Articles tagged with Neurological Disorders
Researchers found that neuroinflammation in the hippocampus significantly alters motivation and behaviour in mice, particularly in females. This study suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in diseases such as Alzheimer's and Depression.
Researchers found that a blunted response to reward feedback in teens predicts the first onset of depression, but not anxiety or suicidal ideation. This study contributes to understanding neural risk factors for mental health disorders and developing new methods to assess mental health risks.
A six-year study examining 38 clinical isolates of Cryptococcus found genes and gene alleles associated with disease severity. The research aims to develop new treatments targeting these genetic variations, predicting disease outcomes and improving patient care.
Researchers analyzed individual cells from two craniopharyngioma subtypes to identify specific cell types, their features, and interactions. The study found distinct cell types linked to tumor development and immune response in both adamantinomatous and papillary craniopharyngiomas.
A meta-analysis of four randomized clinical trials found that endovascular therapy significantly reduces patient mortality and overall post-stroke disability for vertebrobasilar stroke patients. EVT is nearly 2½ times more likely to achieve a positive outcome compared to standard medical management.
Researchers found structural and functional alterations in specific brain regions of individuals with opioid use disorder, including increased global connectivity. Women in the group had smaller medial prefrontal cortex volume compared to men.
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
The American Heart Association has released its list of top cardiovascular research for 2024, focusing on prevention, treatment and the benefits of anti-obesity medications. The research highlights improvements in assessing cardiovascular risk, identifying early prevention opportunities and treating heart failure.
Three Sanford Burnham Prebys faculty members, David A. Brenner, Randal J. Kaufman, and Tariq M. Rana, are recognized for their significant scientific influence. Their publications have been cited top 1% globally by number of citations.
Professor Robert Fledrich has been awarded an ERC Consolidator Grant for his research on the regeneration of peripheral nerves. His team aims to investigate the conditions required for successful nerve regeneration, focusing on glial cells' metabolic dynamics and communication pathways.
Researchers propose a new model for understanding how information is transmitted in the brain by describing a unique axon morphology that changes size and modulates action potential speed
Recent studies suggest a connection between the protein G3BP1 and ALS disease, with toxic dipeptide repeats impairing normal cellular functions. The findings provide valuable insights into the underlying mechanisms of neurodegenerative disorders.
The partnership integrates Answer ALS’s Neuromine Data Portal with the AD Data Initiative's AD Workbench, providing a unified platform for data sharing and analysis. This collaboration enables integrative analysis of ALS and Alzheimer’s data, streamlining efforts and enhancing research impact.
Researchers reported positive long-term results of bilateral capsulotomy for severe obsessive-compulsive disorder treatment, with high patient satisfaction even at 10 years. The study suggests MRgFUS capsulotomy may also be effective in managing other psychiatric diseases.
Bentham Science journals Central Nervous System Agents in Medicinal Chemistry and CNS & Neurological Disorders – Drug Targets accepted for PsycInfo database indexing, enhancing global visibility of research. PsycInfo provides extensive coverage of behavioral and social sciences, making this move a significant step forward.
A new disease severity staging system for NOTCH3-associated small vessel disease (NOTCH3-SVD) has been developed to standardize research and improve patient care. The system is expected to facilitate individualized counseling, monitoring, and management of the condition.
A study found that soccer heading causes structural brain abnormalities similar to those seen in CTE, affecting the frontal lobe and verbal learning. The research suggests repeated head impacts may harm brain health even without serious injury.
Researchers found lower pulmonary gas exchange may be associated with impaired cognitive function in patients with long COVID. The study also showed a potential treatment strategy using methods that target improved gas exchange, suggesting a causative relationship between cognitive dysfunction and lung dysfunction.
The WHO's Technical Advisory Group on Genomics published an article outlining challenges and actions to promote the use of genomics in public health. The group aims to increase awareness and provide technical guidance to accelerate access to genetic technologies, enabling preventive measures and targeted treatment for various diseases.
A new approach profiles gene activity in the living brain, providing insights into neurological conditions like epilepsy. The study enhances understanding of seizure networks, potentially improving surgical interventions.
The Deutsche Forschungsgemeinschaft is establishing seven new Collaborative Research Centres (CRC) with a total funding of €92 million. The CRCs focus on innovative research projects in sustainable construction, electronic systems, and ecosystem services. Seven new Transregios are also being funded to tackle long-term challenges.
Researchers created an animal model with a targeted mtDNA mutation to advance understanding of mitochondrial genetic disorders. The study found significant changes in brain structure and function, as well as metabolic abnormalities, linking mitochondrial dysfunction to cognitive-metabolic impairments.
Researchers from the University of South Australia and Middle Technical University have developed an AI-powered voice analysis tool that can detect subtle changes in a person's voice to diagnose Parkinson's disease. The algorithm achieved high accuracy rates, up to 99%, and has the potential to improve early detection and remote monito...
Researchers have discovered two human antibodies that can recognize and target proteins causing severe malaria. These broadly reactive antibodies may represent a common mechanism of acquired immunity to severe malaria, offering insights for the design of a PfEMP1-based vaccine or treatment targeting severe malaria. The breakthrough cou...
Hepatitis E viruses can directly infect nerve cells, which are unable to protect themselves due to a low immune response. This discovery may explain the neurological effects of HEV infections.
Research highlights edoxaban's effectiveness in reducing stroke and blood clots for patients after bioprosthetic heart valve replacement. Edoxaban was found to be equally or more effective than warfarin, with a predictable pharmacokinetic profile and reduced burden on patients.
Global experts and medical professionals gathered in Tashkent to address rare diseases, enhancing patient care. The forum highlighted key findings on diagnosis and treatment of rare genetic disorders in Uzbekistan.
Researchers have created a comprehensive database of protein changes in mice tissues due to aging, providing new insights into age-related diseases. The study reveals proteins that increase with age and improve understanding of the molecular mechanisms underlying aging.
Researchers at Rice University developed a minimally invasive neural interface technique called endocisternal interfaces (ECI), allowing for simultaneous access to the brain and spinal cord without skull surgery. The innovative method uses cerebral spinal fluid as a pathway to deliver targeted devices, enabling new possibilities for th...
Researchers have discovered a mechanism to detach and recycle parts of cellular canal membranes as needed. The study, conducted with supercomputer simulations, shows that protein regions can cause the membrane to bulge and pinch off, forming vesicles for recycling.
A higher Brain Care Score (BCS) significantly reduces the risk of stroke, late-life depression, and dementia in individuals with a higher genetic predisposition to these conditions. The study's findings suggest that adopting healthy lifestyle choices can protect brain health regardless of genetic risk.
Researchers developed a method to visualize AMPA receptors using PET scans, revealing differences in density and distribution between healthy subjects and those with psychiatric disorders. This discovery may lead to new diagnostic and therapeutic approaches for conditions like schizophrenia, bipolar disorder, and autism spectrum disorder.
Researchers found that specific enzymes in neurons mediate the toxicity of diets rich in palm oil, leading to mitochondrial damage and neurodegeneration. Inactivating these enzymes provides neuroprotection, suggesting a potential pathway for slowing diet-induced symptom severity in MS patients.
The new center will advance multiple areas of active research on campus, including neurocognitive sciences and musculo-skeletal health. With support from across campus, UTA aims to improve research capabilities to enhance undergraduate and graduate educational opportunities.
A new study led by the University of Michigan suggests that polyphosphate may play a crucial role in neurodegenerative diseases. Researchers discovered that polyphosphate is present in fibrils found in patients' brains, which could help explain their devastating effects.
Researchers develop transcranial ultrasound stimulation (TUS) as a non-invasive therapy for brain-related issues, with potential for personalized treatments. A 'search and rescue tool' for the brain, TUS enables precise targeting of specific areas before treatment.
A comprehensive evidence review on tethered spinal cord found that while surgery can benefit symptomatic patients, data for asymptomatic patients is lacking. The study also highlights the need for more research into conservative management and potential risks of surgical complications.
A study found that 4.6% of Nigerian participants with COVID-19 experienced neurologic symptoms, with some still experiencing symptoms two years after their initial episode. Researchers plan to treat these patients using similar techniques used in the US, aiming to alleviate their suffering.
A study in mice reveals that individualistic reward-seeking strategies predict responses to nicotine, with profiles influenced by personality traits and dopamine activity. The findings suggest environmental adaptations shape behavioral traits and sensitivity to nicotine, potentially contributing to addiction susceptibility.
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
A new therapeutic approach combining cognitive behavioral therapy (CBT) and lucid dreaming has shown promise in reducing nightmare severity and frequency in patients with narcolepsy. The study, published in the Journal of Sleep Research, found overall reductions in nightmare symptoms in all six participants tested.
Scientists have identified a key driver of brain inflammation in neurological diseases, proposing a new treatment approach by neutralizing fibrin. This protein, involved in blood coagulation, triggers neurologic diseases by hijacking the immune system, resulting in damaged neurons.
Researchers have made a breakthrough in understanding the rare autoimmune disease anti-NMDAR encephalitis, which can cause psychosis, hallucinations, and blackouts. The study found that different antibodies bind to NMDA receptors in unique ways, suggesting personalized medicine may be key to treating the condition.
Glioblastoma, the most malignant primary brain tumour, has an 18-month median survival rate despite treatment. New research from the University of Ottawa suggests a drug used to slow ALS progression may also suppress glioblastoma's self-renewing cancerous stem cells.
New research confirms that young adults are at risk for large vessel occlusion acute ischemic strokes, which were previously thought to occur mainly in older adults. The study found that nearly 20% of a cohort of 1,200 young adult patients had these strokes, highlighting the need for regular check-ups and prompt treatment.
A University of Michigan-led study found that treatment with either modafinil or cognitive behavioral therapy alone was associated with significant reductions in fatigue over 12 weeks. A combination of both treatments worked as well as each individual treatment but did not result in better fatigue scores.
Researchers are creating microphysiological systems to simulate infection and treatment in vitro, linking human lung and brain tissue models. This project aims to explore the relationship between respiratory diseases and neurological symptoms, potentially leading to new treatments.
Studies show that the cerebellum is critical for forming stable memories for sensorimotor skills, largely independent of short-term memory systems. Researchers found that longer time intervals between trials increased reliance on impaired long-term memory.
A new study found that toxic SOD1 protein trimers interact with various proteins in different tissues, contributing to cellular dysfunction and degeneration in ALS. Septin-7 is identified as a potential therapeutic target, potentially slowing or disrupting ALS progression.
Researchers found that two human-specific genes, SRGAP2B and SRGAP2C, regulate the SYNGAP1 gene involved in autism spectrum disorder. The study provides a direct link between human brain evolution and neurodevelopmental disorders.
A randomised clinical trial shows that integrating physiotherapy and cognitive-behavioural therapy is effective in improving symptoms and physical aspects of the quality of life of patients with functional movement disorders. The study suggests this approach could be cost-effective and opens up new lines of research.
A team of scientists, led by Anne Bang, is working to establish clearer connections between genes and their effects on brain function and mental health. They will use high-throughput screening technology to study over 100 genes in brain cells.
A UCLA-led study has mapped DNA modification in the developing human brain, shedding light on how gene regulation evolves and shapes lifelong mental health. The research provides new insights into early brain development and its connection to neuropsychiatric conditions like schizophrenia and autism spectrum disorder.
A new University of Colorado Boulder study sheds light on why paternal mitochondrial DNA is eliminated during development. The research found that delaying this process can lead to lasting neurological and behavioral problems in adults. Treatments such as Vitamin K2 may offer new hope for preventing or treating these disorders.
Researchers identify modifiable determinants of cerebral blood flow (CBF) and arterial transit time (ATT) in older adults. A higher BMI was associated with lower CBF and longer ATT, while cardiorespiratory fitness linked to longer ATT in specific brain regions.
Damage to the brainstem, the brain's control centre, is behind long-lasting physical and psychiatric effects of severe Covid-19 infection. Researchers used ultra-high-resolution scanners to observe the damaging effects of Covid-19 on the brain, finding inflammation in key regions associated with breathlessness, fatigue and anxiety.
A study by UC San Francisco found that more screen time is associated with severe symptoms of depression, anxiety, inattention, and aggression in 9-10 year olds. The effects were small but consistent, with activities like video chatting and playing video games strongly linked to depressive symptoms.
Researchers have identified liver X receptor beta as a promising target for treating depression and anxiety, with key findings including LXRβ's role in regulating neurotransmission and neurogenesis. This breakthrough could lead to novel therapies for treatment-resistant depression and personalized medicine approaches in psychiatry.
Incident stroke accelerates long-term cognitive decline in older stroke survivors. The study using pooled data from 14 cohorts found a significant association between stroke and accelerated cognitive decline.
Researchers have created the largest and most complete map of the fruit fly brain, detailing over 50 million connections between neurons. The study provides critical information about brain wiring and underlying signals, paving the way for future studies on larger-brained animals.