Articles tagged with Nuclear Receptors
A research consortium has developed mini-antibodies that can reactivate mutated p53, a key tumor suppressor protein. These DARPins bind selectively to p53 mutants, restoring stability and functionality, making them potentially useful against various types of tumors.
Researchers characterized the structure and function of a protein that regulates sugar and fat levels, finding it can work with an unexpected partner - itself. This partnership may drive the expression of different genes than its usual partner, offering new therapeutic targets for diseases like liver cancer and diabetes.
Scientists have identified an alternative binding site on nuclear receptors, allowing for the design of more selective PROTACs. This discovery offers new therapeutic options for treating diseases linked to nuclear receptors, such as cancer and drug resistance.
Researchers review nuclear receptor role in brain cancer development and explore their potential as therapeutic targets. Modulating these receptors with selective agonists or antagonists may offer new avenues for therapy, such as blocking androgen and estrogen receptors.
This review highlights the critical role of epigenetics in nuclear receptor function, affecting metabolic and hormone-driven disorders. Emerging therapies targeting epigenetic mechanisms hold promise for restoring proper nuclear receptor function.
Researchers at U of T discover a ginger compound called furanodienone that selectively binds to and regulates nuclear receptor PXR, reducing inflammation in the colon. FDN has been shown to increase tight junction proteins, repairing damage to the gut lining caused by inflammation.
Researchers at Baylor College of Medicine discovered estrogen's fast actions are mediated by the coupling of ER-alpha with ion channel protein Clic1, controlling chloride ion flux and enabling rapid neuronal responses. This finding sheds light on estrogen's role in regulating various physiological processes.
Researchers at U of T have identified two compounds, diindolylmethane and diindolylethane, produced by gut bacteria that can regulate the nuclear receptor CAR, potentially treating diseases like diabetes, fatty liver disease, and small intestine ulcerative colitis.
In a mouse model of laser-induced CNV, RORα expression was highly increased in the choroidal/RPE complex post-laser, while loss or inhibition of RORα worsened CNV with increased lesion size and vascular leakage. RORα negatively regulates pathological CNV development by modulating angiogenic response and inflammatory environment.
A study found that high fat diets and synthetic substances in unregulated athletic performance enhancers can activate a receptor accelerating the progression of pre-cancerous lesions to pancreatic cancer in mice. Limiting exposure to these substances may help prevent pancreatic cancer development.
Defects in a nuclear receptor, LXRβ, in the brain's dentate gyrus have been linked to autism spectrum disorders. Early changes in neurogenesis of this region may provide an aberrant template for social function circuitry.
Researchers at RIKEN Brain Science Institute discovered that prenatal lack of DHA and AA fatty acids can lead to offspring developing schizophrenic-like symptoms as adults. The study found epigenetic changes in gene expression, affecting nuclear receptor genes and oligodendrocyte-related genes, which may be traced back to DNA methylation.
Researchers found that targeting REV-ERB nuclear receptor can suppress cholesterol-related enzyme genes, leading to reduced LDL cholesterol levels. The study suggests that this approach may be an effective method for treating diseases associated with high cholesterol.
Researchers identify genetic switches controlling metabolic response to HCV infection and show how these genes affect virus lifecycle. Blocking certain metabolic processes can actually increase HCV replication, presenting a new approach to treat virus infections by targeting metabolic regulation.
Researchers at Eindhoven University of Technology have identified a novel site on the RORγt nuclear receptor that can be targeted by drugs without inducing resistance. This discovery could lead to new treatments for autoimmune diseases like rheumatism and Crohn's disease.
Researchers at Sanford-Burnham Medical Research Institute have determined the complete three-dimensional structure of HNF-4alpha protein, a key player in rare diabetes. The study reveals new pockets that could be targeted with therapeutic drugs to alleviate MODY1 symptoms.
Researchers will use x-ray crystallography and NMR to understand the structural rules governing nuclear receptors' activity. The goal is to fill gaps in knowledge about these proteins' role in metabolism, cancer, inflammation, and bone health.
A $1.5 million NIH grant will support a four-year research project led by Frances Sladek to characterize SNPs' effects on nuclear receptors and predict disease susceptibility and response to drug treatments. The study aims to bring personalized medicine closer for patients.
Dr. Mangelsdorf has identified several new molecules that activate orphan nuclear receptors, providing a new approach for treating parasitic infections. His work holds important implications for the treatment of several diseases, including those related to cholesterol and lipid metabolism.
Researchers at Thomas Jefferson University have found that two nuclear receptors, EcR/Usp and E75A, work against each other during Drosophila metamorphosis. The study reveals that E75A replaces EcR/Usp to repress genes in the absence of ecdysone hormone.
A recent study published in the Journal of Biological Chemistry suggests that vitamin A plays a more direct role than previously believed in various physiological functions. The study found that vitamin A itself is active in activating nuclear receptor TR4, which plays roles in sperm cell production, lipid regulation, and central nervo...
The Scripps Research Institute has been awarded $3.17 million over four years to develop compounds that counteract disruptions of the human biological clock, associated with sleep disorders and bipolar disease. The grant supports research on nuclear receptors, a promising drug target for various diseases.
Researchers at UT Southwestern Medical Center discovered gene expressions in lung tumors and normal tissue that predict patient survival time and guide effective treatments. The study found specific nuclear receptors associated with good prognosis and identified potential drug targets for personalized therapy.
Researchers have identified a novel mechanism regulating circadian rhythms that could provide a new target for treating jet lag, shift work, sleep disturbances, diabetes, obesity, and some types of cancer. The discovery offers hope for modulating the body's core clock using synthetic ligands targeting nuclear receptors.
A new study found that DC-SCRIPT has prognostic value in breast cancer, regulating nuclear receptor activity and affecting tumor behavior. Lower DC-SCRIPT expression levels were associated with poorer outcomes in ER- and/or PR-positive tumors.
Researchers from Baylor College of Medicine discovered a molecular switch involving nuclear hormone receptors and microRNAs that coordinates stage transitions in Caenorhabditis elegans. This finding may provide insights into cancer development, particularly hormone-dependent cancers. The study suggests a link between development and en...
Jan-Åke Gustafsson, a renowned hormones expert, has joined the University of Houston faculty thanks to a $5.5 million grant. He will lead the Center for Nuclear Receptors and Cell Signaling, collaborating with other top researchers to develop treatments for diseases such as cancer and diabetes.
A study published in PLOS Biology reveals the molecular structure of COUP-TFII, a nuclear receptor regulating gene expression in cells. The findings suggest potential drug targets for diseases related to heart development, human embryonic development and female infertility.
Researchers analyzed nuclear hormone receptors in the honey bee genome, finding that they play a role in regulating adult brain growth and behavior. The study also identified a unique gene found only in the bee's compound eye, with potential connections to human eye development.
Researchers created the first 'encyclopedia' of nuclear receptors, revealing their role in regulating reproduction and nutrient metabolism. The study found that certain receptors form networks to control processes such as diet-derived lipid use for energy.
Researchers identify how nuclear receptors work to suppress inflammatory responses, potentially leading to more powerful anti-inflammatory drugs with fewer side effects. This discovery could lead to better therapeutic results in treating diseases such as arthritis and arteriosclerosis.
The new technique improves specificity of human estrogen receptor alpha by 100 million times, allowing for targeted activation or deactivation of genes in living systems. This breakthrough could lead to advances in gene therapy, metabolic engineering, and animal disease model studies.
Researchers discover that the nuclear hormone receptor nhr-49 controls two opposing pathways regulating fat metabolism in nematodes. The discovery reveals a complex feedback system controlling fat consumption and composition, with potential implications for understanding human metabolic disorders such as diabetes and obesity.
Orphan nuclear receptors are structurally related to well-known hormone receptors but lack known ligands. Dr. Forman's work identifies novel signaling pathways and regulatory molecules that contribute to critical diseases, including fat cell formation, insulin sensitivity, and cholesterol homeostasis.
Scientists have developed a method to re-engineer nuclear receptors, allowing them to bind to specific small molecules. The technique enables the detection of common drugs, chemical weapons, and other important molecules. By hijacking cellular machinery, researchers can create new sensing mechanisms.
Researchers Ronald M. Evans and Pierre Chambon received the prize for their discovery of nuclear hormone receptors and its impact on human physiology and disease prevention. The award highlights the significance of their work in developing new treatments for cancer, diabetes, and other diseases.
UCSF researchers identified a signaling cascade that regulates steroidogenic factor 1, a nuclear receptor involved in sexual differentiation and stress response. The finding suggests a ligand-independent mechanism of action for SF-1, potentially explaining resistance to hormone therapies in certain cancers.