Articles tagged with Lung Metastasis
The UVA Weber Symposium will discuss the latest research and advancements in metastasis, a complex area of cancer research and care. The event will bring together top scientists and physicians to present findings on cancer metastasis, genetics, and treatment considerations.
Fusobacterium nucleatum drives immunosuppression and metastasis in triple-negative breast cancer (TNBC) by reprogramming tryptophan metabolism and activating the IL4I1-dependent pathway, leading to reduced CD8+ T-cell infiltration and increased tumor growth, invasion, and pulmonary metastasis.
Tumor-derived extracellular vesicles exhibit intrinsic organotropism and participate in establishing premetastatic niches, making them promising vehicles for targeted imaging probe delivery. However, current imaging approaches have limitations, including difficulty distinguishing between tumor-derived EVs and normal host cell-derived EVs.
Researchers found that radiation to the thymus during NSCLC treatment increased cancer spread and mortality risk in patients with relatively healthy thymus. Thymic health scores were associated with T-cell diversity, longevity, and cancer outcomes.
Researchers have identified a protein called integrin alpha-5 as the cargo in tumor-derived extracellular vesicles that promotes lung blood vessel leakiness and lung metastasis in several types of cancer. The discovery could lead to new ways of monitoring and reducing lung metastasis risk in cancer patients.
A study published in Cancer Cell identified a six-gene signature in microscopic colorectal cancer liver metastases that may help predict recurrence after treatment. The findings suggest these tiny tumor deposits could serve as a tissue-based marker of residual cancer cells, recurrence risk and chemotherapy resistance.
A new national analysis found that mesothelioma deaths and diagnoses continue to rise in the US, with little improvement in survival rates. The disease disproportionately affects women and several high-risk states tied to shipbuilding, mining, and legacy asbestos exposure.
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
A recent study published in Nature Communications provides a comprehensive characterization of Large Cell Neuroendocrine Carcinoma (LCNEC), a rare and aggressive type of lung cancer. The research team analyzed data from 590 patients and found that LCNEC shares features with other types of lung cancer, yet has distinct aspects. They ide...
The study found that high levels of aspartate in the lungs are associated with aggressive lung metastases, triggered by an alternative translation program driven by aspartate signaling. This discovery suggests a common feature of cancer cells growing in the lung and provides a potential target for new therapeutic interventions.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Researchers at the Salk Institute discovered that combining two therapeutic drugs, entinostat and trametinib, can significantly reduce tumor volume and number in mice with LKB1-mutated non-small cell lung cancer. The findings could lead to clinical trials in humans and potentially transform treatment for cancers beyond NSCLC.
A retrospective cohort study of 27 patients with sarcoma lung metastases found high primary technical success rates for percutaneous image-guided microwave and cryoablation. The treatment modality and tumor location did not affect local progression, and smaller tumors showed lower cumulative incidence of local progression.
Researchers developed a treatment using cowpea mosaic virus nanoparticles that target lung tumors, slowing tumor growth and preventing cancer spread. The treatment showed efficacy against aggressive cancer cell lines and may offer protection to patients at high risk of metastatic disease.
Eosinophils, a type of white blood cell, play a crucial role in destroying malignant tumors by recruiting T-cells and releasing destructive proteins. The study, published in Cancer Research, reveals that eosinophils combat cancer effectively but require the help of T-cells to do so.
Kanazawa University researchers discover that interstitial and alveolar macrophages play key role in spreading liver cancer to lungs. The study reveals the production of inflammatory lipid leukotriene B4 promotes tumor growth and invasiveness, sparking hope for novel treatment approaches.
Researchers discovered that ADAM28 inhibits VWF-mediated apoptosis in cancer cells, leading to increased lung metastases. Inhibition of ADAM28 expression or activity significantly reduced lung metastases and increased cancer cell apoptosis.
The study found that liver transplantation can significantly improve survival for patients with lung metastasis from primary liver cancer. The researchers identified liver transplantation as a key factor in extending patient survival, and recommended it as a standard treatment option for these patients. Additionally, the study suggeste...