Articles tagged with Brain Tumors
Research at Johns Hopkins Medicine found that underprivileged African-American, Hispanic, and low-income patients with brain tumors are significantly less likely to be referred to high-volume specialty hospitals. This finding contradicts federal health care agency recommendations for equal access and quality of care.
Glioblastoma cells use miR-451 to sense glucose availability, slowing cell proliferation and increasing migration. High miR-451 levels correlate with shorter survival, suggesting the molecule as a biomarker for predicting patient prognosis.
Recent clinical and scientific advancements in nervous system cancers have improved our understanding of molecular changes and new therapies for patients. The March issue of Archives of Neurology features articles on various topics, including increased melanoma risk among Parkinson's disease patients and new insights into glioma risk.
Researchers at Stanford University School of Medicine have found that disrupting the SDF-1/CXCR4 interaction can prevent the recruitment of vasculogenic cells to the tumor site, blocking postirradiation development of functional tumor vasculature and tumor regrowth. This approach may be applicable to treating glioblastoma multiforme.
Researchers at Stanford University have discovered a way to prevent glioblastoma cells from growing back after radiation by blocking their access to oxygen and nutrients. The discovery, using the small molecule AMD3100, has shown promise in preventing tumor recurrence.
Researchers at Stanford University School of Medicine found that blocking blood vessel formation prevents brain tumor recurrence in mice. Disrupting the SDF-1/CXCR4 interaction prevented tumor regrowth by abrogating functional tumor vasculature.
Researchers have identified a potential therapeutic target for brain cancer, the A20 protein, which is highly expressed in glioblastoma stem cells. Decreasing levels of A20 in these cells reduces their growth and induces cell death, increasing survival rates in animal models.
A key mechanism that makes certain brain cells become tumorous has been identified by researchers. The tumours occur most often spontaneously but can also be part of inherited disease Neurofibromatosis type 2.
Research finds that selective brain damage, particularly in parietal regions, can modulate human spirituality and religious attitudes. The study identified a causative link between specific brain lesions and changes in self-transcendence, a personality trait reflecting spiritual feeling and behavior.
A phase 2 trial of denosumab has shown encouraging results in treating a rare type of brain tumor. The study found that 86% of patients experienced a tumor response, including some with lung lesions, and reported clinical benefits such as reduced pain and improved mobility.
Alexander Ksendzovsky, a third-year medical student, has been awarded the Lucien Rubenstein Award for his groundbreaking research on a potential vaccine to fight malignant brain tumors. The American Brain Tumor Association recognized his outstanding work as part of their annual Research Award Program.
Researchers discovered that gliomas can evade EGFR inhibitors by expressing alternative genes like KLHDC8, which halts tumor growth. This finding provides potential new targets and treatment strategies for brain tumors.
Researchers have identified two genes, C/EPB and Stat3, which are responsible for the most aggressive forms of human brain cancer. These genes work together to transform normal brain cells into highly aggressive cells, making them a major target for new treatments.
Researchers at the University of Central Florida have found a protein, TRPC6, that could hold the key to treating GBM, a type of malignant brain tumor. Knocking down this protein's expression can stop tumor growth and spread.
The new guidelines offer a range of therapeutic options and provide evidence-based recommendations for treating brain metastases. The guidelines aim to improve patient outcomes by identifying best treatment practices and fostering support for ongoing research.
Researchers identify specific DNA segment C19MC containing miRNA genes associated with aggressive CNS-PNET tumors. High expression of these miRNAs stimulates growth and prevents normal neural stem cell development.
Atoh1, a transcription factor critical for fetal development, is necessary for the development of many forms of medulloblastoma. Shutting down Atoh1 in susceptible brain cells prevented medulloblastoma from developing in mice, suggesting it as a potential target for new drug treatments.
A recent study published in the Journal of the National Cancer Institute found no significant link between increased cell phone usage and brain tumor incidence. The research analyzed data from Denmark, Finland, Norway, and Sweden over a 30-year period, concluding that induction periods may be longer than previously thought.
Researchers found that the master gene Math1 is critical to the development of medulloblastoma, a deadly disease that affects children and young adults. Removing or inactivating Math1 may work as a treatment, but its effectiveness depends on the stage of brain development.
Duke University researchers have found a way to increase the effectiveness of radiation therapy against glioma brain tumors by blocking a specific signaling pathway in cancer stem cells. This breakthrough could lead to more effective treatment options for patients with glioblastoma and other brain cancers.
Researchers at Ohio State University have developed a tumor-attacking virus that kills brain-tumor cells and blocks the growth of new tumor blood vessels. The virus, called RAMBO, was tested in animal models and showed promise in treating aggressive brain cancer with a survival rate of 54 days.
A new miniature microscope enables neurosurgeons to visualize brain tumors in real-time, allowing for more precise removal and accurate diagnosis. This technology has the potential to reduce surgery time by up to 40 minutes and improve patient outcomes.
Researchers found that multiple sessions of stereotactic radiosurgery (SRS) result in less brain swelling compared to a single high-dose treatment. This innovative approach offers good tumor control with fewer side effects and less time than conventional therapy.
Long-term brain tumor survivors in childhood experience ongoing cognitive problems, with lower levels of education, employment, and income compared to siblings and other cancer survivors. Medical complications such as radiation and surgery also play a significant role in these impairments.
Researchers at University Hospitals Case Medical Center report promising results from a study treating glioblastoma multiforme with Gamma Knife radiosurgery, increasing patient survival rates by almost four months compared to traditional radiotherapy alone.
Two UCSF teams, one for diabetes and one for brain tumors, have received grants from the California Institute for Regenerative Medicine to advance stem cell-based therapies. The goal is to file new drug applications with the FDA within four years, driving potential therapies toward clinical trials.
The first national and evidence-based guidelines for brain metastases have been released in the US, providing a framework for treating patients with brain tumors. The guidelines cover various therapeutic options, evidence-based decision-making, and demographic factors that influence clinical decisions.
ANG1005 demonstrates disease control in over 70% of patients with progressive gliomas and brain metastases, with significant reductions in tumor size observed. The drug successfully crosses the blood-brain barrier without CNS toxicity or immunogenicity.
The Translational Genomics Research Institute has been awarded $691,930 to develop brain tumor research using in silico simulations. The project will utilize comprehensive genomic data involving 40 brain tumor models and 20 proven types of targeted therapies.
Researchers have found that a standard treatment protocol can improve survival rates nearly two-fold for pediatric patients with choroid plexus tumors. The study suggests that chemotherapy and radiation can be effective in reducing mortality rates, contradicting previous research on surgical resection.
A Johns Hopkins study found that Hispanic children diagnosed with brain tumors receive specialized care at one-third the rate of other children, despite efforts to equalize access. The research highlights persistent gaps in care among certain patients and raises concerns about the future impact on this growing demographic.
Fernandez-Valle's research aims to identify proteins that could deliver cancer-fighting drugs to NF2 tumors, potentially improving lifestyles and extending patients' lives. She has established nationally affiliated clinics in Florida, bringing together physicians with expertise in treating the disease.
Patients with brain tumors treated with WBRT plus SRS experience significant decline in learning and memory function compared to those receiving SRS alone. The study concludes that SRS alone combined with close clinical monitoring is the preferred treatment strategy for patients newly diagnosed with one to three brain metastases.
A new approach to treating malignant brain tumors has been discovered, with chemotherapy alone proven to be just as effective as traditional radiation therapy. The study identified a key gene mutation called IDH1 that predicts a better prognosis for patients, regardless of treatment.
Researchers at Weizmann Institute discovered a new protein partnership between TrkA and CCM2 that leads to pediatric tumor regression. This finding may lead to the development of drugs that induce tumor regression. The study found that TrkA and CCM2 are always expressed together in tumors with high regression rates.
Researchers have discovered a small peptide that stops lung cancer tumors from growing by inhibiting blood vessel formation. The study showed significant reduction in tumor size and fewer blood vessels compared to untreated animals.
Researchers have developed a targeted cancer treatment using nanomaterials that selectively kills brain cancer cells while leaving healthy cells unaffected. The therapy uses titanium dioxide nanoparticles bonded to biological material and targets specific cell surface receptors on cancer cells.
A protein called Huwe1 normally functions to eliminate unnecessary proteins, acting as a tumor suppressor in brain cancer. Deregulation of Huwe1 function is involved in tumor development and may be an important factor in the development of brain cancer.
Researchers found that STAT3 inhibits the growth and self-renewal of glioblastoma stem cells, suggesting a promising target for cancer therapy. The study demonstrates the potential of STAT3 inhibitors to stop tumor formation and offers a new approach to treating this devastating brain cancer.
Patients who received radiotherapy for low-grade glioma brain tumors showed significant cognitive decline compared to those who did not receive treatment. The study found that attentional functioning, executive functioning, and information processing speed were lower in patients given radiotherapy. Deferring treatment or using modern r...
Researchers at the University of Washington developed nanoparticles that cross the blood-brain barrier, illuminating brain tumors and improving MRI and optical imaging. This breakthrough could lead to more precise surgery and earlier cancer detection.
UCLA researchers developed a new way to scan brain tumors and predict which ones will respond to the drug Avastin before treatment. By linking high water movement in tumors to positive drug response, they predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy.
The Peninsula College of Medicine and Dentistry has received a grant to study the role of brain tumors in deafness and develop non-invasive therapies. The research aims to identify how tumors grow and cause hearing damage, and test drug-based treatments.
Researchers at Cedars-Sinai Medical Center have isolated stem-like cells from benign pituitary tumors and shown they can generate new tumors in laboratory mice. The study supports the cancer stem cell hypothesis, suggesting similar mechanisms may be involved in malignant and benign tumor formation.
Researchers discovered that glioma cells use microglia, the brain's immune cells, to grow and expand rapidly. By manipulating microglial cells' receptors, gliomas can clear the way for further growth.
A recent study published in JAMA Network has found a network of altered genes that appear to play a crucial role in the development and progression of brain tumors. The researchers identified seven landscape genes that are associated with patient prognosis and survival.
A network of 31 mutated genes has been identified as the driving force behind glioblastoma growth. Annexin A7, a vital guard gene, is lost in most cases, allowing tumors to flourish. The discovery offers new therapeutic targets and potentially extends patient survival.
A new medical treatment using bevacizumab has successfully improved hearing and alleviated symptoms in patients with neurofibromatosis type 2 (NF2). The study shrank characteristic tumors, including vestibular schwannomas on the balance and hearing nerves.
Scientists at Virginia Tech have developed a hands-off process for filling fullerenes with radio-active material, increasing control of radiation therapy. The new material allows for targeted localization and potentially fewer side effects in brain tumor treatment.
Researchers at Mayo Clinic and University of California San Francisco have discovered a connection between DNA alterations on human chromosome 9 and glioblastoma. The study found that individuals with specific single nucleotide polymorphisms (SNPs) are 50% more likely to develop the aggressive brain cancer.
Researchers have identified a fruit fly tumor suppressor gene, PP2A, that can prevent brain tumors from forming. The study suggests that the protein's counterpart in mammals may also play a crucial role in regulating neural stem cell divisions and controlling tumor development.
Researchers design a minimally invasive system combining ultrasound and chemotherapy to target brain tumors without surgery or radiation. The approach aims to provide real-time imaging and localized temperature increases to melt liposome shells and release chemotherapy directly to the tumor.
PTEN-deficient cells have defective checkpoints that allow them to bypass DNA repair and continue growing despite radiation damage. Researchers found that correcting faulty checkpoint processes could increase radiation sensitivity in tumors with PTEN mutations.
A new MRI test involving breathing oxygen may help oncologists determine the best treatment for some cancer patients. The BOLD technique detects oxygen levels in tumors without invasive procedures, providing insight into how tumors behave and what treatments might be effective.
A University of Cincinnati study found that performing stereotactic needle biopsies in eloquent areas of the brain, associated with language or other critical functions, carries no greater risk than in non-eloquent areas. The study compared complication rates between functional and non-functional brain regions.
A UCF researcher is developing a computer program to analyze brain scans and automatically measure tumor size in 3D. The program has shown up to 90% accuracy compared to human analysis and could help determine treatment plans for patients.
A new mathematical model developed at the University of Texas Health Science Center at Houston suggests that tumor growth and invasion can be predicted using biophysical laws. The model, which links molecular and cellular properties to tumor behavior, consistently reproduced patterns of tumor invasion observed in experiments and patien...
Researchers found a biological link between tumors and negative mood changes in animal models, suggesting that tumor-induced molecules may be responsible for depression. The study also showed that disruptions in gene expression and stress hormone production are associated with tumor development.
Researchers created a mathematical formula that incorporated equations describing tumor evolution and growth, predicting oxygen consumption rates and cell growth. The computational model was validated with human brain tumor samples and successfully mimicked natural biological tumors.
Co-transplanting bone marrow stem cells with embryonic stem cells eliminates tumor formation in spinal cord injury (SCI) laboratory animals. The study suggests that BMSCs induce differentiation of undifferentiated ES cells into a neuronal lineage, resulting in suppression of tumor growth.