Articles tagged with Vaccination
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A new Finnish study found that healthcare workers who received two doses of the Pfizer-BioNTech vaccine had strong antibody responses to SARS-CoV-2, with similar effectiveness against the alpha variant as the original virus. The immune response was weaker against the beta variant, but still provided relatively good protection.
The UK's official list of COVID-19 symptoms is too narrow, say experts, and expanding it could help identify more cases sooner. This would require careful implementation, but new data suggests that testing people based on combinations of unofficial and official symptoms could be used to achieve this.
Researchers found that vaccinated individuals have a lower viral load, shorter infection time and milder symptoms than unvaccinated people. The study also showed a significant reduction in the risk of having COVID-19 with an accompanying fever.
New research shows that early testing for blood clots in AstraZeneca/Oxford vaccine recipients led to successful treatment of patients. The study emphasizes the importance of increased clinical vigilance to detect symptoms among vaccinated individuals.
A recent study reports four cases of acute myocarditis following mRNA COVID-19 vaccination. The condition can lead to serious heart problems, highlighting the need for cautious monitoring and research into vaccine safety.
A new paper proposes actions to increase access, speed time to market, and decrease costs of vaccines globally. Regulatory harmonization, manufacturing capacity building, and streamlined IP arrangements are key opportunities to address challenges in vaccine development and deployment.
A study found 23 cases of myocarditis in US military members following mRNA COVID-19 vaccination, highlighting a potential risk factor for the condition.
The Spanish Foundation for Science and Technology's third Social Perception Survey reveals that 83% of the population trusts COVID-19 vaccination, a 25-point increase from January. Attitudes towards vaccine uptake have improved significantly since July 2020, with compliance with COVID-19 preventive measures also showing a positive trend.
A novel adjuvant developed with NIH funding has contributed to the success of COVAXIN, a highly efficacious COVID-19 vaccine. The adjuvant, Alhydroxiquim-II, has been shown to activate key immune receptors and stimulate an effective response against the virus.
A new study found that many young adult cancer survivors are reluctant to obtain COVID-19 vaccinations due to concerns about their weakened immune systems. The study suggests that cancer survivors, particularly females and those with lower education levels, may be more hesitant to receive vaccines.
Researchers found 23 men in the U.S. military developed severe chest pain and elevated cardiac troponin levels within four days of receiving a second dose of mRNA COVID-19 vaccines, but most recovered quickly. The risk of myocarditis from vaccination is low compared to COVID-19 infection.
A study published in Cancer Cell found that multiple myeloma patients exhibited a widely variable response to COVID-19 vaccines, with some showing undetectable antibodies after mRNA vaccines. This variation underscores the importance of routine blood tests and continued precautions for these patients.
A randomised controlled trial of 550 young people found two doses of CoronaVac to be safe and provoke a strong antibody response. Most adverse reactions were mild or moderate, with pain at the injection site being the most commonly reported symptom.
Researchers found that COVID-19 vaccines induce a robust and potentially long-lasting immune response with the formation of germinal centers in lymph nodes. Vaccination led to high levels of neutralizing antibodies effective against three variants of the virus, including the Beta variant from South Africa.
A single case report describes a 65-year-old man who developed thrombocytopenia with thrombosis following COVID-19 mRNA vaccination, highlighting the need for increased awareness and vigilance. The authors conclude that while rare events may occur, the benefits of vaccination should not be dissuaded.
Researchers from Massachusetts General Hospital found that the BCG vaccine significantly lowers blood sugar levels in type 1 diabetics, with faster response times and greater changes in HbA1c for younger patients. The vaccine also restores gene expression in regulatory T cells over three years.
A new study reveals structural changes in the Alpha and Beta SARS-CoV-2 variants, suggesting reduced effectiveness of current vaccines against the Beta variant. The research found that mutations in the Beta variant change the shape of the spike surface, making it less bind to neutralizing antibodies.
The MucoRice-CTB vaccine, a new edible cholera vaccine made from genetically modified rice, has shown no obvious side effects and a good immune response in its Phase 1 human trial. The vaccine stimulates the mucosal immune system through the gut to induce antigen-specific antibodies, producing IgG and IgA responses.
A survey of hospital employees found that mRNA COVID-19 vaccines often cause skin reactions like rashes and itching after injection. The study aimed to investigate the frequency and characteristics of such reactions in this population.
A study by Massachusetts General Hospital found that COVID-19 vaccine skin reactions are rare, affecting approximately 1.9% of recipients after the first dose. The majority of these reactions did not recur after a second dose, providing critical reassurance to individuals with concerns about vaccination.
A single dose of either the Pfizer or Astra Zeneca COVID-19 vaccine offers around 60% protection against infection from SARS-CoV-2 in residents of long-term care facilities aged 65 and over. Vaccination also reduces the risk of transmission and infectivity, with a protective effect evident from 4 weeks after vaccination.
A new study suggests that people who had COVID-19 need only one vaccine dose for protection and that boosters could be necessary for everyone in the future. The Pfizer-BioNTech and Moderna vaccines triggered antibody levels similar to those seen after mild COVID-19 infections with one dose.
The NIH's MOMI-VAX study aims to assess antibody responses, transfer of antibodies to infants, and vaccine safety in vaccinated participants and their newborns. The study will enroll up to 750 pregnant individuals and 250 postpartum individuals, followed through the first year after delivery.
A $200,000 grant will help promote vaccine confidence and uptake among farmworkers and other marginalized populations in 8 New York counties. The project aims to address health disparities and build equity through effective vaccination partnerships.
Vaccine developers suggest that documented side effects are a byproduct of an effective immune response. The authors argue that fatigue and headache after vaccination should be viewed positively as a necessary step towards herd immunity.
Researchers have identified hotspots of undervaccinated children across Montana using spatial scan analysis. The study found that parental hesitancy on vaccination is concentrated in the western part of the state, while structural or access barriers are more prevalent on the eastern side.
A comprehensive review of literature on mRNA COVID-19 vaccine cutaneous reactions found that most reactions are harmless and transient, resolving within two to five days. Rare reactions such as herpes zoster reactivation have been reported, but the overall safety profile of the vaccines remains reassuring.
Two studies report a rare variant of Guillain-Barre syndrome characterized by prominent facial weakness following COVID-19 vaccination. The frequency of the condition was estimated to be up to 10 times greater than expected in areas where the vaccine was administered.
A multinational study published in The BMJ found significant differences in adverse event rates among over 126 million people across four continents. The study highlights the importance of considering population differences when monitoring vaccine safety.
A new study published in Cell journal suggests that COVID-19 antibodies lack the ability to enhance disease in animals. The research used mice and monkeys to test human antibodies, finding that they exert their defensive powers against SARS-CoV-2 infection, not exacerbating it.
A recent study analyzed access to COVID-19 vaccination sites in Brooklyn, finding significant racial and ethnic disparities. The research revealed that Black and Hispanic populations faced barriers to accessing vaccination sites, highlighting the need for targeted interventions to address these disparities.
A RUDN mathematician built a COVID-19 spread model to predict the disease's behavior and forecast subsequent waves. The model accurately predicted the epidemic course in countries without mass vaccination until the vaccination effect began.
Researchers found that COVID-19 vaccines pre-prepared in syringes can be safely transported under minor precautions, with messenger RNA remaining stable for at least three hours. The study aims to streamline vaccination processes, particularly in rural and less developed areas.
Researchers report on seven patients hospitalized for acute myocarditis-like illness following COVID-19 vaccination. All symptoms resolved before hospital discharge after treatment with beta-blocker and anti-inflammatory medications.
A study found that receiving the Moderna vaccine reduced SARS-CoV-2 infection rates among health care workers, beginning eight days after the first dose. The vaccine's efficacy in preventing infections was demonstrated through this association.
A new study reveals that current vaccines may lack essential viral material to trigger a holistic immune response in humans. The researchers identified 25% of viral protein fragments that trigger the immune system, which could lead to more effective and powerful vaccines.
A $1 million grant will be used to develop fluorochemical dispersants, known as FTags, which coat proteins in vaccine liquids to stabilize them thermally. This technology aims to eliminate the need for refrigerated supply chains and ensure vaccines can be transported at elevated temperatures.
The COVID-19 Vaccine Data and Safety Monitoring Board reviewed three formal interim efficacy analyses of trials for Moderna, Janssen, and AstraZeneca. The board's goal is to assure public independence and lack of interference while operating under exceptional conditions.
Researchers have developed two COVID-19 vaccines that elicited durable neutralizing antibody responses to SARS-CoV-2 in pre-clinical research. The Moderna mRNA vaccine and a protein-based vaccine candidate showed strong immunity in infant rhesus macaques, with no adverse effects.
The Southwest National Primate Research Center (SNPRC) has been awarded $37 million from the NIH to house and care for nearly 2,500 non-human primates. The funding will support critical work in finding new treatments and vaccines against infectious diseases.
A recent study found that daily COVID-19 testing in the NFL enabled early detection of infections, even among asymptomatic individuals. The study also revealed disparities in vaccination rates among healthcare workers, with lower rates among Black and Hispanic employees compared to their Asian and White counterparts.
Researchers at Brown University developed a new modeling approach that captures the impact of behavioral components on infectious disease transmission. The model accurately reproduces case rates throughout the pandemic in the US and individual states, providing valuable insights for forecasting future trends and scenarios.
Care home residents over 70 have a delayed and weaker immune response to vaccines compared to younger individuals, making them more susceptible to SARS-CoV-2 infections. This phenomenon has been confirmed by researchers from Charité - Universitätsmedizin Berlin.
Two studies demonstrate the impact of gender-neutral HPV vaccination on overall protection against HRHPV infections, even with low vaccination coverage. In Finland, communities with both boys and girls vaccinated saw a significant decrease in cervical HPV16/18 infections, including among unvaccinated women due to the herd effect.
A survey study among women with breast cancer in Mexico found a high hesitancy rate toward COVID-19 vaccination due to concerns about vaccine safety and efficacy. The study highlights the need for healthcare providers to address these concerns and improve access to vaccination services for this vulnerable population.
Researchers found that a single-shot COVID-19 vaccine generated strong immune responses against all SARS-CoV-2 variants. The study suggests non-neutralizing antibodies and T cell responses may contribute to protection against COVID-19, particularly in regions with variant prevalence.
Experts warn that India's current vaccination approach is causing huge numbers of avoidable deaths and is deeply inequitable. The government's focus on younger age groups has resulted in unequal access to vaccines, with rural areas and disadvantaged urban populations receiving limited coverage.
Scientists at McMaster University have developed a new treatment approach for people suffering from VITT, combining anti-clotting drugs with high doses of intravenous immunoglobulin. The treatment's effectiveness was shown in three Canadian patients who received the AstraZeneca vaccine and developed VITT.
A new study reveals that COVID-19 vaccination leads to strong T cell responses against the virus in all patients on dialysis, and nearly 58% of kidney transplant recipients. However, low antibody responses were observed in kidney transplant recipients, raising concerns about their protection from COVID-19.
Research found that COVID-19 vaccines are safe for patients with inflammatory bowel disease (IBD), who experience chronic digestive symptoms. Most side effects were mild and short-lived, with gastrointestinal issues being the most common. IBD patients on biologic therapies reported even fewer side effects due to the modulating effect o...
A large study found that COVID-19 vaccines induce a strong immune response in patients with various types of cancer, with high seroconversion rates among solid tumor patients. However, those receiving treatments for blood cancers had lower but still significant rates, highlighting the importance of vaccination in vulnerable populations.
The Murdoch Children's Research Institute is conducting a global study to better understand COVID-19 variants and the effectiveness of vaccines in preventing their spread. The BRACE trial, funded by the Bill & Melinda Gates Foundation, investigates biomarkers that indicate protection against COVID-19 infection.
Dr. Katalin Karikó's groundbreaking research on modifying nucleosides in mRNA led to the development of mRNA vaccines with over 94% efficacy against COVID-19. The Vilcek Prize for Excellence recognizes her contributions to science and medicine.
Researchers have developed a technology to manipulate viruses synthetically, allowing for rapid analysis and mapping of new potential virus variants. This innovation enables scientists to mimic natural selection processes safely in a controlled laboratory environment.
A new Northwestern Medicine study found that routine check-ups have several health benefits, including better detection and treatment of chronic illnesses, increased vaccinations and screenings, and improved patient-reported outcomes. These benefits are particularly important for at-risk populations.
A new vaccine called KCONVAC has been shown to be safe and induce antibody production in healthy Chinese adults. The phase 1 and 2 clinical trials demonstrated that the vaccine is well-tolerated and generates a robust immune response, with stronger antibody production seen when participants received their second dose four weeks apart.
A study of UK dental care professionals found that natural infection alone is unlikely to generate meaningful, durable herd immunity, emphasizing the importance of vaccinations. The data also suggest that previous infection with SARS-CoV-2 leads to a faster and stronger immune response following vaccination.
A study of over 1,500 UK dental professionals found 16.3% had SARS-CoV-2 antibodies, highlighting the occupational risk of infection. The study also showed ethnicity was a significant risk factor and that COVID-19 vaccination provided rapid and high antibody responses.
A five-pronged strategy addressing behavioural and socio-demographic factors is proposed to combat vaccine hesitancy. Confidence in vaccine safety is crucial, while addressing complacency among younger people and those of lower socioeconomic status is essential for increased uptake.
Researchers at ETH Zurich developed a vaccine that guides bacteria's evolution to make them a weaker pathogen, rather than trying to kill them. The combination vaccine was shown to be more effective in preventing Salmonella infections than existing vaccines.