Articles tagged with Migraines
Researchers at Beth Israel Deaconess Medical Center identified a new visual pathway that underlies sensitivity to light during migraines. This pathway involves melanopsin photoreceptors and converges on specific neurons in the brain, which become electrically active during migraine, leading to pain intensification.
Researchers at Johns Hopkins Medicine found that migraine headaches are associated with more than two-fold higher chances of ischemic stroke. Women with migraines have a particularly high risk, with a 2.9 times higher risk compared to men.
Researchers present findings on experimental stem cell therapy for peripheral nerve injuries, suggesting adipose-derived stem cells may aid in healing. Additionally, a study on liposuctioned fat for breast augmentation finds the procedure to be safe and effective with excellent long-term graft survival.
Researchers followed 79 patients with migraine headaches for five years after surgery, finding promising outcomes for treating trigger sites. The study found that 88% of remaining patients maintained initial positive response to surgery, with 29% experiencing complete elimination of migraines.
Researchers found that rats with migraine-like headaches reacted to alcohol-induced pain, whereas those without migraines did not. The study suggests dehydration or impurities in alcohol are not responsible for hangovers.
The Migraine Research Foundation has awarded $300,000 in research grants to investigate the genetic association between migraine and cardiovascular events. The grant recipients will also explore the impact of opioids on migraine pain.
A new study published in Plastic and Reconstructive Surgery found that surgical treatment of migraine headaches is safe and effective, with nearly 60% of patients experiencing complete elimination of symptoms. The procedure involves removing trigger sites that cause migraines, which can lead to significant improvements in quality of life.
Most children with chronic daily headache can expect to improve their symptoms as they enter young adulthood. By age 8, 75% of affected children were no longer experiencing symptoms, and by 12 years old, 60% had outgrown the condition entirely.
A follow-up study confirms a significant reduction in breast cancer risk among women with migraines, regardless of menopausal status or other factors. The association remains strong despite previous findings suggesting potential triggers like alcohol consumption and hormone replacement therapy.
A recent study published in The Journal of Headache and Pain found that smoking more than five cigarettes a day increases the frequency of migraine attacks. The research involved 361 medicine students who were aware of their migraine status and reported higher prevalence of smokers among those with migraines.
A study published in JAMA Network reveals a strong association between midlife migraines with aura and an increased prevalence of brain lesions in older age. Women were more likely to develop cerebellum-related lesions, suggesting a potential link between migraine with aura and brain function.
Researchers at Thomas Jefferson University found that half of patients with cluster headaches experience cutaneous allodynia, a common migraine pain condition. This discovery suggests overlap in mechanisms for pain between migraines and cluster headaches, potentially leading to new treatment implications.
Researchers redefine migraine as a potentially chronic disease, requiring a collaborative healthcare model with patients and professionals. This new understanding offers opportunities for personalized care and improved disease management.
A Phase IIa clinical trial suggests that targeting glutamate receptor mGluR5 with ADX10059 may prevent migraine attacks before they start. The study found that patients taking ADX10059 were more likely to be pain-free two hours after treatment than those receiving a placebo.
Researchers at UCSF have developed a novel therapy using transcranial magnetic stimulation (TMS) that blocks the abnormal brain waves believed to cause migraine aura. The study found that TMS therapy is effective in treating migraine sufferers who cannot tolerate medication, offering a potential new treatment option.
A Phase IIa clinical trial shows that ADX10059, a negative mGluR5 allosteric modulator, significantly improves pain-free status and pain improvement in patients with acute migraine attacks. The study's findings support the potential of targeting mGluR5 signaling for migraine prevention.
Recent research reveals that migraine mice have an imbalance in excitation and inhibition, leading to increased neuronal activity. Glutamate release is found to be elevated, facilitating the propagation of cortical spreading depression (CSD), a phenomenon linked to migraine aura.
A study of over 7,000 patients found that higher air temperature and lower barometric pressure contribute to severe headaches, challenging the notion that weather triggers headaches. The research suggests that headache sufferers should identify personal triggers with their doctors, including environmental factors.
A new study published in JACC: Cardiovascular Interventions found significant improvement in migraines following catheter-based closure of patent foramen ovale. Patients with severe migraine, large PFO, and silent brain lesions showed greater numbers of patients who had cessation of migraine attacks and over 50% reduction in migraine a...
A new study has found a potential link between a gene variant and the risk of stroke and heart attacks in women who experience migraines. Women who carried certain genotypes were found to be at double the risk of stroke and heart attacks, while those with other genotypes were not. Further research is needed to confirm these findings.
A study of 22,211 people found that abdominal obesity increased the risk of migraine headaches in those aged 20-55, especially in women. Losing weight around the stomach area may be beneficial for reducing migraine risk in this age group.
Migraine affects millions worldwide, causing substantial decreases in functioning and productivity. Recent clinical studies suggest it may be a progressive disease with cardiovascular and neurologic effects, requiring major reconsideration of treatments.
Research in mice reveals genetic and hormonal factors contribute to migraines with aura, affecting women more frequently than men. Hormonal fluctuations, particularly estrogen, modulate an individual's susceptibility to migraines.
Telcagepant has shown efficacy in treating moderate to severe migraines, offering a safer alternative to triptans with fewer side effects. The study analyzed 1380 patients and found telcagepant 300mg to be more effective than placebo for freedom from pain and other symptoms.
A study found that overusing medications containing barbiturates or narcotics can lead to more frequent migraine attacks. The use of these medications was associated with an increased risk of transformed migraine headaches, a form of migraine characterized by 15 or more days of headache per month.
Research at Fred Hutchinson Cancer Center found that women who suffer from migraines have a 30% lower risk of breast cancer compared to those without migraines. The association is thought to be linked to hormonal fluctuations and estrogen levels.
Recent studies confirm the prevalence of migraine remains stable, with aura doubling heart attack risk and increasing cardiovascular disease mortality. New treatments targeting calcitonin gene-related peptide (CGRP) show promise, with olcegepant and telcagepant demonstrating effective pain relief.
A novel nerve stimulator alleviates pain in patients with hemicrania continua, a rare form of chronic daily headache. The study found that five of six patients reported sufficient benefit to recommend the device.
A recent study by the American Academy of Neurology found that people with migraines are more likely to develop venous thrombosis or blood clots in their veins. The research, which involved 574 participants in Italy, revealed a significant association between migraine and increased risk of blood clots.
Women with migraines, especially those with aura, may be at higher risk for heart disease and stroke due to a specific gene variant. A study found that women with this gene variant had more than three times the risk of cardiovascular disease, including four times the risk for stroke compared to those without the gene.
A combination of sumatriptan and naproxen sodium taken within an hour of migraine onset significantly relieved symptoms in patients. The study, published in Neurology, showed that 50% of those who received the drug were pain-free after two hours, compared to 16% of those who took a placebo.
Researchers at Vanderbilt University Medical Center have found genetic mutations linked to rare familial hemiplegic migraine type-3 that alter sodium channel function in the brain. These mutations may prompt migraines and suggest medications targeting sodium channels as potential treatments.
The OptiNose Phase II study demonstrated that its nasal device combination achieves rapid and efficient migraine relief without needle-stick injuries. The results show that 74.3% of patients experienced headache relief within 60 minutes and 83.8% after 120 minutes.
A portable transcranial magnetic stimulator (TMS) device has been found to be safe and effective in eliminating headaches during the onset of migraines. The device's pulses interrupt the electrical storms in the brain that lead to throbbing head pain, offering a promising new treatment option for those suffering from chronic migraines.
Researchers discuss inhibiting glutamate receptors as a promising approach for treating chronic pain, migraine and muscle spasticity. Glutamate receptor antagonists like tezampanel have shown potential in clinical trials for treating various conditions.
Research finds a strong correlation between migraines and sleep disorders in children, including obstructive sleep apnea (OSA) and tooth grinding. Children with migraines are twice as likely to have OSA and experience shorter REM sleep, highlighting the importance of addressing sleep issues in pediatric headache management.
Research found that people with migraine are more likely to experience exacerbated skin sensitivity or pain after daily activities, particularly those with chronic migraines. The study also identified risk factors for migraine progression, including allodynia and depression.
A recent study found that children with migraine are twice as likely to have sleep apnea and experience shorter total sleep time compared to their peers. This association was also observed in children with non-specific headache and those who were overweight.
Research found that women with weekly migraines are three times more likely to have a stroke, while those with low migraine frequency may face increased risk of heart attacks. The study suggests that migraine frequency may be an indicator for cardiovascular disease.
Researchers developed a new analysis technique to identify genes influencing migraine susceptibility. By studying 1700 patients and their relatives, they found a significant genetic locus linked to female migraineurs and discovered that specific types of pain are more closely linked to specific genetic loci.
A study published by the American Academy of Neurology found that people who use barbiturates and opioids for only eight days a month are twice as likely to develop chronic migraine. The study suggests strict limits on these medications for people with migraine to prevent migraine progression.
Research found people with high blood pressure are up to 40% less likely to have a headache or migraine compared to those with healthier blood pressure rates. Higher pulse pressure was linked to reduced headache and migraine frequency in both men and women.
Research published by the American Academy of Neurology found no difference between oxcarbazepine and placebo in reducing migraine attacks. The study suggests that other epilepsy drugs like topiramate and gabapentin may be more effective due to their ability to regulate GABA neurotransmitters.
Researchers at Queen's University have found a link between locusts' reaction to stress and human migraines. The study shows that the locust's coma-like state is similar to what happens in people during a migraine, suggesting an evolutionary connection.
A study published in Neurology has found familial genes for sporadic hemiplegic migraine in people without family history. The research identified variants of three known genes in 18% of participants, suggesting genetic testing may help diagnose and treat the condition.
A study published by the American Academy of Neurology found that people with migraines have a thicker somatosensory cortex area, which processes pain and sensory information. This could lead to increased sensitivity to stimulation and contribute to other pain disorders.
Researchers at UCLA found that female mice have a lower threshold for cortical spreading depression (CSD), a key contributor to migraines. Memantine, a medication approved for Alzheimer's disease, shows promise in preventing migraines in patients with high frequency of attacks.
Adolescents from low-income families are at higher risk of developing migraines due to stress, poor diet, and limited access to medical care. In contrast, teenagers from affluent households have a lower prevalence of migraines, with only 2.9% experiencing symptoms annually.
A recent study published in Neurology found that teenagers from low-income households are more likely to suffer from migraine compared to those from upper-income families. The study surveyed over 18,700 adolescents and their parents, revealing a significant association between socioeconomic status and migraine prevalence.
A study published in Neurology found that middle-aged individuals with a history of migraine and other headaches are more likely to develop retinopathy, which can lead to severe vision problems or blindness. The association was strongest among those with migraine headaches and aura.
A study published in Neurology found that people with migraines are 1.3-1.5 times more likely to develop retinopathy than those without headaches. The association was strongest among those with migraine headaches and other headaches with aura, even after controlling for diabetes, glucose levels, and blood pressure.
Research suggests that Iraq veterans with migraines are more likely to also have symptoms of post-traumatic stress disorder, depression, or anxiety. The study found a significant association between migraine headaches and psychiatric conditions in soldiers returning from deployment.
Migraines significantly impact employers, resulting in $28.7 billion annual losses. Employers who screen for and treat migraines may see improved productivity, reduced absenteeism, and lower costs.
Women with migraines during pregnancy are at higher risk of stroke, heart attack, and heart disease. Migraines have been linked to preeclampsia and a connection to the mother's age also exists.
A study by the American Academy of Neurology found that teens with migraine headaches are at a higher risk of suicide and more likely to experience other psychiatric disorders such as depression and panic disorder. The research highlights the importance of screening for psychiatric disorders in teens with chronic daily headaches.
Research in mice shows migraines can lead to brain damage, with areas of the brain experiencing oxygen shortage. The study emphasizes the importance of preventing migraines through avoiding triggers and using prescribed medications.
Migraines in men are associated with a higher risk of cardiovascular disease and heart attacks. The study found that men who experienced migraines had an increased risk of myocardial infarctions, with an incidence rate of 10.4 per 10,000 men per year.
A study of pharmaceutical sales visits found that almost half led to doctors intending to increase gabapentin prescriptions. Nearly 40% of visits discussed off-label uses not approved by the FDA.
A community-based study found that women with a lifetime history of migraine performed worse on cognitive tests initially but showed a 17% less decline in performance over time compared to those without migraines. Lifestyle factors such as diet and behavior may play a role in protecting memory.
A combination of sumatriptan and naproxen sodium is more effective in treating migraine than either medication alone, with superior efficacy in headache relief and sustained pain-free response. The treatment targets multiple pathogenic mechanisms in migraine, offering advantages over single therapy.