Articles tagged with Clinical Trials
A recent study published in The BMJ found that first-time mothers with an epidural who adopt a lying down position during the second stage of labor are more likely to deliver their baby without any medical intervention. The study involved 3,093 women and found a 5.9% increase in the chance of spontaneous birth in the lying down group.
A portable 3D scanner has been developed to measure swollen limbs in patients with elephantiasis, a parasitic disease causing major swelling and deformity of the legs. The device provides highly accurate results in just a fraction of the time required by traditional methods, making it easier to assess treatment effectiveness.
Neuren Pharmaceuticals will conduct a Phase 3 clinical trial for trofinetide, showing promise in treating Rett syndrome symptoms in children and adults. The trial aims to provide a treatment that addresses the underlying biology of the disease.
Two Ebola vaccine candidates elicited strong and long-lasting immune responses in a randomized, placebo-controlled trial. The study found that 71% of one vaccine and 84% of another developed antibodies to the Ebola virus within a month, with antibody responses maintained for at least a year.
PharmaMar's Phase I/II trial combining PM1183 with doxorubicin shows a progression-free survival of 5.3 months, surpassing historical data for topotecan. The study also reveals manageable adverse events with no mucositis or neuropathy, paving the way for the pivotal Phase III Atlantis trial.
TBA-7371 and sutezolid have entered phase 1 clinical trials after early preclinical development. These novel drugs show promise in treating TB with no pre-existing resistance, addressing a growing concern in the disease's increasing resistance to older treatments.
Indiana University will establish a network of sites to study early-onset Alzheimer's disease, a rare variant that affects people under 65. The Longitudinal Early-onset AD Study (LEADS) aims to bridge the gap in clinical trials for this population by collecting robust longitudinal data on genetic risk factors and treatment options.
The SIREN network pools resources to boost patient numbers for emergency medicine clinical trials, targeting vulnerable populations and life-threatening emergencies like heart attacks, lung disease, trauma, and more. The network aims to improve treatments and outcomes for patients in critical care situations.
A new analysis highlights the importance of considering pharmacokinetic and pharmacodynamic aspects in establishing drug doses. The study found that more trials used pharmacology endpoints in 2015 compared to 2007, but some still escalated without documented assessment.
A clinical trial found that virtual reality tours of operating rooms reduced preoperative anxiety in children. The study used a 4-minute video showing Pororo the penguin visiting the OR, explaining its contents in a friendly manner.
A new study published in JAMA Internal Medicine found that game-based interventions can increase physical activity among adults. In a 12-week clinical trial, participants who engaged with gamification elements showed significant improvements in step goal achievements and average daily steps compared to those in the control group.
A study on swine farm volunteers found that levels of MRSA in nasal passages became virtually undetectable after two hours of exposure. Airborne transmission was the primary route of infection, not direct physical contact with animals. The risk of transmission to non-farm dwellers is considered negligible due to this decline.
A computer model developed by InSysBio scientists suggests that activating beta-amyloid degradation is key to preventing protein plaques in the brain. The model found that starting treatment at age 60 can lead to relative normalization of indices, highlighting the importance of early intervention.
A landmark trial found that older stored red blood cells are safe and associated with fewer side effects, including transfusion reactions. The study, published in the New England Journal of Medicine, challenged common practice of allocating the oldest available compatible blood.
The committee's efforts focus on increasing the number of sites hosting research studies, expanding potential study volunteers, and reducing duplicated efforts. By leveraging public-private partnerships, they aim to develop effective medicines for children with kidney disease.
A study found that cancer clinical trials lack appropriate representation of ethnic minorities and the elderly, resulting in findings that may not be generalizable to all patients. The study analyzed enrollment data from 2003 to 2016 and showed a decline in African-American and Hispanic representation over time.
A phase III trial has confirmed the effectiveness of pelvic radiation as a standard treatment for high-risk stage I-II endometrial cancer. The study found that adjuvant pelvic radiation provided better pelvic control and fewer severe side effects compared to a brachytherapy-chemotherapy combination.
A phase II trial found that patients with HPV-related oropharyngeal cancer who received half the standard radiation dose achieved equally high cure rates at two years, with 95% tumor control and 89% disease-free survival. The reduced treatment also resulted in lower side effects compared to standard therapy.
Researchers recommend expanding flu vaccine recommendation to middle-aged adults with chronic health conditions due to modest effectiveness of standard-dose vaccine. High-dose and recombinant trivalent vaccines show promise in providing better protection for high-risk patients.
A study found that a non-burdensome scientific reframing intervention improved patients' understanding of clinical research and its differences from clinical care. The 12-minute slideshow had no significant effect on participants' desire to enroll, but reduced therapeutic misconception scores by about 6 points.
A randomized trial of over 45,000 people found that frequent blood donation increased blood collected by 33% in men and 24% in women, with no major impact on quality of life or physical activity. However, some donors reported minor symptoms like tiredness and restless legs.
A new study published in PLOS Medicine found that HPV testing detects a higher number of precancerous cervical lesions compared to cytology-based Pap smears in women offered HPV vaccination. The study showed significant improvements in detection rates for high-grade cervical intraepithelial neoplasia (CIN2+) with HPV testing.
Long-term follow-up of postmenopausal women using hormone therapy found no association with overall or cause-specific mortality. The study, published in JAMA, analyzed data from the Women's Health Initiative trials and included over 27,000 participants.
A recent study analyzed over 100 clinical trials and found that many were unregistered and unpublished. Prospective registration was significantly associated with subsequent publication, as well as being published with the same primary outcomes as defined in the protocol.
The KEYNOTE-040 trial found that pembrolizumab significantly improved outcomes in patients with recurrent or metastatic head and neck squamous cell carcinoma, especially those with high PD-L1 expression. The study also showed a better side-effect profile for pembrolizumab compared to standard treatments.
The phase III RANGE trial showed that ramucirumab plus docetaxel significantly prolonged investigator-assessed progression-free survival compared to placebo plus docetaxel. The treatment also nearly doubled the objective response rate in patients with platinum-refractory advanced or metastatic urothelial cancer.
The KEYNOTE-045 trial demonstrates pembrolizumab's superiority in overall survival and adverse event profile compared to chemotherapy in platinum-pretreated urothelial cancer patients. The medication offers durable responses and a favorable safety profile.
A randomized trial of over 600 patients confirms chemoradiation as the standard treatment for locally advanced cervical cancer, with no improved disease-free survival seen with neoadjuvant chemotherapy followed by surgery. The findings suggest that chemoradiation should remain the standard treatment.
A nationwide study in Ireland found that most oncology patients consider clinical trials important but struggle with central concepts like chance and randomization. The study aimed to understand factors influencing patients' decisions about participating in clinical trials.
The PACIFIC trial showed that durvalumab improved progression-free survival in patients with locally advanced, unresectable stage II-III NSCLC, decreasing the probability of disease progression by 48%. Durvalumab also reduced treatment-related adverse events and improved overall response rates.
The FLOT4 trial has confirmed the superiority of docetaxel-based triplet therapy over standard care in patients with resectable oesophago-gastric cancer. The treatment improved curative resection rates, progression-free survival, and overall survival.
The Pediatric Blood and Marrow Transplantation Consortium, headquartered at CHLA, will conduct a clinical trial comparing outcomes for young patients with newly diagnosed severe aplastic anemia. The study aims to determine whether using unrelated-donor blood and marrow transplant is better than immune suppression therapy.
The MIRO trial found that hybrid minimally invasive esophagectomy (HMIO) significantly reduces postoperative morbidity compared to open oesophagectomy. Long-term results show improved three-year overall survival in the HMIO group, indicating an oncologically sound procedure.
Researchers from Brigham and Women's Hospital are set to present groundbreaking findings on cardiovascular treatment at the ESC Congress 2017. These studies, including CANTOS and RE-DUAL PCI, will provide new insights into the effectiveness of anti-inflammatory therapy and dual antithrombotic therapy in patients with atrial fibrillation.
A new analysis of the FOURIER trial found that very aggressive reduction of LDL-cholesterol to ultra-low levels was associated with fewer cardiovascular events without increased safety risks. The study suggested that lowering LDL-C levels below current guidelines can further reduce recurrent cardiovascular events in high-risk patients.
A study found that transdermal estrogen therapy improved sexual function in early postmenopausal women, but oral conjugated equine estrogens did not show the same benefits. The treatment also reduced pain and increased lubrication compared to placebo.
A large clinical trial found that oxygen therapy did not reduce mortality rates in patients with suspected myocardial infarction. The study enrolled over 6,200 patients and showed no significant difference in mortality rates between those who received oxygen and those who did not.
The University of Arizona College of Medicine - Tucson is part of a team selected for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN), a new initiative by the National Institutes of Health. The SIREN grant aims to improve emergency care and clinical outcomes through large multi-site clinical trials.
A clinical trial demonstrates the safety and efficacy of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) for treating osteoid osteoma, a benign but painful bone tumor in children. The procedure eliminates incisions and ionizing radiation exposure, offering a faster treatment option with improved outcomes.
Three large trials found that screening for type 2 diabetes and cardiovascular risk factors does not reduce mortality in the general population, but individuals diagnosed with diabetes experience reduced mortality rates. The studies suggest that benefits to the general population may be increased by targeting screening to those at grea...
A new meta-analysis finds that plant-based vegetarian diets are linked to lower total cholesterol and reduced risk of heart disease. The study highlights the benefits of a well-planned vegan diet, which can lead to weight loss, lower blood pressure, and improved cardiovascular health.
Researchers have developed and validated a nomogram that can predict overall survival and progression-free survival for patients with oropharyngeal squamous cell carcinoma treated with radiation-based therapy. The nomograms were derived from clinical trials NRG Oncology/RTOG 0129 and 0522.
A recent study published in JAMA found that many studies supporting changes to high-risk medical devices are poorly designed and lack rigor. The researchers analyzed 83 supplement approvals for these devices and found similar problems with data quality and analysis procedures as seen in premarket approval studies.
A study found a nearly 60% increase in exclusion criteria for lung cancer trials from 1986 to 2016, making it difficult to conduct clinical trials. The rise in exclusions is largely due to new medical concerns and complexities with targeted therapies, which are often given in pill form.
Lung cancer clinical trials have complex requirements that act as a barrier to development and patient enrollment. A retrospective study found an increase in eligibility criteria for medical therapy trials, particularly for cardiac, concurrent medications, and immunotherapy-related treatments.
A recent study demonstrates the safety of immunotherapy in treating type 1 diabetes. The treatment showed metabolic effects without accelerating β-cell destruction, suggesting a viable option for patients.
Researchers at Trinity College Dublin advise caution against aggressively lowering blood pressure in older people due to increased risk of falls and blackouts. A recent US trial's results suggest benefits of aggressive treatment may be offset by potential harms, highlighting the need for individualized assessment.
A clinical trial has observed noticeable changes in the behavior of immune systems of type 1 diabetes patients treated with peptides. The treatment has a noticeable effect on the immune system and suggests a potential way to protect remaining beta cells.
A clinical trial has demonstrated the safety and effectiveness of a new treatment using virus-specific cells to treat viral infections in patients who have received a hematopoietic stem cell transplant. The treatment resulted in an overall complete or partial response rate of 92% in patients with severe, drug-resistant viral infections.
A clinical trial at the University of Cincinnati is investigating a drug combination therapy using sirolimus and resveratrol to induce disease remission in patients with lymphangioleiomyomatosis (LAM). The study aims to identify a regimen that will eliminate LAM cells, which currently only suppress growth.
International researchers developed a mathematical model predicting docetaxel discontinuation due to adverse events, incorporating five clinical factors. The combined model stratified patients into low and high risk groups, with the high group having more than double the likelihood of discontinuation.
A study found that ONC201 alters the gene expression of cancer stem cells before killing tumor cells, providing a potential biomarker for response. This effect was not observed in resistant cells, suggesting a predictive gene expression signature may help forecast treatment outcomes.
A new study published in Thorax found that smokers who undergo a low-dose CT scan of their lungs are more likely to quit smoking. The UK Lung Cancer Screening trial involved 4,055 participants and showed a 15% success rate in quitting after two years.
The DAWN trial demonstrates the effectiveness of mechanical thrombectomy for acute stroke caused by large vessel occlusion performed more than 6 hours after onset. The study results offer hope to patients who miss the traditional 6-hour treatment window, allowing doctors to offer life-saving neurointerventional surgery.
A first patient has been successfully treated with the DIALIVE system, a novel liver dialysis device designed to remove toxins that trigger inflammation in liver failure patients. The trial aims to establish the device's safety and performance in 24 patients across Europe, with plans for an additional study enrolling over 100 patients.
Approval rates climbed steadily from 85% to 95% among privately insured patients, with fewer delays in clearance. The ACA provision required private insurers to cover clinical trial participation, benefiting those with insurance.
According to a revised pipeline analysis, six Alzheimer's drugs will conclude Phase III trials in 2017, bringing much-needed solutions to families in the near future. The late-stage pipeline offers hope to 5.5 million Americans with the disease and their caregivers.
A new study published in JAMA found that giving healthy children high doses of vitamin D during the winter did not reduce the number of colds they got. The study, led by Dr. Jonathon Maguire, involved 700 children who received either a standard or high dose of vitamin D, with no difference in cold frequency between the two groups.
A large-scale trial found that goal-oriented therapy significantly improves people's ability to engage in important daily tasks and maintain independence. The therapy, which involves setting and achieving individual goals, shows promising results for supporting individuals with early-stage dementia to live fulfilling lives.
Researchers found that regularly doing word puzzles like crosswords is linked to better brain function in later life. Participants who engaged with word puzzles performed better on tasks assessing attention, reasoning, and memory.