Articles tagged with Exosomes
Researchers discovered that cells can pack and release ephrins and Eph receptors through extracellular vesicles, allowing them to transmit signals over a distance. This discovery has significant implications for understanding cell communication and developing new treatments for diseases such as cancer and neurodegenerative disorders.
A team of Cornell University researchers has devised a method for isolating one specific enzyme activity of SIRT6, a protein with multiple biological functions. The study used a mutant form of SIRT6 to determine its contribution to various functions, including genome stability and metabolism.
A $1.7 million NIH grant will help a Florida State University scientist uncover how cancer-causing viruses manipulate cell communication through exosomes. The research could lead to more effective and less harmful ways to treat diseases like cancer.
Researchers at Rice University discovered that cancer cells can consume amino acids directly from exosomes, tiny packets of proteins and nucleic acids, to fuel tumor growth. This finding contradicts the long-held Warburg effect theory, suggesting each type of cancer has a unique metabolic profile.
Researchers at UNC-Chapel Hill have created a new cancer treatment that uses immune bubbles to deliver chemotherapy directly to tumors. This innovative approach reduces the need for high doses of chemotherapy, potentially leading to more effective treatment with fewer and milder side effects.
Researchers have developed an innovative approach to treat drug addiction using RVG-exosome delivered RNAi against the opioid receptor mu (MOR). This method successfully down-regulates MOR in mouse brain and rescues opioid relapse. The study demonstrates the potential of this therapy for treating CNS diseases.
Researchers have identified specific combinations of integrins associated with metastasis to certain organs, including lungs and liver. These 'zip code' proteins guide tumour cells to specific locations, supporting Paget's 'seed and soil' theory.
Researchers at McGill University Health Centre uncover mechanism behind Leishmania parasite's infectious life cycle, revealing exosomes play key role in boosting infection. The study provides potential vaccine targets and diagnostic tools for Leishmania and other parasitic diseases.
Microglia facilitate the spread of tau fibrils between neurons by releasing exosomes, which could lead to a novel therapeutic target for Alzheimer's disease. Pharmacologic depletion and inhibition of exosome production suppress tau spread, restoring neural excitation.
Researchers at Tufts University discovered that exosomes can induce human mesenchymal stem cells to differentiate into neuron-like cells. The study suggests a promising approach for treating nerve injuries and potentially reversing paralysis.
A team of Temple researchers led by Dr. Raj Kishore used stem cell exosomes to induce the repair of damaged mouse hearts, improving heart function and reducing scar tissue. The study's findings suggest a unique way to regenerate the heart without using stem cells.
Researchers at Children's Hospital Los Angeles found that exosomic miRNAs released within the tumor environment affect resistance to chemotherapy in neuroblastoma. The exchange of specific microRNA called MiR155 between tumor cells and tumor-associated macrophages leads to increased telomerase activity and resistance to chemotherapy.
Researchers at UNC Chapel Hill use exosomes to deliver catalase, a potent antioxidant that counters neuron-killing inflammation, to the brain. This delivery method bypasses the blood-brain barrier and avoids immune detection.
Cancer exosomes, tiny particles released by cells, contain proteins that promote tumor growth and metastasis. Researchers have identified Dicer as a key player in this process, suggesting new avenues for diagnosis and treatment.
Scientists at the University of Kansas have developed a miniaturized biomedical testing device for exosomes, promising earlier detection and improved survival rates for patients. The lab-on-a-chip technology uses magnetic beads to isolate exosomes from plasma samples, enabling minimally invasive and cost-effective cancer diagnosis.
Researchers found that exosomes from glial cells increase neuronal stress tolerance and improve signal conduction, biochemical signaling, and gene regulation. This discovery could lead to new strategies for treating neuronal diseases.
Male fruit flies use exosomes to reprogram female cells, making them less inclined to remate. The findings suggest that BMP signaling plays a role in regulating female behavior and may be involved in human cancers of tissues that secrete exosomes.
Exosomes secreted by cardiac stem cells carry messages that reduce cell death, promote growth of new heart muscle cells and encourage development of healthy blood vessels. The researchers pinpointed one microRNA as responsible for some of the benefits, suggesting it may be an attractive alternative to living-cell transplantation.
Researchers have discovered a potential therapy to enhance brain repair after a stroke by stimulating the brain's inherent plasticity with molecular components of stem cells. This approach has shown promising results in promoting neurological recovery and may lead to revolutionary treatments for other diseases.
A study by Loyola University Medical Center researchers could lead to the development of a 'liquid biopsy' test for bladder cancer using microscopic droplets shed by cancer cells in urine. This non-invasive test would require only a simple urine sample, potentially informing treatment decisions.
Researchers at EPFL have discovered that the lethal factor of anthrax bacteria can travel undetected through the body for days using exosomes, evading the immune system and medical analysis. This mechanism explains why some organisms succumb to the disease up to two weeks after the disappearance of bacterial presence.
Researchers at the University of Chicago are developing a new therapy for multiple sclerosis using exosomes containing specific microRNAs that promote myelination. The therapy has shown promising results in improving brain health and may also be useful in slowing the degradation of myelin with normal aging.
Researchers have developed a novel treatment for stroke using exosomes containing genetic material from bone marrow stem cells, which significantly improved neurological function in lab rats. The treatment, tested on lab rats with induced stroke, showed gradual and eventually significant improvement over four weeks.
Researchers at Johannes Gutenberg University Mainz have discovered a new form of communication between brain cell types, where oligodendrocytes release exosomes with protective proteins and genetic information to neurons, protecting them against stress. This bidirectional communication plays a significant role in preserving nerve fibers.
A new study by Henry Ford researchers reveals that a specific microRNA released by stem cells via exosomes contributes to better neurological recovery after a stroke. The study provides fundamental insight into how stem cells affect injured tissue and offers potential for developing novel treatments.
Researchers at Lund University have discovered that exosome molecular profiles reflect the aggressiveness of brain tumours, offering a new approach for diagnosis and treatment. The study's findings suggest that exosomes could serve as biomarkers to guide patient care and monitor treatment response.
Researchers discover exosomes shuttle protein Syt4 from neurons to muscle cells, enabling cell-to-cell signaling mechanisms. This finding may lead to loading therapeutic agents like RNAi into exosomes to target disease-carrying cells.
Exosomes from mesenchymal stem cells reduce lung inflammation and prevent pulmonary hypertension in a mouse model. The findings suggest exosome research could lead to new stem cell-based therapies for chronic lung disease and other inflammatory conditions.
Researchers at TGen developed a method to isolate protein-rich urinary exosomes, which can help discover biomarkers for better CKD diagnosis and treatment. The study found that the new method produces high yields of miRNA and mRNA, making it suitable for downstream genetic profiling experiments.
Scientists have identified proteins as the key to maintaining self-renewal in human epidermal progenitor cells and stem cells. The discovery highlights the importance of exosomes in regulating transcription factors, enabling cells to produce new skin cells throughout life.
Researchers at VIB and KU Leuven discovered a novel mechanism for exosome formation involving Alix, syntenin, and syndecan proteins. This finding has implications for understanding the role of exosomes in cancer, metastasis, and other diseases.
Researchers discovered that cancer cells release exosomes containing pro-metastatic proteins that fuse with distant organs, establishing a nurturing environment for tumor growth. This discovery offers fresh diagnostic and treatment potential, including the use of exosomal protein profiles to predict tumor aggressiveness.
Researchers at UNC identify cellular communicators for cancer virus, revealing a new mechanism by which the Epstein-Barr virus manipulates cells and induces uncontrolled growth. The study shows that infected cells can produce altered exosomes that enter recipient cells, changing their growth patterns.
CD82 and CD9 proteins are found to suppress tumor metastasis by releasing beta-catenin in exosomes, thereby inhibiting Wnt signaling. This mechanism may be compromised in certain cancers, where Wnt signaling is hyperactive.
Researchers found that tumor-secreted exosomes increase myeloid-derived suppressor cells, inhibiting immune activation and accelerating tumor metastasis. The study identified the role of MyD88 in this process, suggesting potential strategies to develop immune-stimulating tumor vaccines.
Glioblastoma cells release exosomes containing RNA and proteins that promote tumor growth, but also carry data that can be used to guide targeted therapy. The study identified factors in these exosomes that could be used as biomarkers to monitor treatment response.
Exosomes are chopped into pieces that trigger autoimmunity in people with PM/Scl overlap syndrome. Researchers have identified an exosome-associated protein recognized by antibodies, which may be a new marker for diagnosis.
Researchers reveal a new, tightly regulated layer of the plant transcriptome that is controlled by the exosome complex. The study provides a genome-wide atlas of Arabidopsis exosome targets and sheds light on the mechanisms of RNA quality control in plants.
HIV scientists discovered that cells use small sacs known as exosomes to export proteins, including the virus's major protein Gag. This means HIV can leave infected cells and infect new ones, raising hopes for new treatment options.
Researchers have discovered that tiny exosomes extracted from donor cells can capture recipient immune cells, promoting transplant tolerance by delivering antigen. This approach may provide a promising alternative to traditional immunosuppression therapies.
A new mechanism called nonstop decay recognizes and destroys abnormal messenger RNA, potentially interfering with drug treatments for genetic diseases like cystic fibrosis. Thwarting this mechanism may make these treatments more effective.