Yale researchers identify O-GlcNAc transferase enzyme as key regulator of fat droplet doorman, which controls cellular access for nutrients and lipids. Mice lacking the enzyme exhibit reduced fat cell size and improved lipid burning, while overexpression triggers obesity by increasing carbohydrate intake.
A new study suggests that state-mandated notifications on mammogram reports intended to inform women of the health risks related to breast density are not worded effectively, particularly for those with lower education levels.
Scientists found that nerve cells release infection-fighting cytokines to combat bacterial invaders, rather than immune cells. This discovery provides new insights into the body's response to food poisoning and other illnesses.
A Yale University study has identified six genetic variants linked to anxiety in approximately 200,000 military veterans. The research provides the first convincing molecular explanation for the coexistence of anxiety and depression, suggesting shared genetic risks.
A Yale study found that treating at least 20% of people with opioid use disorder who inject drugs in Ukraine could prevent over 10,000 new HIV infections and nearly 18,000 deaths. The current rate is only 2.7%, highlighting the need for expanded access to evidence-based treatment like methadone and buprenorphine.
Researchers at Yale University found that cancer-causing gene mutations can cause rapid cell division, leading to malignant cancer traits. In one form of blood cancer, normal cells with these mutations can remain healthy unless they divide quickly, suggesting a new mechanism for cancer development.
Researchers found that out-of-network billing at in-network hospitals occurs in about 10% of cases involving anesthesiologists, pathologists, radiologists, and assistant surgeons. This practice can lead to unexpected and expensive medical bills for patients with private health insurance.
Researchers found that a molecularly similar regulator to PD-1, PD-1H, can cause immune system attacks in lupus patients. This discovery suggests novel ways to restore function and provide new therapy for the disease.
Researchers at Yale University discovered that safety signals, such as symbols or sounds not associated with danger, can relieve anxiety. This approach differs from behavioral therapy and may be an effective way to augment current therapies for anxiety-related disorders.
Researchers at Yale University unveil a new approach to reconstructing the evolutionary tree of life for mammals, revealing why some branches are weighed down with thousands of species while others hold just a few. The study provides comprehensive information about species diversity and relationships, past and present.
A Yale University analysis found that online grocery delivery systems cover 90% of food deserts, increasing access to nutritious food for low-income communities. The study suggests that online shopping can reduce obesity and improve health outcomes by providing essential nutrients and promoting better eating habits.
A Yale-led group developed a new mathematical model to predict acute kidney injury (AKI) risk in patients undergoing percutaneous coronary intervention. The model accounts for individual differences and complex associations between contrast levels and AKI risk, providing more accurate estimates.
A new Yale study found a clear association between neurohormonal blockade therapy and increased survival and quality of life for patients with left ventricular assist devices. The study, which analyzed over 12,000 patients, showed a 56% survival rate for those taking NHB therapy compared to 43.9% for those not on the medications.
A new study from Yale University finds that a ketogenic diet can enhance the body's natural response to influenza by activating gamma delta T cells, which produce mucus in lung cell linings. The research suggests that the way the body burns fat may fuel the immune system's ability to fight flu infection.
A study by Yale researchers has found that adipose B cells in belly fat unexpectedly proliferate with aging, contributing to increased inflammation and metabolic decline. The expansion can be reversed by reducing macrophage signals and removing adipose B cells.
Researchers identified gene expression changes specific to early, progressive and end-stage fibrosis, as well as distinct molecular regulators for each stage. The study provides the first computational model of disease progression in IPF lung, accompanied by an interactive website.
A new study by Yale researchers found that physicians rate EHR systems poorly, with an average score of 45, leading to increased frustration and burnout. The study suggests that the steep learning curve and lack of intuitive design contribute to this outcome, affecting specialties such as dermatology and general surgery.
A Yale professor and his team discovered an abrupt 60-year megadrought that led to the collapse of the Neo-Assyrian Empire. The drought weakened the empire's agricultural base, allowing neighboring forces like the Babylonians to conquer Nineveh in three months.
Yale researchers have discovered hyperhotspots in the human genome that are up to 170-times more sensitive to ultraviolet radiation, potentially leading to a new way of predicting skin cancer risk. By analyzing these hyperhotspots, doctors could gain a better understanding of a patient's exposure history and skin cancer risk.
A Yale-coauthored paper in Lancet analyzed data from 4.9 million patients to compare the safety and effectiveness of five classes of first-line hypertension medications. Thiazide or thiazide-like diuretics were found to be better at preventing heart attack, heart failure, and stroke than ACE inhibitors.
Researchers have identified glial and vascular cells as contributing to the development of age-related macular degeneration, a leading cause of blindness in the elderly. The study provides new insights into the disease, highlighting potential targets for novel therapies.
A study by Yale University found that sentinel lymph node biopsies do not reduce the risk of death from breast cancer or decrease invasive cancer development in women with ductal carcinoma in situ (DCIS), a non-invasive breast cancer. The procedure also increases the risk of pain, wound infection, and lymphedema.
Researchers discovered a two-atom catalyst that enables efficient oxygen production from water under low-light conditions. The study's findings mimic the activation of photosystem II during photosynthesis, suggesting that similar two-atom catalytic cores might be suitable for achieving efficient water splitting.
A Yale study reveals that hiring managers judge candidates' competence and fitness for a job based on socioeconomic position inferred from brief speech patterns. The study shows that these snap perceptions influence hiring decisions in ways that perpetuate inequality.
A Yale University study reveals that the Cretaceous-Paleogene extinction event was triggered by a sharp drop in ocean acidity, leading to the demise of marine calcifiers and a 50% decline in species productivity. The research provides new insights into the recovery of marine life after the event.
A new system developed by Yale scientists uses viral gene therapy and CRISPR gene-editing technology to make cancer cells stand out from the crowd, helping the immune system spot and eliminate tumors that other forms of immunotherapies might miss.
A Yale-developed drug stimulates immune cells to shrink or kill tumors in mice, with lasting effects and broad immune response. The therapy is effective alone or in combination with existing cancer immunotherapies, and has shown synergistic effects when combined.
A Yale-led study found that total fertility rates (TFRs) increased across all educational groups in Generation X women, with the greatest increase seen in college-educated women. College-educated women tend to have a three-child norm, driven by a larger proportion of those with two children having a third child.
Researchers at Yale University are developing new materials that can mimic neurons, compute with magnets, and calculate using quantum mechanics. The team used a precision measurement technique to create artificial crystals composed of elements from the periodic table.
A Yale study finds that rural residents face long drive times to obtain methadone, a treatment for opioid addiction, compared to urban counties. Methadone can be prescribed at Federally Qualified Health Centers (FQHCs), potentially reducing drive times.
A new Yale University study reveals that supermassive black holes grow in tandem with their host galaxies, influenced by the rate of star formation. The research provides a sharper understanding of the intricate relationship between these cosmic entities.
A study conducted in New Haven found that community-oriented policing improves attitudes toward police with brief, friendly door-to-door visits. The research showed that a single positive nonenforcement-related encounter enhanced the legitimacy of police officers and increased people's willingness to cooperate with the police.
Researchers found that as the Indian Ocean warms, it generates additional precipitation, drawing air from other parts of the world to dilute its salinity. This results in saltier water in the Atlantic Ocean, which accelerates its circulation, providing a potential 'jump-start' for the AMOC.
Researchers at Yale University have discovered that a woman's bone marrow plays a crucial role in determining her ability to start and sustain a pregnancy. Bone marrow-derived stem cells travel to the uterus, where they help transform the uterine lining for implantation, essential for embryo implantation and pregnancy maintenance.
A new study suggests that opioid treatment medications can increase the number of teens who remain in treatment and decrease their opioid use. Medications like methadone, buprenorphine, and naltrexone have shown promise in treating severe opioid use disorder in adolescents.
Researchers at Yale Cancer Center have identified a key metabolic pathway that enables cancer cells to adapt to their microenvironment and respond to nutrient availability. The study suggests that targeting this pathway with drugs may help treat various forms of cancer by preventing cancer cells from growing in nutrient-rich environments.
A recent Yale study found that high-fat diets stimulate hypothalamic inflammation, leading to changes in microglial cells and regulating energy homeostasis. The research suggests a neurological mechanism controlling food intake, with potential implications for obesity and diseases like Alzheimer's.
A Yale-led study reveals that transforming growth factor beta (TGFß) proteins trigger inflammation in endothelial cells, leading to plaque buildup and atherosclerosis. Disrupting TGFβ receptors with RNAi drug reduces inflammation and plaque effectively.
Researchers detected a large unreported Zika outbreak in Cuba during 2017, using virus genomics and travel patterns to identify the outbreak. The study suggests that effective mosquito control campaigns can delay outbreaks, emphasizing the need for alternative detection methods when local case reporting is limited.
A Yale study has trained adolescents with Tourette Syndrome to control their tics through real-time fMRI, achieving significant symptom reductions. The technique, called rt-fMRI-NF, involves monitoring brain activity in real time and adjusting it towards healthier patterns.
A new study predicts that an additional dose of rotavirus vaccine at nine months old will provide a modest 5-16% reduction in RVGE incidence over the first three years. The study found that lower vaccine effectiveness during the second year of life is not necessarily due to waning immunity, but rather due to high rates of rotavirus tra...
A Yale-led team of astronomers has simulated a large patch of the intergalactic medium (IGM), revealing how cold, dense gas clouds organize themselves within larger sheets or pancakes of matter. The findings suggest that these gas clouds can be pristine and metal-free, challenging previous assumptions about their formation and composit...
A new study shows that average Americans can evaluate mathematical arguments for beauty, using criteria such as elegance and universality. The research found that people share the same aesthetic sensibilities about math as they do about art and music, with consensus on what makes something beautiful.
Researchers at Yale University have developed a promising combination immune therapy to dramatically reduce the recurrence of genital herpes. The prime-and-pull strategy involves a vaccine and medicated cream that work together to block the virus from spreading.
A new Yale University study reveals that banning tobacco sales to people under age 21 significantly reduces smoking rates among 18- to 20-year-olds. The study found a 10% drop in smoking among these age group when local tobacco-21 laws are implemented, with effects expected to be even greater at the state level.
A recent study by Yale researchers has identified middle-aged adults as a vulnerable population to serious falls due to medication use. Polypharmacy and the simultaneous use of benzodiazepines, muscle relaxants, and prescription opioids increase fall risk.
A Yale-developed scorecard has been found to promote better clinical trial data sharing among pharmaceutical companies, with 33% of companies meeting standards after being given the opportunity to improve their practices. The scorecard assesses companies' data-sharing practices and provides a ranking system to encourage transparency.
Researchers found three distinct brain circuits involved in making good and bad decisions, with the third circuit storing memories of past choices. The study may help explain addiction and inform novel treatments for substance abuse.
A recent study published in JAMA Internal Medicine found that the use of 3D mammography has risen substantially in the US, with DBT being more rapidly adopted in areas with higher incomes, greater education, and larger white populations. However, disparities in care persist, reflecting uneven adoption across regions and demographics.
A Yale-led study reveals the mechanisms by which leptin increases appetite in response to low energy levels. The research found that reductions in plasma leptin concentrations stimulate food intake through a chain of events involving the brain, endocrine system, and AgRP neurons.