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Gene analysis generates spatial map of intestinal cells and traces their trajectories during gut inflammation

A new study using spatial transcriptomics has generated a unique spatial atlas of intestinal cells in both healthy and inflamed states. The research reveals the evolution of cell populations during inflammation, particularly highlighting the significance of fibroblasts in response to gut inflammation.

SourceBrigham and Women's Hospital·JournalCell·TypeExperimental study·DateApr 2, 2024

Collaborative University of Cincinnati Cancer Center team opens Phase 2 brain tumor trial

The University of Cincinnati Cancer Center team has opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas, a deadly form of brain tumors. The treatment uses letrozole, a drug that targets an enzyme present in breast cancer cells, and temozolomide, a chemotherapy drug already approved as a GBM treatment.

SourceUniversity of Cincinnati·JournalClinical Cancer Research·TypeRandomized controlled/clinical trial·DateMar 26, 2024

Collaboration between medical department staff and their IT colleagues on an EHR optimization project leads to improved productivity

A four-month department-wide EHR optimization project led to improved usability and reduced administrative burdens. The study demonstrates that successful EHR workflow optimization is possible at the departmental level through ongoing collaboration between EHR users and IT colleagues.

SourceAmerican Academy of Family Physicians·JournalThe Annals of Family Medicine·DateMar 25, 2024

Rehabilitative reform

University of Missouri researcher Kelli Canada is using a $2.8 million grant to transform prison conditions in four Missouri prisons. Her multi-pronged mission includes staff training, physical space changes, skill building for residents, and community connections.

Overeating and starving both damage the liver: Cavefish provide new insight into fatty liver disease

Researchers have identified a gene responsible for the development of starvation-induced fatty liver in cavefish, which are able to protect their liver due to reduced fat accumulation. This genetic basis has implications for understanding and addressing liver conditions in humans, including Type 2 diabetes and obesity.

SourceStowers Institute for Medical Research·JournalLife Science Alliance·TypeExperimental study·DateMar 18, 2024

Shedding new light on brain calcification

Researchers at the University of Bergen have identified a new gene linked to primary familial brain calcification (PFBC), a rare neurodegenerative condition. The discovery provides new insight into how brain calcifications occur and may help explain the development of dementia.

SourceThe University of Bergen·JournalNature Communications·DateMar 14, 2024

A breakthrough in all-solid-state battery technology, enhancing the performance of the lithium from the bottom

A research team developed an anode protection layer to prevent random electrodeposition of lithium, promoting stable 'bottom electrodeposition' and reducing unnecessary consumption. The breakthrough results in all-solid-state batteries with stable electrochemical performance over extended periods using ultrathin lithium metal anodes.

The dangers of misaligned product co-development contracts—and how they can derail innovation in high-tech firms

Researchers found that firms with mismatched positioning strategies, functional capabilities, and governance modes experience reduced innovation outcomes. Strong marketing capabilities are associated with increased innovation performance in joint development agreements for high differentiation-oriented firms.

SourceAmerican Marketing Association·JournalJournal of Marketing·DateMar 5, 2024

New study unveils scalable and efficient photoelectrode modules for green hydrogen production

Researchers at UNIST have developed a scalable and efficient photoelectrode module for green hydrogen production, overcoming challenges of efficiency, stability, and scalability. The team's innovative approach achieved unprecedented efficiency, durability, and scalability in producing green hydrogen using solar energy.

The severity of the disturbance plays a pivotal role in determining the long-term recovery dynamics after an industrial disaster

A 10-year study monitored the recovery of macroinvertebrate communities after a red sludge disaster in Hungary, finding that severe disturbances hinder long-term recovery. Community recovery dynamics were found to vary with disturbance severity.

SourceHun-Ren Ökológiai Kutatóközpont·JournalScience of The Total Environment·TypeObservational study·DateFeb 22, 2024

UT Health Science Center researchers partner on multi-institutional $20 million award to develop new radiopharmaceutical cancer therapies

Researchers at UT Health Science Center, in collaboration with Oak Ridge National Laboratory and the University of Tennessee, Knoxville, will develop new radiopharmaceutical therapies to treat cancer. The team aims to advance precision cancer treatment using targeted alpha-emitting radioisotope constructs.

Nanoscale manipulation of exciton–trion interconversion in a MoSe2 monolayer via tip-enhanced cavity-spectroscopy

Researchers have developed a novel 'nano active control platform' to control excitons and trions, providing valuable insights into the optical properties of two-dimensional semiconductors. The breakthrough discovery enables real-time analysis of nano-light properties with exceptional spatial resolution.

New water batteries stay cool under pressure

A global team of researchers has invented recyclable water batteries that don't catch fire or explode, addressing safety concerns in lithium-ion technology. The batteries use abundant materials like magnesium and zinc, reducing manufacturing costs and environmental risks.

SourceRMIT University·JournalAdvanced Materials·TypeExperimental study·DateFeb 21, 2024

Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer

A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...

SourceUniversity of Ottawa·JournalNature Cancer·TypeMeta-analysis·DateFeb 13, 2024

New study finds life on land is more vulnerable to mass extinctions than life in the oceans and takes longer to recover

A new study published in Proceedings of the Royal Society B found that the end-Triassic extinction had a greater impact on terrestrial ecosystems than marine ecosystems. Terrestrial ecosystems took longer to recover from mass extinction events, with higher extinction severity and fewer groups occupying key ecological roles.

SourceNatural History Museum of Los Angeles County·JournalProceedings of the Royal Society B Biological Sciences·TypeData/statistical analysis·DateFeb 12, 2024