News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
A new study from Wake Forest University School of Medicine found that changes in the gut microbiome significantly impact cocaine use and cravings after withdrawal. The researchers discovered that a depleted microbiome led to increased cocaine-seeking behavior and altered neurobiological markers in reward-related brain structures.
Researchers found that blocking dopamine transporters during mid-adolescence increases adult aggression, impulsivity, and the behavioral response to amphetamine in mice. Artificially stimulating dopaminergic neurons also exacerbated impulsive behavior in tasks. The study suggests potential harm from stimulant exposure in healthy teens ...
Researchers discovered that stimulating dopamine neurons in mice's midbrain triggers orofacial movements, which are linked to brain-wide neuronal activities. The study identified two distinct orofacial movements: transient actions upon reward expectation and active, sustained movements upon receiving a reward.
Researchers propose disease-oriented dosing of rapamycin to delay age-related diseases and increase lifespan. By decelerating early development of these diseases, rapamycin may help individuals live longer.
A study published in PLOS ONE found a significant surge in bird feeding interest worldwide during the pandemic, with countries having higher bird diversity exhibiting more Google search activity. The researchers analyzed data from 115 countries and found an average increase of 511 bird species in countries with higher search interest.
Sea urchins struggle to 'get a grip' as climate change causes lower salinity levels, affecting their ability to attach to surfaces. The study found that low salinity conditions negatively impact righting response, movement, and adhesive ability.
A team of scientists has successfully elucidated the structure and function of LITE-1, a biomolecule used by Caenorhabditis elegans to detect danger. The researchers used artificial intelligence to predict the structure of LITE-1, which is a channel protein that forms a pore in the cell membrane allowing charged particles to pass through.
Researchers aim to treat pancreatic ductal adenocarcinoma by targeting amino acid transporter SLC6A14 and compensatory nutrient scavenging mechanisms autophagy and macropinocytosis. Using alpha-methyl-L-tryptophan and hydroxychlorquine, the study seeks to improve therapeutic outcomes in patients with pancreatic cancer.
Researchers found that invasive red swamp crayfish populations in Japan developed genetic changes enhancing cold resistance, including changes in the protective outer layer and peptidase inhibitors. These findings provide insights into molecular mechanisms of invasive species and may have potential medical applications.
Researchers developed a novel maze design that allows for the tracking of mice's navigational strategies, revealing three primary approaches: random, spatial, and serial search. The study provides valuable insights into how animals select these strategies based on environmental factors.
A recent study published in Nature Mental Health emphasizes the need for further research on sex differences in depression. The study, led by Georgia Hodes and Dawson Kropp, aims to uncover effective and sex-specific biomarkers for depression onset and target better treatment options.
Researchers at North Carolina State University identified a specific blend of pheromone chemicals used by male moths during courtship, including an aphrodisiac called methyl salicylate. Female moths can recognize this chemical through two smell receptors, and its presence in males' hairpencils is linked to mating success.
A new study led by UNSW Sydney reveals the pygmy right whale's behavior is quite different from its larger relatives, with no long-distance migrations to Antarctic waters. The whales instead remain in mid-latitude waters off southern Australia, feeding on krill and copepods throughout the year.
Researchers have identified a genetic cause for virgin birth in female flies, allowing them to reproduce without males. The ability is passed down through generations of females and can be induced in an animal that usually reproduces sexually.
A study published in Neuron found that a structure in rat brains called the periaqueductal gray is essential for play and laughter. The researchers used tickling to simulate playful environments and measured brain activity, finding strong neural responses to both tickling and playing.
Researchers found that Period 1 gene becomes more active in memory-forming region of brain in daylight hours after learning, playing crucial role in consolidating memories. Mice exhibit improved daytime memory performance compared to nighttime.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
Researchers from IU School of Medicine have diagnosed a Sumatran Orangutan named Mila at the Indianapolis Zoo with Alkaptonuria, a rare autosomal recessive disorder. The diagnosis was confirmed through molecular analysis of DNA, providing veterinarians with crucial information on Mila's health and treatment options.
Researchers at the University of Copenhagen used a new method to collect airborne DNA particles and found evidence of 64 different animal species in a single football field-sized area. The findings suggest that this technique could be a valuable tool for monitoring biodiversity and tracking the spread of diseases.
A study found that pdm09 influenza A virus has crossed from humans to swine nearly 370 times since 2009, resulting in evolutionary changes and potential for zoonotic transmission. The analysis suggests managing human infection can help prevent pig-to-human transmission.
A University of Maryland study found that tree species diversity increases spider populations, providing a natural pest regulation service. Spider populations in diverse plots increased by 23-50% compared to single-species plots during late summer months.
Researchers found that nearly all Purkinje cells in the human cerebellum have multiple primary dendrites, which contradicts the traditional understanding of a one-to-one relationship between climbing fibers and Purkinje cells. This discovery was made possible by analyzing thousands of cells from both human and mouse tissue using immuno...
Under warming temperatures, lizards may skip over potential mates to quickly choose a partner. Researchers found this behavior in a social lizard species due to environmental changes.
A new study led by UCL researchers found that Caenorhabditis elegans' lifespan is limited by its reproductive self-destruction. The finding raises questions about the validity of insights from this model organism for human ageing advances.
A new study suggests that replacing traditional protein sources with mealworms in high-fat diets can slow weight gain and improve immune response, inflammation, energy metabolism, and cholesterol profiles. Mealworm protein also beneficially alters the ratio of good to bad cholesterol.
Researchers found that aphid-infested tropical milkweed is less inviting to monarch butterflies, with reduced egg-laying and slower caterpillar development. Aphid-free plants, on the other hand, provide a better chance for monarchs to thrive.
Researchers have identified podoplanin as a key protein driving the spread of mucosal melanoma, a rare and aggressive form of skin cancer. Eliminating this protein could lead to a potential treatment through antibody therapy, offering hope for patients with this devastating disease.
A new study suggests that Arctic terns, which fly on the longest migrations of any animal, may be resilient to climate change due to their vast habitats. However, researchers warn that multiple small effects could harm this long-lived species and other species unable to adapt.
A recent study analyzing over 2 million UK dogs found that mixed-breed, Labrador retrievers, and Jack Russell terriers are the most common breeds. Meanwhile, flat-faced breeds like French bulldogs and pugs increased health risks, with predictions of a canine healthcare crisis in the UK.
Researchers found that Korean Red Ginseng (KRG) can restore spatial working memory and reduce withdrawal symptoms in mice exposed to alcohol. KRG suppresses the PKA-CREB signaling pathway and inhibits neuroinflammation, suggesting its potential as a novel therapeutic intervention for treating alcohol use disorder.
Biologists found that glyphosate impairs aversive learning in bumblebees, reducing their ability to associate threats with visual cues. This impairment could increase mortality rates and impact colony success.
Researchers discovered that adult and aged mice demonstrated improved performance in behavioral tasks after environmental enrichment, with MSK1 playing a vital role. The study highlights the importance of MSK1 in converting positive experiences into cognitive benefits across the lifespan.
A new species of marine cryptofauna, Gnathia jimmybuffetti, was discovered in the Florida Keys. The roughly three-millimeter-long isopod has been characterized using photomicrographs and genetic sequencing, providing valuable insights into coral reef biodiversity and parasite impact.
In a study published in Animal Behaviour, researchers found that male field crickets adjust their song patterns based on the proximity of rivals. When another cricket is within one meter, males are less likely to sing, suggesting they prioritize territorial defense over courtship displays.
A study from Konstanz and Baltimore reveals that around 4.2 million animals have been used for hazard assessment under REACH, with many more expected due to a 2022 revision. Animal-free alternative methods are advocated by researchers, who argue that they provide more meaningful results than animal testing.
Researchers found that post-menopause females have lower incidence of tooth marks in their social unit, implying they may be protecting their sons from conflict. This suggests a new pathway for the adaptability of menopause in killer whales.
A new study reveals that reptiles demonstrate spontaneous associations between visual and auditory information, including tortoises associating low sounds with large shapes and high pitch sounds with small shapes. This discovery shows how brains are prepared to predict visuo-acoustic correspondences likely to occur in the natural world.
A study published in Science reveals that ganglia in the neck region are responsible for disrupting melatonin production and causing sleep disturbances in people with heart conditions. Researchers found that macrophages accumulate in the ganglion, leading to inflammation and scarring, which can be treated with drugs.
New research shows that post-menopause female killer whales protect their sons from fights with other whales, reducing the incidence of socially inflicted injuries. This unique behavior suggests that females prioritize helping their male offspring, who have more genetic potential for passing on their mother's genes.
Scientists discovered two peptides in fruit flies that specifically target common bacteria, showing how the immune system evolves to combat threats. This research provides insights into human susceptibility to infections and may lead to new approaches to fighting antibiotic-resistant infections.
A new study highlights the diverse impact of climate change on animal welfare across five domains: nutrition, environment, behaviour, physical and mental health. The review examines how animals respond to stress and provides a tool for researchers to evaluate the effects of climatic variability.
Researchers found significant relationships between the cows' genetic merit and their calves' performance. The genomic prediction tool allowed farmers to make informed decisions that enhance sustainable profitability.
Researchers at the Max Delbrück Center have identified a potential new biomarker for Alzheimer's disease, protein Arl8b. The study found that patients with Alzheimer's have significantly more Arl8b in their cerebrospinal fluid than healthy controls.
A study by Kyoto University found that Daphnia's phenotypic plasticity is strongly related to its body size and the type of predator. Medium-sized Daphnia are more vulnerable to predation by both Chaoborus larvae and fish, which prefer larger prey.
Researchers reveal a crucial link between DNA copy number and autophagy in embryonic development. High levels of autophagy are observed in cells with multiple copies of DNA, which can lead to programmed cell death.
A review of animal evolution in response to fire may help inform conservation strategies, as changing fire regimes impact species. By analyzing nearly 100 papers, the authors identified various adaptations, such as infrared sensory pits and behavioral changes, that enable animals to survive fires.
The digitization of Johanna Bonne-Wepster's field notes has filled significant gaps in mosquito research and tropical medicine. The collection contains valuable information on vector-borne diseases and their spread, which can inform current public health issues and future disease modeling.
Two species of hairworms are missing genes responsible for producing cilia, a feature present in all other known animals. This loss likely occurred early in the evolution of the group and may impact their parasitic behavior, but its exact effects remain unclear.
A new study found that the unique oceanographic conditions in Florida's Dry Tortugas National Park provide the ideal environment for elkhorn coral to flourish, with enhanced growth and survivorship. The research highlights the importance of food availability, particularly zooplankton, for coral survival and restoration efforts.
Research reveals e-cigarettes carry potential health risks, including increased blood pressure and heart rate. Long-term studies are needed to fully understand the effects of e-cigarette use on the heart and lungs.
The BioRescue project has made significant progress in creating cryopreserved northern white rhino embryos, with a recent collection yielding five new embryos. The consortium is also identifying and selecting wild southern white rhino females as potential surrogate mothers to support the breeding efforts.
A study reveals high levels of insecticide resistance among Aedes aegypti populations in Dhaka, compromising mosquito control and increasing dengue burden. Researchers recommend non-insecticidal approaches, such as Wolbachia-infected mosquitoes, to effectively manage dengue vectors.
Researchers found a 43% drop in fish and shrimp density around the mining zone and a 56% decrease in surrounding areas. The study suggests that sediment plumes from deep-sea mining can contaminate food sources for ocean animals.
Researchers have discovered a new mechanism underlying the neuroprotective effects of physical activity on Parkinson's disease. Intensive exercise has been shown to slow disease progression by restoring striatal synaptic plasticity and improving dopamine release, leading to better motor control and visuospatial learning.
Researchers found that fruit flies prefer larger quantities, but struggle to distinguish between 3 and 4 objects, highlighting the importance of ratio perception. LC11 neurons are essential for comparing quantities in fruit flies.
Researchers used wearable sensors and automatic feeders to monitor dairy calves and identify behavioral changes indicative of bovine respiratory disease. The approach achieved an accuracy of 88% in labeling sick and healthy calves, with 70% of sick calves predicted four days prior to diagnosis.
A new study published in Human-Animal Interactions suggests that owning pets does not significantly improve the wellbeing, depression, anxiety, or loneliness scores of individuals with severe mental illnesses. Researchers found a strong human-animal bond among pet owners, but no significant benefits to their mental health.
Researchers at Georgetown University Medical Center discovered the biological mechanism of TTP488, an experimental drug that impairs aggressive triple-negative breast cancer from metastasizing. The finding enables clinical trials to explore the drug's effectiveness in preventing TNBCs from spreading, offering new hope for patients with...
Scientists found that cooling or warming the striatum region slows down or speeds up activity patterns, which correlates with rats' timing judgements. This provides evidence for the 'population clock hypothesis', suggesting that brains use decentralized and flexible sense of time.
Researchers have identified 30 basic units of 'synteny' that exist in all butterflies and moths, dating back to their common ancestor with caddisflies. This study improves understanding of chromosome evolution in Lepidoptera and may provide insights into other animal or plant groups.