Articles tagged with Human Immunodeficiency Virus
A new method to cure HIV using umbilical cord blood stem cells has yielded long-term successful results for a middle-aged mixed-race woman with leukemia and HIV. The approach broadens the opportunities for people of diverse ancestry to attain cures.
A newly funded research project is exploring the link between HIV-induced aging and Alzheimer's disease. The team aims to develop a drug delivery system to increase HIV suppression in the brain and decrease associated neurocognitive disorders.
A new study examines the concerns of parents of sexual and gender minority (SGM) adolescents regarding HIV pre-exposure prophylaxis (PrEP) use. Parents cited effectiveness and adverse effects as key factors in their decision-making, while also expressing questions about how to discuss PrEP with their children.
Researchers have discovered that HIV creates reservoirs as early as the first days of infection, hiding and persisting during antiretroviral therapy. This finding is a major obstacle to curing HIV, but it also offers new opportunities for treatment development.
After a stem cell transplant from a donor with the CCR5-delta 32 mutation, a man was able to stop his antiretroviral treatment without viral resurgence. Four years later, no HIV virus could be detected in his body, indicating probable cure. This case joins two previous reported cases and offers further proof that HIV can be cured.
A new study published in the British Journal of Sports Medicine reveals that physical activity is 1.5 times more effective than counselling or medications in managing depression. The review of 97 reviews and 1039 trials shows that exercise interventions, especially those lasting 12 weeks or less, can significantly reduce mental health ...
A study has identified a severe form of mpox with a 15% mortality rate in people with advanced HIV disease and immunosuppression. The researchers recommend adding this form of mpox to the list of AIDS-defining conditions to guide management of immunocompromised individuals.
A study found that long-acting injectable ART suppressed HIV in people with unstable housing, mental illnesses, and substance use disorders. The treatment improved outcomes in underserved patients, overcoming daily treatment barriers such as housing insecurity and untreated mental illnesses.
A new study has confirmed that people living with HIV who switch from efavirenz to dolutegravir may gain more weight and have a higher risk of developing high blood pressure. The study found that patients on dolutegravir gained an average of 1.78 kg in 12 months, compared to those on efavirenz.
A 53-year-old man has been cured of HIV after receiving a stem cell transplant, marking the third person to achieve this. The patient's genome contained a mutation in the CCR5 gene, making it impossible for most HIV viruses to enter his CD4+ T-lymphocytes.
Researchers found that doxycycline postexposure prophylaxis did not prevent chlamydia or gonorrhea among cisgender women in a clinical trial. The lack of efficacy was attributed to differences in anatomy and antibiotic resistance.
The AIDS Clinical Trials Group (ACTG) will present 29 presentations at the Conference on Retroviruses and Opportunistic Infections (CROI) 2023. The studies focus on COVID-19, HIV cure, pathogenesis, treatment, long-term complications, tuberculosis, hepatitis C, and contraception.
A team of researchers from UNC and CDC developed an injectable implant that can release HIV PrEP medications for up to six months, providing full protection. The technology has shown promise in non-human primates and could potentially be adapted for human use.
A Rutgers study found that older people living with HIV/AIDS face unmet mental health needs and are more likely to experience PTSD, substance dependence, and suicidal thoughts. Resilience may play a crucial role in increasing adherence to antiretroviral therapy, which is essential to ending the AIDS epidemic.
The institutions will develop trials to screen cervical cancer patients in low-resource countries, aiming to prevent advanced cancer. The collaboration aims to achieve the World Health Organization's goal of eliminating cervical cancer by adapting and innovating prevention strategies.
A Rutgers study found that pregnant people with HIV have higher levels of chronic systemic inflammation and immune activation, leading to poor growth in children. The study aimed to investigate the impact on babies exposed to HIV but not infected.
A Phase 3 clinical trial testing an experimental HIV vaccine regimen found the treatment to be safe but ineffective in preventing HIV acquisition. The trial involved over 3,900 volunteers and concluded that the number of HIV infections were equivalent between the vaccine and placebo arms.
Research reveals that commonly used antiretroviral drugs TAF and TDF directly impact mitochondria's energy production in immune cells. The study suggests a larger energy reduction when combined with other antiretrovirals, sparking concerns about potential long-term effects on human cells.
A UCSF study suggests people who identify as lesbian, gay, bisexual, transgender, or non-binary may have a higher risk of stroke at a younger age. Non-traditional stroke risks include HIV and syphilis infections.
Researchers discovered host proteins APOBEC3 can aid HIV's latency, a major hurdle to cure research. The finding raises questions about the role of these proteins and potential ways to block their activity to inhibit viral persistence.
A new study finds epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV. Participants showed accelerated biological age and different brain activity patterns compared to controls, suggesting a link between biological aging and neural function in PWH.
A new study published in The Lancet HIV reveals that women experiencing recent intimate partner violence are three times more likely to contract HIV. The research highlights the intersectional epidemic of IPV and HIV in Sub-Saharan Africa, where women face increased risk of HIV acquisition and less frequent viral load suppression.
A new study suggests that expanding Medicaid coverage in Houston, combined with increased use of PrEP and antiviral medications, could lead to a significant decline in new HIV infections among young Black gay, bisexual, and other men who have sex with men. The model projects a potential decrease in HIV incidence rate to almost 50% with...
A recent study by Texas A&M University reveals that rural family medicine physicians are less comfortable providing sexual risk reduction counseling to adolescents compared to their urban counterparts. This disparity highlights the need for increased awareness and training of PrEP-related clinical activities among rural providers, whic...
Researchers at Scripps Research, IAVI, Fred Hutch, and VRC publish study data in Science, revealing a stepwise approach to producing antibodies capable of targeting wide range of HIV variants. The Phase 1 trial shows favorable safety profile and induces targeted response in 97% of vaccinated individuals.
A systematic review of national clinical practice guidelines in Europe found that fewer than half include HIV testing recommendations for patients with medical conditions indicating HIV infection. This omission hinders efforts to stop the spread of HIV through timely diagnosis, affecting the lives of people living with HIV.
Researchers found that people living with HIV have a significantly delayed internal body clock, consistent with the symptoms of jet lag. This disruption may contribute to increased health problems experienced by those with HIV. The study suggests a strong need for further research on younger people living with HIV in other countries.
Researchers found a significant increase in Kaposi's sarcoma incidence among young Black men in the South, with rates jumping by 3.3% per year. The study suggests that HIV infection and social determinants like poverty and lack of access to medical care contribute to this disparity.
A study by Brigham and Women's Hospital found that specific immune system biomarkers are linked to the acquisition of both HIV and genital herpes. The researchers identified unique predictors for each disease, providing new targets for preventive treatments.
The Midwest AIDS Training and Education Center at UIC will expand its services nationwide, using the $3 million grant to train medical professionals in patient care. The center aims to increase access to care and end the HIV epidemic by 2030.
A new Danish-led study has demonstrated a way to strengthen the body's own ability to fight HIV, even when standard treatment is paused. The study found that monoclonal antibodies and Romidepsin can help the immune system recognize and kill infected cells.
Researchers at KTH Royal Institute of Technology developed a method to track the growth of the HIV virus by highlighting its essential molecules. This breakthrough could lead to the creation of new therapies that target these molecules to prevent viral growth.
Researchers develop custom vaccines that induce broadly neutralizing antibodies to protect against HIV variants. The team uses a modified HIV spike protein to prime the immune system, paving the way for an effective HIV vaccine.
Researchers found pre-existing differences in gut bacteria between people with and without HIV, including decreased Bacteroides species and increased Megasphaera elsdenii. These changes were present even before infection occurred, suggesting a potential link between gut microbiome and HIV susceptibility.
A recent study published in The Lancet HIV found that individuals with viral suppression through antiretroviral therapy (ART) medications can live longer and experience less disability compared to those with unsuppressed HIV. This research highlights the critical importance of maintaining support for HIV treatment programs to ensure op...
Research found that people with HIV who also have untreated hepatitis C virus have a higher risk of heart attack as they age. The study analyzed health data from 23,361 people with HIV and found that those co-infected with hepatitis C had a significantly increased risk of heart attack compared to those with HIV alone.
Researchers found that a 'slow delivery, escalating dose' vaccination strategy can prompt B cells to spend months mutating and evolving their antibodies, leading to more effective long-lasting vaccines. This breakthrough has implications for vaccines against pathogens like influenza, malaria, and SARS-CoV-2.
A synthetic prophylactic gel developed at KTH Royal Institute of Technology has shown promising results in lab tests, with a 70% effectiveness rate against HIV and an 80% effectiveness rate against herpes.
A 21% relative risk reduction in reported high-risk HIV behavior was found for single mothers with a State-level Earned Income Tax Credit (SEITC) of 10% or above the Federal EITC. A 10 percentage-point increase in SEITC was also linked to a 38% relative reduction in high-risk behavior.
Research found annual earnings for men in same-sex couples decrease by $2,650 when PrEP drugs become available. Part-time employment also increases by 10.7% among young white men taking HIV prevention drugs.
The CHEETAH Center is a leading institution for HIV research, publishing over 300 papers on the virus's inner workings and potential treatments. Researchers are focusing on understanding HIV's life cycle, identifying key components essential for viral infection and replication.
A Rutgers University study found that simultaneously focusing on kids, caregivers, and community members produces better outcomes than interventions targeting children in isolation. The study suggests that multilevel programs can strengthen mental and behavioral health of children affected by extreme adversity.
The new tuberculosis vaccine candidate VPM1002 shows its safety and efficacy in a study of HIV-exposed and non-HIV-exposed newborns. The vaccine has fewer side effects compared to the existing BCG vaccine, and elicits a similar immune response.
A national PrEP program is proposed to improve access to the highly effective yet underutilized preventive treatment, which could greatly reduce HIV rates. The special issue supports increased access, affordability, especially among Black and Latino populations.
A new study found that HIV-1 Tat expression accelerates age-related diseases in male mice by disrupting neuroendocrine function. Researchers discovered that Tat alters steroid hormone levels, leading to anxiety-like behavior, cognitive errors, and reduced grip strength.
A study published in eLife suggests that combining broadly neutralizing antibodies (bNAbs) based on viral genetics can help prevent viral escape and rebound in HIV treatment. The researchers identified a combination of three bNAbs, PG9, PGT151, and VRC01, which reduces the chance of viral rebound to less than 1%.
A new study finds that large-scale HIV screening and peer support successfully reduced uncontrolled HIV in people who inject drugs by 40% in Haiphong, Vietnam. The intervention improved HIV identification and care among this at-risk population.
Researchers have found that treating high-grade squamous intraepithelial lesions (HSILs) in people with HIV significantly decreases the progression to anal cancer. The ANCHOR trial enrolled over 4,000 participants and showed a 57% reduction in anal cancer cases.
A longitudinal cohort study found significant reductions in liver disease and mortality among people with HCV infection who received treatment. The study's findings suggest that continued testing, treatment, and community-based interventions could lead to the elimination of HCV infection within the next decade.
Researchers aim to develop a gene therapy that could suppress HIV replication and eliminate the need for life-long antiretroviral therapy. The study uses an AAV vector to produce leronlimab, a monoclonal antibody blocking HIV entry into immune cells.
Researchers found that HIV prefers to infect memory CD4 T cells with large amounts of specific sugars, including fucose and sialic acid. The study also reveals that HIV boosts the production of these sugars in infected cells, highlighting a new target for potential treatments.
Researchers developed a nomogram to predict anal cancer risk in persons with HIV infection, highlighting increased risk among those living with the virus. The model estimates quantitative risk based on patient characteristics, informing screening decisions.
A large clinical trial found treating anal precancerous lesions reduces the risk of developing anal cancer in people with HIV by 57%. The study highlights the need for screening and treating high-grade squamous intraepithelial lesions (HSIL) as the standard of care for older HIV+ individuals.
A study found that despite PrEP's effectiveness in reducing HIV risk by 99%, many male couples underestimate its benefits and experience high levels of stigma. Joint education for male couples may improve PrEP adoption rates, and providing information to both partners can facilitate open discussions and concerns about the medication.
A large clinical trial found that treating high-grade squamous intraepithelial lesions (HSIL) reduces the risk of anal cancer in people with HIV. The study showed a 57% reduction in anal cancer cases after treatment, highlighting the importance of screening and treatment for HSIL in this population.
Researchers aim to understand how HIV affects cardiovascular health and the impact of substance use on this relationship. They plan to develop a human bone marrow chip model to study HIV pathogenesis and explore potential strategies for caring people with HIV who face cardiovascular disease.
A new study from Tel Aviv University developed a unique treatment for AIDS that may be developed into a vaccine or a one time treatment. The treatment involves engineering type B white blood cells to secrete anti-HIV antibodies in response to the virus.
Researchers found that combination broadly neutralizing anti-HIV antibodies (bNAbs) can effectively suppress HIV in individuals without daily antiretroviral therapy (ART), with median duration of time off ART being 39.6 weeks.
A new grant will help Missouri parents make informed decisions about vaccinating their children against various diseases. The grant aims to provide factual, evidence-based information to address common concerns and promote public health outcomes.
The program aims to increase trained cancer researchers in Tanzania and prepare them for HIV-associated cancer diagnostics, genomics, and therapy. It will focus on molecular detection, epidemiology, and biology of common HIV-associated malignancies.