Articles tagged with Antidepressants
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A new study from King's College London found that a common antidepressant does not improve breathlessness in patients with respiratory disease and may cause side effects. The researchers call for further research into potential therapies for severe breathlessness and recommend using non-pharmacological approaches to treat the symptom.
A cross-sectional study of commercially insured patients suggests that there may be meaningful heterogeneous associations between cannabis policy and state-level outcomes, as well as between cannabis policy and drug class, with implications for patient substance use and mental health outcomes.
The September issues of APA journals focus on depression risk factors and treatments, as well as noninvasive brain stimulation therapies. The American Journal of Psychiatry explores the promise of these therapies in treating depression.
A study found that ketamine clinics have inconsistent policies on pregnancy-related safeguards, including inadequate warning systems and contraception prescription. This is concerning given the potential harm of ketamine to developing fetuses.
A new study explores how older adults in a South Florida retirement community coped with the pandemic, finding they grew stronger and more resilient. Participants discovered new interests, deepened relationships, and used technology to adapt, leading to increased confidence and life appreciation.
A disproportionality analysis of World Health Organization data revealed a signal of semaglutide-associated suicidal ideation, particularly among patients with co-reported antidepressant use. This finding warrants urgent clarification and highlights the need for further research on the safety profile of semaglutide.
A new study found that Cannabigerol (CBG) significantly reduced feelings of anxiety at 20, 45 and 60 minutes after ingestion, with stress ratings also decreasing. CBG's effect on memory was unexpectedly positive, enhancing the ability to recall lists of words.
The use of mood-altering drugs among children and young people is rising steadily, with a tendency to prescribe them for longer periods. Experts emphasize the need for better understanding of psychotropic medications' risks and safe doses in different age groups.
A nationwide study found a marked increase in new GLP-1RA prescriptions for obesity, particularly since 2020. Semaglutide was the most prescribed GLP-1RA, but prescriptions among those with obesity without type 2 diabetes spiked, worsening existing racial and ethnic disparities.
The college will develop a Knowledge-enhanced Antidepressant Recommendation Dialogue System (KARDS) to engage users in a conversation to identify the appropriate antidepressant medication. The AI chatbot aims to address medication needs of Black and African Americans with depression, a gap in current management.
A new American Heart Association scientific statement highlights the benefits of palliative care in managing symptoms and improving quality of life for people with cardiovascular disease. Palliative care complements standard cardiovascular care by reducing physical symptoms, emotional distress, and assisting patients in making decision...
A study of over 183,000 adults found that certain antidepressants can cause significant weight gain or loss, while others have little to no effect. Bupropion was consistently associated with the least weight gain among 8 first-line antidepressants, which may impact medication adherence and patient treatment decisions.
Researchers have discovered that the Z-isomer of doxepin has a higher affinity for the H1 receptor, which could lead to the development of more effective antihistamines. The study also sheds light on how the binding environment enhances selectivity for the Z-isomer.
A new study found that bupropion is associated with the least amount of weight gain among common antidepressant medications, with users being 15-20% less likely to gain clinically significant weight. The research also highlights the varying weight gain effects of different antidepressants.
A recent study published in JAMA Network Open reveals that nearly half of long-term antidepressant users can successfully taper off their medication with the help of general practitioner support and internet or telephone helplines. The study found lower rates of depression, fewer withdrawal symptoms, and improved mental wellbeing among...
A University of Otago-led trial found that extended-release ketamine tablets significantly improved depressive symptoms in adults with treatment-resistant depression. The tablets showed good tolerability and minimal side effects compared to traditional injection or nasal spray methods.
A new ketamine tablet form has shown promise in treating severe depression with negligible side effects and convenience. The study found that patients on the strongest dose of ketamine had the best results compared to placebo.
A new study reveals that depression and antidepressant use are associated with an increased risk of all-cause mortality in postmenopausal women. Epigenetic age acceleration, measured by GrimAge DNA methylation age acceleration, partially mediates the relationship between antidepressant use and increased mortality risk.
Antidepressants, such as SSRIs and SNRIs, work by restoring connections between brain regions, rather than correcting a chemical imbalance. The framework highlights the importance of these medications in alleviating depressive episodes, even if MDD isn't caused by a lack of serotonin.
A systematic review and meta-analysis of over 20,000 patients found that one in six to seven patients will experience discontinuation symptoms directly caused by stopping the medication. Severe symptoms occurred in about 3% of patients, with certain antidepressants increasing the risk.
A systematic review and meta-analysis found that one in three people reports symptoms after discontinuing antidepressant treatment. The nocebo effect, where negative expectations contribute to symptoms, is estimated to be responsible for half of these effects.
A new study found that almost two-thirds of prescribed tricyclic antidepressants were above the safe dosage threshold, with Black patients more likely to receive these high-dose medications. The research highlights the need for routine evaluation of drug efficacy in clinical care environments.
Researchers at George Mason University used artificial intelligence to analyze data from over 3.6 million patients and create personalized antidepressant recommendations. The free website MeAgainMeds.com provides evidence-based guidance for clinicians and patients, enabling faster symptom relief and reduced medication trial time.
Researchers from the University of South Australia have developed a new coating that targets the gut microbiome to improve antipsychotic medication absorption, mitigating unwanted weight gain. The reformulated Lurasidone reduces weight gain by 8-fold and boosts serotonin levels by over 250%.
The study reveals that noradrenaline transporter forms a homodimer mediated by cholesterol and lipids, regulating substrate binding. Six different antidepressants bind to NET with overlapping but distinct modes, conferring subtype selectivity.
New research emphasizes the importance of integrated care for children with epilepsy and co-occurring psychiatric conditions. The study reveals that fragmented care can lead to negative outcomes, including disjointed treatment plans and inadequate seizure control.
A new study from the University of Toronto found that adults with higher depression symptoms are less likely to engage in physical activity, while being more active is linked to better mental health. The research suggests that current physical activity can have a lasting impact on future depression symptoms and vice versa.
A head-mounted device generating an ultra-low frequency magnetic field has improved symptoms of four male patients with major depressive disorder. The study suggests that future trials may offer a safe and non-invasive way to treat depression.
Researchers developed a new method for nose-to-brain drug delivery using HS15 micelles to target insoluble drugs. The study found that the micelles provided higher and more sustained brain distribution, with rapid entry into the brain region after intranasal administration.
A study published in The Lancet Gastroenterology & Hepatology found that dietary adjustments, such as a low FODMAP diet and low-carbohydrate diets, resulted in significantly reduced IBS symptoms for over seven out of ten patients. In contrast, medication-based treatment showed fewer symptom improvements.
A study found that social stress during adolescence in female mice leads to prolonged cortisol elevation after giving birth, similar to women exposed to adverse early life experiences. The researchers suggest alternative treatments may be more effective for postpartum depression.
A study analyzing 8,384 clinical appointments found that women aged 45 are the majority of patients treated at public psychiatric outpatient clinics in Brazil. The patients had sadness, anxiety, and irritability as primary symptoms, with selective serotonin reuptake inhibitors being commonly prescribed medications.
A new study identifies multiple emotion regulation systems in the human brain, providing targets for therapy. The research reveals that regions in the anterior prefrontal cortex and higher-level cortical hierarchies are involved in emotion regulation.
A trio of studies show increased diagnosis and treatment of anxiety, depression, and PTSD in pregnant and new mothers with private insurance, but disparities persist. The findings suggest that policy changes and increased awareness have contributed to the rise in diagnoses and treatments.
Research highlights treating anxiety and depression in people with heart disease can significantly reduce emergency room visits, hospitalizations, and even death. The study found that talk therapy and antidepressant medications improved heart outcomes among those with blocked arteries or heart failure.
A study of 104 patients found that 83.5% had divergent phenotypes, with a significant increase in CYP2D6 poor metabolizers due to phenoconversion. The results highlight the importance of pharmacogenetic testing and personalized treatment approaches in psychiatric care.
The latest American Psychiatric Association journals feature new treatments across the lifespan for anxiety, depression, and substance use disorder. The March issue of The American Journal of Psychiatry highlights several studies with these findings.
Researchers discovered that ketamine's sustained effects involve increasing immature cells' activity, while rapid effects rely on newborn neurons firing more rapidly. This breakthrough opens doors to developing new antidepressant treatments.
A new study found that antidepressant dispensing to adolescents and young adults increased sharply after March 2020, particularly among females, indicating a worsening mental health crisis. The rate rose nearly 64% faster, with females experiencing a 130% increase in dispensing rates.
Researchers at Flinders University uncovered a major breakthrough in understanding the gut-brain axis, revealing that serotonin released from gut cells must communicate via diffusion to activate sensory nerve endings. This discovery has profound implications for drug development and treatments of mental health and digestive problems.
Researchers from Osaka University found that (R)-ketamine can improve social impairments in mice with depression by restoring neuronal activity in the anterior insular cortex. The study suggests that (R)-ketamine may be a more effective treatment for social cognition than its counterpart (S)-ketamine.
A new study of 488,000 Finnish mothers found that those with healthy, near-by grandparents were less likely to take antidepressants. In contrast, antidepressant use was highest among mothers whose grandparents were elderly and lived far away due to stress from caring for them.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
Researchers developed an AI algorithm to analyze brain scans and clinical data, predicting treatment response with 8-week accuracy.
A large long-term study found that women's antidepressant use increases after later life divorce or break-up, with a significant increase in the 4 years leading up to the event. Women's use tends to tail off only slightly and briefly after re-partnering, while men's use returns to pre-break-up levels within a year.
A preliminary study found that most stroke survivors can safely take two common types of antidepressants without increasing the risk of hemorrhagic stroke. However, patients on dual anti-platelet therapy may be at increased risk of bleeding.
A study of 215 veterans found that nearly half experienced significant depression score drops, while about one quarter saw a halving of their scores. About 15% achieved full remission after six weeks of ketamine infusions, suggesting the treatment can provide substantial relief for those with complex mental health needs.
A survey of 2,800 Canadians found that nearly 80% believe psilocybin-assisted therapy is a reasonable medical choice to treat existential distress in patients at the end of life. Researchers suggest that familiarity with palliative care and personal experience with psilocybin may contribute to higher support rates.
A comparative effectiveness trial found that behavioral activation psychotherapy and antidepressant medication management significantly reduced depressive symptoms in patients with heart failure. Psychotherapy recipients experienced better physical health-related quality of life and fewer hospital visits.
New research suggests people can experience emotional and social difficulties, as well as changes in their thinking patterns, when stopping antidepressants like Prozac. This is especially true for sudden stops or inadequate supervision by a doctor.
New research found that rapid-acting antidepressants modulate affective biases associated with learning and memory. The study proposes a neuropsychological mechanism explaining both immediate and sustained effects of these drugs.
The latest issues of APA journals focus on improving clinical outcomes, exploring disparities in school-based support, and addressing civil commitment hearings. These studies aim to inform new interventions and improve mental health care.
Brazilian researchers developed a 3D zinc oxide photocatalyst that efficiently degrades sertraline, an emerging pollutant contaminating groundwater. The material's high photocatalytic activity and stability make it suitable for wastewater treatment.
A recent review of opioid medicines for cancer pain found surprisingly large gaps in evidence regarding their true benefits. Non-steroidal anti-inflammatory drugs (NSAIDs) may be at least as effective as some opioids for background cancer pain, offering potential alternatives to reduce dependence and waning analgesia over time.
A small molecule called YM022 has been discovered to block aversive memory formation in mice, offering a new direction for developing anti-depressants. The study found that YM022 suppressed neuroplasticity-caused aversive memory formation and reduced depressive behaviors in mice.
A new study suggests that genetic testing for depression could lead to significant cost savings and improved patient outcomes. The test, known as pharmacogenomic testing, can help match patients with medications that are more likely to be effective and cause fewer side effects.
Researchers have identified a gene called LHPP that interacts with stress to mediate aspects of treatment-resistant MDD in an animal model. Increased expression of LHPP aggravated depression-like behaviors by dephosphorylating two protein kinases, CaMKIIα and ERK.
Acute sleep loss in mice increases dopamine release and enhances synaptic plasticity, leading to a rapid reversal of depression for several days. The prefrontal cortex plays a crucial role in this process, with neurons forming tiny protrusions that change in response to brain activity.
A study by Brigham and Women's Hospital researchers found no correlation between anxiety and depression in men on fertility treatment, nor was there a negative impact from antidepressant medication. Despite stress concerns, the study suggests men with anxiety should continue their treatment without fear of harming IVF outcomes.
Scientists identified two genes, ADRA2A and IRX1, that predispose individuals to Raynaud's phenomenon. The genes affect the body's ability to regulate blood vessel constriction, leading to white fingers and toes in response to cold or stress. The study provides new insights into the disease and potential treatment options, including th...