Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A team of researchers has discovered a novel approach to treating juvenile Batten disease by activating a protein called TFEB, which stimulates the cell to produce more lysosomes and degrade cellular waste. This breakthrough may lead to improved neurological symptoms in patients with the condition.
A USU ecologist has found evidence of Pando's recovery through the use of fencing to limit herbivore access, supporting a growing body of research suggesting this approach can help protect western aspen communities from decline. The study suggests that limiting herbivory can give Pando and other aspen clones a fighting chance at survival.
A case series analysis of 22 patients with frontal sinus fractures found that 20 treated without surgery showed improvement, with no complications. The minimally disruptive treatment protocol promises to revolutionize the treatment of frontal sinus fractures by prioritizing sinus preservation.
The UT Southwestern Medical Center review article proposes an evidence-based medicine approach to prevent overtreatment of type 2 diabetes. It suggests balancing absolute benefits and harms with the physician's judgment and patient values, recommending more modest blood-sugar goals for frail and older individuals.
A long-term study found that continuous glucose monitoring significantly lowers blood sugar levels in persons with type 1 diabetes, reducing the risk of complications. The treatment also leads to increased well-being and improved treatment satisfaction.
A new study from the University of Utah's National Center for Veterans Studies found that a simple intervention, crisis response planning, significantly reduced suicide attempts among active-duty soldiers. The study showed a 75% reduction in suicide attempts compared to contracts for safety.
A multicenter study of infants and children who suffered cardiac arrest found that body cooling had no significant benefits compared to maintaining a normal temperature. The study included 329 patients aged 2 days to 18 years old, but the results showed no difference in survival rates or brain function between the two groups.
Two studies found that continuous glucose monitoring improved blood sugar levels and reduced hypoglycemia in type 1 diabetes patients using multiple daily insulin injections. The studies showed significant reductions in hemoglobin A1c levels and glycemic variability, with improved treatment satisfaction.
A systematic review found that both endovascular (EVAR) and open surgical (OSR) repairs for abdominal aortic aneurysm (AAA) can lead to renal function impairment. The study included six studies with over 2,100 patients, revealing similar risks of renal decline in EVAR and OSR groups.
Indigenous patients with diabetes in Canada face culturally unsafe care, leading to poorer health outcomes. A study found that negative experiences with healthcare systems can trigger traumatic memories and disengage patients from care.
A positive relationship between counselor and patient is key to successful alcohol treatment, according to a new study. Patients with stronger alliances reported fewer days of drinking and heavier drinking between sessions.
Researchers found disruptions in brain network communication affect memory regions in individuals with PTSD, linked to avoidance symptoms. The study suggests treatments targeting enhanced communication may improve PTSD symptoms.
A survey of over 1,000 participants found strong evidence that individuals with depression and psychopathy are attracted to satanic practices for magical power. This correlation yields new perspectives on early-onset depression and highlights the need for verification in psychiatric hospitals.
A new report in JAMA Surgery found that only one in six gunshot patients with serious injuries are treated at designated trauma centers. The study found that these 'undertriaged' patients were more likely to live on the south and west sides of the county, where trauma centers are scarce.
Research suggests that acupuncture can effectively treat infantile colic by reducing the frequency and duration of excessive crying in babies. The study involved 147 babies who received either standard care or tailored acupuncture treatment, resulting in a significant reduction in crying time for those who received acupuncture.
Researchers emphasize the need for continued study of Zika virus due to its serious complications and the importance of developing effective vaccines and treatments. Lessons learned from other arboviruses like West Nile and Chikungunya highlight the risks of fading interest in diseases that transition to endemicity.
The Austen Riggs Center is launching an MRI-based characterization program to explore complex psychiatric disorders and develop better characterizations. This project builds upon recent developments in mental health research, including the Human Connectome Project and the Research Domain Criteria (RDoC) Matrix.
Research reveals that African Americans are more likely to experience eosinophilic airway inflammation, making them less responsive to standard asthma treatments. This study highlights the need for personalized therapies tailored to individual airway inflammation patterns.
A new review found functional rehabilitation and minimally invasive surgery to be effective treatment options for Achilles tendon tears, especially in recreational athletes. Surgical repair may be optimal for high-performance athletes, offering improved strength and power.
A new study suggests that natural progesterone supplementation can increase pregnancy success in women with a history of recurrent pregnancy loss. The research found that over two-thirds of pregnancies were successful in women who received progesterone, compared to barely half in those who did not.
A high-fiber diet triggers microorganisms in the gut to produce short-chain fatty acids, which induce neutrophil apoptosis and resolution of inflammation. This finding has important implications for treating gout and possibly other inflammatory diseases.
Researchers found that a mobile, tablet-based game called Project: EVO improved cognitive benefits and mood in people with late-life depression. A second study showed similar results, with improvements seen in all groups, including the placebo.
Grapes are the third most common cause of food-related choking after hot dogs and sweets in young children. The small airways, lack of teeth, and easily distracted nature make them prone to choking hazards.
Patients who underwent weight loss surgery often experience indigestion and food intolerance, especially for high-fat or sugar content foods. The study aims to provide guidance for physicians and patients considering gastric bypass surgery.
Researchers propose that visual stimulation with frequencies close to alpha rhythm can interfere with natural brain activity, leading to increased amplitude and epileptic seizures. This phenomenon is linked to the brain's dynamic properties, such as resonance, which can trigger seizures at specific frequencies.
A consortium of researchers will assess various interventions, including bovine colostrum and elemental diets, to improve gut health and reduce mortality rates. The research aims to address the high mortality rate of severe acute malnutrition, particularly among children in low-income countries.
Professor Ari Waisman receives prestigious Sobek Prize for groundbreaking multiple sclerosis research, enabling deeper insight into inflammatory cell role and regulation in the brain.
Researchers developed a method to read and amplify high confidence states using decoded neurofeedback, boosting participants' confidence without awareness. The effect was reversible, with confidence decreasing when the pattern was no longer detected.
A team of researchers from the University of Toronto has developed a proprietary peptide-hydrogel biomaterial that promotes skin cells to 'crawl' together, closing chronic, non-healing wounds caused by diabetes. The treatment closed wounds 200% faster than no treatment and 60% faster than existing collagen-based products.
A new study by PolicyLab found that only 20% of medically diagnosed child abuse and neglect cases in US Army dependent children between 2004 and 2007 were substantiated. The rate is significantly lower than the civilian Child Protective Services rate, suggesting under-reporting or a breakdown in communication.
A new treatment strategy that creates new nerve synapses in the brain may improve recovery after stroke, allowing for faster learning and motor function recovery. The study found sustained improvement in mice treated with C3a peptide, which was administered through nasal drops.
Elyn Saks, a professor of law and psychology at USC, received the ACNP Media Award for her tireless efforts to educate the public about mental illness. Her work, including her memoir The Center Cannot Hold, has helped advance compassionate care and legal protections for people with mental illness.
Over 300 participants from 80 nations share expertise on torture rehabilitation, addressing issues like Syria's refugee crisis and Guantanamo Bay survivors' denied rehabilitation. The symposium aims to deliver on the right to rehabilitation, a UN-recognized right for victims of torture.
Researchers at Drexel University have developed a portable device that uses low-frequency ultrasound to heal chronic wounds. The device, which is battery-powered and compact, has shown promising results in clinical trials, with patients experiencing improved healing by 15% per week.
Smokers under 50 are significantly more likely to have a major heart attack than older smokers, with the risk dropping with age. The study found that younger smokers face an almost 8-fold higher risk of STEMI than non-smokers, making them particularly vulnerable.
Australian researchers have discovered that the platypus and echidna have evolved changes in the hormone GLP-1, making it resistant to rapid degradation. This finding has potential for developing new type 2 diabetes treatments with a long-lasting form of insulin.
Researchers aim to create highly personalized approach to treating cystic fibrosis by analyzing mucus hydration and clearance in patient nasal cells using nuclear imaging techniques. The study could lead to a more effective treatment, increased life expectancy, and improved quality of life for CF patients.
Researchers recommend combining dry-injection technology with modified traditional hollow-tine aerification programs for growing healthy ultradwarf bermudagrass putting greens. The optimal combination improves soil physical properties, such as bulk density and water infiltration.
Research suggests elevated urate levels may be associated with musculoskeletal pain in asymptomatic individuals. Cross-sectional study found ultrasound evidence of monosodium urate crystal tissue deposition in intra- and extra-articular structures.
A randomized clinical trial found that individual cognitive processing therapy improved PTSD severity more than group therapy, with patients receiving individual sessions experiencing twice the improvement. Depression and suicidal ideation also improved equally with both forms of therapy.
A decision aid significantly increased the rate of total knee replacement surgery among black patients, who were more likely to undergo surgery when informed about treatment risks and benefits. The intervention also led to a higher uptake of surgery among those willing compared to unwilling patients, women, and younger patients.
Research from the University of Southampton discovered that Alzheimer's disease proteins can accumulate in the retina and damage it, leading to Age-related Macular Degeneration (AMD). The study found that Amyloid beta proteins entered retinal cells within 24 hours and damaged the cell's structure.
Genetic defects in sucrase-isomaltase gene variants are associated with an increased risk of irritable bowel syndrome. The study found that rare mutations were twice more common among IBS cases than healthy controls, and a common variant with reduced enzymatic activity was also linked to increased risk.
The Society of Vascular and Interventional Neurology (SVIN) aims to enhance global efforts to improve stroke care by increasing the rate of mechanical thrombectomy from less than 100,000 procedures today to 202,000 annually by 2020. This initiative seeks to reduce global stroke disability and improve patient outcomes.
Researchers found that increased sensitivity to uncertain threat is a common trait among anxiety disorders, including panic disorder and social anxiety disorder. This finding could lead to more impactful and efficient treatment approaches by targeting shared neurobiological characteristics.
A new online calculator estimates individualised chances of couples having a baby through IVF or ICSI, considering specific characteristics and treatment information. The tool provides cumulative chances over up to six cycles, helping clinicians communicate personalised chances to couples and shape their expectations.
Researchers have identified a novel protein, Tmem135, that regulates retinal aging and causes age-dependent diseases like macular degeneration in mice. The study reveals that irregular levels of the protein lead to symptoms of macular degeneration.
The Sexual Medicine Society of North America renamed its Lifetime Achievement Award to honor Dr. Lewis, a pioneer in treating male sexual dysfunction. He made significant contributions to promoting standards and ethics in sexual medicine, serving as president and chairing various committees.
A study published in Spine found that surgery significantly improves sex life-related pain and disability in patients with degenerative spinal conditions. After three months, less than 20% of patients still experienced pain, compared to 40% without surgery. The improvement persisted for four years.
A study presented at TCT 2016 found the Watchman device had a successful procedure rate of 95.6% with low major complications, including pericardial effusion and embolization. New operators performed 50% of procedures, yet complication rates remained favorable.
Research published in BMJ Open found that people with health anxiety were twice as likely to develop heart disease as those without it. The study, based on 7,052 participants, suggests that health anxiety can be a significant risk factor for coronary artery disease.
A study published in the journal Obesity found that a simple brain scan can predict weight loss success in elderly individuals with high accuracy. The researchers used MRI scans to measure brain gray and white matter volume, which provided higher prediction accuracy than using either one alone.
Researchers at The University of Manchester have discovered a potential therapy for alleviating chronic pain by tuning the brain's frequency. This new approach uses visual and auditory stimulation to reduce pain intensity in patients.
UBC researchers created a new classification system to help police solve sex crimes, identifying subtypes of high-risk sexual offenders. The tool can predict characteristics of offenders and behavior before a crime takes place.
The Nordic-Baltic-British Left Main Revascularization Study (NOBLE) found that CABG reduced the five-year risk of MACCE compared to PCI for LMCA disease. The study demonstrated superiority of CABG over PCI in reducing non-procedural myocardial infarction and stroke.
A new CBTI treatment program using trained 'sleep coaches' significantly improved sleep quality in older adults. Participants took less time to fall asleep, woke up fewer times, and reported better overall sleep quality.
Researchers at James Cook University have identified a protein secreted by hookworms that suppresses asthma in mice and shows promise as a treatment for humans with allergies. The study builds on previous research into possible treatments for inflammatory bowel disease.
Researchers studied COPD patients with moderate oxygen deficiency and found no significant difference in time to death, hospitalizations, or quality of life between those who received supplemental oxygen and those who didn't. The study suggests that long-term oxygen therapy may not be necessary for all COPD patients.
A randomized controlled trial found no significant differences between ultrasound and sham treatment for tibial fracture healing or functional recovery. The study suggests abandoning low-intensity pulsed ultrasonography (LIPUS) as an ineffective treatment option for patients with tibial fractures.
The Geoffrey O. Hartzler Master Clinical Operator Award is presented to Dr. Patrick Whitlow, a renowned physician who advanced the field of interventional cardiology through his technical expertise and innovations. He was a pioneer in developing new devices and procedures for angioplasty and chronic total occlusions.