Articles tagged with Vaccination
A synthetic DNA vaccine for MERS-CoV induced robust antibody neutralizing antibodies and cellular immune responses, protecting against MERS-CoV in NHP models. The low-dose regimen with intradermal delivery was more impactful in controlling disease than the higher dose delivered intramuscularly.
A study published in PLOS Biology suggests delaying the second dose of COVID-19 vaccines for 9-15 weeks after the first dose can avoid more hospitalizations, infections, and deaths. The researchers found that prioritizing widespread inoculation with available first doses is critical to mitigating adverse outcomes.
A new study published in Frontiers in Immunology suggests that the gut's immune response to COVID-19 infection may not provide long-lasting systemic immunity from the virus. The researchers found relatively few immune cells with a specific marker in the blood of patients with COVID-19, indicating limited protection for other organs.
Researchers identified serum amyloid A (SAA) as a potential biomarker for COVID-19 risk, with higher levels associated with increased inflammation, clot abnormalities, and organ damage. This biomarker could help facilitate early identification of patients requiring aggressive management and monitoring.
Research finds mRNA COVID-19 vaccine may have reduced efficacy in individuals with chronic lymphocytic leukemia and multiple myeloma. Patients with CLL who are treatment-naive or in remission tend to respond better to the vaccine.
A recent study published in Social Influence found that when people are explicitly told they are free to accept or reject propagandistic claims, their likelihood of choosing a moderate view increases. This approach, based on self-determination theory and psychological reactance theory, aims to disrupt the radicalization process among v...
A majority of 2,400 participants in a Penn State study supported requiring students and staff to be vaccinated against COVID-19. The survey found that Democrats were consistently more supportive of vaccine mandates than moderates or Republicans.
A new vaccine for leishmaniasis has demonstrated safety and induced immune responses in patients with the disease. The vaccine, called ChAd63-KH, is being tested to determine its potential as a therapy for different forms of leishmaniasis.
A new study from the University of Pennsylvania School of Medicine suggests that individuals who have recovered from COVID-19 may only need one vaccine dose to produce a sufficient antibody response. In contrast, those who have not had COVID-19 require two doses to achieve strong levels of immunity.
A Kaiser Permanente study found that child vaccination rates declined significantly during the COVID-19 pandemic, with measles vaccination coverage remaining substantially reduced in many age groups. The decline was more severe and persistent in older children, highlighting concerns about vaccine-preventable diseases.
A new study found that individuals with negative attitudes towards vaccines and conspiracy suspicions are more likely to be hesitant about getting vaccinated against SARS-CoV-2. The research suggests that communication strategies must account for the polarising nature of conspiracy theories to increase vaccine compliance.
Scientists have developed a method to create crystalline exoskeletons around delicate liposomes and lipid nanoparticles, stabilizing them at room temperature for up to two months. This breakthrough could help address the need for COVID-19 vaccines to be kept at below-freezing temperatures during transport and storage.
A recent survey of youth aged 14-24 found that most are willing to get vaccinated against COVID-19, with 75% unconditionally willing or already vaccinated. Black young people were more likely to express concerns about vaccine safety.
Experts argue that the Tokyo Olympics and Paralympics should not be held this summer due to ongoing COVID-19 concerns. They point out that vaccine roll-out has been inequitable, reducing access in many low-income countries, and that Japan's lack of control over community transmission poses a significant risk.
Researchers from NIH propose a new method to estimate vaccine efficacy by following original placebo recipients after vaccination, allowing assessment of durability and potential delayed harm. This approach enables timely access to the vaccine for placebo recipients while maintaining unbiased estimates.
Author Michael Dahlstrom's paper examines how narratives or storytelling can help counter misinformation on vaccines by providing context and connection between facts. This approach recognizes the disproportionate influence of narratives on attitudes and behaviors, and highlights their potential as a tool for public health education.
A surveillance project found high COVID-19 vaccine acceptance among physicians and advance practice providers, but lower rates among nurses and nonclinical healthcare workers. The authors suggest educating these groups about the vaccine's safety profile to enhance vaccination rates.
A survey study examines US adults' beliefs on who should be prioritized for access to COVID-19 vaccines. The study found that some groups, including young children and individuals with underlying health conditions, are more likely to be prioritized over others.
Functional neurological disorder (FND) is a disruption in the brain's normal mechanisms for controlling the body and can be triggered by physical or emotional events, including vaccinations. Individuals with FND may experience symptoms such as limb weakness, gait problems, jerky movements, tremor and facial spasms.
A recent study examines potential associations between COVID-19 vaccinations and functional neurological disorder, a condition characterized by symptoms similar to those experienced during a neurologic event. The researchers aim to better understand the relationships between vaccination and neurological side effects.
A new study from Aarhus University found that 89% of Danes are willing to be vaccinated against COVID-19, unchanged after the AstraZeneca vaccine was paused due to rare blood clots. The low level of confidence in the safety of the AstraZeneca vaccine is an important signal to health authorities.
A Canadian Medical Association Journal analysis found 75% of adults have at least one risk factor for severe COVID-19. The study suggests considering geographic and occupational risks to refine vaccination strategies and promote equity goals.
Experts recommend a more nuanced approach to COVID-19 vaccine prioritization, taking into account job site and neighborhood risks. At least 75% of Canadian adults have at least one risk factor for severe illness, highlighting the need for targeted vaccination strategies.
Beth Israel Deaconess Medical Center shares five key lessons on health equity from its COVID-19 vaccination campaign, including obtaining reliable patient data and addressing structural inequalities. The health system's approach aims to reach marginalized communities with trust-building strategies.
The NIH is conducting a clinical trial to assess the risk of systemic allergic reactions to the Moderna and Pfizer-BioNTech COVID-19 vaccines in people with mast cell disorders or severe allergies. The study aims to identify potential genetic patterns that may predict who is at most risk for these reactions.
A new report confirms polyethylene glycol (PEG) as a cause of anaphylaxis following COVID-19 vaccination. The authors note that PEG allergy is rare and that COVID-19 vaccines remain safe despite the risk.
A USC study found Hispanic immigrants aged 20-54 are 11 times more likely to die from COVID-19 compared to U.S.-born non-Hispanic individuals. Younger populations, particularly those of Asian/Pacific Islander and Black descent, also face higher mortality rates.
Patients with kidney failure undergoing hemodialysis developed a positive antibody response after COVID-19 vaccination, but at lower levels than healthy individuals. The findings highlight the need to reconsider vaccination schedules for this patient group.
A new model has been developed to estimate the risk of SARS-CoV-2-related death among patients in the Veterans Affairs health care system, enabling healthcare professionals to prioritize vaccination strategies.
Case report describes two patients who underwent a successful second dose of the Moderna vaccine using a graded dosing protocol after experiencing immediate hypersensitivity reactions. Both patients responded well and developed IgG antibodies, suggesting effective vaccination despite the modified dosing schedule.
A recent study found that a higher percentage of people in Appalachia are unlikely to receive the COVID-19 vaccine compared to national numbers. The researchers also tested interventions to stop the spread of misinformation, finding that subtle warnings from trusted health influencers can make a difference.
A study by Cedars-Sinai researchers found that individuals with prior COVID-19 infections who received a single dose of the Pfizer-BioNTech vaccine developed an antibody response similar to those without prior infection. The findings suggest that a single booster dose may be sufficient for previously infected individuals.
A UConn researcher has developed a successful Zika vaccine in preclinical studies using a novel platform technology. The vaccine, based on a viral vector and enhanced expression of the virus antigen, was found to mount a strong immune response and protect against Zika virus infection.
The NIH has started a Phase 1 clinical trial to evaluate the safety and immunogenicity of Moderna's COVID-19 variant vaccine, mRNA-1273.351, designed to protect against the B.1.351 SARS-CoV-2 variant. The trial enrolls approximately 210 healthy adult volunteers and aims to assess the reactogenicity and immune response of the vaccine.
Researchers developed a tamper-proof temperature indicator to monitor mRNA vaccine storage conditions. The system can alert healthcare workers when the vaccine reaches an unsafe temperature for a certain period, ensuring effective distribution and use of the vaccine.
A new mathematical model suggests that easing lockdown must be accompanied by wider and more effective use of control measures like facemasks to suppress COVID-19. The model shows that non-spatial control measures can limit virus particle spread between people.
Researchers found that CD8+ T cells in recovered COVID-19 patients can recognize virtually all mutations in recent SARS-CoV-2 variants, offering protection against emerging strains. This suggests that vaccination may still be effective against new variants, and booster vaccinations may be needed to maintain immunity.
A study in the San Francisco Bay area found that COVID-19 vaccine uptake differed significantly across racial and ethnic groups. Among health workers, vaccination rates were highest among white healthcare providers and lowest among Asian-American healthcare workers.
The UCLA-led PREVENT project will enroll 10,000 health care personnel at 16 medical centers to study the effectiveness of COVID-19 vaccines among vaccinated and non-vaccinated workers. The results will help determine how effective vaccines are at preventing infection.
Researchers found a correlation between Henry Ford's universal mask policy and a significant drop in the rate of healthcare workers testing positive for SARS-CoV-2. The study suggests that mask-wearing is effective in reducing the risk of acquiring COVID-19, supporting the institution's decision to implement the policy.
A large study found that COVID vaccines produce high levels of antibodies in pregnant women, which can be passed to newborns through breastmilk and the placenta. The study also showed that lactating women receive a similar immune response, providing benefits for both mothers and infants.
A recent study found that about half of Americans intend to get vaccinated as soon as possible, while others are hesitant or unlikely to get vaccinated. The survey highlights the need for targeted outreach to address vaccine hesitancy and build trust with communities, particularly among African American and Hispanic respondents.
A study by the University of Birmingham suggests that prioritizing COVID-19 vaccination for surgical patients can prevent thousands of post-operative deaths. Vaccination is estimated to reduce COVID-19-related deaths among high-risk patients, such as those undergoing cancer surgery.
A study by researchers at the Annenberg Public Policy Center found that news coverage of expert scientific evidence on vaccine safety increases public acceptance of vaccines. In contrast, personal narratives about real side effects diminish the positive effect of such messages. The experiment tested six video clips featuring experts an...
A survey of Geisinger employees showed increasing acceptance of COVID-19 vaccines after vaccine availability announcements, public events, and news coverage. 55.3% of employees indicated they intended to receive a vaccine, with most citing safety concerns as the main reason for hesitation.
A recent study by Johns Hopkins Medicine has found that COVID-19 vaccines may not produce sufficient antibody response in people who have received solid organ transplants and are immunocompromised. Only 17% of participants developed detectable antibodies against the SARS-CoV-2 virus after receiving their first dose of the vaccine.
A survey of healthcare workers in a health system assessed their intentions to receive a COVID-19 vaccine and explored reasons for hesitancy. The study found that many workers were hesitant due to concerns about vaccine safety and efficacy, as well as perceived risks to vulnerable populations.
Vaccinating healthcare workers reduced positive COVID-19 cases by over 90%, with infection rates lowest among fully vaccinated employees, according to data from UT Southwestern Medical Center. The institution saw a significant reduction in required isolations and quarantines.
A partnership between Loma Linda University and local churches has successfully vaccinated over 400 people in the predominantly Black community of San Bernardino County. The initiative, which included mobile vaccine clinics in church parking lots, resulted in an increase of 3.6% in Black attendance at mass vaccination clinics.
Researchers at Ben-Gurion University found the Pfizer vaccine to be moderately less effective against the South African variant, while still providing protection against the British variant and the original strain. The study was published in Cell Host and Microbe and suggests that future variants may require a modified vaccine.
A study by McGill University researchers found that delaying second COVID-19 vaccine doses can have benefits, but effects depend on population immunity. Increasing vaccination rates or changing dosing regimes can mitigate longer-term epidemiological effects.
A recent study of vaccinated healthcare workers found a low overall positivity rate among fully immunized individuals, supporting high protection rates of COVID-19 vaccines. However, the authors noted an elevated risk of infection after vaccination, possibly due to differences in demographics and behaviors.
The AstraZeneca vaccine demonstrated high vaccine efficacy of 78.9% against symptomatic COVID-19 disease, including severe disease or hospitalization. The vaccine also showed no increased risk of thrombotic events or cerebral venous sinus thrombosis among vaccinated participants.
A new study found that people with inflammatory bowel disease (IBD) treated with infliximab are less likely to develop antibodies after COVID-19 infection, which may boost susceptibility to reinfection. The study suggests that careful monitoring is needed to ensure patients mount a strong enough antibody response.
A University of New Mexico study analyzed data from four US cities and found that as vaccination rates increase, it becomes economically advantageous to relax social distancing measures and open businesses. The study suggests a gradual relaxation of restrictions can minimize economic costs while reducing public health risks.
Researchers found that nudges can reduce socioeconomic disparities by facilitating selection of welfare-enhancing options, particularly for low-SES consumers. The study generalized its findings across multiple types of nudges and decision contexts.
A modelling study suggests that vaccination alone may not prevent the spread of COVID-19 infection in the UK, even with high vaccine uptake and gradual reopening. Gradual easing of measures and high vaccine protection can minimize future waves of infection.
A study led by McMaster University aims to understand how well vaccination works in residents of long-term care homes and identify factors linked to outbreaks. The research, involving over 2,000 participants, will inform health policy and help keep residents safe and healthy.
Asymptomatic and pre-symptomatic transmission poses a significant challenge in controlling the COVID-19 pandemic. Experts warn that relying solely on vaccination is unlikely to be effective in preventing transmission, highlighting the need for robust surveillance measures.
Scientists have discovered a lesser-known site on the pandemic coronavirus that is recognized by COVID-19 infection-fighting antibodies, which potently prevent the virus from infecting cells. These antibodies were found in blood samples from previously infected patients and were as strong as those targeting the receptor-binding domain.