Articles tagged with Regulatory Genes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a method to quantify mRNA transcription and degradation rates within individual cell types, uncovering varied regulatory rates across genes. The study provides novel insights into how pluripotent cells adopt specialized identities through gene expression.
Researchers found a strong association between favorable survival outcomes and high populations of tissue-resident memory T cells in melanoma patients. The study identified 11 distinct gene signatures that correlate with T cell abundance and patient survival, suggesting a crucial role for T cells in immunomodulation.
Kumamoto University researchers discovered HSF5's crucial role in the completion of meiosis and activation of genes essential for sperm formation under non-stress conditions. HSF5 is distinct from other Heat Shock Factors, which primarily regulate gene expression in response to stress.
A research team has discovered that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls gene expression underlying long-term memory formation. The study revealed the causal mechanism underlying G4-DNA regulation, involving site-directed deposition of the DNA helicase DHX36.
Researchers investigate senescence phenotypes of human corneal endothelial cells upon treatment with ultraviolet (UV)-A. Cells exhibit enlarged morphology, increased β-galactosidase activity and decreased proliferation. UV-A-induced senescent cells show similar gene expression profiles to ionizing radiation (IR)-induced cells.
The Purdue-USDA team developed a web-based tool to identify genes regulating plant traits without conducting experiments. The tool uses machine learning to analyze large datasets and accurately predict transcription factors involved in seed oil biosynthesis, increasing oil content by up to 12%.
Researchers found a shared triple network of long noncoding RNAs, microRNAs, and messenger RNAs that exacerbates Parkinson's disease symptoms in the context of COVID-19 infection. The study identified key genes and lncRNAs as potential biomarkers for PD diagnosis and progression.
Brain stem cells express genes for both maintaining their identity and differentiating into neurons without conflicts. Researchers found that messenger RNAs of stem cell genes are retained in the nucleus, preventing translation and allowing cells to maintain their status as stem cells.
A new study from MIT researchers has found that many genes involved in drug metabolism follow a circadian rhythm, affecting how much of a drug is available and how effectively the body breaks it down. The study's findings have implications for developing better dosing schedules for existing drugs.
Researchers have substantially enhanced the 'Taizhong 6' genome annotation, identifying 360 new genes and refining gene nomenclature. The updated annotation includes detailed miRNA expression profiles, benefiting gene functional studies in sweetpotato and advancing genomic analyses across the Convolvulaceae family.
A team of researchers found that immune cells maintain their alertness through the JAK-STAT signalling pathway when there is no immediate threat. This discovery could lead to new approaches for enhancing the immune system's attention and preventing autoimmune diseases.
A new study reveals that gut microbiota significantly impacts host amino acid and glucose metabolism, leading to a second liver-like function. The research identifies specific bacterial metabolic genes responsible for depleting amino acids, which can be targeted to treat conditions such as type 2 diabetes and inflammatory bowel disease.
A study found that agastric fish lack specific genes required for gastric functions, such as slc26a9, kcne2, cldn18a, and vsig1. These findings suggest a genotypic convergence where gene losses correlate with stomach loss in various fish lineages.
Researchers discovered that mutations in noncoding regions of cancer-driving genes can alter mRNA abundance, leading to increased or decreased protein production. This discovery may lead to the development of prognostic testing tools and a better understanding of gene regulation mechanisms in cancer progression.
A grapevine DELLA protein mutation enhances the conversion of tendrils to inflorescences, revealing a unique role in promoting flower development. The study identifies thousands of differentially expressed genes and highlights the central role of VvDELLA1 in modulating hormonal response pathways.
This study sequences the chloroplast genome of 'Xinxuan-4', a new pecan cultivar, uncovering genetic stability across the Carya species. The findings reveal gene variations, codon preferences, and SSRs, aiding in understanding evolutionary dynamics and potential breeding strategies.
Researchers at IRB Barcelona have identified 'coldspots' in the cancer genome with lower mutation rates, linked to low DNA methylation. This discovery could facilitate targeted therapies and diagnostic tools to monitor specific genomic regions and prevent cancer development.
A research team from the IBMCP has identified a gene called FUL that regulates the duration of flowering in crops like peas, leading to increased seed production. This finding could provide a biotechnological tool to prolong reproductive phases and boost yields in leguminous crops.
Researchers have developed a statistical method called SCENT to establish links between regulatory elements and genes, pinpointing probable causal gene loci for common and rare diseases. The study applied SCENT to multimodal single-cell datasets from various human tissues, discovering insights into DNA regulation in specific cell types.
New research at Hokkaido University reveals that acoustic fat bodies in toothed whales were once jaw muscles and bone marrow. The findings suggest an evolutionary tradeoff between auditory and feeding ecology, leading to the loss of chewing muscles and adaptation to echolocation.
Researchers identified a gene mutation associated with impaired natural killer cell function, leading to increased susceptibility to viral infections in people with a rare genetic condition. Oleic acid supplementation shows promise as a potential therapy for these patients.
Scientists discovered that p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response, identifying 340 target genes and strengthening the role of cohesin complex in this process. This new mechanism may inspire new therapeutic approaches for cancer treatment.
This study explores the MADS-box gene family in passion fruit, revealing their role in floral organ morphology, non-floral organ development, and stress responses. The analysis identifies specific genes involved in regulating floral structure and highlights the adaptability of these genes to environmental stimuli.
Researchers at Kyushu University identified a new type of tumor cell population, steroids-producing nodules (SPNs), which lead to cortisol-producing adenomas. The study provides clues into the formation and maintenance of the human adrenal cortex.
An international study led by the University of Granada used artificial intelligence to show that our personalities alter the expression of our genes. The findings suggest that certain outlooks on life are conducive to a healthy and long life, while others lead to stress and short life.
A study by Washington State University found that cats with the MDR1 genetic mutation are at high risk of experiencing serious adverse effects from products containing eprinomectin. Cats without this mutation appear safe when using these products, but many cases of severe reactions have been reported.
Researchers at Kyoto University have discovered a signal protein called ERK that plays an active role in causing growing lung tissue to curve. This finding reveals a previously unknown regulatory system governing the development of intricate branching patterns in mouse lungs.
Researchers discovered that MEIS2 plays a critical role in activating genes necessary for the formation of inhibitory projection neurons, vital for motion control and decision-making. A MEIS2 mutation found in patients with intellectual disability disrupts these processes.
Researchers at the Francis Crick Institute have made significant discoveries about the proteins controlling fertility in female mice. By identifying a crucial protein called USP7, they found that it plays a vital role in maintaining ovarian function after birth.
Researchers from Tokyo University of Science found that rose essential oil increases the transcript levels of PIR1 and PIN2, key plant defense genes, in tomato plants. The study also showed that REO reduces leaf damage caused by pests and attracts beneficial predators to protect against herbivores.
Four studies conclude that longer genes are most susceptible to aging due to increased potential sites for DNA damage. Long genes have more sites for damage, making them prone to degradation with age, contributing to conditions like Alzheimer's disease.
Research reveals that FoxO6 upregulates ApoC3, leading to increased lipid accumulation and liver damage in aged rats on a high-fat diet. The study suggests that targeting this pathway may offer therapeutic strategies against hepatic steatosis.
A faulty beta-catenin gene helps tumours evade immunity by stopping tumor cells releasing message-containing cargoes called exosomes. Silencing mutant-beta-catenin could be a viable therapeutic strategy to trigger immune cell infiltration and increase tumour-to-immune cell communication.
The study reveals Brat's role in regulating wing imaginal discs regeneration by modulating downstream growth factors. Flies with reduced Brat demonstrated improved wing regeneration but also exhibited deficiencies in cell-fate specification, highlighting the delicate balance required for proper regeneration.
Researchers have identified a gene responsible for the development of starvation-induced fatty liver in cavefish, which are able to protect their liver due to reduced fat accumulation. This genetic basis has implications for understanding and addressing liver conditions in humans, including Type 2 diabetes and obesity.
Researchers have identified a potential therapeutic target for Borjeson-Forssman-Lehman Syndrome, a neurodevelopmental disorder characterized by seizures and intellectual disability. The study found that PHF6 gene mutations impair Ephrin receptor regulation, leading to neural stem cell misregulation.
Researchers have identified a genetic variant in SIRPβ1 gene that affects the immune system's response to beta-amyloid deposits, leading to altered Alzheimer's disease progression. The mutation has been shown to increase cognitive decline in early stages but slow it down in advanced stages.
Researchers developed chronological age prediction models by analyzing gene expression changes in the prefrontal cortex, identifying genes associated with aging and potential mechanisms. The models showed high correlation with age and demonstrated female and male-specific differences.
A Kyoto University research group developed RENGE, a computational model to estimate gene regulatory networks in multicellular organisms. The method measures time-series gene expression and uses the proprietary model to infer regulatory dynamics.
Scientists discovered a shift in gene regulation by enhancers during embryonic development, showing both 'instructive' and 'permissive' modes of regulation. The study found that developmental stage determines which mode is dominant, allowing for rapid gene expression changes and tissue-specific control systems.
Researchers identified genes controlling sorghum flowering and found that overexpressing one gene can delay flowering, increasing plant growth and biomass. The study provides new insights into optimizing sorghum for bioenergy goals.
Researchers at the University of Southern Denmark have discovered a new function of the MYC protein, which plays a crucial role in cancer cell growth and division. The study shows that MYC can activate genes on both promoters and enhancers, driving cancer progression.
Researchers at the University of Buffalo have discovered that fusion proteins hijack gene regulatory complexes through their unfolded domains, causing cancer. The study found that these disordered domains interact with high specificity and form liquid-like droplets, enabling cancerous genes to be activated.
Researchers have discovered two genetic variants associated with generalized pustular psoriasis (GPP), a rare and serious condition characterized by widespread skin lesions and inflammation. These variants, found in the MEFV gene, may hold promise for new diagnostic and therapeutic approaches to GPP.
Researchers at the University of Cincinnati Cancer Center have identified a new protein called p47 that helps prevent breast cancer metastasis. The study found that lower p47 expression was correlated with higher breast cancer metastasis, and that increasing p47 function could potentially lead to new therapies.
A genetic mutation in a quarter of all Labradors hard-wires them for obesity, making them hungrier between meals and burning fewer calories. Owners must be strict with feeding and exercising their dogs to keep them slim.
A bioinformatics analysis identified 71 differentially expressed genes in colorectal cancer, with Krüppel-like factor 4 (KLF4) emerging as a key player. KLF4 was associated with immune cell infiltration and poor prognosis in overall survival analyses.
Researchers found that the SYNGAP1 gene has a dual function in regulating synapses and synaptic plasticity, which may lead to new treatments for children with SYNGAP1 mutations. The study suggests that targeting just one aspect of SynGAP's function is not enough to have a significant impact.
A study published in Cancer Research Communications reveals a potential genetic marker associated with better survival outcomes in patients with head and neck cancer. The researchers found that the presence of a specific genetic variant and higher expression of the GAN gene product gigaxonin may contribute to improved survival rates.
Researchers discovered similar genetic elements underlying vocal learning in humans, bats, whales, and seals. AI-powered analysis identified 50 gene regulatory elements associated with vocalization and autism in multiple mammalian species.
The study investigates how different genes related to autism spectrum disorders affect the brain's neural circuits, resulting in heightened sensitivity to sounds. The researchers aim to identify a potential biomarker for sensory hypersensitivity and develop treatments using optogenetics and minocycline.
A team of researchers has identified the protein ATF7IP2 as crucial for ensuring male fertility. In sperm-forming cells, ATF7IP2 recruits the SETDB1 enzyme to compact X and Y chromosomes, preventing genomic errors. The protein also activates genes on non-sex chromosomes, important in recombination and sorting of chromosomes into sperm ...
A study published in Nature Communications has identified key genes, biological processes, and cell types that may contribute to the development of primary open-angle glaucoma. The research highlights potential mechanisms involving gene expression, cellular regulation, and vascular development.
A new approach has improved heart failure outcomes in an animal model by targeting ERR-alpha receptors. The treatment, called SLU-PP-332 and SLU-PP-915, boosted the metabolism to match the hypertrophy providing enough energy for the heart to sustain the extra activity.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Plants use their circadian clocks to regulate responses to changes in water and salinity levels, offering a new avenue for creating drought-resistant crops. The discovery of the ABF3 feedback loop reveals a delicate balance between boosting stress tolerance and maximizing growth and yield.
Researchers have identified mechanisms of resistance to tazemetostat in epithelioid sarcoma and rhabdoid tumors, leading to the development of a combination therapy strategy. The therapy uses an epigenetic treatment approach to target specific mutations that drive cancer growth.
A study published in PNAS reveals that light controls the post-transcriptional splicing of genes regulating photosynthesis in mesophyll cells. This process is co-regulated by AtPRMT5 and COP1, allowing plants to adapt to changing light conditions.
A team of researchers found that diffuse anaplasia (DA) subtype of Wilms tumor grows despite high DNA damage and TP53 mutation, leading to resistance to chemotherapy. The study suggests that DA histology emerges through accumulating DNA damage and CNAs, creating selection pressure for TP53 mutations.
A new study from NYU Grossman School of Medicine and University of Illinois Urbana-Champaign reveals a trick to understand how genes are turned on and off in bacteria, providing clues to combat antibiotic resistance. The researchers used single-cell sequencing and fluorescence hybridization techniques to track gene activity in real-time.