Articles tagged with Tumor Cells
Researchers create a hybrid compound combining an antibody with a traditional anticancer drug, effectively steering the hybrid towards cancer cells. The approach shows promise in preclinical studies and could be used to design hybrids against multiple cancers.
Women with circulating tumor cells in their blood have a median survival of less than 24 months, compared to over 24 months without them. The presence of cancer cells in the blood predicts prognosis more accurately than other factors, indicating a possible link between blood-circulating tumor cells and aggressive breast cancer.
Researchers found that JNK signaling suppresses tumor development, but its absence actually promotes tumor growth. This discovery could lead to new treatment strategies for certain types of cancer.
Researchers at Cedars-Sinai Medical Center have developed a novel approach that turns on the immune system to attack brain tumor cells, potentially extending survival in patients with highly aggressive gliomas. The therapy uses dendritic cells to recognize and target dying tumor cells, triggering an immune response.
Researchers have identified stem cells in human breast cancer that can form new tumors and are resistant to treatment. The discovery may explain why current treatments for metastatic breast cancer often fail, and could lead to the development of new therapies targeted at these cells.
Researchers have made a significant breakthrough in developing a cancer vaccine by attaching tumor material to antibodies, inducing an immune response against cancer in animal experiments. The vaccine's effectiveness may also be applied to other diseases such as arthritis and whooping cough.
Researchers at Cyclis Pharmaceuticals have discovered a new mechanism for treating cancer, involving the activation of the E2F1 protein with small molecule drugs. The findings, published in the Proceedings of the National Academy of Sciences, show that this approach can selectively kill cancer cells while sparing normal cells.
A new vaccine technique has shown promise in boosting the natural immune response to tumors in patients with advanced non-small cell lung cancer. The vaccine was found to be non-toxic and well-tolerated, with some patients remaining disease-free for over three years after vaccination.
Researchers found that the arginine variant of p53 is more efficient at killing cells and travels out of the nucleus to function in the mitochondria. This discovery could lead to personalized cancer treatment by tailoring therapy based on a patient's p53 variant type.
Researchers identified a protein called CUGBP2 that regulates the production of COX-2, a key culprit in arthritis and cancer. When CUGBP2 levels are high, it triggers cancer cell death by inhibiting COX-2 production.
Researchers at Cedars-Sinai Medical Center have developed a new approach for treating gliomas by engineering neural stem cells to deliver a cancer-killing protein. The treatment, known as NSC-TRAIL, successfully tracked and destroyed glioma cells in mice, while sparing normal brain tissue.
New tri-metallic supra-molecules can be positioned in exact parts of cancer cells and excited by therapeutic light to kill diseased cells. The system enables precise targeting, reducing side effects of chemotherapy.
Researchers have discovered a new genetic mechanism to prevent cancer development by targeting the Cdk4 gene. The study showed that knocking out this gene can make cells resistant to cancer even if their tumor suppressor defense is deficient. Cells then enter senescence, offering a promising new option for cancer therapy.
Researchers from the University of Pittsburgh found that KSHV, a known carcinogenic virus, inhibits immune function and causes cancerous cells to grow through a hormone-like substance called vIL-6. This discovery reveals an overlap between the immune system and tumor suppressor pathways targeted by KSHV.
Researchers have found that Cdk4 expression is essential for Ras-induced cancer development, making it a potential target for therapy. Dr. Hiroaki Kiyokawa and colleagues showed that Cdk4-deficient cells can enter a protective state of senescence when exposed to oncogenes like Ras.
Researchers designed a DNA vaccine that stimulates the immune system to recognize and attack proliferating blood vessels in tumors, depriving them of oxygen and nutrients. The vaccine has shown promise in preventing effective angiogenesis and inhibiting tumor growth, offering potential for novel cancer therapies.
Researchers identified Ski's role in disrupting nuclear signaling proteins, preventing cells from slowing down and stopping division. This finding provides crucial insight into the development of cancerous tumors and offers a potential target for new anticancer drugs.
Researchers at Cedars-Sinai Medical Center found that pituitary tumor cells express abundant PPAR-gamma, a protein receptor linked to growth and metabolism. Treatment with common diabetes drug rosiglitazone effectively shrunk tumors and reduced hormone production in mice with Cushing's syndrome.
Researchers at UIC have identified a compound that inhibits cell migration, a process linked to cancer progression. The discovery uses a high-throughput assay and has the potential to be used in combination therapies against cancer.
A new study has found that a second set of immune cells, known as regulatory T cells, prevent attack cells from acting against cancer. The study discovered that these regulatory T cells communicate with the attack cells via a messenger chemical called TGF-beta.
Researchers at Howard Hughes Medical Institute found that a plant compound called cyclopamine effectively killed cultured mouse medulloblastoma cells and human tumors. The study showed promising results, with all seven tested human medulloblastomas responding dramatically to the treatment.
Researchers at Temple University have discovered that combining the Rb2 gene with gamma radiation treatment speeds up tumor cell death by upregulating p73 and downregulating Bcl-2. This study offers a promising new approach to treating glioblastoma, a malignant brain tumor.
Researchers at University of Illinois Chicago have discovered a way to render cancer cells more susceptible to immunological attacks and chemotherapy. By inserting the E1A gene into malignant cells, they can prevent tumor cells from blocking immune defenses, paving the way for new treatments.
Researchers discovered a compound that selectively inhibits the growth of breast cancer cells engineered to overexpress HER-2, a protein implicated in 20-30% of human breast cancers. The compound, F16, targets the mitochondria of cancer cells, causing them to swell and eventually rupture, leading to cell death.
Researchers at Scripps Research Institute suggest administering an injection of fresh T cells after chemotherapy or irradiation to increase anti-tumor effect. This approach could potentially reduce collateral damage and improve treatment outcomes for various cancers.
The study found that the c-Myc protein has a key cancer-preventing mechanism, causing cell death, but also triggers the growth of invasive tumors when another oncoprotein is activated. Suppressing this mechanism can lead to rapid tumor regression and collapse of blood vessels.
CP461 acts against cancer cells selectively through both apoptosis and anti-angiogenic effects, preventing new blood vessel formation. The compound also disrupts microtubule organization and proper spindle formation, blocking mitosis and promoting cell death in cancer cells.
Researchers at UC Berkeley have developed a microsized microscope that can capture high-resolution images of living cells, shrinking the size and cost of conventional microscopes. The device has the potential to revolutionize medical research and diagnostics, enabling scientists to study genes and proteins in unprecedented detail.
Researchers at Vanderbilt University Medical Center have identified a new protein called Interleukin 24 (IL-24) that is expressed in colon cancer cells and promotes cell growth or prevents cell death. The discovery could lead to the development of molecules to interrupt an autocrine loop, potentially fueling tumor growth.
Researchers used molecular scissors to alter the sugar coats of cancer cells, promoting tumor growth with one fragment and inhibiting it with another. This discovery could lead to targeted cancer treatments by exploiting the biological balancing act between different sugar fragments and signaling molecules.
Researchers have discovered a new target for treating cancer cells that rely on survivin to survive. This finding offers new hope for patients with cancer who are struggling with this aggressive protein.
Researchers found that certain cancer drugs induce features of cellular aging, which can help stop the growth of cancer cells. The study suggests that some cancer treatments may have an unexpected side effect: causing premature aging in tumor cells.
Telomeres, protective caps on chromosome ends, are shorter in people exposed to arsenic, increasing cancer risk. Long-term arsenic exposure has been associated with accelerated telomere shortening, a potential biomarker for arsenic poisoning.
Scientists at the University of Illinois have developed microspheres that enhance contrast in optical coherence tomography, allowing for improved imaging of individual cells and early tumor detection. The microspheres can be targeted to specific tumors, enabling enhanced OCT imaging for surgical guidance.
Researchers discovered that VEGF promotes the growth and survival of malignant tumor cells, affecting a wide range of cancers. The study found that inhibiting VEGF's effects can slow or halt tumor growth and is expected to improve treatment outcomes for some patients.
Researchers at UC Berkeley have discovered a single gene that can stimulate the immune system to reject a range of cancer tumors. The gene, which activates natural killer cells and other immune cells, shows promise as a potential basis for a vaccine therapy.
Researchers have uncovered evidence suggesting that genetic changes leading to breast cancer occur first in epithelial cells of breast tissue. LOH analysis reveals frequent mutations in both epithelial and stromal cells, indicating a multi-step process.
Researchers found that aggressive melanoma cells leave behind a molecular track in the extracellular matrix that contains information and cues. These cues can cause less aggressive tumor cells to become more aggressive when they interact with the same matrix.
Scientists at Massachusetts General Hospital have developed a new imaging technique that allows for the visualization of individual cells within living tumors. This technology enables researchers to monitor gene expression, therapy effectiveness, and tumor-cell interactions with normal cells, providing new insights into cancer biology.
Researchers at UCSF Cancer Research Institute have made an observation that could explain the ability of modified cold virus ONYX-015 to kill cancer cells. The finding suggests that ONYX-015 targets a genetic vulnerability in tumor cells, specifically those with mutations or defects in p53 and p14ARF genes.
Researchers at the University of Wisconsin-Madison have identified two compounds, gamma-tocotrienol and beta-ionone, that suppress the growth of three types of human cancer cells. These isoprenoids, found in cereal grains and fruits/vegetables, work by interfering with cell division and disrupting cholesterol synthesis.
A preclinical study published in Nature Medicine demonstrated that Immunex's TRAIL molecule suppresses tumor growth and induces complete remission in a high proportion of treated mice. The study shows promise for the treatment of various cancers, with the potential for minimal toxicity.
A new strategy to treat and prevent tumors has been developed by University of Pittsburgh researchers using dendritic cells. The approach effectively prevents tumor development in healthy mice and reduces tumors in 80% of mice with established tumors, significantly prolonging their survival.