Articles tagged with Clinical Trials
The American Society of Clinical Oncology will host its 53rd Annual Meeting, featuring more than 2,150 abstracts on various cancer topics. The meeting highlights recent breakthroughs in immunotherapy and precision medicine, with a focus on improving patient care and outcomes.
Researchers developed a prognostic tool predicting end-stage renal disease risk in type 1 and 2 diabetes patients. The test uses biomarker values to identify those at high risk, improving the efficiency and cost-effectiveness of clinical trials.
A collaboration created a 3D-printed phantom of a stenotic intracranial artery to standardize high-resolution MRI protocols for studying intracranial atherosclerotic disease. The phantom enables standardized vessel-wall MRI at multiple sites, facilitating multicenter trials and accelerating research.
A recent study led by the University of Nottingham found that wearing silk clothing does not reduce the severity of eczema in children with moderate to severe eczema. The study involved recruiting hospitals across the UK and assessed the effectiveness of specialist silk garments against standard treatment.
The pivotal MOMENTUM 3 trial found that patients with the new HeartMate 3 LVAS experienced fewer adverse clotting and bleeding events than those with the control device, HeartMate II. The study also developed a novel scoring system to quantify these events.
A clinical trial found that twice-weekly yoga led to better physical, sexual, emotional, and social health in men with prostate cancer. Patients who practiced yoga reported lower fatigue and improved urinary function compared to those without yoga.
A large randomized trial found that monthly high-dose vitamin D supplementation does not reduce cardiovascular disease risk. The study, published in JAMA Cardiology, involved 2558 adults with low vitamin D levels and showed no significant difference in cardiovascular events between the treatment and placebo groups.
A recent study found that multivitamin supplements did not reduce the risk of cardiovascular disease in middle-aged and older men, regardless of their initial dietary intake or nutritional status. The Physicians' Health Study II, a large-scale randomized clinical trial, investigated this potential benefit over an 11-year period.
A new triple inhaler has shown a 20% reduction in chronic obstructive pulmonary disease (COPD) flare-ups in a year-long trial involving 2,691 patients. The study found that the inhaler improved lung function and reduced symptoms, with potential benefits for early diagnosis and targeted treatment.
A Phase 2 clinical trial found that MLE4901 reduced the number and severity of hot flushes by 73% compared to placebo. The treatment was well-tolerated, with no serious adverse events reported. This study demonstrates the potential for MLE4901 as a non-hormonal treatment option for menopausal hot flushes.
A randomized clinical trial will compare surgery and non-operative therapy for patients with rotator cuff tears, considering factors such as age and tear size. The study aims to inform patient care and provide evidence-based information for better health decisions.
A new research project aims to integrate socio-economic data with cancer trial data, providing a broader perspective on treatment effectiveness. By combining this information, researchers can predict how socio-economic factors affect various treatments and shed light on the circumstances of cancer patients in clinical trials.
A Phase 2/2b clinical trial has begun testing an experimental DNA vaccine designed to protect against disease caused by Zika infection. The vaccine aims to gain more safety and immune response data and determine if it can effectively prevent disease caused by natural Zika infection.
The University of Miami is conducting a multi-site study to evaluate the safety, effective dosage and prevention capabilities of the NIH's experimental DNA-based vaccine. Researchers will recruit individuals from Miami-Dade County and compare the rates of confirmed cases of Zika in vaccinated and placebo groups.
A study found that higher doses of vitamin C, particularly 8g per day, significantly reduced the duration of common cold symptoms. The findings suggest a dose-dependent effect and could lead to improved treatment options for individuals with common colds.
A molecule called polyGP accumulates in the CSF and blood cells of patients with C9ORF72 ALS, offering a potential pharmacodynamic marker for therapeutic responses. Detection of polyGP in asymptomatic carriers may help identify patients at risk before symptoms appear.
A leading dementia expert emphasizes the importance of cognitive rehabilitation for people with dementia, sharing similarities with physical rehabilitation. Rehabilitation aims to enable individuals to participate meaningfully in everyday life and family/family activities.
Researchers compiled a list of over 40 online programs with evidence from randomized controlled trials, finding nearly 80% were unavailable to the public. The sites address various health issues, including depression, weight loss, and chronic pain, and offer interactive modules and assignments to complete.
A three-year research collaboration aims to create more accurate ways of measuring cancer progression. The project uses digital images from completed clinical trials to develop drug response metrics, with the goal of identifying optimal tumor burden measurement methods.
A network of clinical trials aims to find the right treatment for the right patient, using individual molecular profiles. The project will recruit 658 patients across the UK, with a focus on matching patients with suitable clinical trials already in progress.
A study found that midazolam was more effective in treating seizures than other benzodiazepines and was adopted by ambulances across the country, increasing from 26.1% to 61.7% between 2010 and 2014. The rate of adoption accelerated after a clinical trial's publication, with EMS agencies adopting midazolam at a rate of 8.9% per year.
A Phase I clinical trial demonstrates the safety of transplanting autologous Schwann cells into a spinal cord lesion, showing no negative effects after 1 year. The study successfully determined safety and feasibility for performing peripheral nerve harvests within 5-30 days followed by intra-spinal transplantation within 4-7 weeks.
A new protocol has been shown to be safe and effective in assessing older people who have fallen. The guidelines reduce further 999 calls and left fewer people without continuing care after their fall by 11%.
Researchers found that a single dose of millions of adult stem cells can aid stroke recovery if given early, reducing destructive inflammation and the risk for serious infections. Early treatment within 36 hours after stroke symptoms surface also showed benefits in physical recovery and reduced disability one year out.
Researchers found that a pacemaker delivering a pacing program designed to detect and stop abnormal heart rhythms can significantly reduce fainting episodes in patients with recurrent syncope. The study, known as SPAIN, showed a seven-fold reduction in recurrences of syncope in patients who used the program.
A recent study found that Embol-X and CardioGard devices did not significantly reduce overall number of brain infarcts during aortic valve replacement, but may affect size. However, patients treated with these devices experienced reduced delirium after surgery. Further research is needed to clarify potential health outcomes.
The SURTAVI trial shows that self-expanding TAVR is non-inferior to open-heart surgery for intermediate-risk patients with severe aortic stenosis, with comparable rates of stroke and death. The study found no significant differences in mortality or disabling stroke between the two groups at 2 years.
The SURTAVI trial shows that TAVR is comparable to surgical aortic valve replacement for intermediate-risk patients, with similar all-cause mortality rates and better mean aortic valve gradient at two years. Near-term results also indicate improved outcomes for TAVR patients, including lower stroke rates and quicker hospital discharge.
A new standard of care has been established worldwide for treating prostate cancer, reducing treatment duration to four weeks without compromising outcomes. The trial found that this compressed regimen resulted in slightly fewer side effects and improved quality of life for participants.
A Florida clinic's unproven stem cell treatment blinded three women with macular degeneration, causing vision loss and other complications. The treatment, which involved injecting fat cells into the eyes, lacked proper scientific design and oversight.
A meta-analysis of three randomized trials found that vitamin E supplementation reduced the risk of contrast medium-induced acute kidney injury (CIAKI) by up to 62%. This may be due to its antioxidant activity, with a pooled effect indicating significant protection against CIAKI.
Researchers discovered that many breast cancer patients have mutational signatures similar to those with faulty BRCA1 or BRCA2 genes, suggesting they may also benefit from existing PARP inhibitor treatments. This opens up the possibility of treating up to 20% of women with these drugs.
The NIH-funded Antibacterial Resistance Leadership Group has reviewed over 70 study proposals and initiated more than 30 clinical studies to address antibacterial resistance. The group's key accomplishments include the launch of the CRACKLE study, a prospective multicenter cohort study designed to characterize CRE infections.
The European Society of Cardiology calls for rewritten clinical trial rules to protect patients and ensure reliable results. The current ICH Good Clinical Practice guidelines need to be based on principles rather than operational details.
A study published in the Journal of Clinical Oncology finds that childhood cancer deaths within a month of diagnosis are significantly higher than previously reported, affecting young children and minority groups disproportionately. The study used a large national database to find that early deaths from some pediatric cancer subtypes w...
A placebo-controlled trial shows that both audiology best practices and OTC models improve outcomes for older adults with mild-to-moderate hearing loss. The study's findings have implications for better hearing healthcare for millions of Americans.
A Phase III clinical trial revealed that blinatumomab significantly increased overall survival and remission rates compared to standard chemotherapy in patients with advanced acute lymphoblastic leukemia. The study showed a median survival of 7.7 months for those treated with blinatumomab versus four months for those on chemotherapy.
Researchers at UNC Lineberger Comprehensive Cancer Center have launched clinical trials testing genetically engineered immune cells to fight cancer. The early-stage trials aim to improve treatment options for patients with relapsed or refractory Hodgkin or non-Hodgkin lymphoma.
A clinical trial has demonstrated that a monoclonal antibody, lanadelumab, significantly reduces HAE attacks without serious side effects. The study found strong efficacy in participants receiving high doses of the treatment.
A clinical trial of 100 patients with ALS found that an eight-week mindfulness-based meditation program improved quality of life and reduced anxiety and depression. The results remained stable over a 12-month follow-up, suggesting a potential tool for increasing well-being in ALS patients.
A Phase 1 clinical trial is underway to test the safety and tolerability of an RSV vaccine in healthy adults. The study aims to assess the vaccine's ability to prompt an immune response and reduce the burden of this important disease.
The ASTER Trial shows no significant difference in revascularization rate and safety between Penumbra's aspiration system and stent retrievers for acute ischemic stroke patients with large vessel occlusions. The study provides evidence supporting the use of aspiration as a frontline thrombectomy approach.
A study published in JAMA and JAMA Internal Medicine found that testosterone treatment improved bone density and anemia, but not cognitive function, in older men with low testosterone. However, it also increased plaque buildup in coronary arteries, raising concerns about cardiac risk.
In less than a year, researchers have developed multiple vaccine platforms providing robust protection against Zika virus challenge in animal models. However, safety considerations and unique challenges associated with the virus must be addressed in clinical development.
Researchers developed a novel strategic framework to improve retention of minority, low-income children in randomized controlled trials. The framework was highly effective, with an attrition rate of only 11%, significantly lower than previous studies.
A new study published in JAMA suggests that testosterone treatments may increase the risk of heart disease in older men. The study found a significant increase in arterial plaque among men aged 65 and older who received testosterone replacement therapy for a year, with a 20% rise in total coronary and noncalcified plaque volumes.
The NIH is conducting a Phase 1 clinical trial to test an investigational vaccine called AGS-v, designed to trigger an immune response to mosquito saliva. The goal is to provide broad protection against mosquito-transmitted diseases such as Zika, malaria, and dengue fever.
A new study published in JAMA and J AMA Internal Medicine found that testosterone therapy improved bone density and strength, as well as reduced anemia in older men with low testosterone levels. However, the therapy had no impact on cognitive function and may worsen plaque in coronary arteries.
Constantine Gatsonis, a leading researcher on cancer screening studies, emphasizes the importance of rigorously produced evidence in health screenings. His work has shed light on the accuracy, cost-effectiveness, and impact of various screening methods, including digital mammography and tomosynthesis.
A systematic review of existing literature suggests that antibiotics are an effective alternative to surgery for acute non-complicated appendicitis in children. No safety concerns were reported, but a recurrence rate of 14% was noted.
Researchers have used gene therapy to treat Fabry disease, a rare inherited enzyme deficiency that can damage major organs and shorten lifespan. The treatment involves transplanted altered stem cells with copies of the fully functional gene responsible for the missing enzyme.
A review of worldwide studies found that high-dose B-vitamins significantly reduce schizophrenia symptoms. The research suggests that B vitamins are most beneficial when implemented early on and used with higher dosages or combined several vitamins.
A phase III trial of a fasting-like diet shows significant benefits for 'at-risk' patients, reducing cardiovascular risk factors, inflammation, and fasting glucose levels. The regimen also shrunk waistlines and resulted in weight loss, with sustained effects even after returning to normal daily eating habits.
A new online tool uses data from the PROMISE trial to predict patients at minimal risk for heart trouble, allowing primary care doctors to safely defer non-invasive cardiac tests. The tool considers 10 clinical variables and can help clinicians quantify minimal risk, opening a conversation with patients on whether a test is worthwhile.
Clinical trials are now enrolling at the University of Virginia Health System to test an artificial pancreas that automatically regulates blood-sugar levels in people with type 1 diabetes. The trials will examine safety, effectiveness, and cost as well as physical and emotional health.
A new assay has been developed to detect genetic mutations in tumors, showing high sensitivity and specificity in detecting actionable genomic variants. The NCI-MATCH trial aims to evaluate tumor biopsy specimens from 6,000 patients using this technology.
Researchers compared informed consent quality in clinical trials of a hookworm vaccine conducted in Brazil and the US. Despite differences in education and healthcare access, there were few statistically significant differences in consent quality between participants in urban and rural locations.
Researchers at Buck Institute for Research on Aging found that alpha-lipoic acid prevented stone formation in a mouse model of cystinuria, a rare inherited disease. The supplement increased the solubility of cystine crystals, providing a new function for alpha-lipoic acid.
A systematic review of 14 randomized trials found that vitamin C significantly reduced the incidence of post-operative atrial fibrillation in high-risk patients. The review also showed that vitamin C decreased hospital stay length and intensive care unit stay, with intravenous administration having greater effects.
A recent clinical trial found that controlling critically ill children's blood sugar levels within a usual care range does not offer significant benefits. In contrast, lower targets increased the risk of hypoglycemia without providing extra advantages.