Articles tagged with Aneurysms
Researchers identified KLF15 as a genetic factor regulating both heart failure and aneurysm disease. The study found that deficiency of this gene predisposes individuals to these cardiovascular diseases, but also discovered potential therapeutic targets through the inhibition of p53.
A Yale-led team has discovered three new genetic factors that significantly increase the risk of developing brain aneurysms. The study analyzed over 20,000 subjects and found that individuals carrying these variants are up to seven times more likely to suffer an aneurysm than those with no risk factors.
A new study reveals that the utilization of minimally invasive aneurysm repair varies by region due to patient risk factors and physician experience. The study found a strong correlation between higher-risk patient populations and physicians more experienced in treating aneurysms.
Researchers found that smoking significantly increases the risk of an intracranial aneurysm in people who carry common gene variants. The risk increased by more than five-fold when combined with smoking, highlighting the importance of quitting to reduce genetic susceptibility.
A study led by Dr. David Granville identified Granzyme B as a protein-degrading enzyme abundant in AAAs, which can be targeted to slow progression and improve survival. This discovery may lead to the development of pharmaceuticals to treat aneurysms without surgery.
A new method developed by Mayo Clinic and IBM uses analytics technology to detect brain aneurysms with a 95% accuracy rate, compared to 70% for manual interpretation. The system can identify images in 3-5 minutes, improving efficiency and saving radiologists' time.
Researchers found that adding three specific molecules to a vaccine increased the effectiveness of protective T cell responses in mice. The quality, not just the quantity, of these responses was enhanced. This discovery could lead to new adjuvants for improving vaccine efficacy.
Researchers at UT Southwestern Medical Center pioneered a technique to replace infected aortic grafts with the body's own veins, proving more durable and less prone to new infection than synthetic or cadaver grafts. The procedure has superior durability and lower long-term amputation rates compared to other operations.
Researchers found that inflammation is critical in aortic dissection and interleukin-6 plays key role. Studies using mice and human samples validate findings, providing new insights into underlying mechanisms.
A new study found that patients who underwent less-invasive endovascular repair of abdominal aortic aneurysms had a lower risk of death in the first 30 days after surgery compared to those who received open repair. The procedure also resulted in reduced blood loss, shorter hospital stays, and fewer complications.
Researchers have identified a new treatment option for patients with ruptured brain aneurysms using stent-assisted coil embolization, which was successful in 72% of cases. The procedure offers an alternative to surgical repair or balloon-assisted embolization, particularly for wide-necked aneurysms.
A recent study of 311 patients with coiled brain aneurysms who underwent retreatment procedures found a low risk of death or permanent major disability, with only 1.28% of patients experiencing adverse outcomes. The study supports the emergence of endovascular coiling as a safe and effective treatment option for recurrent brain aneurysms.
A new procedure called CESA combines endovascular and surgical approaches to treat high-risk aortic aneurysms. The technique has shown excellent results in the first 20 high-risk patients with complex aortic pathology treated with CESA, with a cumulative survival rate of 76% at two years.
A Swedish study found improved long-term survival rates among patients with intact abdominal aortic aneurysms who underwent surgical repair between 1987 and 2005. Patients in their 80s and males experienced higher relative five-year survival rates, likely due to atherosclerosis, whereas advances in postoperative care and endovascular a...
The Society for Vascular Nursing has released a comprehensive guideline for patient care of those with vascular disease, focusing on endovascular repair of abdominal aortic aneurysms. The guidelines aim to improve patient outcomes and ensure continuity of care across the population.
A 30-year analysis of brain hemorrhage patients found a 17% decrease in mortality rates, despite increasing patient age. Regional differences in case fatality rates were also observed, with Japan showing lower rates than Europe and the US.
A new study published in Journal of Neurosurgery found that minimally invasive coil treatments for brain aneurysms are more effective and tolerate better critically ill patients. However, the procedure is currently limited by its high cost due to additional follow-up procedures.
Researchers at UT Houston have identified a single gene defect that causes thoracic aortic aneurysms, dissections, coronary artery disease, ischemic stroke, and Moyamoya disease. The study found that mutations in the ACTA2 gene can lead to increased smooth muscle cell multiplication, contributing to blocked or enlarged arteries.
Long-term follow-up of patients with coiled and clipped aneurysms reveals improved survival rates for coiled aneurysms at five years. However, the risk of rebleeding is slightly higher for coiled aneurysms in the first five years.
A new study found that endovascular repair is effective and durable with low re-intervention rates comparable to open surgery. The minimally invasive procedure redirects blood flow and stops pressure on the weak aortic wall, avoiding major abdominal surgery.
A new study suggests that genetic risk factors for brain aneurysms do not accumulate earlier in the second generation, contrary to previous research. The study found that aneurysm ruptures occur slightly later in life in the second generation.
A new study reveals that smokers with a family history of brain aneurysm are significantly more likely to suffer a stroke. The research found that current smokers were six times more likely to experience a stroke, and quitting smoking could reduce this risk by over half.
A study published in Neurosurgery found that routine testing with cerebral angiography following endovascular treatment of brain aneurysms carries a very low risk of complication. The test was shown to have a complication rate of 0.43 percent, with only one major and permanent complication occurring.
A study published in Nature Genetics has identified three chromosome segments where common genetic variations can create significant risk for ruptured aneurysms, leading to strokes. The findings could lead to new screening tests and therapies to strengthen blood vessels in the brain.
A novel 3D ultrasound probe guides catheter procedures with clearer real-time images, eliminating x-ray radiation and contrast agent risks. The device is portable and provides continuous imaging, enabling wider range of interventional procedures.
Patients with thoracic aortic aneurysms are increasingly being treated with stent grafts, which require minimal incision and rapid recovery. A recent study found that patients receiving stent grafts had significantly lower complication rates compared to those undergoing open chest surgery.
Dr. Edward Duckworth is using less-invasive techniques to remove tumors, repair life-threatening aneurysms, and reduce seizures in epilepsy patients. The procedure involves reaching the brain through smaller openings, resulting in decreased pain and shorter hospital stays.
The study found that implementing endovascular abdominal aortic aneurysm repair reduces overall mortality in patients. Older patients and those who are hemodynamically stable experience the largest improvements in survival, shifting high-risk patients to this treatment option.
Aortic aneurysms affect 5% of Americans, with a mortality rate of up to 80%. Researchers at Carnegie Mellon University are developing a computational system to predict when ruptures will occur. The tool aims to provide physicians with a more scientific understanding of the relationship between blood flow and vascular disease.
A new study from the University of Michigan Stroke Program reveals that women and Mexican-Americans are at a higher risk of suffering a type of stroke related to a ruptured brain aneurysm. Women had a 74% greater chance, while Mexican-Americans had a 67% greater chance, compared to non-Hispanic white men.
A study found black men are less likely to receive elective surgery for abdominal aortic aneurysms compared to white men, even after accounting for disease rates. This disparity suggests potential differences in healthcare access or treatment, warranting further investigation.
A recent study found that contrast-enhanced MRI significantly outperforms 16 slice multidetector CT in detecting endoleaks after endovascular repair of abdominal aortic aneurisms. The study detected 21 endoleaks in 18 patients with 100% sensitivity and accuracy on MRI, while MDCT had lower detection rates.
Researchers found a correlation between smoking history and increased risk of aneurysm recanalization in patients treated with coil embolization. Cigarette smoking is the only factor consistently identified as a predisposition for cerebral aneurysms.
A University of Cincinnati study found that new coiling devices are no more effective than traditional bare platinum coils in preventing brain aneurysm recurrence. The study analyzed 100 patients and found a higher rate of repeated treatments with the newer, more expensive coils.
Researchers analyzed data from over 45,000 Medicare beneficiaries treated for AAA and found that EVAR has a lower mortality rate than open repair, with a significant benefit for elderly patients. While EVAR may require more reinterventions, the risks are balanced by late complications of open repair.
UT-Houston researchers have identified a defective gene mutation in smooth muscle alpha-actin (ACTA2) that affects vascular smooth-muscle cells, leading to thoracic aortic aneurysms and dissections. The study suggests that contraction of the smooth muscle cells in the aorta is crucial in maintaining its health.
Researchers identified a 41-gene signature in blood cells that distinguishes TAA patients from those without the disease with accuracy rates of 78-85%, paving the way for new detection and treatment methods.
Researchers found that suppressing the endothelial nitric oxide synthase (NOS-3) gene led to intracranial aneurysm formation in 33% of study subjects. The study suggests that NOS-3 plays a crucial role in vascular remodeling and may be a marker for increased risk of brain aneurysms.
MDCT angiography is highly accurate in depicting intracranial aneurysms, outperforming digital subtraction angiography (DSA) in diagnostic accuracy. The technique can quickly determine the possibility of using minimally invasive treatment rather than open surgery.
Researchers identified a surprising trend in their study of 53 Ohio children with intracranial arterial aneurysms: most cases occurred spontaneously, without trauma or infection. This finding suggests unknown genetic factors, environmental exposures, or interaction between the two may predispose certain children to aneurysm development.
A study of coronary artery surgery survivors found that patients with inflammatory rheumatic diseases like rheumatoid arthritis and lupus had more chronic inflammatory cell infiltration in their aortic walls. Smoking was also independently associated with increased inflammation, particularly in the inner adventitia.
CT angiography (CTA) has been found to accurately detect ruptured cerebral aneurysms in patients with acute subarachnoid hemorrhage, with a sensitivity of 99.4%. The study, conducted at the Health Sciences Center in Winnipeg, Canada, involved 171 patients who underwent preoperative 3D CTA.
Research suggests that patients with abdominal aortic aneurysms have better survival chances if treated at hospitals with high volumes of these cases. Large centres of excellence can prevent bad outcomes, including death, through specialized care. A minimum of 43 performed surgeries is required for significant success rates.
A team of scientists at WashU Medicine has discovered that the enzyme dipeptidyl peptidase I plays a critical role in promoting the growth of abdominal aortic aneurysms. Without this enzyme, mice do not develop aneurysms due to reduced recruitment of inflammatory cells.
Researchers found that non-white patients, Medicaid recipients, and uninsured individuals were less likely to receive care at high-volume hospitals for certain procedures. The study highlights the need to address disparities in patient access to improve surgical quality of care.
Abdominal aortic aneurysm affects 78.8 million baby boomers, with over half at risk by age 50; researchers seek pharmacological solution with $8.5M NIH funding.
A recent study published in the journal Stroke found that clipping and coiling treatments for aneurysms produce similar long-term outcomes. The study followed 1,010 patients treated between 1996 and 1998 and revealed that rerupture of the aneurysm occurred at a lower rate in clipped patients compared to those who received coiling treat...
Researchers aim to identify patients at high risk of aneurysm rupture using computer simulations of blood flow. The study uses geometric models and fluid dynamics programs to analyze blood flow characteristics and predict patient-specific risks.
Researchers have discovered that losartan can prevent the development of aortic aneurysms in mice with Marfan syndrome, suggesting a potential new treatment. The drug works by lowering transforming growth factor beta activity, which is responsible for the syndrome's catastrophic developmental defects.
The stent-graft approach has been shown to result in less neck nerve injury and faster recovery compared to open neck surgery. This minimally invasive treatment can be performed under local anesthesia and allows patients to resume normal activities within two days.
The study found that endovascular aneurysm repair (EVAR) significantly reduced mortality rates and recovery time for patients undergoing AAA repair, even among older and less-fit patients. The procedure's success has influenced overall AAA repair outcomes.
A new study by Michigan Medicine researchers demonstrates that a minimally-invasive procedure called endovascular thoracic aortic repair (ETAR) can successfully treat many patients with upper aorta problems, offering an alternative to open-chest surgery. The procedure uses stent-grafts inserted through small incisions in the leg or belly.
A new non-surgical approach combining stent-assisted coil embolization has shown success in treating wide-necked brain aneurysms, improving patient outcomes with minimal recovery time. The procedure has been found to have a high rate of complete closure without compromising the parent vessel.
A study published in The Lancet found that minimally invasive coil treatment is more effective than neurosurgical clipping for ruptured brain aneurysms, resulting in a 24% reduction in mortality and disability. Long-term follow-up data showed that the early survival advantage was maintained up to 7 years.
Researchers have identified gene mutations that cause life-threatening aortic aneurysms and dissections, providing a new molecular pathway for therapy development and early warning signs. The study found four families with variations in the TGFBR2 gene, which alters protein structure and sends incorrect signals.
Researchers at Michigan Medicine have made significant discoveries on the formation of abdominal aortic aneurysms (AAAs), a leading cause of death worldwide. Two new studies suggest that neutrophils, a type of white blood cell, play a crucial role in AAA formation, particularly in the early stages of the condition.
Researchers developed a classification system to treat thrombotic aneurysms, finding that one-third can be treated surgically with conventional clipping. The study also discovered that bypass and occlusion procedures yield more favorable results for unclippable aneurysms.
A lab study found that administering male sex hormones to female mice increases their susceptibility to developing abdominal aortic aneurysms. The goal now is to identify the target of these hormones to develop drugs that can lower the incidence of life-threatening aneurysms.
Researchers at the Mayo Clinic have identified a specific genetic variation associated with a 10-fold increased risk of a ruptured brain aneurysm. This discovery could lead to the development of a fast and inexpensive blood test to predict stroke risk, saving thousands of lives annually.
A study published in Annals of Neurology found a strong association between dolichoectasia, a rare blood vessel disorder, and small vessel disease, a significant cause of lacunar or 'mini' strokes. The research may offer new insights into the causes and treatment of this condition.