Articles tagged with Vaccination
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A Phase 1/2 clinical trial has begun at the NIH to assess the safety and immunogenicity of different COVID-19 vaccine booster regimens. Participants will receive a single booster dose of the Moderna COVID-19 vaccine, followed by telephone check-ins and in-person follow-up visits for one year.
A mathematical simulation by researchers at UNC Health Care shows that non-pharmaceutical interventions like mask-wearing and physical distancing can help prevent COVID-19 spikes as vaccines are distributed. The study found that widespread vaccine adherence and adherence to precautions can lead to a sustained decline in new cases.
Researchers investigated mRNA vaccination response in Israeli cancer patients. Patients with cancer who received the vaccine showed seropositivity, indicating an immune response against SARS-CoV-2. The study aimed to assess the safety and efficacy of mRNA vaccines in this vulnerable population.
Researchers developed a DNA vaccine encoding SARS-CoV-2 spike protein, which induced long-lasting antibodies in mice and hamsters. The vaccine showed protective efficacy against COVID-19 infection in hamsters, with no loss of body weight or viral RNA in their lungs.
A survey study explores associations between race/ethnicity, medical mistrust and willingness to receive COVID-19 vaccines. The study found that racial/ethnic group-based medical mistrust is a significant factor in vaccine hesitancy.
A comprehensive review suggests that gut microbiota play a crucial role in immune responses to vaccinations. The study aims to improve vaccine effectiveness by understanding the microbiota's impact on B and T cell immune responses.
A new Finnish study reveals pertussis is more prevalent among middle-aged adults in European countries than previously assumed, leading to concerns about underdiagnosed cases. The study also highlights the low levels of antibodies against diphtheria, indicating decreasing herd immunity.
Scientists from Scripps Research have discovered a cross-reactive coronavirus antibody that neutralizes SARS-CoV-1 and other coronaviruses, including those causing the common cold. The finding is a promising development for the eventual development of a pan-coronavirus vaccine.
A recent investigation by The BMJ found that vaccine advisory committees in the US and UK have different disclosure standards, leaving the public uncertain about experts' industry ties. Experts on these committees rarely disclose conflicts of interest, despite significant financial payments from pharmaceutical companies.
A study using real-world air traffic control data found that vaccination programs alone may not stop the ongoing second wave of COVID-19 infections in the US. Strict social distancing measures remain necessary to prevent a new wave, according to researchers.
Researchers analyzed state health department COVID-19 vaccine website accessibility and usability, finding challenges that create frustration and contribute to ineffective vaccination efforts. The study highlights the need for improved accessibility and usability in healthcare websites to promote equitable health outcomes.
A new study by Brigham and Women's Hospital uses an ultrasensitive test to detect circulating antigen in vaccinated individuals, showing a strong immune response. The test found evidence of low viral protein levels followed by antibody production and clearance of proteins from the blood.
Researchers analyzed COVID-19 swab samples from California counties and found the new variant was more transmissible, infecting people who already had COVID-19. Vaccines showed higher neutralization rates against the variant than antibodies from previously infected patients.
A small case series found that vaccination was not linked to worsening symptoms or reduced quality of life in patients with persistent COVID-19 symptoms. The study included 163 patients who received one dose of either Pfizer-BioNTech or Oxford-AstraZeneca vaccine.
The University of Illinois Chicago is leading a multi-center collaborative to improve community vaccinations, testing, and engagement in clinical research. The Chicagoland COVID Collaborative aims to bolster COVID-19 vaccine confidence and access among Black and Latino communities.
A retrospective cohort study found that autonomous cortisol secretion is associated with a 2- to 3-fold increased risk of death and cardiovascular disease in patients with adrenal incidentalomas. Researchers recommend treating known cardiovascular risk factors and incorporating findings into treatment decisions, including surgery.
A national study found nearly 90,000 people taking immunosuppressive drugs, including steroids, may have a slower or weaker response to COVID-19 vaccines. Researchers are exploring strategies to improve vaccine efficacy in this vulnerable population.
Research by MSU's Morteza Mahmoudi suggests that Covid-19 vaccines developed with nanomedicine may have different efficacies for men and women due to sex-based differences. The study highlights the importance of considering sex in vaccine development and research, particularly in using nanomedicines.
A new study reveals key details of how SARS-CoV-2 variants escape the immune response created by natural infection or vaccination. The research highlights that several mutations are clustered in one site on the spike protein, disrupting antibody binding and neutralization.
Researchers are studying the effectiveness and safety of COVID-19 vaccines during pregnancy, using data from Ontario's vaccination registry and province-wide birth registry. The study aims to inform decision-making for ongoing COVID-19 vaccine administration programs in Canada.
A retrospective study found increased axillary lymph node uptake on PET scans after COVID-19 vaccination, affecting 7.4% of FDG and 23.1% of 11C-choline PET examinations. Ipsilateral deltoid uptake was also observed in 14.5% of examinations.
Researchers developed a microparticle-based cancer vaccine that kickstarts an immune response, increasing the proportion of mice cured of tumors to 75%. Combining the vaccine with immune checkpoint inhibitors greatly improves treatment success, offering a promising approach to improving cancer treatment.
A recent study published in PLOS ONE found that individuals relying on traditional news sources are more accepting of the COVID-19 vaccine. The research highlights the importance of trusted sources in shaping public opinion on vaccination.
Developed by Inserm teams and French company NEOVACS, the conjugate vaccine induces sustained production of antibodies against IL-4 and IL-13, significantly reducing asthma symptoms.
Researchers have successfully treated a patient with vaccine-induced thrombotic thrombocytopenia (VITT) using intravenous immunoglobulin concentrates, cortisone, and specific anticoagulants. Prompt diagnosis and treatment can prevent life-threatening thrombosis.
Researchers have discovered a misinterpreted model of immature flavivirus particles, revealing an unexpected organisation that could lead to new and better vaccines. The study's findings define the exact wiring of the immature virus before it becomes infectious, providing a solid foundation for designing tomorrow's treatments.
A new study examines the safety of COVID-19 vaccines in patients with cancer, providing insights into potential risks and benefits. The research found that while some cancer treatments may interact with COVID-19 vaccines, the overall risk is low.
A UCR study found that messages stressing the Christian doctrine of 'love thy neighbor' and aligning mask-wearing with patriotism can effectively persuade white evangelicals to wear masks. The research also suggests that similar messaging could be used for pro-vaccine efforts, particularly targeting Republican-leaning individuals.
Researchers recommend surveillance, accurate diagnosis, and rapid response to counteract COVID-19 misinformation and disinformation. They also introduce a taxonomy of categories for different types of misinformation related to Covid-19 and vaccination.
A new COVID-19 vaccine developed using the Sementis Copenhagen Vector (SCV) platform is being accelerated for human clinical trials within 18 months. The vaccine aims to provide long-term and broad-ranging immunity against SARS-CoV-2, including mutant strains.
A new study from Beth Israel Deaconess Medical Center found that COVID-19 mRNA vaccines triggered immune responses in pregnant and lactating women, with maternal antibodies transferred to infant cord blood and breast milk. This suggests that vaccinating pregnant mothers may protect infants from COVID-19 infection.
Researchers at Scripps Research have unveiled an innovative Ebola virus vaccine design that stimulates a better protective immune response. The new approach involves tethering copies of the Ebola virus outer spike protein to a spherical carrier particle, resulting in a more stable and realistic-looking virus particle.
A new UNSW Sydney study examines content between December 2019 to November 2020 and found over 103 million people globally shared or reacted with misinformation about COVID-19 vaccines. The study highlights the need for traditional risk communication and community engagement methods to counter misinformation.
Research from the Com-COV study shows that mixing COVID-19 vaccine doses can lead to more frequent mild-moderate symptoms, but adverse reactions are short-lived and no safety concerns were found. The study's findings suggest that mixed schedules could result in increased work absences after vaccination.
A dengue virus vaccine candidate has produced a protective immune response in infected mice, offering a promising alternative to existing vaccines. The UQ-developed vaccine uses an Australian insect virus and can be administered via a microarray patch for easy, needle-free delivery.
A new study by Stanford researchers found that nearly two-thirds of California prison residents who were offered a COVID-19 vaccine accepted at least one dose. Acceptance rates varied across different racial and ethnic groups, with Hispanic and white inmates having the highest acceptance rates.
A US study suggests that delaying the second dose of COVID-19 vaccines for people under 65 could result in lower mortality rates, with estimates suggesting a 20% reduction in deaths. The strategy is optimal when vaccine efficacy from one dose is 80% or higher and vaccination rates are low.
A study published in JAMA Dermatology reports delayed localized injection-site reactions to the Moderna COVID-19 vaccine in 16 patients. The authors highlight this finding as a potential side effect of the vaccine, emphasizing the importance of monitoring for such reactions.
A new Northwestern Medicine study of placentas from vaccinated patients found no evidence of injury, supporting the safety of COVID-19 vaccines in pregnancy. The study adds to growing evidence that vaccination can protect fetuses without increasing harm.
A 2011 CIA-led vaccination campaign in Pakistan led to a significant decline in vaccination rates due to distrust and misinformation. The campaign's misleading tactics created doubt about the integrity of health workers and vaccines, resulting in lower vaccination rates among girls, particularly in districts with high levels of elector...
The Hong Kong Society of Rheumatology has developed consensus recommendations for COVID-19 vaccination in adult patients with autoimmune rheumatic diseases. The guidelines address concerns about vaccine efficacy and safety, as well as considerations for immunosuppressed patients.
Frontline healthcare workers may face temporary redeployment if they refuse COVID-19 vaccination, according to ethicists. A mild form of mandatory vaccination policy is justified to protect patients and colleagues.
A new Strep A human challenge model has been successfully developed, paving the way to test vaccines against the common deadly bacteria that causes sore throats, scarlet fever and skin sores. The model, which deliberately infected healthy adult volunteers with the bacteria in a controlled environment, was found to be safe and effective.
People with dementia have twice the risk for developing COVID-19, with high hospitalization rates and mortality. Alzheimer Europe urges governments to prioritize these groups in vaccination campaigns to prevent further harm.
A study published in JAMA found that two doses of a COVID-19 vaccine provide some protection for people with solid organ transplants, but not enough to dispense with masks and physical distancing. Immunocompromised patients should continue to practice strict COVID-19 safety measures after vaccination.
A new study by St. Jude Children's Research Hospital found that COVID-19 vaccination significantly reduced asymptomatic SARS-CoV-2 infections in employees, with a 79% risk reduction compared to unvaccinated peers.
A new report by the University of Birmingham reveals that only 41.4% of respondents in a UK-wide survey expressed interest in participating in COVID-19 vaccine trials. The study found that male graduates, those aged 40-49 and 50-59, and individuals with no health issues were more likely to be interested, while Black Asian Minority Ethn...
The study found a significant association between the Pfizer-BioNTech BNT162b2 vaccine and decreased risk of symptomatic and asymptomatic SARS-CoV-2 infections in hospital employees. Hospital employees who received the vaccine had lower rates of infection compared to those who did not receive the vaccine.
A study suggests that vaccinating older age groups first can significantly reduce disease transmission, mortality, and long-term health impacts. The research found that prioritizing the elderly and medically vulnerable ahead of younger people yields the greatest impact in minimizing loss of life.
Healthcare workers who received the Pfizer-BioNTech BNT162b2 vaccine had lower incidence of symptomatic and asymptomatic SARS-CoV-2 infections. The study found a significant association between vaccination with the BNT162b2 vaccine and reduced risk of SARS-CoV-2 infections among healthcare workers.
A new study published in the Journal of Infectious Diseases found that vaccinating half the US population by summer can prevent 5.8 million cases and $7.8 billion in societal costs. Increasing vaccination coverage to 70% can save even more lives and reduce medical costs.
Researchers found a slightly increased rate of rare blood clots, including cerebral blood clots and venous blood clots, following AstraZeneca vaccination. The absolute risk remains low, but the vaccine has been removed from Danish and Norwegian vaccination programmes due to concerns.
Two doses of the Pfizer-BioNTech vaccine provide more than 95% protection against COVID-19 infection, hospitalisation, severe illness, and death, including among the elderly. The analysis also reveals a decline in COVID-19 cases following Israel's national vaccination programme.
A new study found that many lupus patients with Medicaid were unvaccinated and required more acute care for vaccine-preventable illnesses. Black patients had a higher risk of needing such care compared to white patients.
A large study found a slightly increased rate of vein blood clots, including cerebral venous thrombosis, after the first dose of the Oxford-AstraZeneca covid-19 vaccine. However, researchers stress that the risk is considered low and the benefits of vaccination still outweigh the risks for most age groups.
A new digital health solution aims to promote COVID-19 vaccination among patients with compromised health conditions like multiple sclerosis. Motivational Interviewing Conversational Agent MintBot will address vaccine hesitancy and facilitate immediate action.
A new case report details the treatment of a patient with VITT (vaccine-induced thrombotic thrombocytopenia) using bivalirudin, an alternative to heparin. Early outcomes suggest that this approach may be safe and effective in treating these rare but serious clot reactions.
A study found that users of conservative and social media were more likely to believe in COVID-19 conspiracies, with a significant increase in belief from March to July 2020. Mainstream news consumption was associated with decreased conspiracy beliefs.
The European Federation of Academies of Sciences and Humanities (ALLEA) releases a report calling for enhanced European exchange and coordination to tackle science disinformation. Key strategies include inoculation, debunking, fact-checking, and media literacy, as well as innovations in science communication.
A new paradigm for usability aims to address accessibility issues worldwide, with a focus on marginalized groups. The approach emphasizes the importance of user-centered design and its potential to drive improvements in various fields.