Articles tagged with Aneurysms
A new study published in the New England Journal of Medicine found that endovascular aneurysm repair had similar long-term overall survival rates as open repair, making it a viable option for patients. The minimally invasive procedure is also less painful and has a shorter recovery period than open surgery.
A new genetic basis of a type of brain aneurysm has been identified, suggesting that an existing cancer drug can counter its effects. Researchers have discovered 'gain-of-function variants' in the PDGFRB protein, which causes it to remain locked in a hyper-active form.
A team of researchers at Cardiff University has discovered that a family of lipids contribute to the development of abdominal aortic aneurysm by driving clotting in blood vessels. The findings suggest new treatments for this potentially life-threatening condition by regulating blood clotting.
Researchers developed a simple nondimensional parameter called 'aneurysm number' to classify the flow mode in both sidewall and bifurcation aneurysms. The parameter can substitute flow factors, potentially reducing the need for cumbersome measurements and simulations.
A recent study published in the Canadian Medical Association Journal found that oral curcumin did not reduce inflammation or improve outcomes in patients undergoing elective abdominal aortic aneurysm repair. In fact, the study showed an increased risk of post-surgical kidney damage in patients taking curcumin.
A recent study has identified 24 genes that are differentially expressed in rats with cerebral aneurysms compared to those without. These genes may enable the development of diagnostic biomarker tests for patients at increased risk of cerebral aneurysm formation.
Thrombospondin-1 plays a critical role in mechanotransduction and elastic fiber organization, contributing to the development of Thoracic Aortic Aneurysms. Deletion of Thbs1 prevents aneurysm formation, restoring aorta biomechanical properties.
A highly flexible and stretchable sensor can measure blood flow in brain aneurysms, reducing the need for expensive diagnostic procedures. The sensor uses capacitance changes to detect fluid flow, enabling real-time monitoring of hemodynamics after surgery.
A study published in The Lancet questions the effectiveness of screening programs for abdominal aortic aneurysms in older men, citing the potential for over-diagnosis and unnecessary treatment. The research suggests that the benefits of screening may not outweigh the harms, particularly with decreasing disease incidence.
A Swedish cohort study of over 130,000 men found that abdominal aortic aneurysm screening did not substantially reduce deaths from the condition. The study suggests that the lower mortality rate may be due to declining smoking rates, and that the harms of screening may outweigh its benefits.
Researchers have identified a new gene, ari-1, linked to aortic aneurysms in humans through a fruit fly study. The study found that mutations in the ari-1 gene disrupt mechanical sensing mechanisms in the body, leading to abnormal nuclei shapes and potentially contributing to the development of aortic aneurysms.
A new study shows that interactive virtual reality (VR) technology improves accuracy and confidence among interventional radiologists when treating complex conditions like splenic artery aneurysms. The VR platform provides a 3D view of internal anatomy, allowing physicians to better plan their approach.
The study found that ACA's Medicaid expansion led to significant increases in insurance coverage and a greater likelihood of patients receiving timely and optimal care for five common surgical conditions. This improvement was particularly notable for patients with serious surgical conditions such as appendicitis or aortic aneurysm.
A study found that former NFL players have significantly larger ascending aortic diameters than non-players, with almost 30% having an aorta wider than 4cm. This could be due to a remodeling process caused by repeated strenuous exercise, increasing their risk of heart disease.
A randomised trial found that keyhole repair is more effective than traditional open surgery for repairing ruptured abdominal aortic aneurysms. The study showed lower mortality rates and reduced hospital stays in the keyhole group, leading to improved quality-adjusted life years.
Researchers have found a link between abnormal tryptophan metabolism and abdominal aortic aneurysm, a permanent enlargement of the abdominal aorta. The study suggests that substances derived from tryptophan metabolism may be biomarkers for the disease and could potentially be used to develop novel therapies.
A new tool, the Ottawa Subarachnoid Hemorrhage Rule, helps identify high-risk patients with potentially fatal brain aneurysms, reducing wait times and unnecessary testing. The rule has been validated in over 1153 patients, showing it can improve survival rates and save lives.
The new Canadian guideline recommends one-time ultrasonography screening for abdominal aortic aneurysms in men aged 65-80, while not screening women or older men. The guideline is based on evidence from randomized controlled trials and aims to reduce mortality, rupture, and emergency procedures.
Lower levels of alcohol may decrease the risk of developing an abdominal aortic aneurysm until approximately 15-20 g/day, according to a large analysis of published studies. The study found that quitting smoking remains the most effective way for people to stay healthy and active for longer.
A novel screening programme for vascular disease saves one life for every 169 men assessed. The combined screening for abdominal aortic aneurysm, peripheral artery disease, and hypertension gained more living years for lower costs than European cancer screening programmes.
Subarachnoid hemorrhages account for 5-10% of all strokes, particularly among younger patients, and can result in long-term neuropsychological effects. Expert treatment is crucial, with high-volume centers and specialized neurosurgeons offering the best outcomes.
A new study published in the Journal of Neurosurgery found that smoking significantly increases the chance of brain aneurysm recurrence. Former and current smokers had a higher rate of recurrence compared to never smokers, emphasizing the importance of quitting smoking after endovascular treatment.
Researchers developed a novel imaging tracer that allows for early assessment of abdominal aortic aneurysm (AAA) risk. The study shows high sensitivity and specificity in detecting vessel wall biology, suggesting a promising tool for AAA risk stratification.
Scientists discovered that changes in mechanical behavior and gene signaling play a crucial role in the development of heart defects, with LOX-deficient mice exhibiting protection against aneurysms. The research provides new insights into the chemo-mechanics of heart defects and its potential applications for disease prevention.
Researchers have developed a new skin cell model to study the genetic mutation ACTA2-R258C, which is linked to early-onset aortic aneurysm and moyamoya-like cerebrovascular disease. The study found that the mutation disrupts cytoskeleton functions, leading to impaired smooth muscle contraction and increased risk of heart disease.
Researchers found that small and very small unruptured intracranial aneurysms have low growth rates, ranging from less than 3% per year. The annual rupture rate for aneurysms smaller than 7mm was 0-1%. These findings may inform patient management and treatment decisions for patients with UIAs.
A new study published in The Lancet found that women with aortic aneurysms fare worse than men at every stage of treatment, leading to increased mortality rates. The researchers call for urgent improvement in how the condition is managed in women.
Naren Vyavahare is advancing research into abdominal aortic aneurysms, aiming to develop new treatments and improve diagnoses using nanoparticles. The goal is to ease anxiety and prevent surgery for thousands of patients with this potentially life-saving therapy.
Researchers found a single compressed stent produces a denser mesh than two overlapping stents, covering at least half of the aneurysm opening. The technique is more effective for large necked saccular aneurysms.
A systematic review found that both endovascular (EVAR) and open surgical (OSR) repairs for abdominal aortic aneurysm (AAA) can lead to renal function impairment. The study included six studies with over 2,100 patients, revealing similar risks of renal decline in EVAR and OSR groups.
Researchers discovered a genetic link between abdominal aortic aneurysm and four genes, which could help doctors understand the condition better. The study found that early detection is key to preventing fatal internal bleeding, and a new research programme will investigate the effect of these genes on AAA growth.
A new study finds that smokers are at nearly twice the risk of developing an abdominal aortic aneurysm compared to non-smokers. Quitting smoking can reduce this risk by substantial amounts, particularly among current and former female smokers.
A study published in the American Journal of Human Genetics identified a rare genetic variation in the RNF213 gene that is linked to an increased risk of intracranial aneurysm in French-Canadian individuals. The study found that 10% of patients with IA had at least one of these variants, compared to 0% in controls.
A research team led by the University of Pittsburgh is using brain tissue samples and computational mechanics to identify biomarkers of wall fragility and develop new treatments to prevent rupture. The goal is to improve risk assessment and treatment options for patients with cerebral aneurysms.
A minimally-invasive procedure to fix an aortic aneurysm, called endovascular aneurysm repair (EVAR), may be associated with a higher risk of long-term complications, including mortality, compared to open surgery. Regular scans can help prevent these complications.
A Kyoto University study found that green tea polyphenol reduces inflammation and promotes elastin production, protecting against aneurysm progression. The researchers suggest daily green tea intake as a new preventative strategy for abdominal aortic aneurysm.
A new study found that Finland's national tobacco policies are responsible for a significant decrease in the incidence of subarachnoid haemorrhage, the most fatal form of stroke. The prevalence of SAH declined by 45% among women and 38% among men under 50 over a 15-year period.
Ender Finol's American Heart Association award supports freezing aortic aneurysms before they burst. Researchers aim to apply the chemical compound pentagalloyl glucose non-invasively to human subjects.
Researchers at MUSC aim to develop novel treatment options for thoracic aortic aneurysms by studying the cellular events leading to their formation. The $1.46 million NIH grant will focus on translating discoveries into potential therapeutics, including region-specific gene therapy and targeted pharmacologic treatments.
Researchers found that flow diversion demonstrates a higher rate of visual improvement and a lower rate of visual decline in patients with paraclinoid aneurysms. Eight out of nine patients treated with Pipeline embolization device showed improved visual outcomes.
A recent study found that a pipeline device can safely and effectively treat difficult-to-treat brain aneurysms located near the front of the brain. The device was used to successfully occlude 77.8% of aneurysms, with a success rate of 70% for previously treated cases.
The June 2016 issue of Vascular Medicine explores the latest developments on aortic disease, medical technological advances, and treatment options. Original research articles and reviews highlight the mechanisms of aortic pathology and novel indices for thoracic aortic size.
Neurofibromatosis 1 (NF1) is a genetic condition that can lead to premature cardiovascular disease due to thickening or thinning of blood vessel walls. Researchers are studying the similarities between NF1-related arterial stenosis and aneurysms to improve diagnosis and treatment.
A new study published in JAMA Neurology found that loss of consciousness is a common presenting symptom in patients after subarachnoid hemorrhage due to brain aneurysm. The researchers suggest that loss of consciousness may be an indicator of severe bleeding and therefore predict death or poor functional outcome one year later.
Patients who took cholesterol-lowering medication before endovascular aortic aneurysm surgery experienced fewer complications and better outcomes. Statin use was associated with a 26% decrease in mortality up to one year after surgery.
A new virtual reality approach has been developed to improve the treatment of aortic aneurysms by providing more accurate visualization of the area needing treatment. The approach uses 3D images and simulations to predict the risk of rupture and optimize treatment options, including open surgery and endovascular grafting.
The study found that ISUIA and PHASES scores may not accurately predict rupture risk, highlighting the need for further research into their effectiveness. The findings suggest that more than 70% of ruptured aneurysms were smaller than 7mm in diameter, regardless of location.
Researchers at Beth Israel Deaconess Medical Center found that endovascular aortic repair provides better outcomes, including lower mortality rates and shorter hospital stays, compared to open surgical repair. The study shows improved long-term results over time, with benefits extending up to eight years after surgery.
Researchers detected four known genetic mutations causing thoracic aortic aneurysms and identified 22 previously unknown variants contributing to the condition. This technology enabled personalized care, including preventive surgery and more frequent imaging tests for patients with high-risk mutations.
Researchers found that patients with larger aneurysms or incomplete occlusion face a long-term risk of aneurysm recurrences after endovascular treatment. The study suggests that longer follow-up protocols may be necessary for some intracranial aneurysm patients who undergo EVT.
A new genetic mutation in the TGFB3 gene has been discovered, linking it to serious aortic disorders. This finding allows for improved diagnostic screening, enabling early identification of patients at risk and potentially preventing aortic aneurysm formation through preventive treatment.
A new study published in Journal of Vascular Surgery found that minimally invasive aortic aneurysm repair can extend lives even in patients with advanced age and kidney disease. However, not all high-risk patients benefit from the procedure, particularly those undergoing cancer treatment.
Researchers argue that aneurysm screening programs should be revised due to reduced benefits and increased harm in modern populations. The screenings are estimated to overdiagnose AAA cases by 176 out of every 10,000 men invited.
Researchers have developed a new device that significantly improves healing of small ruptured brain aneurysms. The HydroCoil device combines a gel-like substance with a platinum coil, allowing it to expand and block blood flow to the aneurysm, reducing recurrence rates by up to 70% compared to standard treatment.
Researchers found that flow-diverting stents associated with ischemic complications in brain territories supplied by parent arteries and small branches covered by the stent. Despite high incidence of clinically silent lesions, low permanent complication rate suggests technique is safe and effective for aneurysm treatment.
A team of researchers has discovered an ancient, deep canyon in South Tibet, which rules out a popular model explaining the formation of Himalayan gorges. The canyon is thousands of feet deep and was carved by a river that once flowed into the Tibetan Plateau.
A new emergency treatment protocol for subarachnoid hemorrhage from ruptured aneurysms significantly reduces in-hospital rebleeding and improves clinical outcomes. Patients treated under the protocol show a lower incidence of repeated hemorrhage within 24 hours, compared to those treated earlier.
Spontaneous intracranial hypotension, a condition causing severe headaches, has been linked to bariatric surgery. A study found that gastric bypass and banding surgeries were associated with a small percentage of people developing the condition.
The new guidelines cover aneurysms, calcifications, congenital diseases, aortic inflammation, and tumors, with improved diagnostic capabilities using imaging technologies. The guidelines recommend opportunistic screening for abdominal aortic aneurysm and the use of hybrid treatments, as well as establishing aortic teams in hospitals.
Researchers found a 42% reduction in preventable post-operative complications and a 72% reduction in mortality for minimally invasive surgery compared to open repair. The study analyzed 70,946 cases of abdominal aortic aneurysm repair over seven years.