Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Researchers discovered a specific gene variant linked to fragile bones in mice with Hajdu-Cheney syndrome, a rare inherited disorder. The study suggests that overactive bone-absorbing cells contribute to the disease's characteristic bone loss and fractures.
A new study reveals that surgical treatment can effectively restore penile length and improve erectile dysfunction in patients with Peyronie's disease. The 'sliding technique' and penile prosthesis implantation showed promising results, with an average lengthening of 3.2 cm.
A large new study found previously unknown risk factors associated with keratoconus, a condition that causes progressive nearsightedness at a young age. The study revealed higher odds of developing keratoconus among men, African Americans, Latinos, and those with asthma and sleep apnea.
A new minimally invasive intervention involving lung coil implantation improved exercise capacity in patients with severe emphysema, with significant short-term costs. The treatment also showed long-term benefits, including reduced lung hyperinflation and sustained quality of life improvements.
Researchers at Vanderbilt University Medical Center have obtained the crystal structure of a toxin from Clostridium difficile, revealing that zinc is required to unleash its damaging effects. This discovery aids efforts to develop vaccines and other novel therapies to prevent fatal consequences of C. diff infection.
New research suggests chronic hypoxia induces neuroinflammation in the developing brain, leading to delayed white matter development and motor learning deficits. Perinatal chronic hypoxia may lead to long-term behavioral deficits, making oxygen supplementation a potential treatment option.
A study published in JAMA Surgery found that nearly one-third of patients who underwent Roux-en-Y gastric bypass surgery experienced hospitalization due to symptoms such as abdominal pain and fatigue. The risk of symptoms was higher among women, younger patients, smokers, unemployed individuals, and those with surgical symptoms before ...
A study by NIH researchers found that children conceived through infertility treatment have similar developmental scores to those conceived naturally, with some increased risks for twins but not ART treatment groups.
A study found that combining botulinum toxin with hyaluronic acid (HA) fillers reduces degradation and increases remaining volume, leading to longer-lasting cosmetic improvements. Chemodenervation using Botox results in a 42% decrease in degradation rate and a 50% increase in HA filler volume at three months.
New research explores wearable device effectiveness in promoting healthy behavior, using a novel trial design that evaluates real-time settings. The study aims to provide insights into when wearable devices can help improve health and when they may exacerbate conditions.
Researchers from Brigham and Women's Hospital re-evaluate guidelines for testing and treating toenail fungus, finding that confirmatory testing may no longer be necessary for certain therapies. The study suggests that blanket recommendations should be replaced with tailored recommendations based on specific treatments.
New evidence on dental implants reveals the importance of tooth preservation in patients with gum infections. The studies suggest that teeth compromised by periodontal disease or endodontic problems may have a longer longevity than average implants.
A study of over 156,947 U.K. women found that extending IVF cycles beyond 3 or 4 treatment cycles can increase the likelihood of a live birth. Live-birth rates continued to rise with each additional cycle, with 65% of women achieving a live birth by the sixth cycle.
A new study finds that treatment resources for non-veterans with PTSD are much less cohesive and helpful than those available to veterans. The review of research literature highlights the need for better guidance on treating PTSD in specific vulnerable subpopulations, such as victims of sexual assault and natural disasters.
Researchers altered brain activity of rats by changing firing rates of neurons in the central thalamus, waking some and putting others into unconscious states. The study uses functional magnetic resonance imaging (fMRI) to scan brain activity and may guide deep brain stimulation therapies for neurological disorders.
A study found that common CF screening tests do not adequately cover genetic variants present in non-white populations, leading to late diagnoses and poorer outcomes. The researchers recommend expanding testing to include more diverse genetic analysis methods to address this disparity.
A new parent-led therapy, PASS, has been successfully tested in India and Pakistan, showing improved interaction between autistic children and their parents. The study, funded by Autism Speaks, adapted a UK therapy method to address language and cultural differences in lower-income countries.
Scientists have discovered a blood test that can predict rheumatoid arthritis (RA) in some individuals even 16 years before the condition takes effect. The test detects antibodies targeting citrullinated tenascin-C, which were found in high levels in joints of people with RA.
A recent study by the University of California, Irvine found that three-fourths of ER stroke cases had some degree of preventability, highlighting the need for improved stroke prevention strategies. The study's results suggest that resources for acute stroke treatment may be misdirected towards patients whose strokes are more preventable.
Researchers used biosolids to create a soil blend that supported healthy bacteria, fungus, and plants, outperforming traditional compost in restoring the degraded surface area of Lake Calumet Cluster Site. The 'dream treatment' has potential to restore poor quality soils in Chicago's dense urban areas.
A Finnish study found that children who were frequently bullied or exposed to bullying had a higher risk of developing psychiatric disorders in adulthood. Treatment for these disorders was associated with frequent exposure to bullying, being a bully, and being exposed to bullying.
The first international patient registry for primary ciliary dyskinesia (PCD) has been launched, aiming to collect data on the disease's effects, treatment options and progression. The registry will help advance understanding of PCD, improve diagnosis and treatment, and facilitate access to clinical trials.
A UTSW-led study identified three neurobiologically distinct biotypes of psychoses, which do not always match conventional clinical diagnoses. The findings suggest that the term 'psychosis' might describe unique psychiatric disorders with distinctive mechanisms and treatments.
A University of Sydney study found that 'no-drill' dentistry can stop and reverse tooth decay without traditional fillings. The Caries Management System (CMS) reduces decay risk and need for fillings by 30-50%, partnering patients with dentists for successful treatment.
Researchers have identified a network of nine genes that play a key role in the onset of Alzheimer's Disease. The study found that some genes delay the disease by up to 17 years, while others accelerate its progress.
Scientists have unraveled the abilities of multinucleated giant cells, which help the body deal with bulky items that obstruct physiological processes. The treatment for systemic amyloidosis has been found to be effective due to the complement system's role in marking and destroying protein deposits.
The Canadian Task Force on Preventive Health Care recommends against screening older community-living adults for cognitive impairment if they are asymptomatic. However, physicians should investigate patients or their family members expressing concern about possible memory loss.
Researchers at UNSW Australia have identified a new molecular mechanism that contributes to synapse loss in Alzheimer's disease, which occurs early on and precedes nerve cell death. This discovery could lead to earlier diagnosis and new treatments.
Researchers at Cornell University discovered that lubricin helps anchor HA at the tissue surface, improving its effectiveness. A new derivative of HA, HYADD4, has been approved for clinical use and is expected to be marketed as Hymovis.
A QUT study found that 44% of child injuries in emergency departments are associated with consumer products, but 13% of cases have inadequate records to determine the cause. The study highlights the need for better injury data to improve product safety initiatives.
A five-year trial of progesterone supplements for recurrent miscarriage shows no improvement in outcomes. Despite disappointing results, the PROMISE trial provides valuable insights into potential alternative treatments and highlights the importance of continued research into reducing miscarriage risk.
A new process removes contaminants from oil sands wastewater using sunlight and nanoparticles, offering a more effective and inexpensive alternative to conventional treatment methods. The technology breaks down persistent pollutants into individual atoms, completely removing them from the water.
A Dartmouth study shows that the brain processes motion differently for animate and inanimate objects, interacting between two visual pathways. This discovery has potential applications in improving motion recognition algorithms for public security systems and treating motion blindness and object agnosia.
A new supplement published by the NIH details a research strategy to tackle global brain disorders, which affect millions worldwide. The initiative aims to improve diagnosis, treatment, and prevention of conditions such as depression, dementia, and substance abuse in low- and middle-income countries.
Researchers at CSIRO Australia have developed a new coating using prebiotic compounds from primordial goo, which can be used to improve the performance and acceptance of medical implants. The coating is bio-friendly, cells readily grow on it, and has potential applications in reducing infection risk.
Research found that exposure to dust mite and cockroach allergens triggers distinct asthma responses, with eosinophilic and neutrophilic asthma requiring separate treatment options. The study suggests that current 'blanket approach' to asthma treatment may not be ideal.
A large-scale randomized control trial found that computerized cognitive behavioral therapy (cCBT) offered little to no benefit over usual GP care in treating depression. Patients generally struggled with sustained engagement and highlighted difficulties with logging onto computer systems while clinically depressed.
QUT research has received a $1M funding boost to explore the use of Australian plants in combating golden staph infections, healing chronic wounds, and treating diseases like Alzheimer's and Parkinson's. The project aims to improve treatment options for millions of people worldwide suffering from these conditions.
A new treatment approach, CIT-S, combines family therapy with culturally-based practices to reduce caregiver burden and shame. The study found that CIT-S was effective in improving caregivers' quality of life and reducing psychiatric symptoms.
A study of nearly 1,300 veterans found that those who completed online expressive-writing sessions showed more improvements than peers who didn't write at all or did factual writing. Expressive writing reduced physical complaints, anger, and psychological distress, but had limited impact on PTSD symptoms.
A follow-up study found that cognitive behavioural therapy (CBT) and graded exercise therapy (GET) improved fatigue and physical functioning in patients with Chronic Fatigue Syndrome, maintaining these improvements over time. The treatments also reduced the likelihood of seeking additional therapy.
The study analyzed data from 10 US stroke centers and found that treatment of post-thrombolysis brain hemorrhage did not significantly reduce mortality or hematoma expansion. Shortening the time to diagnosis and treatment may be key to improving outcomes.
Older adults do not accurately predict their own life expectancy, contrary to common wisdom that they overestimate. A study found that 54.7% of participants had similar estimates to objective calculations, while 32.7% underestimated and 11.5% overestimated.
Researchers used popular animated films to improve visual acuity in young children with amblyopia through dichoptic therapy. Visual acuity improved by 1-4 lines over six sessions of movie viewing, outperforming patching treatments.
A study found that antipsychotic drugs are initiated in Alzheimer's patients 2-3 years before diagnosis and used for over a year. This contradicts current treatment guidelines, increasing the risk of adverse incidents like stroke and death.
Only four out of 27 mental health apps accredited by the NHS provide scientific proof that they work, with many failing to demonstrate clinical effectiveness. The authors urge removal of these apps from the NHS library to prevent potential harm and waste of money.
Researchers studied concussion-like symptom reporting in over 30,000 uninjured adolescents, finding a link between symptom reporting and male sex, preexisting psychiatric and neurological conditions. The study suggests that the definition of 'asymptomatic' after concussion can be challenging to determine.
Researchers estimate that introducing Ebola treatment beds prevented an estimated 57,000 Ebola cases and 40,000 deaths in Sierra Leone. The study suggests that this could have been reduced further if the beds were introduced one month earlier.
Researchers have demonstrated the relative safety and effectiveness of eltrombopag in children with persistent immune thrombocytopenia (ITP). The treatment stabilizes platelet counts, enabling children to participate in social activities without frequent nose bleeds.
Researchers are developing a healing glove that delivers medicine to injured hands and speeds up healing, allowing for earlier rehabilitation. The REHEAL Glove provides positive pressure wound therapy, delivering therapeutics and controlling the wound environment for better and faster healing.
A new study shows that anti-osteoporotic therapy can decrease the risk of subsequent fractures by 40% over three years. The treatment significantly reduces fracture risk for hip, spine, wrist, and upper arm fractures.
A study by CAMH found that 52.8% of workers with significant depressive symptoms did not recognize a need for help, leading to a 33% decrease in work productivity if this barrier is removed. Employers can target these barriers to increase the use of mental health services among workers.
Matthew D. Disney's innovative approach uses cells as reaction vessels to synthesize treatments within disease-affected cells, offering highly specific and precise therapies. This technology has potential applications in treating over 30 incurable diseases, including ALS, fragile X syndrome, and Huntington's disease.
Adult rashes accompanied by a fever of 100.5 or higher warrant immediate medical attention due to potential life-threatening conditions. Quick, aggressive treatment can significantly improve survival rates for patients with underlying conditions such as toxic shock syndrome and staph scalded skin syndrome.
Researchers have developed a less painful treatment approach for Pneumothorax by analyzing gas pressure in the thoracic cavity. The new diagnostic strategy allows physicians to update treatment strategies accordingly, often switching from chest tube drainage to more conservative or needle aspiration methods.
The National Institutes of Health has awarded $38 million in grants to support the BRAIN Initiative, a large-scale effort to understand neural circuit function and capture dynamic views of the brain. The initiative aims to treat devastating brain disorders that affect over one billion people worldwide.
A randomized controlled trial in Peru found that deworming treatment had no significant impact on growth in pre-school children, similar to a placebo. The study highlights methodological challenges and the need for further research to accurately detect the true effect of deworming on growth in early childhood.
A Vanderbilt study found significant differences in social ability among children with autism who participated in a 10-week theatre-based program compared to those who did not. The program improved social cognition, interaction, and communication skills, including face recognition and group play.
The Center for Thrombosis and Hemostasis at Mainz University Medical Center has been awarded €25 million in funding from the German Federal Ministry of Education and Research. The center will focus on translational research to improve treatments for thrombosis-related disorders.
Researchers at Sahlgrenska Academy found that the Fugl-Meyer assessment scale can predict stroke patients who will develop upper limb spasticity within one year. This allows for early treatment to minimize pain, impaired function, and other repercussions of spasticity.