Articles tagged with Pancreatic Cancer
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Researchers have identified a compound, ancistrolikokine E3, from the twigs of the Ancistrocladus likoko vine that kills pancreatic cancer cells when nutrients are scarce. The compound inhibits the Akt/mTOR pathway, which is responsible for the aggressive proliferation of these cancer cells.
Researchers identified TP63 as the culprit behind aggressive pancreatic cancer's addictive behavior. Suppressing its activity could lead to a tumor's demise. The study aims to understand why TP63 gets active in some patients' pancreas, with the goal of developing a treatment to improve their survival.
Research has found a strong link between adolescent weight and an increased risk of pancreatic cancer later in life. The study analyzed data from over 1.7 million Israeli adolescents and found that obesity was associated with a four-fold higher risk of pancreatic cancer, even among those who were not obese.
Researchers are investigating the link between blood clots and pancreatic tumors, which could lead to more effective treatments for patients with pancreatic cancer. The study aims to understand how blood clots form and contribute to tumor growth, potentially leading to new therapeutic approaches.
Researchers developed an antibody to block DKK3, which stimulated cancer growth and resistance to therapy. In a mouse study, the treatment significantly prolonged life and boosted immune cell infiltration.
Researchers found that patients with a non-functional IDO2 gene had more favorable outcomes when receiving radiotherapy, living cancer-free for almost twice as long. The discovery could lead to personalized treatment recommendations and improve patient survival rates.
Researchers at UNIGE and HUG discovered that mucinous tumours of the ovary and pancreas originate from embryonic germ cells that migrate to reproductive organs. These cells can mistakenly stop in other organs, leading to cancer decades later.
A new cell-based immunotherapy using 'educated killer cells' has shown promise in eradicating pancreatic cancer, including cases where tumours have spread to multiple organs. The treatment could potentially be administered to human patients without toxic side effects.
A study found that female-specific genetic mutation ATRX increases susceptibility to pancreatitis and pancreatic cancer. The research team discovered that deleting the gene in females led to increased progression to cancer, while males with the mutation experienced reduced risk of injury and progression to cancer.
A large observational study found that individuals with diabetes are at a higher risk of developing certain cancers, including colorectal and breast cancer. The study also showed that people with diabetes who are diagnosed with cancer have poorer survival rates compared to those without diabetes.
A new drug called Metavert has shown promising results in blocking pancreatic cancer growth in laboratory mice. The study also found that Metavert may prevent patients from developing resistance to currently used chemotherapies.
A study of 50,000 people found that over 80% of those with identifiable genetic risk for breast, ovarian, prostate, and pancreatic cancer are unaware they carry the gene. The findings highlight the need for effective DNA-based screening to identify high-risk individuals before a cancer diagnosis.
Researchers have developed a new blood test that can detect pancreatic cancer in its earliest stages with 96% accuracy, providing a potential breakthrough for earlier diagnosis and treatment. The test uses an antibody microarray to identify specific immune-regulatory proteins and cancer-associated antigens.
The new study reveals that different KRAS mutations have distinct effects on the KRAS protein's molecular-level function. The findings enhance understanding of cancer-causing mutations and may lead to the development of targeted drug therapies.
Researchers at University of Houston develop synthetic compound that inhibits two major pathways of pancreatic cancer. The drug, MA242, targets NFAT1 and MDM2, reducing tumor growth and progression.
The foundation grants four-year, $231,000 fellowships to support novel projects and encourage early career researchers in cancer science. The recipients are working on innovative projects such as developing T-cell receptors for immunotherapy and understanding protein modification in cancer development.
Researchers at the GW Cancer Center will develop a model to study the COMPASS complex in pancreatic cancer and possible targeted therapies. The goal is to identify molecular vulnerabilities and treat patients based on their likelihood to respond to tailored treatments.
A new study found that Cannabidiol (CBD) significantly improved the survival rate of mice with pancreatic cancer when used alongside chemotherapy. The treatment resulted in nearly tripled survival time compared to those receiving chemotherapy alone.
A study found that fitness trackers can supplement current assessments of health status and physical function, showing increased daily activity correlates with positive patient ratings and lower adverse events. Wearable devices may help predict treatment complications and enable timely interventions.
A new study published in the British Journal of Surgery found that breath analyses can identify pancreatic cancer compounds. Researchers detected 12 specific volatile organic compounds indicative of pancreatic cancer, offering potential for early detection and treatment.
Researchers discovered that pancreatic cancer cells' ability to alter their characteristics and shape affects where metastases form. The presence of E-cadherin protein controls this process, with its absence leading to lung metastases but not liver metastases.
A multidisciplinary team from UGR has developed software that can analyze heterogeneous genetic expression data to identify potential pancreatic cancer biomarkers. The new integrative system has identified 5 commonly expressed potential biomarkers and 28 novel genes that are differentially expressed in the meta-analysis.
A new study from MIT and Dana-Farber Cancer Institute found that pancreatic tumors can cause weight loss due to reduced digestive enzymes, but treatment with enzyme replacement did not improve survival. The researchers suggest a potential protective mechanism underlying this process.
Researchers have discovered a potential diagnostic method for pancreatic cancer in patients with early onset diabetes by analyzing blood sugar levels over time. The ENDPAC score model identifies patients at high risk of developing pancreatic cancer, providing a new way to diagnose the disease at an earlier stage.
Researchers found six genes with mutations that substantially increase a person's risk for pancreatic cancer, even in those without family history. The study recommends genetic testing for all pancreatic cancer patients as the new standard of care.
Researchers have obtained key information about proteins in single human cells, revealing molecular happenings inside a cell. The nanoPOTS technology allows for the analysis of samples that are 500 times smaller than previously possible, providing vital insights into cellular behavior.
A new study suggests that recent-onset type 2 diabetes may be an early manifestation of pancreatic cancer. The research found a two-fold increased risk of pancreatic cancer among individuals with recent-onset diabetes compared to those with long-standing diabetes, particularly in African Americans and Latinos.
A new study from the Keck School of Medicine of USC shows that African-Americans and Latinos who are diagnosed with diabetes after age 50 are at increased risk of developing pancreatic cancer. Late-onset diabetes may be an early sign of pancreatic cancer, providing a potential opportunity for screening.
Researchers found that PARP inhibitors, such as rucaparib, showed promise in treating pancreatic cancer in patients with BRCA mutations. In a small study, 32% of patients experienced disease control after treatment.
Researchers developed a precision-medicine approach using patient-derived organoids to predict treatment responses in pancreatic cancer. The method identified specific gene signatures that can guide the selection of chemotherapy regimens, offering hope for improved survival rates and quality of life.
Avoiding excess body weight and maintaining a stable weight in middle adulthood may help prevent several obesity-related cancers in women. High weight gain is associated with a significantly increased risk of pancreatic cancer, breast cancer, and endometrial cancer.
A new diagnostic test developed by researchers at UC San Diego shows promise for detecting pancreatic cancer earlier. The test uses electronic chip-based system to extract exosomes directly from blood, providing results in less than an hour. The findings have the potential to detect cancer early on without invasive surgical procedures.
A phase II clinical trial suggests patients with aggressive pancreatic cancer who harbor BRCA mutations may benefit from rucaparib, a PARP inhibitor approved for ovarian cancer. The study found 32% of patients experienced a clinical benefit, including four patients with responses and two with stable disease.
A small study of adults with pancreatic cancer reveals that patients with BRCA1 or BRCA2 gene mutations have poorer overall survival rates compared to those without the mutations. However, those with BRCA1 or BRCA2 had better survival rates with platinum-based chemotherapy.
A team led by CSHL Professor Douglas Fearon found that dormant cancer cells are already in the liver before surgery, expressing MHC1 and CK19 markers. In a post-operative stress-induced state, these cells re-express markers and begin to divide, forming seeds of metastatic lesions.
Pancreatic cancer researchers and clinicians will work together to build a state-wide biobank, collecting data from diverse patient groups to minimize disparities and personalize care. The goal is to develop more effective therapeutic strategies tailored to individual needs, improving survival rates and quality of life.
Research reveals that obesity suppresses the epithelial defense against cancer, allowing malignant cells to remain and develop tumors. Aspirin treatment enhances this defense mechanism, suggesting a potential role in cancer prevention.
Dr. Christian Marín-Muller developed a microRNA treatment for pancreatic cancer and founded Speratum CR, a biotech company with the goal of creating effective therapies. The company has successfully completed preclinical studies and is planning to initiate its first human trial.
The Pancreatic Cancer Collective, funded by the Lustgarten Foundation and Stand Up To Cancer, will accelerate research for pancreatic cancer patients. The initiative aims to improve diagnosis and treatments, as well as support the next generation of pancreatic cancer investigators.
Seven new grants will support studies on personalized treatments, non-invasive cancer cell killing, and early tumor detection using advanced imaging techniques. These projects aim to improve survival statistics for pancreatic cancer patients and accelerate research progress.
Researchers at UT Health San Antonio have created a novel technology that injects a modified virus into the mouse pancreas with pro-cancer molecules, resulting in human-like tumors. This breakthrough could lead to new insights into pancreatic cancer initiation and progression, as well as spur new drug development.
Research highlights the connection between diet, obesity, and various types of cancer, including breast, colorectal, and pancreatic cancers. Dietary interventions like calorie restriction and low-fat diets may help reduce obesity-related cancer risk.
A study found that bacterial composition differs in patients with pancreatic ductal adenocarcinoma, promoting immune suppression and tumor growth. Eliminating certain bacteria slowed cancer progression and increased T-cell infiltration into tumors.
Research found that gut bacteria dominate in patients with pancreatic cancer, preventing immune system attacks on tumor cells. Antibiotics slowed cancer growth and reprogrammed immune cells to recognize cancer cells again.
The non-profit organization Destroy Pancreatic Cancer is funding a new clinical trial designed by Dr. Daniel D. Von Hoff at the Piedmont Cancer Institute, aiming to improve treatment options for pancreatic cancer patients. The trial will enroll up to 25 patients and is part of TGen's efforts to find a cure for this deadly disease.
Researchers at Binghamton University have developed a new method of treating pancreatic cancer using dual thermal ablation, which combines heating and freezing to kill cancer cells. The study found that this approach achieves complete cell death in pancreatic cancer cells more effectively than heating or freezing alone.
Researchers discovered five new regions in the human genome associated with increased pancreatic cancer risk, including variants in genes that regulate cell growth and tumor suppression. The findings may lead to more targeted treatments and early detection screening for pancreatic cancer.
Researchers at CNIO discovered that a gene controlling inflammation also increases pancreatic cancer risk. The study suggests new strategies for prevention and detection of the disease.
A recent study published in Nature revealed that gene duplication plays a crucial role in explaining the aggressiveness and early metastasis of pancreatic cancer. Researchers discovered that specific gene amplifications occur along various evolutionary pathways of the cancer, leading to tumor development.
Researchers at Queen Mary University of London have successfully modified a common flu virus to target and kill pancreatic cancer cells. The new technique could potentially become a promising new treatment for patients with the aggressive disease.
Researchers link oral health to cancer prevention via bacteria associated with periodontitis. Periodontitis may facilitate the spread of oral bacteria and their virulence factors to other parts of the body, contributing to cancer development.
A new study published in Cancer Cell suggests that stress accelerates the development of pancreatic cancer by triggering the release of 'fight-or-flight' hormones. Beta-blockers, commonly used medications that inhibit these hormones, were found to increase survival in a mouse model of the disease.
Researchers at Tel Aviv University discovered an inverse correlation between a known oncogene and tumor suppressant, leading to extended survival rates in pancreatic cancer patients. A novel nanoparticle delivery system selectively targets cancer cells, rendering them dormant or eradicating the tumor altogether.
A study published in Journal of Cell Biology identifies SUV420H2 as an epigenetic orchestrator of pancreatic cancer cells' aggressive behavior. Reducing SUV420H2 levels makes pancreatic cancer cells more vulnerable to existing therapies.
Researchers at TGen and Baylor Scott & White Research Institute are developing an early detection system for pancreatic cancer using a non-invasive blood test. The goal is to identify patients before symptoms appear or spread, improving mortality rates.
A new molecular test detects telomere fusions in pancreatic tumor and cyst fluid samples to predict high-grade dysplasia and invasive cancer. This assay helps physicians determine whether lesions require surgical resection or can be safely monitored.
Researchers at Ohio State University Wexner Medical Center identified a substance called Gdf-15, released by pancreatic cancer cells, that protects them from immune cell macrophages. GDF-15 inhibits nitric oxide and tumor necrosis factor production in macrophages, allowing tumor cells to survive and grow.
The Sabga Foundation has pledged $1 million to support a clinical trial at the Translational Genomics Research Institute (TGen) in testing revolutionary new treatments for pancreatic cancer. This initiative aims to find answers to eradicate this devastating disease, which claims hundreds of thousands of lives worldwide.
Researchers found that FAIMS technology can effectively differentiate between pancreatic cancer patients and healthy individuals, with a sensitivity and specificity of 85% and 75%, respectively. The test is non-invasive, affordable, and can analyze up to 20 urine samples per hour.
A research team led by BU School of Medicine professor Avrum Spira is developing diagnostic tools to intercept lung cancer at its earliest stage using innovative approaches like nasal swabs and blood tests. The goal is to confirm whether lung abnormalities found on chest imaging are benign lung disease or signs of cancer.