature associated with pro-social and anti-social decisions in monkeys. Monkeys prefer to drink alone when faced with the option of sharing fruit juice with another monkey.
A massive genome analysis identified 179 genes and regulators as cancer 'drivers', but found that thousands of non-driver mutations, or 'passengers', can also contribute to cancer development and have a significant impact on genomic regions. These findings suggest that passenger variants can both hinder and promote tumor growth.
Researchers at Yale Cancer Center discovered that a small amount of the PD-L1 biomarker can predict long-term survival benefits from using pembrolizumab in patients with advanced lung cancer. The study found that overall survival was about 99% one year after discontinuing treatment, and ranged from 23% to 35% three years after treatment.
A multi-institution study finds that level of education is best predictor of life expectancy, outshining racial factors. Higher education levels resulted in 1.37 fewer years of lost life expectancy, suggesting improved access to education could reverse declining life expectancy trends.
A new study by Yale researchers found that a brief introduction to mindfulness concepts can significantly reduce physical pain and negative emotions in people. The study's results showed that even when participants were subjected to high heat on their forearm, their brain responded as if it was experiencing normal temperature.
Researchers have found that a component of the Ebola virus can selectively target and kill glioblastoma brain tumors, providing a potential new approach to treating this deadly form of cancer. The Ebola glycoprotein MLD helps protect normal cells from infection while allowing cancer cells to be targeted by the immune system.
Geneticist Bonnie Bassler received the $500,000 Gruber Genetics Prize for her pioneering research on quorum sensing, a process by which bacteria communicate using molecular languages. Her discoveries have expanded our understanding of the microbial world and opened up new approaches to promoting health and preventing disease.
A team of Yale researchers has discovered a way to reverse type-2 diabetes and liver fibrosis in mice, highlighting the potential for targeting TET3 protein. The studies, published in Cell Reports and Nature Communications, also suggest that TET3 plays a role in fibrosis development and may be a key target for treatment.
Research suggests that a ketogenic diet provides health benefits in short-term, but negative effects occur after about a week. The keto diet works best in small doses, increasing tissue-protective cells called gamma delta T-cells, which lower diabetes risk and inflammation.
A new study by Yale sociologist Emma Zang found that China's 2011 judicial interpretation on property rights during divorce initially harmed women's wellbeing, but couples adapted over time to share property equally. Despite adaptations, the change has lingering costs, including increased housework for women and loss of property rights.
A recent Yale study found that people who recently used psychedelics report sustained improvements in mood and feelings of social connectedness. The study, which surveyed over 1,200 festival attendees, confirms previous laboratory research indicating psychedelic substances enhance mental well-being.
A Yale-led team of researchers argue that asteroid impacts, not volcanoes, were the primary cause of the mass extinction event that killed the dinosaurs. The study's findings contradict recent work on the Deccan Traps, massive eruptions in India that occurred around the time of the K-Pg extinction event.
Scientists have found a novel method to combat glioblastoma, a deadly brain tumor, by introducing VEGF-C into the cerebrospinal fluid of mice. This approach significantly extended survival rates when combined with immune system checkpoint inhibitors, offering new hope for treatment options.
A systematic review of 422 studies found evidence of adverse effects of ageism on mental and physical health conditions, including depression and shorter life expectancy. Ageism also affects access to healthcare treatment, with denied care found in 85% of relevant studies.
A Yale-led team found that parental monitoring and teen awareness of their parents' attitudes on alcohol use can have life-saving effects. The study showed that teens who knew their parents disapproved of drinking were less likely to drive while impaired four years later.
Astronomers have pinpointed an early galactic merger that helped shape the Milky Way, occurring 11.5 billion years ago when Gaia-Enceladus slammed into what then existed of the galaxy. This discovery provides important insights into the accretion process that formed the Milky Way.