Articles tagged with Clinical Trials
The Phase 3 clinical trial data showed statistically significant and clinically meaningful improvements in functional vision and visual field in participants with RPE65-mediated inherited retinal disease. Participants demonstrated marked gains in full-field light sensitivity and peripheral vision.
A randomized clinical trial found tramadol extended-release to suppress opioid withdrawal more effectively than clonidine, and similarly to buprenorphine. The study suggests tramadol ER as a promising medication for opioid use disorder treatment, but notes the need for further research.
A new registry study highlights the unique characteristics of heart failure patients in Asia, including younger age and higher co-morbidity rates compared to Western populations. The study also reveals underutilization of potentially life-saving implantable cardiac defibrillators in Asia.
Entinostat inhibits myeloid derived suppressor cells, leading to enhanced antitumor activity when combined with PD-1 blockade. This preclinical study suggests entinostat may provide an effective combination treatment approach for patients with solid tumors.
A cluster randomized factorial trial found that training and support have a lasting impact on primary care clinicians' delivery of screening and advice to heavy drinkers. The study suggests that repeated training and support can lead to an increase in the volume of brief interventions delivered to heavy drinking patients.
Researchers discovered a molecular signature in patients who responded to the anti-asthma drug amlexanox, which showed significant improvements in blood glucose levels. The study reveals a potential new therapeutic approach for treating type 2 diabetes and identifies key gene changes associated with the beneficial effects.
Researchers found no significant difference in pain intensity after radiofrequency denervation, a procedure that uses electric current to target nerve pain sources. The study involved 681 participants and included three randomized clinical trials assessing the effectiveness of the treatment for different types of low back pain.
A randomized double-blind study involving 51 participants found a 68% improvement in slowing whole brain atrophy in patients with secondary progressive MS. Lipoic acid also improved walking times and reduced falls compared to placebo.
A new trial by University of Exeter researchers found that taking low-dose aspirin before bed can reduce the risk of pre-eclampsia, a condition causing premature birth and maternal and foetal death. The study showed a 62% reduction in pre-term preeclampsia rates.
A new CT Perfusion technology has been developed to measure blood flow and predict how well ovarian cancer patients will respond to treatment. The study found that a decrease in blood flow is associated with longer survival times, while an increase is linked to shorter survival times.
A new global health trial found that family-led stroke rehabilitation is ineffective in reducing disability and improving recovery outcomes. The ATTEND trial, published in The Lancet, suggests that effective rehabilitation requires professionals with years of training and specialized expertise.
A £1.5 million study led by the University of Warwick is investigating two biomarkers to guide safe reduction in antibiotic treatment time for patients with suspected sepsis. The trial will compare survival rates, discharge times, and antibiotic usage across three groups.
A phase 1 trial involving 100 people found that a dissolvable microneedle patch for the flu vaccine was safe and acceptable, with participants reporting high acceptability and preferring it over conventional injection. The patches were stable for one year at 40 degrees Celsius, reducing delivery and storage costs.
A phase I clinical trial found that influenza vaccination using microneedle patches was as effective as traditional shots, generating robust immunity against influenza. The patches were well-tolerated, with no adverse events reported, and participants preferred them over traditional vaccination methods.
A pilot randomized trial found that about 22% of generally healthy adult patients with whole genome sequencing results had a previously unrecognized variant with potential risk for a rare Mendelian disease. However, only about 4% had a clinically relevant abnormality related to a variant.
A large trial involving over 11,000 patients reveals that sitting up or lying flat after a stroke makes no difference to their recovery. The study found that good nursing care is more important than head position in determining outcomes.
A new research tool may predict a patient's risk for developing dementia in Parkinson's disease, enabling the design of 'smarter' trials that require fewer participating patients. The tool was built using data from 3,200 people with PD and evaluates seven known clinical and genetic risk factors.
A phase 1 randomized controlled trial found an Ebola virus disease vaccine developed in Canada to be well-tolerated and effective, with high antibodies present six months after immunization. The vaccine showed no safety concerns and was well-received by participants.
A randomized clinical trial of 230 Head Start mothers found that a problem-solving intervention significantly reduced depressive symptom episodes. The study suggests that such interventions can be an effective approach to addressing maternal depression, particularly among vulnerable populations.
Researchers have discovered a solution to evade the immune system, allowing more patients to participate in gene therapy clinical trials. The altered virus can slip past neutralizing antibodies, making it possible for up to 70% of patients previously ineligible to join trials.
Researchers have developed a new sequential multiple assignment randomized (SMART) trial method to test two hypotheses at once. This approach allows for the simultaneous evaluation of different treatments, potentially leading to more accurate results and increased efficiency in clinical trials.
Researchers found that current assessments are not keeping up with clinical trial advances, highlighting the need for improved treatment outcome measurement tools. Most outcome measures in FXS clinical trials received only a moderate rating due to limited information on reliability and validity.
A Wayne State University research team will conduct a five-year trial to test an intervention on tablet computers that helps parents engage in effective parenting to assist their diabetic adolescents complete daily care. The study aims to improve health outcomes and metabolic control among African American youth with Type 1 diabetes.
New international guidelines aim to accurately diagnose dementia with Lewy bodies, a disorder that shares symptoms with Alzheimer's and Parkinson's diseases. The guidelines focus on clinical features and diagnostic biomarkers to establish an accurate diagnosis and improve management of the complex disorder.
The NCI-MATCH precision medicine cancer treatment trial has reached its goal of sequencing the tumors of 6,000 patients two years ahead of schedule. This is due to wide-scale adoption throughout the NCTN and NCORP networks, resulting in an unprecedented rate of patient enrollment.
Recent clinical trials using different gene transfer approaches have shown acceptable risk and potential for treating heart failure with reduced ejection fraction. Despite mixed results in terms of efficacy, the data support further clinical development of this therapeutic strategy.
A study analyzing SWOG clinical trials found that cancer patients in the US have gained a cumulative 3.34 million years of life due to successful therapies. The analysis calculated that an NCI investment of $125 for each year of life saved was sufficient, making it a cost-effective approach.
A Phase 1/2 clinical trial of an experimental Chikungunya vaccine, MV-CHIKV, is underway in the US. The trial aims to assess the safety and immune response of the vaccine in healthy adults.
A new analysis found that nearly three-quarters of patients with advanced cancer could be referred to a targeted treatment based on their tumor's genetic landscape. Genetic sequencing identified anomalies in 11% of patients, including hereditary variations that increase cancer risk.
A novel sarcoma vaccine has shown an escalating immune response in patients, indicating its potential anti-cancer effects. The findings suggest that the vaccine can generate an immune response and stabilize tumors, making it a promising treatment option.
The study aims to determine the factors influencing frog survival and persistence in the wild. The release trial will help pave the way for successful reintroduction programs, as researchers monitor the frogs' behavior, dispersal, and disease resistance.
At ASCO 2017, SWOG investigators reported trials involving more than 10 cancer types and presented results on treatment-resistant metastatic colorectal cancer, breast cancer chemotherapies, high-risk prostate cancer, and the benefits of public funding for cancer research. The group's research has led to the approval of 14 cancer drugs,...
Ludwig scientists will present four clinical trials of checkpoint antibody combination immunotherapies to treat patients with advanced solid tumors, multiple myeloma, and glioblastoma. They will also share findings on other topics, including circulating tumor DNA in early diagnosis and treatment.
A double-blind, placebo-controlled trial tested the 100-year-old drug suramin in boys with autism, showing significant improvements in language, social interactions, and restricted behaviors. The study's findings challenge the conventional view of autism as a fixed, genetically-driven condition and suggest a treatable metabolic syndrome.
UK researchers have made a breakthrough in treating severe lung disease by developing a home ventilation therapy that reduces hospital readmissions. The study, published in the Journal of the American Medical Association, found patients using this treatment were two-thirds less likely to be readmitted within 28 days.
Researchers found that exposure to blue light before competition can improve endurance during a cycling time trial, especially in the final spurt. This effect was observed even if bright light had no impact on overall performance.
A new trial led by Queen's University Belfast aims to improve survival rates for critically ill patients with respiratory failure. The 'extracorporeal carbon dioxide removal' procedure could significantly reduce mortality rates and provide gentler ventilation, reducing lung damage caused by mechanical ventilation.
A phase III trial of 447 patients with biliary tract cancers showed that giving capecitabine after surgery extended survival by a median of 15 months compared to surgery alone. The treatment was associated with a 20% lower chance of death, but the difference was not statistically significant for the overall population.
A phase III clinical trial shows gefitinib is effective in preventing recurrence after lung cancer surgery, with patients going about 10 months longer without disease-free survival. The treatment causes far fewer side effects compared to chemotherapy, with only 12% experiencing severe side effects versus 48%.
A national trial is underway to compare intensive medical management and surgical interventions for asymptomatic carotid artery disease. Researchers at MCG and AU Health are enrolling nearly 2,500 participants in the CREST-2 study to determine which treatment approach reduces stroke risk more effectively.
A new study found that women and minorities undergoing PCI are at higher risk of recurrent cardiac events due to their race, gender, and socioeconomic status. The PLATINUM Diversity trial enrolled a large sample of diverse patients and showed significant differences in adjusted outcomes between groups.
A subgroup analysis of the BRAVO-3 trial found that patients with balloon expandable valves had a different baseline profile than those treated with non-balloon expandable valves. This suggests that differences in patient characteristics, not valve type, drive TAVR outcomes.
The PRECISION trial demonstrated clinical and technical success for patients undergoing robotic percutaneous coronary intervention (PCI) using radial or femoral access. Technical success rates were higher for transradial access procedures, while clinical success rates showed similar outcomes between both approaches.
Positive data from Phase 1 trials of Nexvax2 in celiac disease demonstrate safety, tolerability, and bioactivity. The vaccine reduces gluten-specific T cells' responsiveness to antigenic stimulation without apparent duodenal injury.
A new analysis reveals that early treatment for Non-ST-Elevation Myocardial Infarction (NSTEMI) patients leads to a significant reduction in mortality. The study found an 87% lower mortality rate and a 38% lower mortality rate for high-risk patients when treated within 24 hours of symptom onset.
Patients with new-onset atrial fibrillation post-TAVR have a nearly five-fold greater risk of early stroke compared to those without AF. The BRAVO-3 trial found that patients with existing or new AF had higher rates of pre-existing comorbidities and were more likely to receive oral anticoagulants.
A panel of international experts recommends against knee arthroscopy for almost all patients with degenerative knee disease, citing limited evidence of long-term pain relief and function improvement. Non-use of knee arthroscopy can be used as a performance measure to reduce unnecessary surgery.
A mock randomized control trial across three countries found that eating red Smarties had no effect on participants' levels of happiness. This study debunks the common assumption that red is associated with feelings of happiness and demonstrates how complex scientific concepts can be made engaging through hands-on learning.
A phase 1 pilot study is examining the feasibility and safety of administering a second T-cell product to increase the long-term persistence of CAR T cells. The goal is to reduce the relapse rate, which is currently around 50%.
A new study investigates the use of oxygen therapy via high-flow nasal tubes in patients with COPD experiencing exacerbations. The short-term trial found lower retained carbon dioxide levels compared to standard oxygen therapy, suggesting a potential benefit.
The RICMAC trial found that dose-reduced conditioning followed by allogeneic stem cell transplantation improved overall and relapse-free survival for patients with myelodysplastic syndrome. Engraftment rates were comparable between the two groups, with higher non-relapse mortality after standard conditioning.
A large randomized controlled trial found that acupuncture significantly improved the quality of life and physical and mental health of patients with allergic asthma. The study involved 1445 participants who received on average 15 acupuncture sessions over three months, with benefits maintained for up to six months.
A randomized clinical trial of 100 obese adults found that alternate-day fasting resulted in similar weight loss to daily calorie restriction (5.3% vs 6.0%). The study suggests that daily calorie restriction may be a more effective option for weight maintenance and cardiovascular disease risk reduction.
A randomized clinical trial found that ivabradine did not improve outcomes in patients with heart failure with preserved ejection fraction. Elevated heart rate is a predictive factor of worse outcomes in these patients, contradicting previous research that suggested benefits for heart failure with reduced ejection fraction.
Serelaxin, a hormone with vasodilatory effects, failed to improve cardiovascular outcomes in the phase 3 RELAX-AHF-2 trial. Despite initial promising results from previous studies, serelaxin showed no significant benefit in reducing worsening heart failure or all-cause mortality.
A global trial of 20,000 women in 21 countries found that tranexamic acid reduces death due to bleeding after childbirth by a third if given within 3 hours. The drug is inexpensive and widely available, making it a promising solution for preventing maternal deaths in low-income countries.
A study published in PLOS ONE found that shortening standard consent documents did not affect comprehension, but early delivery and in-person explanations improved it. Concise forms showed promise in streamlining ethics committee reviews, but further testing is needed.
Several emerging companies are developing innovative neuromodulation therapies to alleviate conditions such as autism spectrum disorder, spinal cord injury, and persistent pain. BioInduction Ltd.'s Picostim and BlueWind Medical's RENOVA iStim aim to provide targeted stimulation for various clinical indications.
A new test evaluates sperm's capacitation ability, allowing for more accurate diagnoses of male infertility. The Cap-Score Sperm Function Test shows promise in increasing conception rates among men with unexplained infertility.
The SARAH trial found SIRT resulted in higher tumor response rates and controlled tumor progression compared to sorafenib, with better side-effect profiles and quality of life scores. However, it did not increase overall survival in HCC patients.