Articles tagged with Immune Response
Vanderbilt University is one of nine US sites participating in a phase I trial of the Merck HIV vaccine, designed to test its safety and ability to stimulate immune responses in healthy volunteers. The study aims to generate cellular immune responses that could prevent the virus from spreading in the body.
Researchers discovered a peptide antigen that targets glioblastoma multiforme, a highly aggressive brain tumor. The immune system recognizes this antigen, triggering an immune response and potentially leading to longer patient survival.
A new study finds that tai chi chih significantly increases immune cell levels and improves physical functioning in older adults with shingles. The exercise program was comparable to hip replacement surgery in boosting immunity and reducing symptoms.
The NIH has awarded $85 million to five cooperative centers for translational research on human immunology and biodefense. Researchers will develop new ways to analyze immune cells and use imaging technologies to study vaccine responses, aiming to strengthen the immune system against diseases.
Researchers found that the abnormally active Bcl10 gene drives B cells to become cancerous, suggesting a drug blocking the gene could be effective treatment for MALT lymphoma. The study also showed that mice lacking Bcl10 genes cannot launch an effective antibody response against bacteria.
Scientists at NIAID and USAMRIID developed a prime-boost vaccine strategy that protects monkeys from Ebola infection. The boost alone shows promise in offering quick but weaker immune response.
A study reveals that elderly humans and patients with Alzheimer's disease exhibit increased T cell reactivity towards Abeta, a protein linked to the aging process. This selective increase in Abeta-reactivity has implications for developing Abeta vaccines and may be connected to disease susceptibility and progression.
A new study shows that a derivative of green algae Chlorella pyrenoidosa improves the body's immune response to influenza vaccines. The study found significant increases in antibody responses after supplementation with two different doses of the extract, with no adverse effects reported.
A recent study published in the Canadian Medical Association Journal investigated the effects of a Chlorella-derived dietary supplement on immune function and influenza vaccination. The results showed no significant increase in antibody response to the flu vaccine overall, although some increase was seen in participants aged 50 to 55.
Researchers at Emory University discovered a novel mechanism of how anthrax disables the immune response by compromising dendritic cell function. The study found that the lethal factor (LF) disrupts mitogen-activated protein kinase enzymes in dendritic cells, leading to lethargy and preventing the activation of the immune system.
Researchers are investigating how exercise affects immune function in older populations, aiming to prevent infections and improve health outcomes. Preliminary data suggests moderate exercise may boost immune function measures and reduce mortality caused by influenza.
Researchers have developed a third-generation lentivector that transduces dendritic cells in vivo, inducing a strong and persistent antigen-specific immune response. This approach may replace costly and labor-intensive methods currently used to elicit tumor-specific cytotoxic T lymphocyte responses.
Researchers use high-speed imaging to track movement of calcium waves in cell signaling, identifying a sequence of amino acids (LTL) that controls the pathway. The findings have implications for treating autoimmune diseases such as arthritis and uveitis.
A study published in JCI Journals identified unique immunological factors produced by immune cells of peanut-allergic children compared to non-allergic individuals and those who outgrown their allergies. These findings suggest the development of allergic reactions depends on host immune response rather than inherent allergenic properties.
Researchers discovered that MHC proteins, including M10, play a crucial role in detecting and modulating pheromone activity in mice. The findings suggest that these proteins may act as escorts for pheromone receptors, allowing them to reach the surface of neurons where chemical reception takes place.
Vanderbilt University Medical Center researchers found that blocking the prostaglandin E2 (PGE2) receptor EP2 may restore the immune system's ability to kill tumors. In mouse models, tumors grew smaller and mice survived longer when the EP2 receptor was absent.
Researchers found leptin significantly correlates with reduction in food intake and weight loss prior to developing EAE symptoms. Modulating leptin concentration through dietary approaches may have potential utility in treating MS and other autoimmune diseases.
Researchers found that a patient's immune system did generate new responses against the unique parts of the virus B, but these responses were not sufficient to prevent re-infection. The study supports the need for a preventive vaccine that targets multiple HIV strains.
Researchers found that patients infected with one strain of HIV can develop superinfection with another strain, compromising treatment. Genetic analysis confirmed the presence of a second type of HIV in the patient's blood, indicating that superinfection is possible and poses unique challenges for vaccine development.
A study in Greenland found that atopy increased by nearly 100% between 1987 and 1998, affecting all age groups. The rise in allergies is linked to a transition from traditional to modern society in Greenland.
Researchers found that CD8 T cell responses from laboratory workers vaccinated decades ago remained robust and long-lasting. The findings suggest a need for reevaluation of the durability of smallpox vaccine-induced immunity.
Researchers have developed a potential treatment for Creutzfeldt-Jakob disease (CJD) by using CpG oligodeoxynucleotides to stimulate the immune system. Studies on mice infected with scrapie prions showed improved survival times, suggesting a possible therapeutic approach for human CJD patients.
A team of researchers will study the role of Rac2, a protein important in phagocytic blood cell function, using mice that lack a functional Rac2 gene and exhibit immune system defects. The long-term goal is to develop novel approaches to control phagocyte function and disease.
A recent study found that CellCept therapy can effectively reverse kidney damage and improve graft survival in patients with chronic kidney function decline. The results showed a significant increase in kidney function reversal or stabilization in patients treated with CellCept compared to those on cyclosporine.
Researchers found that stressed mice exhibited increased diarrhoea responses to egg albumin, while non-stressed mice also showed occasional reactions. The study suggests chronic stress may contribute to food allergies and intestinal diseases like Crohn's disease.
Proteins: From Sequence to Structure is the first book in the Primers in Biology series, covering sequence, structure, and functional properties of proteins from a post-genomic focus. The authors, Gregory Petsko and Dagmar Ringe, are authorities in their field and have received high praise for their comprehensive primer.
Researchers found that Copaxone, a commonly used MS treatment, stimulates CD8 cells in patients, whereas untreated patients show weaker responses. This new approach enables effective evaluation of both CD4 and CD8 cells taken directly from patients.
Researchers discovered that hamsters have higher levels of immune cells in their bloodstream during winter months and in response to acute stress. This enhanced immune response helps the animals prepare for potential injury or infection.
Researchers found that early in HIV infection, CD8 T cells become unresponsive to HIV surface molecules, suppressing their ability to attack infected cells. This leads to a dominant immunosuppressive response mediated by the molecule TGF-beta.
Scientists have identified ILT3 and ILT4, a key pair of molecules that function as a brake for the immune response. Increasing their activity on dendritic cells may create tolerance to foreign tissues, while decreasing it can enhance the immune response against malignant cells.
Research found that regular alcohol intake higher than 70 grams per week is associated with increased total serum IgE levels. Moderate drinking may also lead to abnormal immune responses, affecting the control of the immune system's response to allergens.
A study found that the MDR1 gene variation is associated with immune recovery after HIV treatment. The polymorphism MDR1 3435C/T predicts improved CD4-cell count recovery. This suggests P-glycoprotein plays a crucial role in antiretroviral drug absorption.
Researchers at University of Pittsburgh identified Langerhans cell precursors that can be targeted to initiate or down-regulate the immune response, potentially leading to novel treatments for asthma and transplant rejection. The discovery could also enhance vaccine development.
Researchers found that bovine thrombin causes an immune response similar to lupus in mice and can lead to post-operative complications. Bovine thrombin is a potent enzyme used in surgical procedures, but its use should be restricted to life-saving surgeries due to the risk of autoimmune responses.
A study found that an oral immune-enhancing nutritional supplement improved preoperative host defence, reduced postoperative infections, and preserved renal function in elderly and high-risk patients undergoing elective coronary artery bypass. The supplement contained L-arginine, 3 polyunsaturated fatty acids, and yeast RNA.
Researchers found that minor mutations can significantly impair the immune system's ability to recognize and attack the virus. This means that vaccines targeting these regions may be less effective due to evolving strains of the virus.
A study by Penn researchers found that a common gene delivery system for muscular dystrophy can trigger an immune response in mice unless paired with a muscle-specific promoter. The use of restricted promoters is crucial before expanding clinical trials.
A new study from Penn State suggests that healthy eating habits and good health status can help maintain the ability to fight off germs and reduce illness in older adults. The research found that well-nourished women between 60 and 80 years old have immune systems that function similarly to younger women.
Researchers have identified a substance produced by the tuberculosis bacterium that triggers an immune response, suggesting it could enhance vaccine effectiveness. The substance, combined with vaccines, may push the body's immune system in the right direction to fight tuberculosis and other microbial infections.
Natural T cells are specialized cells that are part of white blood cells and help the body fight disease. Researchers at Penn State's College of Medicine have discovered that CD1d1 associates with glycolipids to transduce signals that 'turn-on' natural T cells, which helps the body fight disease.
Carnegie Mellon researcher Sheldon Cohen suggests that stress reduction may alter immune function, which could lead to better defenses against cancer. However, the evidence for this link is still incomplete, and more research is needed to confirm its validity.
Researchers are developing a new approach to treat cancer by boosting the immune system using dendritic cells, which can be grown in large quantities in culture. The therapy has shown promise in clinical trials, particularly for patients with advanced melanoma or breast cancer.