Articles tagged with Surface Expression
A rare genetic mutation has been discovered that can explain why some people do not respond to newer schizophrenia treatments. The mutation, known as C182F, removes a structural bond in the TAAR1 receptor, blocking its binding site and rendering drugs ineffective.
Researchers from The University of Osaka have identified a protein expressed on malaria-infected red blood cells that can hide from the immune system while also activating immune cells to destroy infected cells. This dual function makes the protein an excellent target for vaccine development and treatment.
A new study from the University of Gothenburg found that titanium micro-particles are consistently present at all examined implants, even those without signs of inflammation. The researchers identified 14 genes that may be affected by these particles, but further research is needed to understand their impact on tissue health.
Researchers used CRISPR to cut a single gene from cancer cells of head and neck tumors, resulting in the elimination of 50% of the tumors after 84 days. This groundbreaking study demonstrates that some genes are essential for cancer cell survival, making them excellent targets for CRISPR therapy.
Researchers at MD Anderson Cancer Center have made significant advancements in treating oligometastatic prostate cancer, advanced urothelial cancer, and triple-negative breast cancer. Personalized risk-based screening is also being explored as a tool to reduce cancer deaths.
Researchers discovered that aggressive breast cancer prompts nearby immune cells to build 'molecular bridges' between themselves, suppressing the immune response. An antibody treatment that blocks these bridges was shown to restore the immune system's ability to attack with force, inhibiting tumor growth in a mouse model.
Scientists have discovered that ADGRF5 helps maintain the integrity of the glomerular filtration barrier, which is critical for filtering waste from the blood. The study found that disrupting ADGRF5 expression led to abnormalities in the glomerular basement membrane and increased albuminuria.
Researchers have uncovered a novel regulator governing how cells respond to mechanical cues, finding that ETV4 bridges cell density dynamics to stem cell differentiation. This discovery has significant implications for controlling cancer cells through mechanical cues.
Researchers have developed a new way to control and manipulate optical signals by embedding a liquid crystal layer into waveguides created with direct laser writing. The new devices enable electro-optical control of polarization, which could open new possibilities for chip-based devices and complex photonic circuits.
Researchers developed an all-light communication network that combines different types of light sources to ensure connectivity in various environments. The network enables real-time data transmission between nodes, facilitating applications such as video conferencing, sensor data exchange, and Internet of Things services.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have identified the protein TYRP1 as a promising target for CAR T-cell therapy. The study demonstrates potent antitumor responses against cutaneous and rare melanoma types, offering new hope for treating these challenging-to-treat cancers.
Using optical traps, researchers controlled bacterial aggregation and biofilm development, finding different types of lasers can stimulate or suppress growth. The study opens up possibilities for creating microscopic building materials from bacteria.
Researchers discovered a malaria protein, PfAP2-P, that plays a key regulatory role in immune evasion and parasite development. This protein acts as an activator of proteins required for the parasite to exit infected red blood cells and invade new ones.
A team of researchers at Kyoto University has found that a deficiency in the enzyme B4GALT3 inhibits tumor growth in mice. The study shows that reduced glycosylation on T cell surfaces correlates with increased CD8+ immune cells infiltrating tumors.
Researchers identified abnormal keratin expression patterns in senescent ocular surface cells, which may contribute to severe ocular surface diseases. Gene expression profiles showed substantial differences between senescent and non-senescent cells, highlighting their potential role in pathology.
The new fabrication approach allows for the creation of a stretchable dipole antenna that can be used in wearable medical devices, separating mobile devices via flexible antennas to form a wireless body-area network. The resonant frequency of the antenna can be tuned by varying applied strain.
A new approach enables the precise transfer of thousands of microscopic semiconductor devices in a single shot, paving the way for large-scale arrays of optical components. The method is scalable, inexpensive, and can be used to manufacture micro-LED displays with high accuracy and resolution.
Researchers explore CEACAM1, CEACAM5, and CEACAM6's pathological significance in cancer biology and immunology. The review highlights their interactions with pathogens and potential avenues for cancer therapy.
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
Researchers developed a metasurface device with three working modes, exploiting nanostructures to manipulate light and create holographic or structural-color nanoprinting images. The device offers two layers of security for anticounterfeiting measures, providing a simple yet effective approach to fight against counterfeiting.
Bladder cancer researchers discovered a subset of CD8 T cells that adapts to tumor evasion strategies, offering a strategy to reduce tumor cells' ability to fight them off. The study also identified potential ways to make immunotherapy more effective against this deadly cancer by targeting the HLA-E/NKG2A axis.
A new study published in Geosphere uses GIS-based analysis to reveal the complex geometry of the Rose Canyon fault zone beneath downtown San Diego. The researchers compiled data from hundreds of individual reports and created a centralized geodatabase to examine the fault zone's shape and potential hazard.
Researchers discovered that porcine deltacoronavirus can infect human cells by binding to aminopeptidase N, which is conserved across animal species; this suggests a possible mechanism of transmission from pigs to other animals and potentially humans.
Researchers developed a high-throughput screening method to characterize and select multipotent cells from adipose-derived stromal cells (hASCs) using flow cytometry. This approach can identify specific cell types advantageous for regenerative medicine and tissue engineering applications.
A new research study by UM Frost School of Music's Music Engineering Technology Group explores the potential of multi-touch surfaces in music performance. The study reveals a custom system that reduces latency to an average of 30 ms while providing programmable haptic feedback.
A study published in the Journal of Leukocyte Biology found that manipulating intestinal microbiota with probiotics and prebiotics could improve celiac disease quality of life. The research also discovered that different types of gut bacteria influence inflammation to varying degrees.
A new study reveals that the Third Franciscan Order had a favourable attitude towards its members' lifestyle and was driven by voluntary participation. The order's development into a more ordered way of life was not solely due to Church pressure, but also an early expression of desire for monastic reform.
The ARVO Foundation for Eye Research recognizes six clinicians with innovative vision research projects. Maria Cristina Malloci and others receive grants to support their work on AMD, ocular surface infections and corneal diseases.
Inhibition of RAGE suppressed neointimal formation in mice upon arterial injury and decreased SMC proliferation, migration, and expression of ECM proteins. Local mucosal immunization leads to antigen-specific IgA production at distant mucosal sites through the interaction between CCR10 and its mucosal epithelial ligand MEC.
Researchers developed an Intrakine blockade to block a specific chemokine receptor, leading to reduced inflammation and modulated immune responses in various disease models. This breakthrough could provide new therapeutic avenues for treating conditions like asthma, autoimmune diseases, and cancer.
A recent study discovered that stimulation of the CD28 receptor can regulate coreceptor expression in activated T cells, potentially preventing HIV-1 infection. This finding may lead to new therapeutic strategies for patients with HIV and other immune deficiencies.