Articles tagged with Pregnancy Complications
Researchers analyzed data from 8,843 women with preeclampsia to evaluate the performance of existing risk prediction models. The study found that these models are most accurate only in the days following diagnosis and deteriorate over time.
A new study led by Penn State researchers found that low vitamin D levels during the first trimester of pregnancy are associated with higher rates of preterm birth and decreased fetal length. Pregnant women with low vitamin D concentrations were four times more likely to experience a preterm birth compared to those with sufficient levels.
A large study on preterm birth found that a maternal biomarker test can reduce neonatal morbidities by 20% and NICU admissions by 20%. The test identified high-risk pregnant individuals, who received targeted treatment and showed significant improvements in neonatal outcomes.
A new study reported that pregnant women with previable premature rupture of membranes (PROM) faced significantly higher risks of severe complications, including sepsis and blood transfusions, after the Texas Senate Bill 8 law went into effect.
Researchers developed a breakthrough technology using Mirvie's RNA platform to identify unique molecular signals in unborn babies. This innovation enables prediction of severe fetal growth restriction, a leading cause of stillbirth.
A study published in Research and Practice in Thrombosis and Haemostasis found that adding amniotic fluid to plasma improves blood's ability to thicken and clot. The research also identified changes in amniotic fluid composition over time, which can affect maternal and fetal health.
A new AI-based analysis of almost 10,000 pregnancies has discovered previously unidentified combinations of risk factors linked to serious negative pregnancy outcomes. The study found that there may be up to a tenfold difference in risk for infants who are currently treated identically under clinical guidelines.
Research suggests that labor and delivery units with adequate nurse staffing have lower cesarean birth rates and higher vaginal birth rates. Hospitals aligned with national standards for nurse staffing saw a 11% decrease in C-sections, indicating improved maternal outcomes.
A cohort study found that women experiencing food insecurity during pregnancy are at a higher risk of perinatal complications. Individuals who received food assistance showed no significant increase in risks, suggesting that access to nutrition support can mitigate these complications.
UCSF researchers identify a molecular timer controlling mouse birth timing, which could lead to new tests for human preterm labor risk and interventions. DNA packaging during pregnancy plays a crucial role in regulating gene expression, with KDM6B working as a 'timer' that winds down over time.
A nationwide Swedish study found that active management and induction of labor in late- and postterm pregnancies significantly reduced the risk of stillbirth and newborn death before 28 days. The study, published in PLOS Medicine, showed a near halving of this risk, suggesting improved maternal and perinatal outcomes.
A recent study found that pregnant individuals with opioid use disorder enrolled in Medicaid are at a disproportionately high risk of severe maternal morbidity. Targeted interventions, such as early Medicaid enrollment and coverage continuity, may be necessary to reduce adverse outcomes in this group.
A UK study published in Diabetic Medicine found that over half of pregnant women with gestational diabetes were undiagnosed due to slow NHS blood test processing. Faster blood processing identified additional cases, leading to improved health outcomes for mothers and babies.
A new analysis of over 3,000 studies reveals that flooding increases preterm births by around 3% and low birth weights in children born during flood events. The study highlights the need for emergency services to evacuate pregnant people before flooding events.
A new study published in JAMA found that women who experience severe maternal morbidity during their first pregnancy are less likely to have more children. The research, which studied over a million women in Sweden, revealed that such events can have a lasting impact on fertility.
A new study from Northwestern Medicine reveals a significant increase in severe maternal morbidity and birth complications in Illinois between 2016 and 2023. The findings highlight the impact of chronic health conditions such as obesity, hypertension, and mental health disorders on pregnancy outcomes.
A new North American population-based study found preterm birth associated with higher mortality risks throughout life, especially during infancy and early childhood. Researchers identified a range of causes contributing to the increased mortality risk after preterm birth.
The large cohort study identified common pregnancy complications, such as premature rupture of membranes and gestational diabetes mellitus, affecting 18.29% and 16.74% of participants, respectively. High-risk groups were also identified, including women with assisted reproductive technology and those aged 35 and older.
A new study found that pregnant people in Massachusetts who made multiple unscheduled hospital visits during pregnancy were more likely to experience severe maternal morbidity. The study revealed that nearly half of these patients visited multiple hospitals, leading to inconsistent treatment and poor maternal outcomes.
A recent study found that every 1°C increase in heat exposure increases preterm birth by 4%, while a heatwave can lead to a 26% increased risk. The review also highlights marked increases in gestational diabetes, stillbirths, and congenital anomalies.
Researchers identified disturbances in glucose regulation after delivery in women who have had gestational diabetes, despite comparable clinical measurements. Continuous monitoring using wearable devices revealed disrupted blood sugar rhythms and internal clocks, suggesting a need for appropriate follow-up.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
Research reveals that antenatal corticosteroids can lead to smaller volumes of key brain areas in preterm infants, affecting emotion processing and motor control. The study suggests a delicate balance between benefits for respiratory health and potential risks to neurological development.
Miscarriage affects 15-20% of pregnancies, causing devastating effects. Outpatient early pregnancy assessment clinics can provide compassionate and tailored care, but services are lagging.
A study published in ACS' Journal of Proteome Research found six proteins that could be used as targets for diagnosing and treating early-onset preeclampsia. These proteins may be linked to cardiovascular complications or the estrogen cycle, suggesting a promising first step toward improved detection and treatment.
A study from Lund University shows that high DNA fragmentation in sperm is associated with doubled risk of preeclampsia and premature birth in women conceived through IVF. The findings suggest that DFI analysis could be used to identify high-risk pregnancies, potentially leading to improved fertility treatment.
Researchers analyzed nationally representative data and found a 76% increase in emergency encounters related to hypertensive disorders of pregnancy. The condition, which causes serious maternal and neonatal complications, accounts for 6.3% of all pregnancy-related deaths in the US.
A recent study published in The Lancet Public Health found that body weight is a significant factor in pregnancy complications, affecting women born in different countries. Researchers estimated that approximately half of all cases of gestational diabetes could be prevented if all women were of normal weight during pregnancy.
Women with recurrent pregnancy loss and anti-β2-glycoprotein I/HLA-DR autoantibodies who received low-dose aspirin or heparin treatment had significantly improved outcomes, with 87% experiencing live births and a reduced risk of complications. The treatment was also effective for women with only the newly discovered antibodies.
A new study found that gestational carriers have a higher risk of severe complications during pregnancy, early postpartum, and related health issues compared to unassisted or IVF conception. The research analyzed linked health datasets for over 863,000 births in Ontario, Canada, between 2012-2021.
A recent Cochrane review confirms that giving women at risk of premature birth a simple magnesium sulphate infusion can prevent their babies from developing cerebral palsy. The drug costs approximately £5 (~$6.50) per dose and has been recommended by the World Health Organization since 2015.
A nationwide cohort study revealed a higher risk of placental problems, premature births, and severe bleeding in subsequent deliveries following uterine artery embolization. Babies born to mothers who underwent UAE also had a higher chance of major birth defects, particularly heart problems.
A new study found that neighborhoods with fewer opportunities are associated with a higher risk of preterm birth, particularly among Black and Hispanic infants. The study suggests that structural racism and discriminatory practices contribute to this racial gap in preterm birth outcomes.
A new study found that Medicaid Accountable Care Organizations (ACOs) in Massachusetts increased prenatal and postpartum office visits, postpartum depression screenings, and timely postpartum care. This value-based model of care addressed inequities in healthcare access for pregnant and postpartum people covered by Medicaid.
A study found that ketamine clinics have inconsistent policies on pregnancy-related safeguards, including inadequate warning systems and contraception prescription. This is concerning given the potential harm of ketamine to developing fetuses.
Research reveals that maternal prenatal smoking can limit a child's academic performance and put them behind their peers at school. The systematic review of 19 studies and 1.25 million participants found that 79% of studies reported reduced academic achievement in children exposed to maternal prenatal smoking.
A Kobe University study establishes a new mouse model to study fetal abdominal inflammation caused by meconium peritonitis. The researchers found that heat-treated proteins in the meconium slurry disrupt digestive enzymes, leading to significant reduction in mortality rates.
A Rutgers University study reveals that women who conceive through IVF and experience placental abruption are twice as likely to deliver early compared to those with only one factor. The research analyzed nearly 79 million hospital deliveries in the US over two decades, highlighting the need for careful monitoring of ART pregnancies.
Researchers at Karolinska Institutet have conducted a Phase 2 UNITY clinical trial involving pregnant women with a history of very severe HDFN. Nipocalimab was found to prevent and mitigate the disease without causing serious side effects in the mother or fetus.
A clinical study in Birmingham has found that nipocalimab can improve the survival rate of unborn babies with rare fetal anaemia. The majority of pregnant patients who received nipocalimab gave birth at or after 32 weeks without needing an intrauterine transfusion, resulting in a perinatal survival rate of 92%.
A new study found that living near areas where pesticides were used during the first trimester of pregnancy or pre-conception increases the risk of stillbirths. Researchers linked pesticide use records to state birth certificate data and found specific chemicals, such as organophosphates and pyrethroids, to be associated with increased...
A study on horse miscarriages revealed that 42% of cases were due to triploidy, a condition characterized by an extra set of chromosomes. This finding provides insight into the frequency of chromosome errors during early human pregnancy, which has been difficult to determine.
The UK has released a pioneering Code of Practice for the use of stem cell-based embryo models in research, providing standards for rigorous ethics and maximizing benefits. The code sets out processes for decision-making in research using these models, allowing scientists to proceed confidently while maintaining public trust.
A world-first study found that low-dose aspirin can create better blood flow to the placenta during pregnancy, potentially preventing complications caused by flu infections. The research also showed that mice treated with low-dose aspirin had improved fetal development and offspring survival.
A recent study has identified three subgroups of gestational diabetes with different treatment needs, enabling personalized therapy and reducing complications for mothers and children. The analysis used cluster methods and machine learning to analyze data from 2682 women with gestational diabetes.
A study found that overexpressing a gene responsible for amino acid transport in the placenta can cause fetal growth to increase by 27%, while also providing insights into pregnancy complications like IUGR and obesity. The research has therapeutic implications, potentially informing treatments to prevent or treat these conditions.
The number of US individuals with chronic hypertension in pregnancy increased significantly, while medication treatment remained low, according to a new study. The findings highlight the need for improved maternal health strategies to address high blood pressure and cardiovascular complications.
A global meta-analysis of 1.8m women found COVID-19 vaccination reduces the risk of infection during pregnancy by 61% and hospitalization by 94%. Vaccination also lowers caesarean section risk by 9%, hypertensive disorders in pregnancy by 12%, and intensive care unit admission for newborns by 8%.
Researchers at Dartmouth College found that fruit fly oocytes can renew chromosome-linking proteins, potentially helping older women reduce pregnancy complications. The discovery could lead to new therapeutic strategies for enhancing protein rejuvenation in human eggs.
A study published in Neurology found that people who give birth to infants less than 5.5 pounds may be more likely to experience memory and thinking problems later in life. The association was equivalent to one to two years of aging for those with low-birth-weight deliveries.
A study found that higher phthalate exposure is associated with increased risk of preeclampsia and eclampsia in pregnant women. Pregnancies involving female fetuses are more susceptible to these hypertensive disorders.
A mobile app survey during the first trimester predicted future depression with a high level of accuracy, identifying modifiable risk factors such as sleep quality and access to food. The study's findings offer a new approach to predicting perinatal depression and tailoring preventive care for pregnant individuals.
Research links higher blood sugar levels at gestational diabetes diagnosis to complications in newborns, including low blood sugar and large birth weight. Women diagnosed with gestational diabetes are also at a higher risk of developing type 2 diabetes after birth.
A new screening algorithm combining maternal history, ultrasound data and several tests for blood markers may predict most preeclampsia cases in the first trimester of pregnancy. The study found that personalized risk-based treatment decisions may improve adherence to preventative measures.
Researchers created panoramic view of infection pathways in human placenta, highlighting potential drug targets for severe pregnancy complications. The study used 'mini placenta' models to map placental response to infections in early development, revealing secondary inflammation as a cause of complications.
A new study finds that military health care beneficiaries are more prone to excessive pregnancy weight gain and substantial postpartum weight retention, leading to costly complications and fitness challenges. Researchers emphasize the importance of weight management before, during, and after pregnancy for military populations.
A study found that quitting smoking during pregnancy reduces the risk of stillbirths by over 80% and premature deliveries by more than 30%. However, smokers who quit may experience extra weight gain and related complications. The researchers recommend nutrition counseling to minimize these risks.
A new study has identified a deficit in the placental expression of IGFBP1 and low circulating levels as associated with insulin resistance during pregnancy. The findings suggest that measuring IGFBP1 levels could help identify people at risk of developing gestational diabetes early in pregnancy.
A new review article highlights the complexities of stroke risk in women, which extends beyond age and includes various modifiable and non-modifiable factors. Women are more sensitive to high blood pressure, and other disorders such as late puberty, early menopause, pregnancy, and hormonal therapy also significantly affect their risk.
Researchers found that first-time mothers carrying a breech baby may experience reduced risks if they choose a planned cesarean delivery instead of attempting a vaginal birth. However, these women also have an elevated risk of experiencing uterine rupture during their next pregnancy.