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How effective are opioid medications for cancer pain?

A recent review of opioid medicines for cancer pain found surprisingly large gaps in evidence regarding their true benefits. Non-steroidal anti-inflammatory drugs (NSAIDs) may be at least as effective as some opioids for background cancer pain, offering potential alternatives to reduce dependence and waning analgesia over time.

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

New clues to the mechanism behind treatment-resistant depression

Researchers have identified a gene called LHPP that interacts with stress to mediate aspects of treatment-resistant MDD in an animal model. Increased expression of LHPP aggravated depression-like behaviors by dephosphorylating two protein kinases, CaMKIIα and ERK.

SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

One sleepless night can rapidly reverse depression for several days

Acute sleep loss in mice increases dopamine release and enhances synaptic plasticity, leading to a rapid reversal of depression for several days. The prefrontal cortex plays a crucial role in this process, with neurons forming tiny protrusions that change in response to brain activity.

Study finds men's antidepressant use did not negatively impact IVF success

A study by Brigham and Women's Hospital researchers found no correlation between anxiety and depression in men on fertility treatment, nor was there a negative impact from antidepressant medication. Despite stress concerns, the study suggests men with anxiety should continue their treatment without fear of harming IVF outcomes.

First genetic causes of Raynaud’s phenomenon discovered

Scientists identified two genes, ADRA2A and IRX1, that predispose individuals to Raynaud's phenomenon. The genes affect the body's ability to regulate blood vessel constriction, leading to white fingers and toes in response to cold or stress. The study provides new insights into the disease and potential treatment options, including th...

Apple iPad Pro 11-inch (M4)

Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.

Amitriptyline helps relieve IBS symptoms

The ATLANTIS trial found that amitriptyline significantly improved IBS symptoms, with participants taking the medication reporting a bigger improvement in symptom scores after six months. The medication was well-tolerated and showed no significant impact on anxiety or depression scores.

Is this how antidepressants work, and why they take weeks to kick-in?

Researchers found that antidepressant escitalopram increases synaptic density in the brain over weeks, leading to greater brain plasticity. This explains why effects of antidepressants take time to kick-in, with significant differences in synapse density between treatment and placebo groups.

Davis Instruments Vantage Pro2 Weather Station

Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.

Esketamine nasal spray effective against depression

A Phase IIIb study published in the New England Journal of Medicine found that esketamine nasal spray achieved higher remission rates (27.1%) compared to quetiapine extended-release (17.6%) in patients with treatment-resistant depression, indicating its potential as a targeted therapy for this population.

Sky & Telescope Pocket Sky Atlas, 2nd Edition

Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.

Obesity particularly hard on people with bipolar disorders

A study by the University of Gothenburg reveals that obesity significantly worsens life expectancy and mortality risks in individuals with bipolar disorders. The findings show a rapid increase in BMI among those with bipolar disorders, leading to a higher risk of premature death and comorbidity.

Nikon Monarch 5 8x42 Binoculars

Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.

People who are in good shape take fewer mental-health related medication

Research based on the Trøndelag Health Study found that people in good physical shape fill fewer prescriptions for anxiety and depression medications. The study suggests that improving physical fitness can help prevent anxiety and depression, with men experiencing greater benefits from exercise than women.

AmScope B120C-5M Compound Microscope

AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.

Biomarkers may hold key to precision mental health diagnosis, care

A Lehigh University professor has received $4 million in NIH grants to develop an AI-driven approach for precision mental health diagnosis and care. The project aims to identify biomarkers in the brain that can predict treatment response and personalize interventions for patients with depression and other mental disorders.

Study deciphers the biosynthetic pathway of the antidepressant orcinol glucoside from the plant Curculigo orchioides and engineers the production of orcinol glucoside in the biotech-friendly yeast Yarrowia lipolytica, with yields over 6,400-fold higher th

Researchers have deciphered the biosynthetic pathway of orcinol glucoside from Curculigo orchioides and successfully engineered its production in Yarrowia lipolytica. The resulting yields are significantly higher, exceeding 6,400-fold that of natural plant extraction.

Fluke 87V Industrial Digital Multimeter

Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.

Meta Quest 3 512GB

Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.

Happy worms have healthy eggs

A new study found that selective serotonin reuptake inhibitors (SSRIs) improved the quality of aging females' egg cells in roundworms by reducing embryonic death and chromosomal abnormalities. Replication in fruit flies confirmed the findings, suggesting a shared signaling system between species.

Study explains how antidepressant increases brain plasticity

A recent study found that antidepressant fluoxetine facilitates the erasure of learned fear responses and enhances spatial learning in mice. The TrkB receptor in Parvalbumin interneurons is primarily responsible for this increased plasticity, suggesting a new target for treating psychiatric diseases.

Rigol DP832 Triple-Output Bench Power Supply

Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.

A closer look at Matcha tea powder’s antidepressant-like effects

Researchers found that Matcha tea powder reduces depression in mice by activating dopaminergic neural circuits and improving mood. The study's results suggest that Matcha's antidepressant-like effects depend on the animal's prior mental state, with stress-susceptible mice showing a significant response.

Robust billing and coding system needed for psychedelic therapies

A new article proposes a de novo billing code approach to address psychedelic therapy reimbursement concerns. Research using adult female rats suggests that psilocybin produces long-lasting normalization of pattern separation and forced swim test activities, indicating potential therapeutic benefits.

DJI Air 3 (RC-N2)

DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.

Antidepressants use for chronic pain on the rise, but are they effective?

A comprehensive review of antidepressant use in chronic pain found that some classes were effective in treating certain conditions, while others showed unclear or unknown benefits. Serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine demonstrated efficacy for various pain conditions.

Antidepressants used for chronic pain on the rise, but are they effective?

Researchers found that some antidepressant classes were effective in treating specific pain conditions, while others showed no benefits or unknown effects. The review of 26 systematic reviews involving over 25,000 participants suggests a more nuanced approach to prescribing antidepressants for chronic pain management is needed.

Most antidepressants ineffective for common pain conditions

Researchers found that while some antidepressants are effective for certain pain conditions, most are either ineffective or the evidence is inconclusive. A more nuanced approach is needed when prescribing antidepressants for pain, say experts.

Do sleep medications increase your chances of dementia?

A new study found that sleep medications increase the risk of dementia in white adults. However, the relationship between sleep medications and dementia risk varies by medication type and socio-economic status. The study suggests that patients with poor sleep should consider alternative solutions before taking medications.

Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)

Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.

Blood pressure drug holds promise for treating PTSD

Researchers found that clonidine, a common blood pressure medication, can reduce the consolidation of traumatic memories in PTSD patients. By interacting with the adrenergic receptor axis, clonidine interferes with cofilin's ability to form mushroom-shaped dendritic spines, which are essential for memory formation. This suggests that c...

GoPro HERO13 Black

GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.

New support for a serotonin deficit in depression

Researchers found reduced serotonin release capacity in individuals with depression, suggesting a blunted serotonin system. The study used novel imaging techniques to measure serotonin levels in the brain, providing crucial insights into the pathology of depression.

Patients with treatment resistant depression at higher risk of death

A new study published in JAMA Psychiatry finds that patients with treatment-resistant depression have a 23% higher risk of death, as well as significantly more outpatient care and hospitalization days. The researchers emphasize the importance of identifying patients at risk of developing treatment-resistant depression to improve their ...

Creality K1 Max 3D Printer

Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.

Study gives peek of how ketamine acts as ‘switch’ in the brain

A new study reveals ketamine dramatically changes neuronal activity patterns in the cerebral cortex, turning off active neurons and turning on silent ones. This switch in brain activity may impact our understanding of ketamine's antidepressant effects and future research in neuropsychiatry.

Treating mood disorders with psychoactive drugs

Researchers are investigating the antidepressant and anxiolytic properties of psilocybin and cannabis to improve treatment options for mental illnesses. The findings suggest that these compounds may offer new avenues for symptom relief in a range of mental health conditions.

How pregnancy changes the parental brain

New research reveals profound effects of pregnancy on maternal brain physiology, mood, and behavior. Maternal mental health conditions like depression and anxiety affect 20% of new mothers in the US, with untreated cases having long-term negative impacts.

Kestrel 3000 Pocket Weather Meter

Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.

Promising results from psilocybin trial for treatment-resistant depression

Researchers conducted the largest clinical trial to date of psilocybin, finding a statistically significant rapid reduction in symptoms of depression. The study suggests that COMP360 psilocybin with psychological support could be an effective treatment strategy for people with treatment-resistant depression.

Apple AirPods Pro (2nd Generation, USB-C)

Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.

Electroshock therapy more successful for depression than ketamine

A meta-analysis of six studies concludes that electroconvulsive therapy (ECT) is more effective than ketamine in quickly relieving major depression symptoms. The analysis, published in JAMA Psychiatry, found no significant differences in ECT's success rate across various age groups and geographic locations.

New insights into lithium’s effectiveness for bipolar disorder

A recent study identifies a specific gene, GNL3, that regulates neural proliferation in response to lithium, which is used to treat bipolar disorder. This gene plays an important role in brain function and has been implicated in risk for bipolar disorder, schizophrenia, and inter-individual variations in intelligence.