Articles tagged with Akt Signaling
A new study reveals that delta opioid receptor agonist KNT-127 has a rapid and effective antidepressant effect with minimal side effects. The research highlights the molecular mechanisms underlying its action, including mTOR signaling pathways and Akt activation in the medial prefrontal cortex.
Researchers discovered that CREB3 inhibits hepatocellular carcinoma (HCC) progression by suppressing AKT signaling through interaction with the insulin receptor and transcriptional activation of RBM38. Lower CREB3 expression in HCC tissues was associated with poorer outcomes.
New findings in The American Journal of Pathology indicate that periostin promotes esophageal squamous cell carcinoma progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts. Periostin may be a promising therapeutic target for treating ESCC.
New research led by Johns Hopkins Medicine reveals that age-related changes in fibroblast cells enable pancreatic cancer tumor growth. The study found that older patients have poorer prognoses due to altered proteins released by fibroblasts, which promote cancer cell growth and spread.
In a new study published in Cancer Research, Moffitt researchers reveal how the antitumor activity of PTEN suppresses cancer-promoting activity through the AKT signaling pathway. PTEN's lipid phosphatase activity inhibits melanoma cell proliferation, invasion, and tumor growth.
Researchers found that verapamil prevents the decline of insulin-like growth factor 1 (IGF-1) in Type 1 diabetes patients and promotes IGF-1 signaling in pancreatic beta cells. This mechanism may contribute to the beneficial effects of verapamil on preserving beta-cell function in Type 1 diabetes.
Researchers at Kyoto University found that a poor, low-yeast diet causes fruit flies' larvae to grow dendrites in an unexpected way. The hyperarborization phenotype is triggered by a simultaneous deficiency in vitamins, metal ions, and cholesterol, which increases the production of Wingless signaling molecules from body wall muscle.
ARID1A-deficient bladder cancers are sensitive to combination therapies with the EZH2 inhibitor GSK-126 and inhibitors of PI3K, acting synergistically. The research found that tumors deficient in ARID1A protein have elevated levels of PIK3R3 and phosphoAKT.
Researchers from Tokyo Tech elucidated the molecular evolution of NRK, revealing a novel mechanism regulating placental development by modulating the CK2-PTEN-AKT pathway. The study showed that NRK underwent rapid molecular evolution to acquire its function in eutherian ancestors.
A study by Weill Cornell Medicine scientists found that blocking a signaling pathway in brain immune cells can protect against Alzheimer's disease features in a preclinical model. The results suggest a new strategy to block the development of the disease or slow its progression.
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.
Researchers at University of Wisconsin-Madison discovered a disrupted Akt protein pathway in men with bipolar disorder, leading to memory problems and weakened brain connections. The findings offer a new target for treating bipolar disorder's often-overlooked cognitive impairments.
Research from Baylor College of Medicine reveals that inhibiting MAPK4 can simultaneously activate and inhibit key cellular signaling pathways driving prostate cancer growth, suggesting a novel therapeutic strategy. This approach may provide a more effective treatment for advanced prostate cancer.
A new study by University of South Florida researchers finds that anxiety-like behavior increases when early life adversity combines with high levels of FKBP5, a protein capable of modifying hormonal stress response. High FKBP5 also alters signaling of the enzyme AKT in the dorsal hippocampus, amplifying anxiety.
A study led by the University of Exeter Medical School found that disrupting genes and pathways regulating splicing factors can reverse signs of aging in cells. Disrupting ERK and AKT pathways reduced senescent cells, increasing splicing factors and leading to cellular rejuvenation.
Researchers at Whitehead Institute have developed a gene pathway that enables the growth of brain organoids with surface folding, a key feature of human brain development. The study also shows potential for modeling Zika virus-caused microencephaly and identifying affected cells.
Researchers found that umbilical cord cells activate the Akt signaling pathway, leading to increased expression of antioxidant genes like Prdx5, which reduces inflammation and promotes neural cell survival. This study suggests that umbilical cord cell therapy could be a promising treatment for stroke and other brain injuries.
Research found ginsenoside Rb1 enhances PI3K/Akt and MAPK signaling pathways, promoting neuronal survival and neurite growth in the hippocampus. The study suggests potential anti-dementia effects of ginsenoside Rb1 in Alzheimer's disease.
Researchers from Boston University School of Medicine have identified a mechanism by which specific viruses acting as oncolytic agents can enter and kill cancer cells. By targeting the AKT signaling pathway, VSV is able to switch off a major cell survival signal, leaving cancer cells vulnerable to attack.
Antipsychotic drugs increase Akt signaling in C. elegans, a common effect across major categories of schizophrenia medication. This finding highlights the importance of Akt signaling in schizophrenia and suggests that medications or dietary approaches targeting this pathway may help alleviate symptoms.
Researchers are exploring the PI3-kinase pathway's role in cancer, with studies showing its inhibition can suppress tumor growth and cell survival. The pathway is also involved in angiogenesis, differentiation, and cell growth, making it a critical target for novel therapies.
Researchers at the Montreal Neurological Institute have made a groundbreaking discovery about the parkin gene, which plays a novel role in nerve cell survival. This finding may help identify potential treatment targets for Parkinson's disease and other neurodegenerative disorders.
Researchers have found curcumin to be an effective compound in reducing cell viability and inducing apoptosis in melanoma cell lines. The study reveals that curcumin suppresses specific proteins involved in preventing apoptosis, suggesting its potential as a potent anti-cancer agent.
Researchers at UCSD School of Medicine have discovered a natural tumor suppressor called PHLPP, which can be turned on in certain cancer cells to prevent tumor formation. By deleting a phosphate molecule from the Akt protein, PHLPP terminates cell-growth signaling and promotes programmed cell death.
Researchers at the University of Pennsylvania identified Pim-2 as a critical enzyme in the survival of cancer cells. The study found that Pim-2 operates independently from the Akt pathway, allowing cancer cells to survive even when starved or deprived of growth factors.
Researchers found that NF-kappaB links growth factor signaling with proto-oncogenes Myc, Akt, and Ras. The molecular mechanism regulates cell growth and death, providing a built-in protection against cancer.