Articles tagged with Antibiotic Resistance
A new monoclonal antibody drug has been developed to prevent infection with A. baumannii, a common cause of hospital-acquired infections. The treatment was shown to be effective in reducing bacterial load in mice, and could potentially become a powerful new weapon against antimicrobial resistance.
The World Health Organisation accounts for around 3.8 million deaths annually from fungal pathogens that are either resistant or rapidly acquiring resistance to antifungal drugs. The narrow focus on bacteria will not combat antimicrobial resistance effectively, and the authors demand a broader discussion on fungal pathogens.
Researchers have discovered a new class of natural antimicrobials called microcins that can target specific strains of bacteria causing cholera, inflammatory bowel disease, and colon cancer. Microcins are highly selective and can potentially remove unwanted bacteria without disrupting the human gut microbiome.
Four plants eaten by western lowland gorillas in Gabon, also used by local traditional healers, show antibacterial and antioxidant properties. Researchers identify four plant species with promising targets for treating multidrug-resistant infections.
Acinetobacter baumannii is a highly resistant bacterial species causing serious infections. Researchers have engineered mutant strains to study anti-Acinetobacter compounds and address AMR preparedness.
Researchers create silver nanoparticles infused with azithromycin that effectively break down biofilms and unveil a new sensing method to assess antimicrobial activity. The novel approach offers a promising solution against antibiotic-resistant bacteria, with potential applications in coating medical devices.
A study by Virginia Tech undergraduate Megan O'Hara found that surface properties significantly influence bacterial twitching motility, allowing for rapid colonization and infection. By manipulating surface properties with detergents like bile salts, researchers can alter the functionality of type IV pili, a critical virulence factor.
Researchers at Gladstone Institutes have developed a streamlined way to engineer bacteriophages, viruses that naturally kill bacteria. The new technique uses retrons to edit phage genomes, allowing for the creation of numerous variants and paving the way for alternative treatments for antibiotic-resistant infections.
Researchers have analyzed over 43,200 ocean microbial genomes, uncovering a wide range of diversity and new insights into immune system adaptations. The study provides new enzymes that can break down common plastics and antimicrobials to combat antibiotic resistance.
The new guideline updates treatment recommendations for Helicobacter pylori infection, shifting away from proton pump inhibitor-clarithromycin triple therapy. Bismuth quadruple therapy and other alternatives are now recommended for treatment-naïve patients.
The World Innovation Summit for Health will explore the need for innovation in healthcare to support vulnerable populations and build resilience. The summit aims to humanize health by addressing pressing global health challenges through evidence-based solutions.
A $2.35 million EPA grant will support a two-year OSU project studying 40 US wastewater treatment utilities to understand the impact of treatment processes on antimicrobial resistance markers.
Researchers warn that animals we eat could be the gateway for a pandemic in the form of antimicrobial resistance. The World Health Organization estimates up to 10 million deaths by 2050 from drug-resistant diseases.
Michigan State University researchers have found a new way to prevent antibiotic resistance by unleashing 'DNA scavengers' in wastewater treatment plants. The enzyme, developed by Syed Hashsham and James Tiedje, breaks up strands of antibiotic-resistant DNA before bacteria can pick them up and take on their properties.
A new study suggests treating all children under 5 with azithromycin in Africa can significantly reduce child mortality. Treating older kids protects younger children from respiratory and lethal infections.
Researchers developed a new 'pan-pathogen' deep sequencing approach to capture multiple bacterial strains simultaneously. This method enables faster and more comprehensive tracking of antibiotic-resistant bacteria, potentially preventing and managing common hospital infections quicker.
Researchers have identified dozens of potential new antibiotics in the human gut microbiome, with one candidate showing promise against multidrug-resistant infections. The discovery uses artificial intelligence to analyze vast amounts of biological data and mine the world's biological information as a source of antibiotics.
Researchers at the University of Sheffield found that C.diff can develop resistance to vancomycin in less than two months, tolerating concentrations up to 32 times the effective dose. This rapid evolution poses a significant threat to UK healthcare, as widespread resistance could remove critical treatment options.
A new study from the University of Maryland suggests that boosting urban soil health with compost and treated manure can reduce the amount of harmful bacteria. The research found that amended soils had lower levels of antibiotic-resistant strains and more beneficial bacteria.
Biocide use can promote well-being when used appropriately, controlling infections and reducing antibiotic use in clinical settings. However, its misuse might contribute to antimicrobial resistance, highlighting the need for a balanced consideration of risks and benefits.
Researchers at WashU Medicine have developed a novel compound that effectively clears bacterial infections in mice, including those causing rare and potentially fatal 'flesh-eating' illnesses. The compound targets gram-positive bacteria, reducing virulence and speeding up post-infection healing.
Researchers at Ben-Gurion University of the Negev have developed a new compound, PL-18, which disrupts bacterial quorum sensing and biofilm formation. This compound has shown promise in reducing bacterial virulence and inhibiting iron uptake, suggesting potential applications in combating antibiotic-resistant bacteria.
Researchers at the University of Illinois Chicago have developed a new dual-action antibiotic that targets two different cellular targets, making it nearly impossible for bacteria to evolve resistance. The antibiotic works by disrupting protein production and DNA structure, rendering random mutations ineffective.
Scientists at ADA Forsyth Institute found that nutrient-deprived polymicrobial community conditions in hospitals favor the growth of Klebsiella, a multidrug-resistant pathogen. The bacteria can thrive for over 120 days after being deprived of nutrition.
Random antimicrobial peptide mixtures significantly reduce the risk of resistance evolution compared to single peptides. These findings support the development of new antimicrobial strategies to tackle growing antibiotic-resistant threats and safeguard public health.
A study by Dr. Takanori Sekito and colleagues reveals a strong association between vaginal pathogenic Escherichia coli and recurrent cystitis in postmenopausal women, suggesting that targeting both the urinary bladder and vagina is crucial for effective treatment.
Dr. Pamela Rendi-Wagner, new ECDC Director, stresses the need to restore and reinforce public trust in science after the COVID-19 pandemic. She highlights challenges such as war, climate change, and social inequalities, which can lead to misinformation and reversed medical advances. ECDC is taking steps to implement its expanded mandat...
Emerging antimicrobial resistance in Salmonella isolates found in retail chicken meat poses a significant threat to public health. The study found a dramatic increase in multidrug-resistant S. Infantis, which has been linked to high levels of antimicrobial resistance and virulence genes.
Researchers developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets. PHAb10 and PHAb11 showed robust antibacterial activity against various bacterial species, including those resistant to traditional antibiotics.
Researchers have identified a mechanism in dogs that may render multiple antibiotic classes ineffective due to the loss of function of specific genes. This discovery opens up new avenues for therapies to treat both animals and humans, and establishes clinical infections in dogs as a surveillance approach for public health.
Researchers at Hokkaido University have developed a comprehensive derivative synthesis method to find new antimicrobial drugs. They identified eight analogs possessing strong MraY inhibitory and antibacterial activity, with one showing promising effectiveness in mouse infection models.
Researchers from Leiden University discuss targeting ABC transporters in pancreatic ductal carcinoma (PDAC), a cancer with poor survival rates. The authors highlight the potential of inhibiting ABC transporters to overcome chemoresistance and suggest developing stratification protocols to identify patients most likely to benefit.
Researchers at University of Cambridge developed machine-learning tool to identify drug-resistant Salmonella Typhimurium bacteria from microscopy images. The algorithm correctly predicted resistance or susceptibility without culturing the bacteria, reducing diagnosis time from days to hours.
Researchers analyzed genomic data and human travel patterns to understand the spread and evolution of Streptococcus pneumoniae. The study found that a pneumococcal vaccine reduced antibiotic resistance but allowed non-targeted strains to gain a competitive advantage, suggesting short-lived protection.
A new study finds that antimicrobial peptide mixtures can delay the evolution of antibiotic resistance in Pseudomonas aeruginosa. The mixtures, which are synthesized in a lab, were found to prevent cross-resistance and maintain drug sensitivity.
A team of researchers from the University of Southern Denmark has discovered a mechanism that reduces the formation of biofilm on the surface of Pseudomonas aeruginosa, a bacterium commonly found in hospitals and resistant to most antibiotics. The biofilm-reducing system is naturally stimulated by cell wall stress, and its discovery of...
A study at Umeã University reveals that an enzyme breaks down the bacteria's protective outer layer, facilitating the transfer of genes for resistance to antibiotics. The researchers identified that only the SLT domain was active in PrgK, but it has an important role in regulation.
A new study suggests taxing certain antibiotics could help manage the threat of antibiotic resistance in humans. By making narrow-spectrum drugs cheaper and broad-spectrum ones more expensive, GPs may be incentivized to prescribe narrower options.
When E. coli detects damage from antibiotic Ciprofloxacin, it sends out an SOS signal that alters cellular activity. The bacteria then mutate their DNA to repair the damage or adapt to resist the antibiotic. Researchers studied this process in detail using bioreactors and found all genes are activated simultaneously at the protein level.
Lopatkin's lab will investigate how bacterial metabolism contributes to antibiotic resistance using sophisticated tools and techniques. The research aims to identify drug-resistance mutations that arise in bacteria adapting to different antibiotics and metabolism-altering chemicals.
A recent study found that antibiotic-resistant strains of bacteria endemic to the UK and Norway are not prevalent in Pakistan despite widespread use of antibiotics. The study used genomic surveillance to map different strains of Escherichia coli, highlighting the importance of understanding bacterial threats in specific regions.
Researchers have gained insight into how a deadly strain of salmonella adapts to invasion, flourishing in hostile environments and evading immune defenses. The study sheds light on the role of fluid shear forces in bacterial behavior, which may accelerate the design of new therapies for life-threatening infections.
Scientists found that a small increase in temperature can drastically change mutation frequency in E. coli bacteria, facilitating resistance development. The results suggest using fever control or antimicrobial drugs at higher temperatures to mitigate antibiotic resistance.
A team of researchers has created a water-soluble version of the bacterial enzyme histidine kinase, which could be used in high-throughput screens to rapidly test potential drugs that target this enzyme. The new protein retains its natural functions despite being converted from a hydrophobic protein.
Scientists at King's College London have developed a rapid method for creating cyclic peptides, an important class of antibiotic molecules, which can be produced in minutes rather than hours or days. This breakthrough could inspire renewed efforts towards developing new antibiotics to combat antimicrobial resistance.
A global research team identified 863,498 promising antimicrobial peptides in marine and soil environments, as well as human and animal guts, to combat antimicrobial resistance. The findings come with a renewed focus on combatting the growing number of superbugs resistant to current drugs.
Researchers discovered that azole fungicides kill fungal pathogens by initiating self-destruction through two pathways: apoptosis and macroautophagy. This mechanism explains why azoles are losing effectiveness against resistant fungal strains.
A recent study has identified over 300 distinct types of bacteria in Roman Baths water, including those with antibiotic-producing capabilities. These microorganisms show promise as a potential source of novel natural products to combat antibiotic resistance.
A European Union-funded project investigates how plastic particles and climate change contribute to the spread of antimicrobial resistance in aquatic environments. The researchers explore the formation of 'plastisphere' colonies where bacteria exchange genes responsible for antibiotic resistance.
Researchers tested seven antibiotics in combination with various natural compounds, finding synergistic effects against multidrug-resistant bacteria. The study suggests combining antibiotics with plant extracts or phytochemicals could be a promising strategy to combat antimicrobial resistance.
A new study demonstrates personalized phage therapy's effectiveness in treating antibiotic-resistant infections in animals, with a case of a cat healing from a persistent wound. The treatment combines a specific anti-Pseudomonas aeruginosa phage with ceftazidime, achieving full healing after 14 weeks.
Researchers at Utrecht University have discovered a new mechanism by which the antibiotic plectasin traps bacteria using a 'Velcro'-like structure. This innovative approach could lead to the development of more effective antibiotics to combat antimicrobial resistance.
A new Lancet Series estimates that over 750,000 deaths associated with antimicrobial resistance (AMR) could be prevented annually through improved prevention methods. AMR poses significant threats to newborns, elderly individuals, and those with chronic illnesses, causing nearly 5 million deaths globally each year.
Researchers mapped wastewater flows on farms and found that copper and zinc footbath water causes fluctuations in antibiotic-resistant bacteria in slurry, highlighting opportunities to reduce AMR pollution through proper waste disposal or recycling.
Researchers analyzed historical milk samples from the 1940s and found that some were resistant to tetracycline antibiotics, defying the conventional understanding of antibiotic resistance. The discovery adds to the growing body of literature on natural antibiotic resistance occurring before humans began using antibiotics.
New study reveals two novel mechanisms that contribute to antibiotic resistance in bacteria, accelerating the growth of resistant bacteria during treatment. These mechanisms can occur independently and are linked to increased gene copy number variation and heteroresistance, complicating treatment for patients.
Researchers have successfully adapted a modified drug molecule to selectively bind to a protein in bacteria, rather than human cells, making it more effective against bacterial infections. This breakthrough could provide a new avenue for treating antibiotic-resistant bacterial infections.
A new study using AI to analyze global antimicrobial resistance research found significant gaps in terminology, methods, and communication across sectors. The findings emphasize the importance of integrating surveillance across regions and regions worldwide to prioritize solutions.
A recent study reveals that a cellular process called transfer Ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance. This breakthrough discovery could help researchers develop new drugs to combat resistance and better tools for studying RNA modifications.
A new therapy has been identified that can penetrate the slime protecting drug-resistant bacteria, allowing it to be killed by the body's immune system or antibiotics. The antimicrobial peptide, derived from cow peptides, targets sugar connections in the slime structure, damaging its integrity and allowing entry.