Researchers discovered a new epigenetic therapy that remained effective in treatment-resistant acute myeloid leukemia (AML) through activating the Hippo pathway, a tumor-suppressing pathway linked to cancer growth and drug resistance. The therapy, NTX-301, consistently reduced leukemia cell survival more effectively than existing hypom...
A USC Stem Cell mouse study has identified shared genes involved in regenerating cells in the ear and eye, which could lead to new treatments for hearing and vision loss. The researchers discovered that inhibiting a specific protein, p27Kip1, can encourage regeneration in both organs.
Scientists at Sanford Burnham Prebys and Vanderbilt University have identified phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) as a key regulator of the hippo pathway, which is dysregulated in cancer. The study suggests that targeting PI5P4Ks may lead to new treatments for cancers with abnormal hippo signaling.
Researchers discovered GZ17-6.02's ability to interact with proteasome inhibitors in a greater than additive fashion to kill multiple myeloma cells and alone inhibit inhibitor-resistant cells. The compound combination also activated key pathways and increased autophagosome formation, leading to tumor cell killing.
Research discovers key contributors to skin tightening in systemic sclerosis, including myofibroblasts and endothelial cells. Targeting the Hippo signaling pathway shows promise for reversing fibrosis.
Australian researchers at Monash University have discovered a new way that epithelial cells form tissues of the right size and shape by adhering to each other through basal spot junctions. This finding is crucial for understanding human diseases, including cancers, where Hippo signalling plays a key role.
A study published in EMBO Reports reveals that microautophagy is crucial for repairing damaged lysosomes, which helps prevent cellular aging. The researchers identified key regulators of this process, including STK38 and GABARAPs, and found that their depletion increases the rate of senescent cells and shortens lifespan in C. elegans.
Researchers found that a combination of AXL and EGFR inhibitors can suppress tumor growth and prevent relapse in patients with certain cancers. The study clarifies the novel regulatory mechanism by which AXL stimulates YAP via the EGFR-LATS1/2 axis.
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
A new study has found associations between plasma miRNAs and cognitive function among cognitively normal men, including those with higher MMSE scores and slower rates of cognitive decline. These findings suggest that extracellular microRNAs may play a role in the early stages of cognitive decline.
A new study reveals that the Hippo signaling pathway is responsible for forming the body axis in Hydra, a process also controlling tissue growth and morphogenesis. This breakthrough discovery sheds light on the evolutionary origins of the body axis in animals.
Researchers from Boston University School of Medicine demonstrate activation of the Hippo pathway, which restrains the growth of melanocytes and prevents their transformation into melanoma. The study suggests that targeted reactivation of the Hippo pathway could be an attractive therapeutic possibility for treating melanoma.
Hippo signaling pathway's core components YAP and TAZ are activated by EGFR, promoting cell proliferation. Researchers uncover novel target for cancer therapies, combining EGFR targeting with YAP/TAZ inhibition.
Researchers at Baylor College of Medicine have developed a novel gene therapy that shows promise in treating human heart failure. The treatment targets the Hippo signaling pathway, which can inhibit heart repair, and has been shown to improve heart function and promote tissue renewal in pig models after a heart attack.
Chronic pancreatitis is a debilitating disease with poorly understood causative factors. Researchers at Osaka University identified disturbed molecular pathways and revealed underlying mechanisms that may inform effective therapy against the disease.
A fundamental way cells interpret signals from their environment has been revealed by researchers at Johns Hopkins Bloomberg School of Public Health. The Hippo pathway, which constrains cell division and regulates organ size, can be activated by multiple signaling inputs.
A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation. Bone morphogenetic factor 6, BMP6, is shown to regulate blood vessel formation via vascular endothelial growth factor receptor 2 (VEGFR2) and Hippo signalling pathway.
A new study from Scripps Research reveals that the protein YAP plays a dual role in regulating cell growth, both promoting and inhibiting proliferation. This finding has significant implications for understanding cancer behavior and developing targeted therapies.
Scientists uncover how lymph nodes' development is controlled by the Hippo pathway, shedding light on their role in regulating immune responses. The research found that impaired Hippo signaling can lead to fibrosis or transformation of fat cells, highlighting potential therapeutic targets for diseases affecting systemic immunity.
Researchers at Baylor College of Medicine discovered that inactivating the Hippo pathway in cardiac fibroblasts promotes cardiac fibrosis and adversely affects cardiac function. This finding highlights the need for specific targeting of the Hippo pathway in cardiac muscle cells for safe and effective heart failure therapy.
Researchers have identified a cellular mechanism that prevents retinal regeneration in mammals, but allows for regeneration in zebrafish. By manipulating this pathway, it may be possible to restore lost vision by activating the retina's regenerative capacity.
A new study has discovered that the enzyme STK25 regulates Hippo signaling in a novel manner, leading to its deregulation in human cancers. This finding may enable the development of new anticancer therapeutic options.
Breast cancer cells exploit the FGFR4 receptor to regulate growth and prevent programmed cell death. Targeting this vulnerability with combination therapies shows promise for improving treatment outcomes.
A team of researchers at Boston Children's Hospital has identified NUAK2 as a critical player in the Hippo pathway, which drives YAP-driven tumors. Inactivating NUAK2 with a small molecule compound strongly curbs cancer cell proliferation and liver overgrowth.
Researchers identified Sav1, a component of the Hippo pathway, as a key mutated gene in fatty liver-associated liver cancer. This discovery may lead to new liver cancer treatments targeting the Hippo pathway.
Researchers discovered the Hippo pathway is essential for normal heart and blood vessel development. The study used single cell transcriptomics to analyze thousands of cells from developing heart tissue, revealing new insights into cellular and molecular processes leading to an adult heart.
A study published in Nature reveals a previously unknown connection between pathways that prevent heart cell renewal. The discovery opens the possibility of developing strategies to promote heart cell growth and regeneration. This finding may also lead to improved cardiac function in children with muscular dystrophy.
Researchers have identified a parallel pathway controlling organ size in fruit fly models, activating at a newly recognized cellular domain. The Hippo signaling pathway plays a critical role in regulating cell function and tissue growth.
Researchers have discovered a signaling pathway in cardiac tissue that helps control inflammatory responses after a heart attack. Activating the Hippo pathway leads to the recruitment of T regulatory cells, which reduce inflammation and promote tissue healing in mice with heart injury.
A new study by University of California San Diego School of Medicine scientists discovered the Hippo pathway's unexpected function in subduing cancer immunity. Deleting LATS1/2 from mouse cancer cells enhanced anti-tumor immune responses, suggesting a potential therapeutic approach to improve immunotherapy efficiency.
Biologists at Johannes Gutenberg University Mainz discovered that the Hippo signaling pathway controls quiescence in Drosophila neural stem cells, regulating growth and cell division. The pathway's activation is necessary to maintain resting phases and prevent premature cell formation.
Researchers found that Hippo signaling pathway activates immune response to combat gram-positive bacteria, linked to organ growth control
Scientists found that abnormal growth in fruit fly tumors depends on ecdysone, a steroid hormone similar to estrogen. This discovery may have implications for studying cancer stem cells and proliferative mechanisms in human cancers.
Researchers at UC San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway that maintains cellular balance by controlling cell growth and promoting cell death. This finding has significant implications for understanding cancer development and potential therapeutic targets.
A molecular pathway permits stem cells to grow rapidly and aggressively in pediatric bone cancers, according to researchers at NYU Langone Health. The transcription factor Sox2 releases the floodgates in the Hippo pathway, allowing for the growth of highly aggressive tumor-forming stem cells.
Scientists at MD Anderson Cancer Center discovered a vital connection between the Hippo pathway and glucose metabolism, which can be manipulated to regulate tumor growth. The study found that regulating blood sugar levels impacts the nutrient source of tumors, ultimately leading to cancer suppression.
Scientists discovered that the Hippo pathway, a tumor suppressor pathway, senses abnormal chromosome numbers in cells and triggers cell cycle arrest. This pathway prevents progression into cancer by halting the proliferation of tetraploid cells with double the number of chromosomes.
Researchers at Stanford University School of Medicine have developed a technique that induces egg growth in some infertile women, allowing five of them to produce viable eggs for in vitro fertilization. The successful pregnancy and birth represent a breakthrough for women with primary ovarian insufficiency, who often rely on egg donation.
Duojia Pan received the Paul Marks Prize for Cancer Research for his groundbreaking work on cell signaling pathways and organ growth. His research has led to a deeper understanding of the Hippo pathway, which regulates tissue growth in animals.
Researchers have identified a novel component, Par-1, of the Hippo signaling pathway, which influences Hippo protein phosphorylation and regulates organ growth. The study found that Par-1 negatively regulates Hippo kinase activity, promoting apoptosis and reducing tissue growth.
Researchers at UBC have discovered that methylation of a protein called Yap is critical for the function of the Hippo pathway. Loss of the Set7 enzyme resulted in cell growth and larger organs, suggesting potential for drugs to activate this pathway to stop cancer cell growth.
Researchers investigated intravaginal immunization and its potential to enhance local immune systems against sexually-transmitted diseases. Additionally, a study on HERV-targeted immune responses found that targeting cellular immune responses could eliminate HIV-infected cells.
Johns Hopkins researchers discovered a cellular mechanism driving meningioma growth and progression. The study identified the activation of YAP1 protein in nuclei as a crucial step in tumorigenesis, suggesting new treatment targets.
Researchers at Instituto Gulbenkian de Ciência found that the actin-capping protein regulates the Hippo complex, leading to abnormal growth and tumour formation. The study provides insights into understanding proliferation gene activation in cancer research.
A protein called Kibra has been found to regulate organ size by controlling cell growth and death. This discovery may hold the key to understanding and treating cancer.
Researchers discovered that the Hippo signaling pathway regulates vertebrate neural development by controlling cell growth and differentiation. The study identified a new transcription factor protein, TEA domain (TEAD), as the cognate partner of YAP in the nucleus.
A recent study published in Cell describes a chemical chain reaction, known as the Hippo pathway, that controls organ growth and may contribute to cancer. The researchers found that this pathway is altered in 20-30% of human cancer cells, suggesting a potential new target for cancer therapy.
Researchers at EMBL have identified a microRNA called bantam as the key regulator of the Hippo signaling pathway, which controls cell division and death. Without bantam, tissues grow too slowly and remain smaller than normal.
A protein called Yorkie controls organ size in fruit flies and, when overabundant, causes increased cell growth and cancer. In humans, a defect in the gene that makes YAP may contribute to cancer.