Articles tagged with Sarcoma
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A 69-year-old Vietnam war veteran was diagnosed with pleomorphic liposarcoma, a rare type of cancer, after exposure to Agent Orange during his service. The patient's cancer has a high rate of local recurrence and ability to spread to other parts of the body, making early detection crucial.
Scientists at UNC Lineberger Comprehensive Cancer Center found that certain short, repetitive DNA sequences contribute to the development of Ewing sarcoma by enhancing susceptibility to an oncoprotein. These sequences interact with histones in a way similar to stem cells, allowing the oncoprotein to change gene expression.
Researchers at Indiana University have discovered a connection between the genetic mechanisms that trigger Ewing's sarcoma and prostate cancer. This finding could lead to the development of new treatments for patients with both diseases.
A multi-center study found significant survival gains in patients with high-risk soft tissue sarcoma of the trunk or extremities treated with neoadjuvant chemotherapy with an anthracycline plus ifosfamide. The regimen showed a 20% improvement in prognosis for these patients compared to those receiving histology-driven regimens.
PharmaMar presents updated clinical trial data for its antitumoral compounds Yondelis and lurbinectedin, demonstrating efficacy in treating solid tumors such as breast, soft tissue sarcomas, and colorectal cancer. These findings support the potential of these molecules as treatments for various types of solid tumors.
A new orthotopic animal model has been created to study metastasis in Ewing sarcoma, allowing researchers to replicate the primary tumor's growth environment. The model provides valuable insights into metastatic processes and may become a tool for analyzing metastatic potential in other sarcomas.
A landmark study published in The Lancet Oncology reveals new genetic risk factors for sarcoma, a disproportionate cause of disease-related death among children and young adults in Australia. Carrying two or more of these rare mutations increases an individual's cancer risk.
A phase 2 clinical trial found that adding olaratumab to doxorubicin increased median overall survival by nearly a year in patients with advanced sarcoma. The combination therapy showed no significant increase in treatment side effects.
Researchers have identified neurotrophin signaling proteins as promising therapeutic targets and biomarkers for childhood cancers. These proteins, including BDNF and NGF, can inhibit tumor growth and make cancer cells more susceptible to chemotherapy, offering new hope for improved treatment outcomes.
Researchers from Memorial Sloan Kettering Cancer Center share results of experience with over 500 patients with pulmonary metastases from STS, identifying prognostic factors associated with improved survival. The study found that leiomyosarcoma histologic subtype, primary tumor size, and minimally invasive resections were significantly...
Researchers have identified two new compounds that show promise in treating Ewing sarcoma, a rare and aggressive form of childhood cancer. The compounds target the transcription factor EWS-FLI1, which plays a key role in gene regulation, leading to uncontrolled cellular proliferation and tumors.
A large prospective post-commercialization study in patients with advanced soft tissue sarcoma (STS) in Europe confirms the long-term anticancer activity of YONDELIS® (trabectedin). The median progression-free survival was 5.5 months, and durable responses were observed in 18 patients still on treatment.
PharmaMar presents new data for YONDELIS (trabectedin) in soft tissue sarcoma and solid tumors, including final overall survival analysis and real-world data from a large prospective phase IV study. Additionally, early clinical studies show synergistic activity for PM1183 in combination with paclitaxel or cisplatin.
The EORTC will present on precision medicine, including a discussion of molecular subgroups and randomized trials. The organization will also focus on survivorship care, exploring the importance of long-term follow-up and evidence-based approaches.
Researchers from Ludwig-Maximilians-Universität München elucidated the molecular level interactions between an inherited mutation and a spontaneous somatic mutation in Ewing's sarcoma. The team discovered that a germline susceptibility variant increases risk for the disease by interacting with a driver mutation, promoting tumorigenesis.
Researchers have found a potential treatment option for children with Ewing's sarcoma by combining two active ingredients, Olaparib and Trabectedin, which achieves complete remission in all cases. The combination enhances the sensitivity of cancer cells to these drugs, increasing its effect.
Results from the EORTC trial 62072 show pazopanib improves progression-free survival in soft tissue sarcoma patients without affecting their health-related quality of life. The study provides valuable data on treatment outcomes and cost effectiveness for this patient population.
PharmaMar presents clinical studies showcasing the efficacy of YONDELIS and PM1183 in treating small cell lung cancer, soft tissue sarcoma, and malignant pleural mesothelioma. The studies demonstrate promising results with a response rate of 67% for PM1183 in SCLC.
A large retrospective study of 885 patients with soft-tissue sarcoma found that YONDELIS treatment was effective, with median progression-free survival and overall survival of 4.4 and 12.2 months, respectively. Early administration as second-line therapy may optimize efficacy.
A large-scale study found a 0.22% incidence of uterine sarcoma in women after hysterectomy, with most cases being unexpected endometrial cancer. Researchers emphasized the need to balance minimally-invasive procedures with cautious preoperative planning.
A study in Lancet Oncology suggests continued treatment with YONDELIS for advanced soft-tissue sarcoma patients who have not progressed after six courses improves progression-free survival. The results also indicate that a drug holiday may worsen outcomes.
A new standard of care for soft tissue sarcomas has been established through a study that shows image-guided radiotherapy can reduce long-term side effects while maintaining survival rates. The treatment delivers smaller radiation doses to tumors, minimizing exposure to surrounding healthy tissue.
A University of Colorado study finds alterations in expression of PIK3R3 and PTEN genes in young-adult Ewing Sarcoma, commonly observed in adult tumors. These findings could lead to adapted therapeutic strategies for adult cancers to treat Ewing Sarcoma.
Researchers suggest inhibition of Sirtuin1 protein as a future treatment option for metastatic Ewing sarcoma. The study found overexpression of sirtuin 1 significantly correlated with metastasis in patient samples, opening the door to treatment of aggressive tumors.
A genetic abnormality drives Ewing sarcoma through two processes: stimulating tumor growth and suppressing cancer development. New therapies may target these mechanisms.
A new study identifies Ewing sarcoma-associated transcript 1 (EWSAT1) as a critical target of the EWS-FLI1 fusion protein, contributing to cancer cell growth and repression of key genes. This finding supports the notion that long noncoding RNAs can drive cancer development and highlights an important mediator in Ewing Sarcoma.
Researchers at IDIBELL and ICO have tested a new therapeutic combination of conventional chemotherapy and rapamycin to combat resistant sarcomas. The Phase I trial showed promising results, with the tumor stopping growth and not recovering after treatment, and has launched a Phase II clinical trial.
A phase I clinical trial found that ex vivo cultured cord blood stem cells showed improved engraftment rates and earlier hematopoietic recovery in patients with hematological malignancies. The study also developed a murine model of Ewing's sarcoma, revealing tumor origins in embryonic osteochondrogenic progenitors.
The EORTC trial 62012 found that adding ifosfamide to doxorubicin improved median progression-free survival, but not overall survival or tumor shrinkage, in advanced soft tissue sarcoma patients. Combination chemotherapy also resulted in more overall responses compared to doxorubicin alone.
EORTC analysis confirms performance status, tumor grading, and hemoglobin levels as key predictors of long-term outcomes in pazopanib-treated patients. Long-term responders and survivors accounted for 36% and 34% of patients respectively.
Researchers identified microRNA-22 as a key player in Ewing's Sarcoma, regulating KDM3A gene expression. Targeting KDM3A with small-molecule inhibitors may provide new therapeutic options for the disease.
The EORTC-ESTRO joint session will present the latest research on soft tissue sarcoma treatment, emphasizing the importance of early patient management. Key experts will discuss optimal timing sequences for radiotherapy in limb and retroperitoneal sarcomas, as well as current concepts in chordoma management.
Researchers at Huntsman Cancer Institute are testing a novel targeted treatment for Ewing sarcoma, which has spread by the time it's diagnosed. The goal is to disrupt cancer growth and spread using LSD1 inhibitors, with preclinical trials underway.
A LSUHSC study found significant racial and ethnic disparities in the incidence of soft tissue sarcomas among adolescents and young adults. The research revealed that African-American and Hispanic males were more likely to develop certain types of cancer, such as Kaposi sarcoma and liposarcoma.
Researchers at Ohio State University Comprehensive Cancer Center discovered that the tumor-suppressor gene A20 is silenced due to the loss of microRNA-29, leading to increased levels of NF-kB and tumor progression. This finding could guide the development of more effective therapies for soft-tissue sarcomas.
A recent study found that orthopedic oncologists and surgical oncologists conducted only 52% of sarcoma surgeries, while general surgeons, plastic surgeons, and orthopedic surgeons performed the remaining 48%. This disparity may impact patient outcomes due to varying levels of expertise in removing deep-seated tumors.
Cornell University engineers have developed a new smartphone-based system for in-the-field detection of Kaposi's sarcoma and other conditions, utilizing a plug-in optical sensor and disposable microfluidic chips. This novel technique provides a quick method to quantify viral DNA levels, requiring minimal training and expertise.
The EORTC 62024 trial found that adjuvant imatinib impacts short-term freedom from relapse in patients with localized, surgically resected, high/intermediate-risk GIST. The trial showed a non-statistically significant trend in favor of the adjuvant arm for Imatinib failure-free survival.
Researchers at UCLA's Jonsson Comprehensive Center have identified liposarcoma tumors that can be imaged by PET scanning using a tracer substance known as FAC, and found these tumors are sensitive to chemotherapy. This discovery has translational potential for liposarcoma patients and may lead to more effective treatment strategies.
Researchers at Huntsman Cancer Institute have discovered a new drug with high potential to treat Ewing sarcoma by targeting the EWS/FLI protein. The study found that an enzyme called lysine specific demethylase (LSD-1) interacts with EWS/FLI to turn off gene expression in Ewing sarcoma.
Researchers found that blocking galectin-1 in mice with established Kaposi sarcomas slowed tumor growth by suppressing blood vessel formation. This breakthrough holds promise for new treatment options for patients with KS and may also be effective for other diseases characterized by aberrant blood vessel growth.
Researchers have discovered that high levels of protein EYA3 are associated with a poor response to chemotherapy in Ewing's sarcoma patients. Lowering EYA3 levels may help increase the effectiveness of existing therapies and improve outcomes.
Pazopanib nearly tripled progression-free survival in patients with metastatic soft-tissue sarcoma whose disease has progressed following standard chemotherapy. The median follow-up was 15 months, and common side effects included fatigue, diarrhoea, and hypertension.
Moffitt Cancer Center researchers identified 39 tyrosine kinases in sarcoma cells, which could drive tumor growth and survival. These enzymes were found to be expressed in multiple tumors, potentially limiting the effectiveness of targeted agents.
Researchers found that viral lytic replication impairs the effectiveness of Nutlin-3, a targeted therapy for KSHV-induced lymphomas. The study suggests reactivating p53 as a selective treatment modality.
A combination of cixutumumab and temsirolimus shrank tumors in some patients with treatment-resistant Ewing's sarcoma or desmoplastic small-round-cell tumors, with two achieving complete responses. The study suggests that managing side effects is vital to maintaining the therapy and slowing disease progression.
Researchers discovered a novel viral oncogenesis mechanism in which KSHV co-opts cellular signaling pathways and modifies the microenvironment for viral replication. The virus induces EndMT, giving rise to infected invasive cells, allowing efficient spread of the virus.
Researchers at Moffitt Cancer Center found MK1775 effective in treating sarcoma cells, inducing apoptosis and causing cell death, regardless of p53 mutation status. The study suggests that Wee1 inhibition by MK1775 may represent a novel approach in treating sarcomas.
Researchers at Joslin Diabetes Center have identified two major molecular signaling pathways that regulate cell growth and division, hallmarks of cancer biology. The study provides new candidate targets for treating soft-tissue sarcomas, which can be controlled but not cured by current treatments.
Researchers from Yale University discovered that a virus from the same family as rabies can target and kill soft tissue sarcomas. The oncolytic activity of VSV-rp30a was found to be effective against 12 out of 13 different sarcoma lines, with resistance overcome by interferon antagonizers.
23andMe has completed its Independent Sarcoma Scientific Advisory Committee, comprising leading researchers and clinicians, to advance understanding of sarcomas. The company aims to combine genetic data with patient-reported outcomes to find patterns in sarcoma biology and treatment response.
Researchers have made a breakthrough in Ewing's sarcoma treatment with the discovery of a novel small molecule that blocks key protein interactions. The $4.37 million NCI grant will fund preclinical toxicology studies to accelerate the development process.
Researchers at TGen have identified two potential anti-cancer drug targets, STK10 and TNK2, for Ewing's sarcoma in children. These kinases play a crucial role in the growth and survival of cancer cells, making them promising therapeutic targets.
Researchers at the University of Leeds have identified PYM as a key protein involved in the replication and spread of Kaposi's Sarcoma-causing viruses. Blocking interactions between PYM and viral proteins could lead to new treatment options for this disease.
Researchers found that combining regional hyperthermia with chemotherapy increases local progression-free and disease-free survival rates in high-risk sarcoma patients. The treatment has shown promise, but the safety profile remains a concern.
Researchers at the ESMO Conference on Sarcoma and GIST discuss exciting new science on rare tumors found in muscle, blood vessels, deep skin tissues, nerves, and joints. Novel treatments are emerging for a large number of sarcoma types, targeting initial molecular alterations driving these tumors.
Scientists have identified CD99 as a crucial marker in Ewing sarcoma development and suggest targeting it to develop new therapies. The protein's role is tied to preventing neural differentiation, a process that contributes to oncogenesis.
Researchers have found that figitumumab has antitumor activity in Ewing's sarcoma, a cancer commonly affecting male teenagers. The drug targets the insulin-like growth factor signalling pathway, and initial studies have shown safety and efficacy in patients with refractory Ewing's sarcoma.
Researchers at UCLA's Jonsson Comprehensive Cancer Center found that the loss of PTEN tumor suppressor gene plays a central role in transforming benign neurofibromas into malignant and deadly sarcomas. The study could lead to new therapies targeting cell signaling pathways regulated by PTEN.
Researchers at University of Utah Health have made a surprising connection between high levels of GSTM4 protein and poor chemotherapy response in Ewing's sarcoma patients. The study suggests that targeting GSTM4 could lead to more effective treatments for individual patients.