Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
Researchers at Yale University found that intensively controlling glucose levels did not definitively reduce the risk of impaired kidney function, dialysis, or death from kidney disease. The study suggests that patients may not be better off with this approach and questions the benefits of aggressive glycemic control in Type 2 diabetes
Researchers found that reducing TB infections in geographic hotspots can significantly reduce citywide transmission rates by up to 29% over 50 years. Controlling these hotspots may have a similar impact on long-term, community-wide TB incidence as achieving the same targets in the remaining population.
Research has found that inhaled anticholinergics are associated with an increased risk of potentially dangerous heart arrhythmias among young asthma patients. The use of these medications for routine asthma management may be linked to a higher risk of arrhythmias, particularly among active users of ipratropium.
A new study by researchers at the Centers for Disease Control and Prevention found that residents of Lower Manhattan who suffered home damage following the 9/11 attacks are more likely to report respiratory symptoms and diseases. The study analyzed data from over 71,000 survivors of the World Trade Center attacks, including those with ...
A randomized trial found that the ARCON regime improves control of cancer at its primary site, disease-free survival, and metastasis-free survival in patients with low Hb levels. However, overall survival remains compromised due to other health problems.
A collaborative care intervention improved depression-free days and quality-adjusted life-years among adults with depression and poorly controlled diabetes. The intervention, which included team-centered care and nurse management, resulted in significant improvements in depression scores and quality of life.
Researchers at Michigan State University have created a satellite-guided plan to effectively control the tsetse fly, which spreads sleeping sickness disease in Africa. The plan uses unprecedented precision to predict where and when to direct eradication efforts, significantly reducing costs and increasing effectiveness.
A new study published in Infection Control and Hospital Epidemiology found a strong link between healthcare-associated infections (HAIs) and patient readmission after an initial hospital stay. Patients with positive clinical cultures for MRSA, VRE or C. difficile were 40% more likely to be readmitted within a year.
A new study published in the American Journal of Tropical Medicine and Hygiene finds that dengue fever inflicts a $37.8 million burden on Puerto Rico each year, with households accounting for almost half of the costs. The study suggests that investing in traditional surveillance and prevention could save $5 for every $1 invested.
A national survey found that hospitals increased focus on CAUTIs and CLABSIs after the 2008 Medicare policy change. While most findings were positive, some IPs expressed concern about resource shifts and emphasis on physician documentation over patient outcomes.
A new group of regulatory molecules called mirror-microRNAs has been discovered to control multiple aspects of brain function. These microRNA genes are produced from the same piece of DNA but have different functions in regulating protein production and movement, doubling the capacity of regulation.
A new study links malaria resurgence to funding cuts, with 91% of episodes tied to weakened control programs. The research highlights the need for sustained financial support to maintain gains in malaria control.
Silicosis, a preventable lung disease caused by silica inhalation, remains a significant occupational health concern globally. Despite prevention efforts, cases continue to rise in developing countries, highlighting the need for improved workplace safety and regular medical assessments.
A recent study found that 91% of documented malaria resurgence events were attributed to weakened control programs, highlighting the need for sustained funding. The researchers emphasize the importance of continued investment in successful malaria control and elimination programs to maintain progress and save thousands of lives.
Global measles mortality decreased by 74% from 535,300 deaths in 2000 to 139,300 in 2010. Despite this progress, India and Africa remain major concerns due to low vaccine coverage. The authors suggest intensified control measures are needed to achieve mortality reduction targets.
Researchers at Northwestern University develop a new theory of networks, establishing relationships between disparate topics such as friendship paradoxes and material properties. The study reveals that cascading processes can be controlled and collective behavior depends on network properties, opening new avenues for disease treatment ...
A new study uses a pathogen-based incidence approach to generate infectious disease burden estimates in Europe, attributing morbidity to specific pathogens. The methodology has limitations but shows the need for further research and integration of demographic changes and infection dynamics.
A study discovered Bacillus cereus bacteria in a pharmacy robot's washing station, contaminating intravenous drugs. The contamination highlights the need for strengthened cleaning and maintenance procedures to prevent life-threatening infections.
Scientists at the University of Southampton have identified a new process that controls artery constriction, which could lead to a better understanding of cardiovascular disease causes and the development of new treatments. By blocking specific enzymes, researchers were able to reduce artery constriction and lower blood pressure risk.
The US CDC proposes to focus investments on six public health functions: strategic epidemiologic information, and strengthening key institutions and infrastructure. The agency aims to engage public health institutions domestically and abroad in health systems strengthening efforts.
A study published in the American Journal of Infection Control found that approximately six percent of Chicago-area ambulance sites sampled positive for Staphylococcus aureus, a bacterium causing serious infections. The research also revealed that 77% of isolates detected showed resistance to at least one commonly used antibiotic
Infection prevention groups outline steps needed to preserve antibiotics by identifying and addressing resistance issues. The role of infection preventionists and healthcare epidemiologists is crucial in preventing the emergence of multidrug-resistant organisms, a major threat to human health.
Between 1975-2000, US lung cancer mortality declined significantly due to reduced smoking rates. Tobacco control measures such as increased taxes and smoke-free laws contributed to this decrease.
Researchers have identified microRNA-155 as a molecule that controls the severity of acute graft-versus-host disease in leukemia patients who receive bone-marrow transplants. Reducing or blocking miR-155 expression decreases GVHD severity and increases survival, suggesting a new strategy for treating the condition.
A study found that smartphone-based data collection was more accurate than traditional paper methods, with fewer errors and faster turnaround times. The method also saved resources and reduced costs, making it a promising tool for disease surveillance in the developing world.
A new study published in the American Journal of Infection Control found that hospitals led by a board-certified director in infection prevention and control have significantly lower MRSA bloodstream infections. The study also suggests that multifacility performance improvement projects are effective in reducing healthcare-associated i...
Researchers found that removing Bim allowed autoreactive T-cells to survive but remain inactive. Understanding this mechanism could lead to new therapies for autoimmune diseases like diabetes.
The International Vaccine Institute (IVI) has been granted two US patents on novel Shigella protein antigens and methods, paving the way for an effective and low-cost vaccine against bacillary dysentery. The vaccine has the potential to provide cross-protection across species and serotypes of Shigella.
Scientists studied children with newly diagnosed type 1 diabetes to understand its initial stages. They found variability in T-regulatory cell activity and increased immune-boosting cells, which may help develop new treatments.
A case report in The Lancet details the death of an 82-year-old woman due to Legionnaires' disease caused by contaminated dental surgery equipment. Laboratory experiments demonstrated genomic matching between the bacteria found in the patient's respiratory secretion and the dental unit waterline.
The US is facing a growing threat of multi-drug resistant gonorrhea, with treatment options rapidly dwindling due to increasing antibiotic resistance. The CDC has seen a 17-fold increase in drug susceptibility, leading scientists to call for collective action from healthcare providers and drug companies.
Researchers found a proactive test-and-treat strategy significantly reduced malaria prevalence, with a sixfold decrease in 2008-2009. The strategy also provided indirect protection to household members and could be targeted to hot spots for further reductions.
A new study found that norovirus was responsible for 18.2% of all infection outbreaks and 65% of ward closures in US hospitals during a two-year period. The study also revealed that medical/surgical units were the most common location of outbreak investigations, with an average duration of 58.4 days.
A new collection of articles in PLOS Neglected Tropical Diseases examines the use of genetically modified (GM) insects for controlling infectious diseases. The articles discuss technological advances, regulatory frameworks, and societal dialogue necessary for widespread application.
Key findings: DNDi highlights the need for enhanced research and development for new treatment and diagnostic tools for NTDs. The organization stresses that filling R&D gaps is crucial to achieving disease control or elimination by 2020.
Researchers at Instituto Gulbenkian de Ciência receive €2.2 million funding to investigate mechanisms behind 'tolerance to infection'. They aim to identify protective genetic programs controlling tissue damage in various diseases, paving the way for new therapeutic interventions.
The CDC completed a comprehensive study of Morgellons, finding no infectious agent and no environmental link. The researchers enrolled 109 persons with symptoms, ruling out infection through extensive testing, and determined the fibers were fragments of cloth or debris.
A new study published in Clinical Gastroenterology and Hepatology found that IBD travelers are not at a higher risk of contracting intestinal infections when visiting developing or tropical countries. Traveling during clinical remission can significantly reduce the risk of illness, according to lead author Shomron Ben-Horin.
A study published in PLoS Medicine found that individuals with access to sanitation facilities are half as likely to contract roundworm, whipworm, and hookworm infections. Regular latrine use further reduces the risk of infection by an additional 5%.
The new malaria maps provide unprecedented detail on the current global pattern of the disease, allowing researchers to track changes over time. The maps reveal complex variations in malaria risk across the globe, highlighting the need for targeted resources and tailored approaches to controlling the disease.
The paper outlines research priorities to develop effective policies and planning for mass gatherings, highlighting the need for evidence-based mitigation measures. The authors propose five key public health research directions to control public health emergencies and reduce adverse health consequences.
A new study published by Kaiser Permanente found that older women who lose more than two inches in height face a higher risk of fractures and death. The research suggests that clinicians should consider bone density testing, counseling, and treatment to help prevent fractures. Women who lost more than two inches in height were 50% more...
Researchers propose using personalized medicine to identify individuals at highest risk for developing type 2 diabetes, allowing for targeted prevention efforts. Current methods are inefficient, but new biomarkers and approaches hold promise for preventing and controlling the disease.
A 2010 outbreak of Legionnaires' disease in Wisconsin was linked to a hospital's decorative fountain, highlighting the risk of indoor water fountains in healthcare settings. The study recommends strict maintenance procedures and periodic bacteriologic monitoring to reduce the risk of Legionella transmission.
A new study assesses the potential reasons for the continued lack of success in preventing and controlling Lyme disease in the US Northeast. The study identifies critical areas where additional knowledge is needed to improve prevention and control strategies, including host infestation rates, habitat diversity, and human behavior.
Researchers release Tamarixia radiata, a parasitic wasp that kills Asian citrus psyllid nymphs, potentially reducing pest densities and protecting citrus trees in California. The natural enemy is part of a larger integrated management program for the invasive pest.
Researchers discovered that mosquitoes can control their body temperature by releasing cooling fluid during feeding, a strategy that protects them from heat stress and potential hosts' defenses. This finding has implications for controlling mosquito populations and diseases they spread.
New research reveals that bed bugs can withstand high levels of inbreeding, allowing them to colonize and expand populations. This is a major contributing factor to the recent surge in infestations across the US and globally.
Researchers at Brandeis University discover that fruit flies use two forms of TRPA1 to sense warmth and chemicals, providing potential solutions for chronic pain and disease control. The study's findings have implications for developing bug sprays and traps to combat mosquito-borne diseases.
Researchers have discovered that toltrazuril can effectively control coccidiosis in piglets, whereas sulfonamides fail to provide sufficient protection. Toltrazuril treatment has been shown to significantly improve health outcomes and reduce diarrhoea in pigs.
A study published by Dartmouth researchers found that pregnant women who consumed rice had higher levels of arsenic in their urine, highlighting the need to monitor arsenic in food sources. The findings also underscore concerns about private well water being a potential source of arsenic exposure.
A study found that only 21% of surveyed medical students could identify correct hand hygiene indications, highlighting a significant gap in knowledge. Medical students believed their own compliance would be higher than nurses', despite data showing the opposite.
A study published in Infection Control and Hospital Epidemiology found that 43 healthcare workers who never used masks during patient encounters became infected with the 2009 H1N1 virus, while 20 who wore masks at least once did not contract the disease. The findings highlight the importance of proper mask use among healthcare workers.
A new study suggests that states could save substantial amounts of money by fully funding tobacco control programs, which have a sustained impact on cigarette demand. The programs would reduce Medicaid payments, medical costs, and lost productivity, resulting in long-term savings for the states.
A new study led by Brown University found that vitamin D does not confer benefits against mortality in postmenopausal women, contrary to previous beliefs. The study controlled for key health factors like abdominal obesity and found no association between high or low levels of vitamin D and reduced risk of death.
A study found that environmental growth of Acinetobacter baumannii was detected in 48% of patient rooms, with surfaces like supply cart handles and floors being most commonly contaminated. Patients with recent or remote MDR-AB colonization or infection showed similar levels of environmental contamination.
A 2010 outbreak involving 13 NBA teams highlights the risk of norovirus among athletes and staff. Strict hygiene measures, including hand washing and disinfecting, can limit transmission and prevent illnesses.
Researchers have identified five high-priority drug targets for the parasitic disease ascariasis, caused by the giant intestinal roundworm Ascaris suum. The discovery provides new insights into treating the condition, which affects millions of people in developing countries and causes chronic effects in young children.
The region of South Asia experiences a disproportionate burden of neglected tropical diseases, including visceral leishmaniasis, lymphatic filariasis, and soil-transmitted helminth infections. Better management of these diseases is crucial to lessen the region's NTD burden.
Dr. Clyde Yancy predicts that people who follow seven simple lifestyle factors can live an additional 40-50 years after age 50, with a 90% chance of living to 90 or 100 without chronic illnesses. Governments are urged to invest in prevention strategies.