2016 Lupus Insight Prize presented to Dr. Ann Marshak-Rothstein
The Lupus Insight Prize recognizes Dr. Marshak-Rothstein's work on Toll-like receptors and their role in regulating lupus pathogenesis, aiming to develop more effective treatments.
Medical Treatments
Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Simple screening tool helps determine COPD risk
A simple 7-item screening tool has been developed to identify patients at risk for chronic obstructive pulmonary disease (COPD). The tool uses predictive factors such as gender, age, smoking history, and breathlessness to assess COPD risk in primary care settings.
Medical device regulation in the EU and US needs urgent reform, say experts
A recent study published in The BMJ found that medical devices approved first in the EU have a higher rate of safety issues, while clinical trial results remain unpublished or unavailable up to five years after approval. Experts call for greater regulatory transparency to enable informed decisions about treatment.
Diabetes raises risk of heart attack death by 50 percent
A recent study published in the Journal of Epidemiology and Community Health found that people with diabetes are at a 56% increased risk of dying from a STEMI heart attack and a 39% increased risk of dying from a NSTEMI heart attack compared to those without diabetes. Researchers tracked over 700,000 people who had been admitted to hos...
Combined $54.5M gift creates a brighter future for children and women
A historic $54.5M donation from hospital foundations will propel women's and children's health research, improving outcomes through peer-reviewed grants, researcher recruitment, and incubator services. The University of Alberta Faculty of Medicine & Dentistry is a key partner in this transformative gift.
Radiological prediction of posttraumatic kyphosis after thoracolumbar fracture
A study investigated risk factors for progressive kyphosis after a thoracolumbar spine injury. The authors analyzed X-rays of patients with traumatic spinal fractures to determine the relationship between fracture type, patient characteristics (AO classification, age, gender, and localization), and post-traumatic kyphosis.
A multi-type queuing network analysis method for controlling server number in the outpatient
A new multi-type queuing network analysis method can effectively allocate server resources in outpatient departments, reducing delays and improving patient treatment. The model considers different types of patients visiting service nodes in varying orders, providing a more accurate representation of real-world scenarios.
SourceBentham Science Publishers·JournalThe Open Automation and Control Systems Journal·DateJun 18, 2016
Unlocking secrets of the immune system could help combat colitis
An international team has identified interactions between immune system pathways that could improve the treatment of diseases such as colitis. The discovery may lead to more effective treatments for millions of IBD sufferers by targeting both adaptive and innate immune systems.
7-day doctors cut weekend emergency hospital visits by 18 percent, study finds
A UK study found that a seven-day doctor surgery pilot significantly reduced weekend emergency hospital visits, admissions, and ambulance call-outs. Elderly patients with moderate injuries or illnesses drove the reduction, as GPs took fewer risks and sent less serious cases home.
The use of Camelid antibodies for structural biology
Researchers developed Camelid antibodies against serine proteases to study catalysis and inhibition. These findings have significant implications for disease treatment and diagnosis involving these enzymes.
A light microscope made only with consumer electronic products
A novel on-chip microscope made from consumer electronics enables simultaneous measurement of nanometer-thick changes over a large volume in transparent objects. The device utilizes phase-shifting interferometry and offers unprecedented field-of-view and depth-of-field capabilities, making it suitable for point-of-care applications.
Military members with PTSD/depression can be treated successfully in primary care settings
A new study found that military members with post-traumatic stress disorder (PTSD) and depression can experience significant improvements in symptoms after enrolling in a treatment program that includes specially trained care managers and telephone therapy options. The approach resulted in better outcomes and improved access to high-qu...
Implantable device cuts obstructive sleep apnea symptoms
The hypoglossal nerve stimulation (HGNS) device shows promise for treating moderate to severe OSA who can't tolerate CPAP, with a 84% reduction in AHI and 11% increase in oxygen levels. The study replicates the success of previous clinical trials, offering an alternative option for patients.
UTMB study shows pulmonary rehabilitation underutilized by physicians and COPD patients
A new study from UTMB reveals that pulmonary rehabilitation therapy is underutilized despite its health benefits and cost-effectiveness in managing chronic obstructive pulmonary disease. The study found that the majority of economic burden of COPD stems from hospitalizations, which can be reduced by PR.
SourceUniversity of Texas Medical Branch at Galveston·JournalJournal of Cardiopulmonary Rehabilitation and Prevention·DateJun 9, 2016
A new biomarker for nerve cell damage
Scientists have identified a new biomarker for nerve cell damage that can be measured in the blood, providing valuable information on disease progression and treatment response. The discovery offers a potential breakthrough for developing therapies and could simplify clinical trials by using a simple blood sample.
Study uncovers clue to deciphering schizophrenia
A new study led by Michigan State University scientist uncovers a clue to deciphering schizophrenia by examining neurotransmitters glutamate and GABA. Reduced levels of both neurotransmitters were found in schizophrenia patients and healthy relatives, but the relatives maintained normal GABA levels.
Study: News stories often wrongly link violence with mental illness
Researchers found that nearly four in 10 news stories connect mental illness with violent behavior, despite less than five percent of violence being directly related to mental illness. The study suggests that this routine linkage paints an unfair portrait of those with mental illness and may have increased stigma.
The biological clock gets a time stamp
Yale researchers have identified key molecular pathways involved in the aging of human eggs, which could lead to new treatments for age-related fertility issues. The study found that oxygen-deprived cells are a major cause of egg damage, leading to chromosomal abnormalities and reduced egg quality in women over 40.
'Bitter brake' activates gut hormones and suppresses food intake
A new bitter plant extract, Amarasate™, has been shown to activate gut peptide hormones involved in appetite regulation and suppress subsequent feeding behavior. The study found significant reductions in energy intake following ingestion of the extract.
State of the art management of aortic disease
The June 2016 issue of Vascular Medicine explores the latest developments on aortic disease, medical technological advances, and treatment options. Original research articles and reviews highlight the mechanisms of aortic pathology and novel indices for thoracic aortic size.
New €5 million project to transform care for multimorbid patients launched
A new €5 million European project aims to transform care for patients with multimorbid chronic conditions by developing a cloud-based system called C3-Cloud. The system will enable personalized treatment plans and improve coordination of care among hospitals, general practitioners, and social care organizations.
Autism care improved, diagnosis time shortened by new MU program
A new MU program trains primary care providers to screen and manage autism spectrum disorders, improving confidence and utilization of resources. Early diagnosis is critical for children with autism, and the program aims to reduce disparities for rural and underserved children.
Telling irregularities
A clinical study confirmed a strong correlation between minor heart rate irregularities and the survival prospects of heart attack patients. The new method, measuring respiratory sinus arrhythmia, produces a specific picture of the body's functional condition.
SourceTechnical University of Munich (TUM)·JournalJournal of the American College of Cardiology·DateMay 27, 2016
Imaging study shows promising results for patients with schizophrenia
A recent imaging study found a subtle increase in brain tissue volume in certain regions of patients with schizophrenia, indicating the brain's ability to reorganize and fight the illness. The study suggests that despite severe damage, the brain may constantly attempt to rescue itself or limit the damage.
Study shows area undamaged by stroke remains so, regardless of time stroke is left untreated
Researchers analyzed untreated acute stroke patients and found no correlation between salvageable penumbra and time. However, they discovered a significant association between salvaged penumbra and collateral blood flow rerouting of the blocked arteries.
Canada announces major contribution for Stop TB Partnership's TB REACH initiative
The Government of Canada has pledged CA$85 million to support innovations in TB detection and care through the Stop TB Partnership's TB REACH initiative over the next five years. This funding will help reach, treat and cure millions of people affected by TB who lack proper care.
Parents favor boys over girls for free heart treatment in Northern India
Research reveals significant gender disparity in referrals to a cardiac center in Northern India, with boys outnumbering girls by more than two-to-one. The study suggests that societal attitudes towards the value of girls contribute to this disparity, prompting calls for medical professionals and policymakers to address these issues.
Swallowable, gas-filled balloons aid fight against obesity
A new treatment option is being developed to help people with obesity - swallowing gas-filled balloons that reduce hunger and increase feelings of fullness. Patients using the Obalon 6-month balloon system lost an average of 6.81 percent of their weight, compared to 3.59 percent in the control group.
World report on fertility treatments reveals high use of intracytoplasmic sperm injection
The report shows that ICSI use is approaching 100% in some regions, despite being developed for male infertility. The editor highlights the need to make decisions based on evidence, warning against unnecessary and costly care.
SourceEuropean Society of Human Reproduction and Embryology·JournalHuman Reproduction·DateMay 20, 2016
Scientists getting warmer on mimicking anti-freeze in nature
Researchers from the University of Leeds have discovered a way to prevent ice crystals from forming in water as it is cooled to -35°C using glycerol. This breakthrough has important implications for improving cryoprotectants used in fertility treatments and food storage.
Sleep disorders common in athletes -- but easily fixable
A Finnish study found that one in four professional athletes suffer from significant sleeping disorders, and most athletes slept too little. The study showed that general guidance, examinations when necessary, and personalized treatment plans significantly improved athletes' sleep quality.
To operate or not to operate: A serious question with no clear answers
Researchers found that surgeons differ in recommending surgery based on how they perceive risks and benefits, rather than just the patient's diagnosis. A surgical risk calculator can lead to more accurate predictions, but does not change a surgeon's likelihood of recommending an operation.
SourceUniversity of California - Los Angeles Health Sciences·JournalAnnals of Surgery·DateMay 19, 2016
Compared with men, women with AFib have more symptoms, worse quality of life, although higher survival
A study published in JAMA Cardiology found that women with atrial fibrillation (AF) exhibit more symptoms, functional impairment, and poorer quality of life compared to men. However, women also demonstrated a higher risk-adjusted survival rate and lower cardiovascular death rate despite their AF-related challenges.
3-D-bioprinted placenta could lead to new treatments for preeclampsia
Scientists have bioprinted a 3-D model of placenta tissue that mimics the organ's complex structure, which could lead to better understanding and treatment options for preeclampsia. The 3D model includes trophoblasts, epidermal growth factor, and other key components, showing improved cell migration towards the growth factor.
Simple, rapid TB diagnosis feasible in low-resource, high-burden settings
A streamlined TB diagnosis approach using a single sputum sample and rapid results proved feasible in rural Uganda, increasing treatment initiation rates. The method uses fluorescence microscopy for quick analysis and GeneXpert testing for accurate results, with 73% of patients diagnosed correctly.
The ATS and Sunovion Pharmaceuticals Inc. release landmark survey
A landmark survey by the ATS and Sunovion Pharmaceuticals Inc. reveals that seven in ten pulmonologists believe hand-held small volume nebulizers are more effective than metered-dose inhalers (MDIs) for managing acute exacerbations of COPD, particularly in severe cases. The survey also highlights gaps in physicians' knowledge about tre...
JFK Partners joins launch of Spark, nation's largest autism research study
SPARK, the nation's largest autism research study, aims to collect data from 50,000 individuals with autism and their families to accelerate research and discovery. The study, led by Children's Hospital Colorado, will utilize web-based registry and DNA analysis to improve understanding of the causes of autism and develop new treatments.
New way to predict COPD progression; new treatment may be on the horizon
Researchers discovered that NETs are strongly correlated with airway infection and disease severity in COPD patients, suggesting a potential biomarker for identifying those at risk of progression. This finding may lead to the development of new treatments targeting NET formation.
The gluten-free diet in children: Do the risks outweigh the benefits?
The gluten-free diet is not supported by scientific evidence for healthy children without CD or wheat allergy. It can lead to nutritional deficiencies and quality of life issues, posing more risk than benefit.
Children of depressed parents at high risk of adverse consequences into adulthood
The offspring of depressed parents have a higher risk for depression, morbidity, and mortality that persists into middle age. Children with a family history are more likely to experience recurrent episodes of depression as they mature.
SourceColumbia University Irving Medical Center·JournalAmerican Journal of Psychiatry·DateMay 11, 2016
LED treatments enhance lettuce phytochemicals, antioxidants
Continuous LED light significantly decreases nitrate content in preharvest lettuce, increasing nutrient contents. Researchers found that RB LED light was more effective than white LED light in facilitating lettuce growth, leading to enhanced free-radical scavenging activity and increased phenolic compound concentrations.
SourceAmerican Society for Horticultural Science·JournalJournal of the American Society for Horticultural Science·DateMay 10, 2016
Severe stroke prognoses differ depending on the doctor
A new study reveals vast differences in treatment recommendations among physicians for brain hemorrhage patients. The variation was found to be influenced by factors such as the physician's specialty and experience with the condition. Researchers recommend that clinicians consider these variations when communicating with families, as i...
The price of IVF: Study examines financial savings vs. medical complication costs
A new UVM study examines the trade-offs between IVF financial savings and medical complications from multiple embryo transfers. The research found increased rates of cesarean-section deliveries, premature births, and low birth weight with two or more embryos transferred into the mother at one time.
Newborn screening test developed for rare, deadly neurological disorder
Researchers at WashU Medicine have developed a newborn screening test for Niemann-Pick type C, a progressive neurodegenerative disease that typically isn't diagnosed until age 2. The test quickly identifies infants with NPC using a two-tiered testing strategy and measures levels of bile acid produced by the liver.
New guidelines explain how to monitor and treat hyperthyroid cats
The new Guidelines from the American Association of Feline Practitioners provide a concise explanation of what veterinary professionals know about the etiology and pathogenesis of clinical feline hyperthyroidism. The guidelines outline six clinical categories with associated management strategies to treat all hyperthyroid cats, regardl...
Study shows long-term improvement in health-related quality of life after bariatric surgery
A long-term follow-up study found significant improvement in health-related quality of life after bariatric surgery for patients with BPD-DS. The study evaluated 27 patients who underwent the procedure and compared their outcomes to pre-surgery scores and those from the general population.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalBariatric Surgical Practice and Patient Care·DateMay 2, 2016
Surgery for chronic temporal headaches -- simplified approach shows good results
A new surgical technique uses an incision originally designed for cosmetic forehead-lift to relieve pressure on nerves involved in chronic temporal headache. Surgery provides significant relief from symptoms, with an average score decrease of 80 points after treatment.
Veterans and their partners see less trauma and distress symptoms after intensive retreat
A recent study found that veterans and their romantic partners who participated in an intensive retreat model showed a significant reduction in trauma symptoms. The retreat, which included therapeutic group and couple counseling, as well as relaxation activities, was effective in reducing both veteran and partner distress levels.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalJournal of Couple & Relationship Therapy·DateApr 27, 2016
'Walk-DMC' aims to improve surgery outcomes for children with cerebral palsy
A new quantitative assessment called Walk-DMC predicts which children with cerebral palsy are likely to benefit from invasive surgeries. Higher Walk-DMC scores before treatment correlate with better surgical outcomes.
Poorer patients in UK less likely to get hip replacements
A recent study published in The British Medical Journal found that deprived patients and those admitted at weekends are least likely to receive the recommended total hip replacement surgery. Despite national guidelines setting out who should get the procedure, substantial variation in compliance between hospitals was observed.
Discovery could lead to better asthma treatment
Researchers at Cardiff University discovered a signaling molecule that can alleviate asthma symptoms such as mucus production and airway constriction. The study found that blocking this molecule can help regulate the allergic immune response, potentially leading to improved treatment options for asthma sufferers worldwide.
Stent retrievers improve odds for ischemic stroke patients
Patients treated with stent retrievers within 2.5 hours of symptom onset had a 91% chance of functional independence, compared to 81% for those treated between 2.5-3.5 hours. Inter-facility transfer times can significantly delay treatment.
Immune study offers treatment hope for arthritis patients
Researchers have discovered how compounds produced by the body's immune system help to dampen inflammation and prevent damage to healthy tissues. These compounds, called alpha defensins, may act on cells of the immune system to prevent excessive inflammation.
SourceUniversity of Edinburgh·JournalProceedings of the National Academy of Sciences·DateApr 18, 2016
Neonicotinoid seed treatments produce higher soybean yields in the Southern US
Scientists found neonicotinoid seed treatments yield higher results in southern U.S. states, with economic benefits in four out of 10 years studied.
UAlberta & Little Warriors change the trajectory of child sexual abuse victims
The four-week intervention program significantly reduces psychological impacts of child sexual abuse, with a 25% reduction in PTSD scores and fewer children experiencing depression and anxiety. The Be Brave Ranch offers comprehensive treatment to child survivors, providing individual and group therapies alongside peer support.
SourceUniversity of Alberta Faculty of Medicine & Dentistry·JournalJournal of Child and Adolescent Behaviour·DateApr 18, 2016
Additional benefits of type 2 diabetes treatment found for non-alcoholic fatty liver disease patients
A study found that acute exenatide administration enhances glucose uptake and reduces insulin resistance in the liver and adipose tissue of patients with non-alcoholic fatty liver disease. This treatment also improves glucose control in the liver and fatty cells, offering promising benefits for individuals with this condition.
California mental health stigma-reduction campaign creates economic benefits
A new RAND Corporation study finds that California's investment in a social marketing campaign to reduce mental illness stigma may provide the state with significant economic benefits. For every dollar invested, the state can expect an estimated $36 in higher tax collections and up to $1,251 in economic benefits over several decades.
QUT leads world-first new treatment for alcohol addictions
A study led by QUT researchers has shown that pindolol, a drug already approved by the FDA, can reduce ethanol consumption and is a promising treatment option for alcohol use disorders. The preclinical study suggests that pindolol could be an inexpensive and effective approach to treating alcohol dependence.
Expanding insurance for single-embryo IVF could improve pregnancy outcomes
A national survey of IVF cycles found that elective single-embryo transfer results in fewer adverse outcomes and ideal pregnancy outcomes, including single, full-term babies of normal birth weight. The study also shows that insurance coverage for infertility treatment is associated with increased use of elective single-embryo transfer.
SourceUniversity of Colorado Anschutz Medical Campus·JournalFertility and Sterility·DateApr 13, 2016
Early treatment for post-traumatic stress accelerates recovery but does not sustain it
A new study finds that early treatment for post-traumatic stress disorder (PTSD) significantly reduces symptoms, but does not prevent long-term suffering. The research suggests that prolonged exposure and cognitive therapy can shorten the recovery time, but may not reduce PTSD prevalence.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalJournal of Clinical Psychiatry·DateApr 12, 2016