Articles tagged with Drug Therapy
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A large-scale study shows that introducing sophisticated biologic therapies early in treatment improves response to medication and reduces the need for surgery. Patients treated with biologic therapies earlier were significantly less likely to need steroids and required fewer surgeries related to their Crohn's disease.
A Canadian study found that off-label prescribing is common in primary care, with 11% of medications prescribed for indications not approved by regulators. The study also identified medications with multiple approved indications as having lower rates of off-label use.
A mobile stroke unit (MSU) strategy roughly halves the time from initial call to treatment decision and can increase the number of eligible patients receiving life-saving treatment. The MSU approach breaks reported times for stroke management and substantially reduces delays in diagnosis and therapy.
John A. Kaufman, a professor and Frederick S. Keller Chair of Interventional Radiology, was awarded the 2012 Dr. Charles T. Dotter Lecture for his extraordinary contributions to the field. The award also recognizes his dedication to interventional radiology training and education.
A clinical trial involving 14 TNBC tumors explores the use of whole-genome sequencing to identify potential treatment options. The study aims to advance personalized medicine and guide treatment for individual patients.
Researchers found that over 68% of participants failed to take medication daily, with young men who smoke and drink alcohol being the least likely to follow treatment. High rates of hypertension remain steady in the region, contrary to Western Europe's decline.
Researchers from BUSM and BUSPH have developed a modified version of the Short Inventory of Problems (SIP) to help identify patients with drug use consequences. The new tool, SIP-Drug Use, is valid and brief, making it suitable for primary care physicians.
A new study by the University of Leicester has demonstrated that botulinum toxin is an effective treatment for overactive bladder, providing relief from symptoms such as urinary incontinence and urgency. The study found that 4 in 10 women became completely continent again after six weeks and a third remained continent after six months.
A team of researchers at Case Western Reserve University School of Medicine has developed a new theranostic agent for the treatment of acute lymphoblastic leukemia (ALL). The agent combines a diagnostic test with targeted therapy to provide personalized treatments for pediatric leukemia.
The $3.4 million grant from the U.S. Department of Health and Human Services will provide medication and treatment to uninsured patients in the Augusta area, while also expanding rapid testing and education efforts. With this funding, nearly 1,300 HIV-positive patients can receive life-long treatment with a single pill daily.
A recent study published in JAMA found that patients with epilepsy who underwent brain surgery soon after failing to respond to drug treatment had a lower risk of seizures during the 2nd year of follow-up. The study showed that 73% of participants in the surgical group were seizure-free, compared to 0% in the medical group.
Researchers found that inhalation of interferon-gamma three times a week for at least 80 weeks improved lung function in patients with idiopathic pulmonary fibrosis. The treatment was well-tolerated and showed no systemic side effects.
A new drug has been developed by a Canadian scientist that protects the brain against damaging effects of a stroke, preventing brain cell death and preserving brain function. The study used cynomolgus macaques as an ideal model for humans and showed remarkable recoveries in several scenarios.
A new study found that patients with chronic myeloid leukemia (CML) who have not responded to interferon treatments experience significant long-term benefits when switching to imatinib. Up to 93% of patients survive at least eight years, compared to only three to six years prior to imatinib.
Researchers at Karolinska Institutet discovered that pridopidine binds to the sigma-1 receptor, a previously unknown mechanism of action. This finding could lead to new treatments for schizophrenia, Parkinsonian tremors, and neurodegenerative diseases.
A new study reveals that secondhand smoke results in graft rejection in transplant patients, with a specific enzyme's expression being key to the process. Researchers found that SHS suppressed an enzyme produced by innate immune cells, hindering long-term islet allograft survival.
Research suggests that daily or nightly dialysis sessions at home or in the clinic may provide more benefits for some patients with kidney failure, improving their health and survival. However, additional research is needed to determine if extended or more frequent treatments are beneficial for all dialysis patients.
The study will review evidence of practices used to support children with ADHD that do not involve drugs, such as classroom management programmes or psychological therapies. The research aims to identify which methods work best to reduce the symptoms of ADHD and provide best value for money.
A new iPad app, DASH II, is being trialled in Newcastle and North Tyneside hospitals to help doctors and patients make informed decisions about stroke treatment. The app provides visual interpretations of risks and benefits, enabling medical teams to explain predicted outcomes clearly.
A nano-enabled intranasal formulation of teriparatide is being developed to treat osteoporosis, with the potential to provide easier administration and enhance efficacy. The project combines Critical Pharmaceuticals' nanotechnology expertise with the University of Nottingham's world-leading research capabilities.
Researchers developed a predictive model that differentiates between dengue fever and its deadly form, dengue hemorrhagic fever (DHF), using protein biomarkers. The model is based on IL-10 and seven distinct proteins, accurately predicting DHF in 100% of cases.
Researchers have created a computer simulation to identify bottlenecks in the emergency stroke care process, allowing for earlier clot-busting treatment. The analysis of over 1400 episodes has led to a doubling of patients receiving treatment within three hours.
Age-related macular degeneration (AMD) cases in the UK are projected to increase by a third by 2020, with 679,000 individuals affected. The majority of these cases will be in women, and prevalence rates will rise sharply with age.
A new schedule pinpointing the length of time it takes for therapeutic drugs to work out of a horse's system has been developed, providing greater certainty for horse owners, trainers, and vets. This will enable them to make better-informed decisions about treatment regimes and reduce the risk of false positives.
A study published by the NIH shows that Kineret therapy is effective in stopping the progression of organ damage in people with neonatal-onset multisystem inflammatory disease (NOMID). By preventing organ inflammation, scientists were able to preserve organ function in most patients.
Researchers at the University of Minnesota developed an antidote for cyanide poisoning called Sulfanegen, which can be administered rapidly by intra-muscular injection. The treatment could save lives in mass casualty emergencies and smoke inhalation incidents, where current treatments require medical professionals' expertise.
The US is facing a growing threat of multi-drug resistant gonorrhea, with treatment options rapidly dwindling due to increasing antibiotic resistance. The CDC has seen a 17-fold increase in drug susceptibility, leading scientists to call for collective action from healthcare providers and drug companies.
The Solitaire With the Intention for Thrombectomy (SWIFT) trial showed that the new device opened blocked vessels without causing symptomatic intracranial hemorrhage in 61% of patients, compared to 24% with the MERCI retriever. The device also led to better survival three months after stroke, with a 17.2% mortality rate versus 38.2% wi...
A new mathematical model assesses the impact of therapies on tumor-immune interactions, optimizing treatment dosage and duration to minimize tumor growth while maximizing immune cell activity. The study aims to improve cancer therapy by identifying personalized treatment protocols tailored to individual patient conditions.
Frequent anti-infective shortages can alter clinical care, leading to worse outcomes for patients, particularly hospitalized individuals. Multidisciplinary stewardship programs and enhanced regulatory oversight are proposed solutions to mitigate the impact of these shortages.
A study published in the American Journal of Ophthalmology reveals a significant reduction in new cases of legal blindness in Denmark, with the rate of blindness from AMD falling by over 50% between 2000 and 2010. The introduction of new treatment for wet AMD has been credited with this progress.
The new resource, Seeking Drug Abuse Treatment: Know What to Ask, highlights critical questions people should ask when choosing a treatment program. It recommends five key questions to help individuals and families make an informed choice during a stressful time.
Scientists developed a new strategy to fight infectious diseases by blocking pathogen entry into cells rather than killing the bug itself. This approach targets specific elements of the infection process inside the host body and has shown promising results in treating Leishmania parasites.
Researchers found that AICAR, an experimental therapy, protected animals from heat-induced sudden death and may hold promise for treating people with enhanced susceptibility to heat stroke. The drug works by reducing calcium leakage from RYR1, thus diminishing heat-induced contractions and muscle damage.
A study of over 26,000 patients found that therapeutic hypothermia was used in only 0.35% of out-of-hospital cardiac arrest cases in the US. Despite its proven benefits in reducing mortality and improving neurologic outcomes after a heart attack, hypothermic therapy is not being widely adopted in clinical practice.
A new study published in the Archives of Physical Medicine and Rehabilitation found that aquatic therapy beginning 6 days after TKA significantly improved results. In contrast, delaying its onset after THA may be more appropriate. Aquatic therapy has been shown to reduce effusion in the knee joint, leading to less pain.
Patients treated with diuretic chlorthalidone had significantly lower death rates and longer life expectancy compared to placebo, according to a study published in JAMA. The researchers found that long-term antihypertensive therapy was associated with 1 day prolongation of life expectancy free from cardiovascular death per month.
Research finds that ACE inhibitors and ARBs have different effects on heart health in dialysis patients, with some benefiting from one over the other. The findings emphasize the need for tailored treatment approaches, highlighting the importance of long-term clinical trials.
A new study has identified the most effective ways to assess progression in Huntington's disease, which could speed up the development of disease-modifying drugs. The findings suggest that measures derived from brain imaging techniques are the most effective at detecting disease progression over time.
Researchers at Northwestern University have discovered a second faulty gene, sequestosome1, contributing to the degeneration of motor neurons in ALS. The study provides new insights into the disease's progression and potential targets for drug therapies.
A new therapeutic target, EGFR, has been identified for treating Cushing disease. Clinical trials are necessary to investigate the effects of gefitinib in patients with this condition.
Researchers are studying two enzymes to combat the flu virus, which causes 36,000 US deaths and 200,000 hospitalizations annually. The goal is to identify targets for drug therapies that can block the spread of the influenza virus.
A new study finds mycophenolate mofetil superior to azathioprine as a maintenance therapy for lupus nephritis, with improved patient outcomes and reduced side effects. The study included 227 patients from 19 countries and showed that mycophenolate mofetil was more effective in treating the condition.
A novel point-of-care genetic test has been shown to be clinically feasible and accurate, enabling rapid personalization of anti-platelet therapy for patients at risk. The study demonstrates that tailored treatment successfully protected all patients with the at-risk genetic variant from adverse events.
A first-of-its-kind study found that brain stimulation significantly reduced 'medically refractory' epileptic seizures in adults. The NeuroPace Responsive Neurostimulation System delivered electrical pulses to stop seizures, providing a new treatment option for patients who have tried multiple medications and surgery without success.
A study found that patients with juvenile idiopathic arthritis who responded well to etanercept treatment had lower disability scores, younger age at onset, and fewer disease-modifying antirheumatic drugs used before treatment. These factors are associated with a better long-term outcome.
A new study found that a drug treatment called fasudil prevents the formation of lesions in cerebral cavernous malformation, a brain blood vessel abnormality. The treatment was tested in mice and showed promise as a potential replacement for complex surgery.
Researchers have developed a potent compound that selectively kills cancer cells while leaving healthy ones intact. This breakthrough has the potential to revolutionize leukemia treatment and could be a game-changer for patients with this life-threatening disease.
A Mayo Clinic study suggests that patients taking the age-related macular degeneration drug ranibizumab may experience increased intraocular pressure, a potential risk factor for glaucoma. The research found that a subset of patients had higher-than-normal eye pressure, regardless of pre-existing risk factors.
A commonly prescribed blood pressure-lowering medication appears to kick start recovery in the unaffected brain hemisphere after a stroke by boosting blood vessel growth. The study found that candesartan increased levels of growth factors and a 'pro-survival' protein, suggesting potential healing properties beyond the area of damage.
A new RAND Corporation study found that the US Department of Veterans Affairs provides high-quality mental health care to its veterans, comparable to privately insured and Medicare/Medicaid populations. The study highlights areas for improvement, including increasing evidence-based treatments and addressing regional variations in care.
A new study found that African-American women were more likely to continue a counseling approach to treating substance abuse, but their issues continued. The study suggests that Motivational Enhancement Therapy may be effective in reducing drug abuse, particularly among African-American men.
A study highlights the importance of screening for depression and vision loss in people who have experienced mild strokes. The study found that nearly a quarter of participants were clinically depressed, while many faced challenges returning to work or driving after their stroke.
Researchers at Stanford University School of Medicine have identified EP4 as a potential new treatment target for stroke. A selective EP4 agonist administered after stroke reduced brain damage and long-term behavioral deficits in mice, suggesting its therapeutic potential.
Cognitive therapy has been shown to improve the lives of severely impaired schizophrenic patients, reducing symptoms and promoting recovery. By helping patients set concrete goals and overcome defeatist beliefs, treatment encourages engagement in activity and motivation, leading to better functional outcomes and reduced hallucinations.
Researchers at Johns Hopkins Medicine found that oxaliplatin, a widely used chemotherapy drug for colorectal cancer, causes permanent nerve damage in some patients. A new study suggests using simple skin biopsies to track nerve cell degeneration and develop new treatments to prevent or slow the damage.
A Wayne State University professor is developing multifunctional therapeutic agents to slow Parkinson's disease progression and alleviate symptoms. The research aims to promote survival of dopamine neurons, which degenerate in the disease.
A new combination therapy for kala azar has been developed, reducing treatment time from 30 days to 17 days and decreasing costs. However, without international funding, too few patients will benefit from this new treatment.
Digna Biotech receives FDA approval for cardiotrophin-1 as an acute liver failure treatment. The medicine is expected to work by acting as a messenger to damaged liver cells, helping them recover and restoring function. Cardiotrophin-1 has been shown to stimulate hepatic regeneration and protect hepatocytes during acute hepatic damage.
A new study found that humor therapy reduces agitation in dementia patients by 20%, comparable to widely used antipsychotic drugs. This approach also improves happiness and positive behaviors, but effects are short-lived once the program ends.