Articles tagged with Chemotherapy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Oregon Health & Science University have found that treatment with sodium thiosulfate significantly reduces hearing loss in brain tumor patients receiving carboplatin chemotherapy. This breakthrough could help combat the hearing loss associated with platinum-based chemotherapy treatment for other types of cancer.
A synthetic detergent, nonylphenolethoxylate (NPE), commonly used in household cleansers, has been discovered to block a drug pump in cancer cells, reducing the need for chemotherapy drugs. The researchers found NPE present in human urine and suggest it could be a useful adjunct to standard treatments.
BioNumerik's novel chemoprotecting agent BNP7787 appears to completely protect against major toxicities associated with widely used platinum anticancer drugs. The company's Karenitecins demonstrate potent oral antitumor activity and bypass common drug resistance mechanisms.
Duke researchers have identified a lung condition in breast cancer patients that can limit therapy choices if not treated promptly. The disorder, DPTS, is successfully treated with inexpensive corticosteroids, improving pulmonary function by 17%.
Researchers at St. Jude Children's Research Hospital are developing new brain tumor treatment protocols that use 3D imaging to accurately target tumors, reducing radiation doses and side effects. The protocols involve combining lower-dose radiation with chemotherapy to increase survival rates and minimize long-term damage.
The MiCK assay measures how light scatters off of leukemia cells to determine the effectiveness of drugs being used to attack the cells. This technique allows for more accurate identification of which drugs will be most effective for each patient, revolutionizing leukemia therapy.
Researchers developed a synthetic human hormone that triples platelets received from each donor, improving recovery of platelets in patients undergoing chemotherapy. An increased supply would give physicians more options for treating chemotherapy patients and make transfusions more affordable.
The study reveals that a low-dose pretreatment with certain DNA-crosslinking agents can temporarily suppress P-glycoprotein production, increasing the sensitivity of drug-resistant cells to chemotherapy. This approach may increase the efficacy of cancer chemotherapy in patients and minimize drug interactions.
Researchers at University at Buffalo and Roswell Park Cancer Institute found no link between chemotherapy use and cancer risk in children's offspring. The study analyzed health records of 153 children born to 91 chemotherapy patients, showing none developed cancer.
AmBisome, a liposomal formulation of amphotericin B, has been shown to sterilize the CSF significantly earlier than conventional amphotericin B, with at least equal clinical efficacy and lower nephrotoxicity. In a randomized multi-center study, low-dose AmBisome therapy produced a response rate of 68% in treating invasive aspergillosis.
Duke University researchers identify a new target for stopping drug resistance in cancer cells by targeting the cellular pump that expels chemotherapy drugs. The study found that certain immunosuppressive drugs can block this pump by removing a vital activator, FKBP12, allowing chemotherapy drugs to be effective.
Researchers at Georgia Institute of Technology have developed a new method to examine and quickly map how nucleic acid ligands bind to and alter DNA at the molecular level. This allows for direct visualization of individual DNA molecules, providing crucial information on drug binding and mode of action.
Scientists have detailed the structure of yeast topoisomerase II, a key player in cell division. This knowledge could lead to the development of new anticancer drugs that target this enzyme. The discovery also has implications for the design of antimicrobial drugs and the treatment of cancer.