Articles tagged with Aneurysms
Aneurysms occur when blood vessel thins and expands, leading to increased stress on walls and rising rupture probability. The new model uses computed tomography scans to reconstruct geometry and blood flow patterns.
A large Kaiser Permanente study found that most patients with a thoracic aortic aneurysm less than 5.5 cm are not at high risk of experiencing dissection or requiring surgery. The study's findings support the current consensus guidelines recommending surgery for patients with larger aneurysms.
Researchers have developed an injectable shear-thinning hydrogel that exhibits enhanced cohesive strength, resisting fragmentation even under pulsating liquid flows. The gel, similar to toothpaste, retains its structure when force is removed, making it a potential breakthrough in treating critical vascular conditions.
A study published in JAMA Cardiology found that the mortality rate for patients with a torn aorta has decreased significantly, from 37% in the 1950s to nearly 6% today. However, patients who did not receive surgery died at a rate five times higher than those who underwent treatment.
Researchers developed nanoparticles to deliver anti-inflammatory payloads directly to inflamed blood vessels, significantly increasing survival chances and delaying rupture onset. Targeting specific NF-kappaB subunits improved therapeutic effects with fewer adverse effects.
A Rutgers study found that women are more likely to die or require repeat surgery five years after abdominal aortic aneurysm repair. The researchers highlighted the need for increased inclusion of women in aortic device creation and trial enrollment, given differences in aortic anatomy between men and women.
Researchers found significant decrease in national Kawasaki disease cases in 2020, coinciding with school closures and masking mandates. KD cases rebounded after lifting of masks and return of in-person schooling, hinting at respiratory portal of entry as trigger.
A study of over 3,000 adults found that RAAS inhibitors lowered aneurysm rupture risk by 18%. Using proper antihypertensive medications can decrease the risk of a ruptured aneurysm. The study suggests that nearly 18% of ruptured aneurysms may be prevented with RAAS inhibitors.
Researchers found that cancer patients who underwent elective AAA repair were associated with longer hospital stays, renal failure, respiratory problems, and infection. However, a cancer diagnosis did not increase the risk of in-hospital mortality or cardiac complications.
A novel mesh plug treatment, Woven EndoBridge (WEB), has been shown to be equally effective in treating sidewall brain aneurysms compared to bifurcation aneurysms. The study found a complication rate similar between the two approaches and demonstrated the safety and efficacy of WEB for sidewall aneurysms.
A new robotic system allows surgeons to remotely treat patients experiencing a stroke or aneurysm, providing teleoperated endovascular treatment during the critical golden hour. With just one hour of training, neurosurgeons can successfully operate the system to guide a wire through complex vessels and reach difficult-to-reach areas.
Researchers developed a novel method of measuring aortic growth, called vascular deformation mapping, which outperforms standard manual rating methods. The technique uses high-resolution CT imaging to calculate three-dimensional changes in the aortic wall, achieving an accuracy of less than 1 millimeter.
Researchers compared two treatment methods for wide-neck aneurysms: microsurgery with clips and coils/stents deployed via catheters. Microsurgery was found to be longer-lasting, but endovascular therapy showed superior clinical outcomes in unruptured aneurysms.
Researchers at NYU Tandon have discovered the mechanical basis for abdominal aortic aneurysm (AAA), a complex vascular disease. They identified Piezo1, a novel culprit of mechanically fatigued aorta in AAA, and found that inhibition of Piezo1 prevents mice from developing AAA by alleviating pathological vascular remodeling.
A recent study published in Stroke found that the Woven Endobridge (WEB) device is safe and effective in treating brain aneurysms, with adequate occlusion occurring in 85.7% of cases. The device also showed low rates of blood clot-related complications and no re-ruptures after treatment.
Researchers found that chronic use of sildenafil aggravated the development of abdominal aortic aneurysms in mice, disrupting smooth muscle cells' ability to contract. The study suggests caution when prescribing PDE5 inhibitors like sildenafil for patients with existing aortic aneurysmal lesions.
Researchers at Yale University discovered a key gene that contributes to the development of life-threatening brain aneurysms in adults. The study found that mutations in the PPIL4 gene are significantly more common in individuals with intracranial aneurysms, highlighting a potential new target for diagnosis and treatment.
A team of researchers used deep learning to analyze cardiac images and identified genetic variations linked to aortic size. The findings may lead to the development of a polygenic score to identify individuals at high risk of aneurysm, as well as new drug targets for aortic enlargement.
New research suggests that insomnia may be a potential risk factor for brain aneurysm rupture, along with well-known factors such as smoking and high blood pressure. The study found associations between insomnia and increased risk of intracranial aneurysms and subarachnoid hemorrhage.
Researchers have discovered a more effective treatment for children with Kawasaki disease and multisystem inflammatory syndrome in children (MIS-C), a rare COVID-19 reaction. The new therapy, infliximab, reduces fever duration, hospitalizations, and anemia compared to standard IVIG treatment.
Researchers found that clot-busting drugs rarely cause aneurysms to rupture after a stroke. For people with larger saccular aneurysms, additional consideration should be taken regarding treatment to minimize risk of aneurysm rupture.
A study published in BMJ Open found a significant link between asymmetric brain arteries and the likelihood of developing a cerebral aneurysm. The research suggests that MRI and CT angiograms can be used to screen people with asymmetrical brain arteries for cerebral aneurysms, providing a new tool for monitoring those at risk.
A recent study found that fenestrated-branched endovascular aortic repair significantly reduced mortality rates for patients with complex aortic aneurysms, with a 1% risk of mortality at 30 days compared to 21% in open surgical repair. The procedure also showed better outcomes regarding major adverse events, including spinal cord injury.
A team of researchers is developing a smartphone-based device that can predict the size of aortic aneurysms and detect fluid overload in postpartum women. The device uses arterial waveforms, which can be easily recorded with a smartphone camera or smart scale, to provide a non-imaging solution for AA screening.
Researchers developed a new balloon stent that can maintain downstream arterial blood flow while closing off aneurysms. This technology has the potential to reduce aneurysm regrowth and save lives by allowing surgeons more time to effectively assess and treat patients.
A new study reveals that the TCF7L2 gene plays a key role in smooth muscle cell death and replenishment, potentially reducing aortic aneurysm risk. Researchers analyzed blood samples from over 1,300 individuals with aortic aneurysms and found a significant genetic link to the disease.
The Vascular Bioengineering Lab at the University of Pittsburgh has received a $100,000 award to develop a predictive model for abdominal aortic aneurysms. The model will use machine learning algorithms to classify different types of aneurysm outcomes and provide personalized management plans for patients.
Researchers successfully replicated traditional clinical trials using virtual patient populations, speeding up the trial process by months. The in-silico approach shows huge potential for optimizing medical device design and reducing risks associated with treatment.
A University of Kentucky team will study the culprit behind thoracic aortic aneurysms with a $5.6 million grant from the NIH. The goal is to find new medical options to prevent surgical intervention.
An international team used Raman microspectroscopy and imaging to identify signatures in the elastic and collagen fibers of the aorta that indicate the presence of an aneurysm. The study found biomarkers for thoracic aortic aneurysms, which could enable early detection and potentially save lives.
Scientists have discovered that the nitric oxide pathway is overactivated in Marfan Syndrome and causes aortic aneurysms. Inhibiting this pathway completely reverses the disease in a mouse model. The study identifies new therapeutic targets and markers for monitoring disease status.
A new treatment method for cerebral aneurysms uses a biocompatible embolization material that fills the aneurysm at high rates and maintains structural stability. The innovative material exhibits excellent biocompatibility and can safely prevent rupture, reducing financial burden and risks associated with current coil embolization.
A new, low-profile thoracic aortic endograft device has demonstrated safety and effectiveness in treating descending thoracic aorta aneurysms and PAU diseases. The RELAYPro endovascular device achieved 89.2% one-year treatment success rate with a reduced risk of complications.
A team of researchers has discovered that JMJD3 enzyme promotes inflammation in monocyte/macrophages, leading to the development of abdominal aortic aneurysms. Blocking this enzyme prevents aneurysm formation, providing a potential new target for treatment.
A team of researchers at the University of Pittsburgh is developing a new model to predict the risk of human aneurysms, using mechanical testing and biomechanical simulations. They aim to identify patients at high risk of rupture and improve patient prognosis by guiding surgical intervention.
A study found EVAR has a lower hospital mortality rate but a higher readmission rate compared to traditional open repair for ruptured abdominal aortic aneurysms. Researchers identified additional risk factors specific to EVAR, including prior EVAR repair and chronic kidney disease.
Scientists at the University of Pittsburgh have identified a new, primary phase of blood vessel restructuring that begins immediately after an aneurysm forms. This immediate adaptation enables the vessel to better handle new loads and reduces the risk of rupture.
A team of specialists developed an award-winning 4D simulator technology to train neurosurgeons and reduce complications during brain aneurysm surgery. The simulator accurately models blood vessels, pulse, and flow, enabling enhanced planning and pre-op practice.
Scientists have discovered 17 genetic abnormalities that cause brain aneurysms, providing a new understanding of the disease and potential markers for instability. The study also highlights the importance of genetic predisposition to high blood pressure and smoking in developing intracranial aneurysms.
The final 2021 Medicare Physician Fee Schedule will result in a 10% reimbursement cut for neurointerventional procedures, putting patients at risk of losing access to life-saving care. The Society of NeuroInterventional Surgery warns that this measure could further exacerbate challenges faced by the field due to the COVID-19 pandemic.
A deep learning system has been developed to detect cerebral aneurysms with a sensitivity of 97.5%. The algorithm detected 633 of the 649 cerebral aneurysms and found eight new aneurysms overlooked by human readers.
Researchers use 3-D rotational angiography images and data on flow-diverting devices to construct computational fluid dynamics models of cerebral aneurysms. They investigate hemodynamic differences between immediate occlusions and long-term patency, as well as possible causes of hemorrhages after treatment.
Researchers created a synthetic tubular scaffold from biodegradable polylactic acid, which forms an artificial vessel in its place. The scaffold showed high patency rates and was proven to be non-toxic.
Researchers have identified over a dozen new genes associated with abdominal aortic aneurysm, adding to the understanding of disease mechanisms. The study found that diastolic blood pressure is likely a significant factor in developing the condition.
Treatment of unruptured intracranial aneurysms has become substantially safer over the past decade due to advancements in microsurgical techniques and endovascular technology. Endovascular embolization has shown a higher rate of favorable clinical outcomes compared to microsurgical clipping.
Research published in the Journal of Neurology Neurosurgery & Psychiatry found that women smokers are four times more likely to have unruptured brain aneurysms than non-smokers. High blood pressure further increases the risk, with smokers being seven times more likely to harbour the condition.
A Vanderbilt University Medical Center study found that doxycycline did not reduce the growth of abdominal aortic aneurysms in patients over a two-year period. The study included 254 patients who were randomly assigned to take either doxycycline or a placebo, with no differences in aneurysm growth between the two groups.
Researchers found that taking doxycycline had no effect on reducing the growth of abdominal aortic aneurysms over two years. The finding could lead to a change in treatment for life-threatening vascular conditions.
A new genetic risk score identified more men at increased risk for abdominal aortic aneurysm and could benefit from screening to detect it prior to rupture. The study suggests that current screening recommendations should be extended to include testing for those with high polygenic risk scores.
A Swedish study has found that abdominal arterial aneurysm is associated with elevated subtypes of white blood cells in older men. Quitting smoking also appears to positively impact the disease's course.
Researchers successfully treated brain aneurysms using a robotic system, enabling precise stent and coil placement. The technology has the potential to deliver rapid care through remote robotics, improving patient outcomes and expanding access to cutting-edge care.
A study published in Radiology found that patients with abdominal aortic aneurysms and blood clots on the aorta wall experience faster growth and increased rupture risk. The researchers suggest adjusting imaging follow-up schedules for these patients to reduce the risk of rupture.
Researchers at NAU are developing a polypropylene glycol-based biomaterial to treat cerebral aneurysms, aiming to improve outcomes and reduce recurrence rates. The material, PPODA-QT, is designed to fill the aneurysm space effectively, leaving a smooth surface for healing.
Researchers developed a promising methodology for monitoring postoperative abdominal aortic aneurysm progression using CTA image registration and biomechanical strain analysis. The approach correlates with patient long-term prognosis, offering a new tool for assessing post-EVAR risk of rupture.
Researchers found an association between aspirin use and decreased intracranial aneurysm growth rate. Growth is crucial as it increases rupture risk. The study suggests that aspirin may exert a protective effect against aneurysm growth and future rupture, but findings are observational and require further interventional studies.
Researchers at the University of Dundee develop a blood test to detect desmosine, an amino acid released by diseased aortas into the blood and urine. This test improves diagnosis and monitoring of aortic aneurysms, potentially saving lives by identifying patients at risk.
A stretchable wireless sensor can monitor the healing of cerebral aneurysms by detecting changes in blood flow. The sensor, fabricated using aerosol jet 3D printing, can be seamlessly integrated onto existing medical stents and measures an incoming blood flow to determine how well the aneurysm is healing.
A study of 812 ADPKD patients found that 9% had undiagnosed brain aneurysms, with those with hypertension and smoking more likely to have aneurysms. The overall rupture rate was approximately 5 times higher than in the general population.
A groundbreaking trial has started to test the safety and effectiveness of a novel, off-the-shelf device designed to treat complex aortic aneurysms. The investigational GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE) allows for minimally invasive endovascular repair, avoiding traditional open surgical approaches.
Wearing magnetic eyelashes during MRI can create substantial artifact, obscuring entire phantom. The eyelashes detached from the phantom after scanning, attracted to each other due to friction and adhesion.