Cancer drug helps combat asthma in mice
Dasatinib, a cancer treatment, reduces inflammation and improves lung mechanics in mice with allergic asthma. The drug targets tyrosine kinases involved in asthma's signaling pathways.
Allergic Asthma
Articles tagged with Allergic Asthma
Allergic asthma: UFZ researchers identify a key molecule
Researchers at Helmholtz Centre for Environmental Research (UFZ) discovered a protein called syndecan-4 that plays a critical role in developing allergic airway inflammation. The study found that syndecan-4 helps immune cells migrate to T-cells, initiating an immune reaction and sensitization to specific allergens.
SourceHelmholtz Centre for Environmental Research - UFZ·JournalNature Communications·DateOct 12, 2015
Scientists at Mainz University identify a new population of regulatory T-cells
Scientists at Mainz University have discovered a new sub-population of regulatory T cells linked to allergic asthma. The Treg cell type plays a decisive role in developing and manifesting the disease, making it a promising early diagnostic indicator.
New cellular pathway triggering allergic asthma response identified
Researchers have discovered a novel signaling pathway critical to the immune response of cells associated with allergic asthma. Increasing cAMP levels inhibited the cells' inflammatory response, suggesting a potential target for new therapies.
SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·DateJan 19, 2015
Researchers discover new potential antibody treatment for asthma
Researchers at McMaster University have successfully tested an antibody that can improve the quality of life for individuals with asthma by relieving inflammation in the lungs. The study found that blocking a specific protein in the lungs with an antibody alleviates baseline inflammation and provides resistance to allergens.
Researchers find potential target for drug to treat allergic asthma
A new study suggests that the enzyme Cbl-b could be a target for drugs used to treat allergic asthma and other autoimmune disorders. Mice lacking Cbl-b exhibited severe allergic asthma symptoms, highlighting its vital role in controlling immune response.
Bacterial protein in house dust spurs asthma according to NIH study
A NIH study found a bacterial protein in common house dust may worsen allergic responses to indoor allergens, leading to asthma. Researchers discovered flagellin boosts allergic reactions in mice with asthma, suggesting cleaning could reduce symptoms by removing bacteria.
SourceNIH/National Institute of Environmental Health Sciences·JournalNature Medicine·DateOct 15, 2012
Exposure to antibiotics linked to severity of allergic asthma: UBC research
UBC researchers found that certain antibiotics alter gut bacteria, increasing severity of asthma in mouse models. Early life is a critical period for establishing a healthy immune system, as the impact of antibiotics on asthma susceptibility disappears in adult mice.
Adding new anti-asthma drug to therapy may limit seasonal attacks in children
A new anti-asthma medication has been found to nearly eliminate seasonal asthma attacks in children and young adults with allergic asthma. Researchers found that the treatment improved asthma control, reduced symptoms by 25%, and decreased asthma attacks by 30%.
Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
Researchers found that people with allergic asthma are more susceptible to respiratory viruses like the flu due to impaired immune response. Elevated IgE levels in dendritic cells may interfere with antiviral proteins, worsening asthma symptoms.
Research in PNAS by Hydra shows that TRP ion channel drug can treat allergy-induced asthma
A study published in PNAS identified TRPA1 as playing a key role in allergic asthma and demonstrated that HC-030031 effectively treated the condition in mice. This breakthrough research could represent a new avenue of treatment for asthma.
Rodent studies suggest mother's diet can affect genes and offspring's risk of allergic asthma
Research suggests that a mother's diet during pregnancy can induce epigenetic changes in her offspring, increasing their risk of developing allergic asthma. The study found that high-methyl-donor diets led to more severe airway disease and increased IgE levels in the blood.
Handling pesticides associated with greater asthma risk in farm women
Research on farm women reveals an increased risk of allergic asthma associated with pesticide use. The study found a significant increase in asthma prevalence among women who applied or mixed pesticides, with some compounds like parathion linked to nearly tripled risk.
SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateDec 28, 2007