Articles tagged with Ophthalmology
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Researchers developed an AI foundation model for eye care that can identify sight-threatening eye diseases and predict general health. The model, RETFound, was trained on millions of eye scans from the NHS and outperforms existing state-of-the-art AI systems across complex clinical tasks.
A study by Lena Havstam Johansson found that nearly 5% of 70-year-olds had undiagnosed glaucoma, which damages the optic nerve and affects vision. Those with glaucoma reported poorer quality of life due to impaired vision, leading them to avoid social activities and feel frustrated.
A large UK Biobank study of 427,000 adults found that calcium channel blocker use was associated with an increased prevalence of glaucoma. The study suggests that calcium channel blockers may be a modifiable risk factor for glaucoma through a mechanism that is independent of intraocular pressure.
A study found that a chatbot could generate responses comparable to those of ophthalmologists, without significantly more incorrect information or harm potential. The results suggest that AI can provide adequate support for patients seeking eye care advice, with minimal risk of adverse effects.
A new study found that fewer than a third of children have had their vision checked in the past year, with uninsured and public-insured kids having lower rates than privately insured peers. The disparity in screening rates is linked to disparities in primary care visits focused on prevention and early detection.
A new study published in BMJ Oncology has found that relatively short-term use of immunosuppressant medications to control inflammatory diseases is not associated with an increased risk of developing cancer. The research included over 10,000 participants and tracked their cancer incidence for an average of 10 years.
A study found low primary care vision testing rates for children and adolescents, with lower rates among those without private insurance. Despite yearly testing recommendations, less than half of those with private insurance received testing.
Researchers highlight the need for effective treatment strategies for adenoid cystic carcinoma (ACC) of the head and neck, which is a highly malignant tumor with variable localizations. Proton therapy shows decisive advantages in long-term survival rates for ACC.
A new study published in JAMA Ophthalmology found that vision problems are more common in older adults with dementia. The study of nearly 3,000 older adults showed that even mild vision issues were associated with a higher risk of dementia.
University of Melbourne researchers have discovered that T cells patrol the human eye, protecting it from pathogens and inflammation. The study uses a new imaging technique to capture dynamic behavior of these cells in response to different stimuli.
Researchers found a significant correlation between vitreous humor biomarkers and pathologically confirmed cases of Alzheimer's disease and Chronic Traumatic Encephalopathy. Biomarkers in the vitreous humor may serve as a proxy for neuropathological disease, offering potential early diagnosis and prognostication.
In 2021, 9.6 million Americans had diabetic retinopathy and 1.84 million had vision-threatening forms. The number of people living with diabetes-related eye disease has grown since the last prevalence estimate in 2004.
A clinical trial found that repeat intraocular corticosteroid injections improved vision in people with persistent or recurrent uveitis-related macular edema, reducing retinal swelling by 35% compared to ranibizumab and methotrexate.
A study by Brigham and Women's Hospital found that higher levels of diglycerides and triglycerides are associated with an increased risk of primary open-angle glaucoma. The research suggests that these lipid metabolites play a role in the disease's pathogenesis, highlighting potential new targets for prevention or treatment.
Researchers developed Eye2Gene, an AI system that accurately identifies genetic causes of inherited retinal diseases from retinal scans. The system achieved higher accuracy than human experts in identifying causative genes, with a ranking score above 70% in over 70% of cases.
Researchers developed an AI model to estimate best-corrected visual acuity from fundus photographs in patients with diabetic macular edema, achieving accuracy within one to two lines on a standard chart. The study's findings support the potential of AI in clinical settings, with opportunities for further improvement.
Researchers have developed a custom OCT setup that incorporates a vertical cavity surface emitting laser (VCSEL) diode, which could increase access to OCT imaging and help catch eye problems early. The system performed well in imaging the eye of a healthy volunteer and showed potential for use in biometric eye scanner systems.
A randomized clinical trial suggests that low-dose atropine may provide a treatment option for childhood myopia progression. The study observed a significant reduction in myopia progression over 3 years.
A new study by Flinders University research team led by Professor Justine Smith has found that women are more likely to experience recurrent cases of toxoplasmosis eye disease. The study also revealed significant differences in the type and characteristics of the disease between men and women.
A diagnostic study using 4,095 retinal fundus images found that biomarker-based AI algorithms can be susceptible to racial bias, even when trained on raw images. This issue highlights the need for careful evaluation of AI performance in diverse populations.
Researchers discovered that a certain short-wave or blue sensitive cone circuit is absent in marmosets and differs from the macaque monkey's circuit. This finding suggests that humans have unique neural wiring for color vision that may be linked to recent evolutionary adaptations.
A recent study assessed an AI chatbot's ability to answer ophthalmic questions, finding it answered approximately half correctly. The results suggest that while AI has medical advances, the current chatbot is not yet ready for substantial assistance in board certification preparation.
A deep learning AI model has been developed to screen for retinopathy of prematurity (ROP) in infants at risk of blindness. The tool was trained on images of newborns and found to be as effective as senior paediatric ophthalmologists in discriminating normal retinal images from those with ROP that could lead to blindness.
A study found ChatGPT answered less than half of the test questions correctly, scoring 46% initially and 56% after a month. The AI tool performed well on general medicine questions but struggled with ophthalmology subspecialties.
Scientists from Centre for Ocular Research & Education (CORE) unveiled multiple advancements in 3D printing, accelerating development of drug delivery systems, biodegradable contact lenses, and pharmaceuticals. CORE's innovations include a novel method to fabricate PDMS microfluidic chips with high throughput.
A large study of over 3 million patients receiving the mRNA COVID-19 vaccine found extremely rare cases of retinal vascular occlusion. The researchers concluded that there is no evidence suggesting an association between the vaccine and newly diagnosed RVO, rates similar to those of other vaccinations.
Research by State University of New York College of Optometry suggests that reading lacks diversity in visual inputs, potentially leading to myopia development. The study proposes a mechanism where sustained reading reduces activation of ON pathways, causing eye growth beyond its focus plane and blurring vision at far distances.
Researchers discovered that 'dormant' cone photoreceptors in retinal degeneration continue to produce responses to light and drive retinal activity for vision. The study found that while cones have reduced sensitivity, ganglion cells retain their ability to respond to visual stimuli with similar spatial and temporal sensitivity.
Research suggests Medicare reimbursements for complex cataract surgery are far lower than simpler procedures, resulting in a 'negative' margin. This disparity affects ophthalmologist practice patterns and patient accessibility, particularly for vulnerable populations.
UVA scientists have discovered a new contributor to abnormal blood vessel growth in the eye, which could lead to new treatments for macular degeneration and other vision loss conditions. The discovery identifies a key protein that determines VEGF levels, blocking it has reduced VEGF levels significantly without unwanted side effects.
Disparities in access to pediatric ophthalmological care have increased over the past 15 years, with lower socioeconomic status being a significant factor. Online sources can lead to inaccurate databases, highlighting the need for accurate publicly available information.
Researchers compared two methods of corneal transplant tissue preparation, finding the new DMEK EndoGlide technique to be safe and effective while providing a faster process. The study suggests this method may lead to better long-term outcomes for patients with Fuchs' dystrophy.
Researchers at Boston Medical Center discovered that Black and Hispanic patients had significantly worse vision outcomes after surgical treatment for retinal detachment compared to their White counterparts. The study suggests higher rates of proliferative vitreoretinopathy (PVR) may contribute to these findings.
A Canadian study reveals that obesity reprograms immune system cells, making them destructive to the eye as it ages. The research sheds light on the molecular mechanism behind AMD and may lead to tailored treatments in the future.
Mount Sinai researchers discovered that age-related macular degeneration (AMD) may be caused by two distinct types of deposits in the retina: drusen and subretinal drusenoid deposits (SDDs). Early intervention with vitamin supplements can slow down drusen formation, while SDDs pose a greater threat to advanced AMD.
Researchers at Osaka Metropolitan University found that closed-eye perception of brightness is remarkably stronger than previously reported, with values up to 10 times higher. The color of the light also affects perception, with red being perceived as brighter and blue as darker.
A review of 75 publications found significant knowledge gaps on health inequities affecting the LGBTQ+ community and minority groups, including American Indian and Alaska Native individuals. The study emphasizes the importance of investigating barriers to clinical studies and medical trainee recruitment in under-resourced areas.
Machine learning is being explored as a tool to speed up the identification of biomaterials. Researchers have also developed a guide on how to incorporate ML into research programs. Additionally, studies have investigated ways to model polymers at multiple scales and created a self-healing hydrogel for sustained release of medications.
A pilot study found that nearly half of patients treated with aflibercept could safely stop eye injections without vision loss, while only 17% of those on bevacizumab were able to do so. The findings suggest that matching patients with the right therapy may reduce the need for lifelong treatment.
A new study suggests that human retinal endothelial cells have a protective system against hyperglycemia, which delays the onset of diabetic retinopathy. Prolonged exposure to high glucose actually promotes cell recovery and resistance to damage.
A new study using artificial intelligence has found that a simple eye test can accurately predict the risk of heart disease. The researchers developed an algorithm that can analyze retinal images to assess cardiovascular health, providing a non-invasive alternative to traditional risk scores.
A new UCI-led study shows that repeated stress accelerates aging of the eye, leading to retinal ganglion cell death and visual defects. The research highlights the importance of early diagnosis and prevention in managing age-related diseases like glaucoma.
A new study from Mount Sinai Hospital finds a strong association between age-related macular degeneration and severe forms of heart disease, including heart failure, heart attacks, and stroke. The study highlights the importance of increased screening for eye disorders to diagnose undetected heart disease.
A new study reveals less than half of people over 50 worldwide have received spectacles or contact lenses needed to correct refractive error. The World Health Organisation aims to increase treatment coverage by 40 percentage points by 2030.
Researchers at the University of Pennsylvania School of Medicine have developed a gene therapy that rapidly restores night vision in adults with LCA, a common form of congenital blindness. The treatment has been shown to improve rod-based visual functions and correct severe visual deficits in patients.
Researchers developed an AI algorithm to assess retinal vasculature, predicting cardiovascular disease and death. The model captured half to two-thirds of circulatory disease deaths in those most at risk, outperforming traditional risk frameworks.
Researchers found that cataract surgery patients experienced fewer systemic complications than those undergoing other low-risk procedures, even without anesthesia experts present.
A recent study has found that people who wear reusable contact lenses are nearly four times as likely to develop a rare sight-threatening eye infection. The study identified multiple factors that increase the risk of Acanthamoeba keratitis, including reusing lenses or wearing them overnight or in the shower.
A team of scientists created a digital mask that can erase identifiable features from facial images while retaining disease-relevant information, allowing for precise diagnosis and reducing the risk of data breaches. The study found that patients are more willing to share their medical data if such a measure is implemented.
Claes H. Dohlman, considered the founder of modern cornea science, is honored with the prestigious Champalimaud Vision Award for his groundbreaking research on corneal physiology and its applications in treating dry eye disease, corneal burns, and keratoprosthesis.
Adolescent children from marginalized backgrounds exhibit poorer subjective visual function and worse objective visual acuity testing outcomes. These racial and socioeconomic disparities are concerning indicators of potential long-term vision problems.
A recent study found that private equity firms acquiring physician-owned medical practices increase patient volume and billing for visits, raising concerns about the corporatization of healthcare. The study examined 578 physician practices acquired by private equity firms between 2016 and 2020.
Researchers at the University of Bonn have tested color-coded fundus autofluorescence as a supportive novel diagnostic method for posterior uveitis. The results indicate that this ratio can be very characteristic and helpful in differentiating various posterior uveitis subtypes.
A new study has partly restored the function of retina's cone receptors in two completely colorblind children using gene therapy. The treatment has been shown to activate previously dormant communication pathways between the retina and brain, drawing on the plastic nature of the developing adolescent brain.
Visual acuity testing at home and in a clinical setting have been compared for their accuracy and feasibility. The study found that both methods produced similar results, but the home-based test was faster and more convenient.
Adults with vision or hearing disabilities have lower COVID-19 vaccination rates compared to those without disabilities. The study suggests that initiatives promoting equitable and accessible vaccination may be necessary to address these disparities.
Researchers developed a non-invasive ocular imaging method to detect flavoprotein fluorescence in the eye, indicating mitochondrial oxidative stress. This technique may predict glaucoma progression earlier than current methods, with similar sensitivity to visual field changes.
Researchers used multimodal adaptive optics imaging to study photoreceptor and retinal pigment epithelium relationships in eyes with vitelliform macular dystrophy. The study provides valuable insights for developing new therapies to treat this rare eye disorder.
A new study successfully introduces healthy photoreceptor cells derived from stem cells into the retinas of dogs, marking significant progress toward a cell-based therapy for blindness. The treatment enables cells to survive and form connections with existing retinal cells, paving the way for a regenerative medicine approach.
A new study found that Black patients are six times more likely to have advanced vision loss after a glaucoma diagnosis, highlighting the need for early eye screening in this population. The research analyzed nearly 210,000 participants and used artificial intelligence to identify visual field loss patterns.