The Protein Data Bank (PDB) is celebrating 50 years of sharing scientific knowledge, with millions of users accessing its data for fundamental biology, energy, and biomedicine. The event highlights the PDB's role in understanding protein folding, including SARS-CoV-2, and structural biology's impact on medicine and drug discovery.
A new study by Simon Fraser University finds that ancient Indigenous-managed forests, or
A new species of deep-sea dumbo octopus has been identified using a combination of non-invasive and minimally invasive techniques. The study utilized MRI, micro-CT, and gene analysis to gather morphological and molecular information on the specimen without causing harm.
The NRG-BR001 trial found SBRT to be safe for patients with multiple metastases, with no dose-limiting toxicities and over 50% of participants alive at 2 years. The study used extensive radiation QA processes and was the first to require 3D image guidance during treatment.
A new study published in Astrobiology finds that Martian meteorites contain the necessary ingredients to support microbial life, including water and radioactive elements. The researchers believe that wherever there's groundwater on Mars, there's a good chance of finding habitable environments for subsurface microbial life.
Researchers at Northwestern University have discovered a new biomanufacturing platform that can increase protein-based vaccine yields by five-fold and reduce production costs to $1 per dose. The technology utilizes enriched cell-free extracts with cellular membranes, significantly broadening access to potentially lifesaving medicines.
Researchers at University of Helsinki and Aalto University created an AI model that can predict T cell targets for previously unmapped viruses, including COVID-19. The model helps understand how T cells identify their targets using a key-lock principle.
A case series reports acute ischemic stroke incidence in male patients aged 50 years or younger during the convalescent phase of COVID-19. Risk factors and features of the stroke are also discussed in detail.
Researchers are using 3D printed models to study ground motion after earthquakes, providing a novel platform for seismic experiments. The models replicate complex topographical features and allow scientists to simulate how seismic waves interact with the Earth's surface.
Salk researchers have traced the development of spinal cord neurons using genetic signatures, revealing new ways of classifying and tagging subsets of cells. The findings offer a precise way to study the function of spinal cord neurons and their role in regulating body movements.
A major study reveals COVID-19 survivors have an almost 60% increased risk of death over six months compared to the general population. The research catalogued numerous diseases associated with long-term complications of COVID-19, pointing to a massive health burden.
Researchers successfully generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. The study provides strong evidence that the system is a good model for studying early embryo development, shedding light on the mechanisms of totipotency and the causes of early pregnancy loss.
A synthetic DNA vaccine for MERS-CoV induced robust antibody neutralizing antibodies and cellular immune responses, protecting against MERS-CoV in NHP models. The low-dose regimen with intradermal delivery was more impactful in controlling disease than the higher dose delivered intramuscularly.
Researchers used engineering tools to investigate the pelvic floor hypothesis, which states that trade-offs exist between supporting childbirth and protecting organs. A larger pelvic floor would facilitate easier childbirth but risk deforming under weight, causing organs to fall downward.
Nagoya University researchers discovered a molecular pathway that enhances chemotherapy resistance in some pancreatic cancer patients. Targeting the taurine upregulating gene 1 (TUG1) RNA could improve patient response to therapy and increase overall survival.
Researchers used asteroseismology to measure the spin of older stars, finding they rotate faster than predicted by magnetic braking theories. The study provides new insights into the weakening effects of magnetic braking on older stars.
A UT Southwestern Medical Center review of Texas Cancer Registry data found that Black and Hispanic patients under 40 with cancer have lower survival rates compared to their white counterparts. The study also showed that poverty and lack of insurance coverage exacerbate these disparities.
Researchers from Sandia National Laboratories used 22-foot-wide tethered balloons to collect dust samples, confirming the new solar-power technology's safety. The technology stores heat in heated particles, which can store energy for days or weeks, stabilizing power output.
A new type of plastic, poly(diketoenamine), can be recycled indefinitely without losing quality, offering a sustainable alternative to traditional plastics. The material's production and recycling processes are designed to be inexpensive and energy-efficient, making it commercially competitive with conventional plastics.
A new study found that people's mobility declined sharply in March and April but quickly recovered to pre-pandemic levels from April through June. However, during the second wave, there was very little change in mobility despite the pandemic becoming more severe.
In a survey of 1,062 adults aged 45-75, most preferred fecal immunochemical tests (FIT/FOBT) or multitarget stool DNA (mt-sDNA) over colonoscopy. The preference for mt-sDNA was higher among younger age groups and non-Hispanic white individuals, while older adults and minority groups preferred colonoscopy.
Researchers at Rice University reveal a two-step process by which silver ions are released from nanoparticles, with the possibility of stabilizing the alloy through gold manipulation. The discovery could lead to the development of new catalysts and materials for various applications.
A study found that babies born to mothers with cannabis use disorder were more likely to experience negative health outcomes, including preterm birth and low birth weight. Infants born to these mothers were also at a higher risk of infant mortality.
The Duchenne Regulatory Science Consortium (D-RSC) database will share individual-level data with qualified researchers to accelerate therapy development for Duchenne muscular dystrophy. The database includes data from clinical trials and natural history studies, and is fully de-identified to ensure participant anonymity.
Two Norwegian University of Science and Technology professors have been awarded prestigious ERC Advanced Grants. The grants will fund research on mobile robots with advanced chemistry, providing up to NOK 25 million in support over five years.
A study investigated racial/ethnic representation in ophthalmology drug trials approved by the FDA. It found significant disparities, highlighting a need for increased diversity in clinical trial participation.
A new mitochondrial peptide called MOCCI regulates inflammation of blood vessels and immunity after viral infection. Researchers discovered that MOCCI dampens the activity of Complex IV in mitochondria to reduce inflammation.
As fish shift to deeper waters, they may face challenges distinguishing colors, affecting mating, prey location and predator avoidance. Climate change is likely to exacerbate this issue, particularly for species unable to relocate to cooler areas.
Researchers discovered early flocks of domesticated sheep in the Iberian Peninsula fed and reproduced on a controlled diet, with births occurring outside optimal seasons. This study reveals significant advances in animal husbandry during the Neolithic period.
Astronomers have released a new all-sky map of the Milky Way's outer halo, revealing a massive reservoir of dark matter. The map also shows a wake of stars stirred up by the Large Magellanic Cloud, set to collide with the Milky Way in about 2 billion years.
A global phase 3 clinical study confirms the effectiveness of targeted antibody drug conjugates against refractory metastatic triple-negative breast cancer. The ADC drug sacituzumab govitecan delivered a high dose of a cancer-killing drug to tumor cells, improving progression-free and overall survival.
Researchers developed a unique identification system using a 3D printer's hot end, allowing for accurate tracking of intellectual property and security threats. The 'ThermoTag' method compares the printing process to a human fingerprint, enabling precise identification of printer models.
New research reveals that people with hearing impairment experience abnormal binaural pitch fusion, which can lead to sound blending together and difficulties with understanding speech in noisy environments. This discovery suggests the possibility of targeted rehabilitation strategies to improve speech perception in noise.
A new study found an aggregation site of great white sharks in the Gulf of California, with estimated mortality rates potentially three times higher than previously thought. This discovery raises concerns about conservation efforts and highlights opportunities for sustainable eco-tourism.
Astronomers have discovered a pulsar, a dense and rapidly spinning neutron star sending radio waves into the cosmos. The finding is significant as it hints at a large population of pulsars awaiting discovery in the Southern Hemisphere, with the potential to be detected by the Square Kilometre Array telescope.
Researchers at UC Berkeley have developed a method to make biodegradable plastics break down easily in weeks, solving the problem of single-use plastics not being biodegradable. The process involves embedding polyester-eating enzymes in the plastic, which degrades into small molecules when exposed to heat and water.
Scientists studied how many bubbles form in beer when poured into a glass. They estimated between 200,000 and 2 million bubbles can be released from a half-pint of lager before it goes flat.
Researchers are developing new conditioning therapies with fewer side effects, targeting specific proteins on hematopoietic stem cells to make room for healthy ones. This could lead to more patients being able to safely undergo stem cell treatments, reducing complications and improving outcomes.
An international team of scientists has identified 267 genes linked to creativity that differentiate Homo sapiens from Neanderthals, suggesting this genetic difference enabled humans to replace them. These genes are also associated with superior adaptation to the environment, resilience to ageing and disease, and greater physical fitness.
Researchers have developed an enzyme-activated compostable plastic that can break down into its building blocks and be reformed into a new product. This innovative material has the potential to diminish microplastics pollution and offers a promising solution for plastics upcycling.
A new study found that short-term exposure to hazardous air quality from wildfire smoke can harm skin health, particularly for those with eczema. The research, conducted during the Camp Fire in 2018, saw a significant increase in patients visiting clinics with concerns of eczema and general itch.
An analysis of US school shootings between 1990 and 2017 found that following a shooting, the risk of additional incidents in the same and neighboring states increases significantly. The study suggests that media coverage can minimize the risk of provoking further shootings by finding a balance between reporting on these events.
Researchers at Linköping University developed a stable, high-conductivity n-type polymeric ink, known as BBL:PEI. This breakthrough paves the way for innovative printed electronics with improved energy efficiency. The new ink is eco-friendly and can be deposited using a simple spraying process.
A survey of 6,894 pregnant and postpartum women in 64 countries found that a substantial number scored high for symptoms of anxiety, depression, loneliness, and post-traumatic stress in relation to COVID-19. High information seeking from any source was associated with increased odds of elevated post-traumatic stress and anxiety/depress...
Researchers developed a hybrid material that effectively transports protons at high temperatures and humidity, solving a major challenge in proton-based fuel cell technology. The material demonstrated high proton conductivity at 368 degrees Kelvin and 50% humidity.
A new study from Ohio State University reveals that women with high-risk profiles struggle to access genetic counseling and testing due to financial constraints. The research emphasizes the need for greater transparency in healthcare pricing and policies to eliminate barriers to early cancer detection.
Researchers have successfully altered feeding and anxiety-like behaviors linked to anorexia in mice by targeting the MC3R receptor. The study suggests that fine-tuning the receptor's activity could help change feeding habits and promote weight gain in patients with eating disorders, offering a potential new treatment for anorexia.
A study found that women with a history of migraine before menopause are at a 29% higher risk of developing high blood pressure after menopause. This association was observed even among those without aura and could be linked to early signs of arterial stiffness.
Researchers from Northwestern University develop technology allowing microbes to produce drugs with self-regulating feedback control systems, improving reaction conditions and product yield. The innovation has vast implications for producing other drugs and products, potentially making therapeutics more accessible.
Researchers found that kiwi populations differ genetically between areas, but lack understanding of local adaptations and breeding changes. The study emphasizes the importance of strategic sample regimes and informative markers for developing effective conservation policies.
Researchers analyzed tooth remains from Middle Neolithic to Late Bronze Age populations in the Great Hungarian Plain, revealing less abrasive and processed foods during this period. The study combines stable isotope and dental microwear analyses, providing new data on ancestral diets.
Osaka University researchers report a stable and reusable nickel phosphide nanoalloy catalyst that achieves high activity and selectivity in the selective hydrogenation of maltose to maltitol. The catalyst's cooperation with its support enhances performance, allowing for efficient production of this sugar alcohol.
Researchers at Toyohashi University of Technology developed a virtual walking system that induces illusory walking sensations without actual limb movement. The system combines a head-mounted display, four vibrators, and a walking-avatar to simulate footsteps.
Research reveals that submarine volcanic eruptions can release massive amounts of energy, enough to power the whole US, by forming megaplumes and dispersing ash. The study suggests that these eruptions lead to rapid emptying of hot fluid reservoirs within the earth's crust.
A new study uses a citizen science approach and AI to analyze vast amounts of 3D coral reef imagery, providing insights into the health of coral ecosystems. The NeMO-Net video game harnesses the power of citizen scientists to generate training datasets and classify coral species.
A new study suggests that microplastic ingestion by zooplankton can significantly affect the marine ecosystem's nutrient cycling and oxygen levels. Even low concentrations of microplastics can lead to a strong impact on ecosystems.
Researchers at MUSC developed an AI software to predict CAD blockages' significance without catheterization. The software analyzes CT images of heart vessels and plaques, estimating blood flow and identifying high-risk features. This noninvasive method saves time, costs, and risks for patients and clinicians.
Researchers identified two dietary patterns associated with an increased risk of cardiovascular disease and death in middle-age. The first pattern includes high intakes of chocolate, confectionary, butter, and white bread, while the second is characterized by high sugar-sweetened beverages, fruit juice, and preserves.
Researchers developed a fluorescent polymer that binds to blood in fingerprints without damaging DNA, creating high-contrast images on various surfaces. This technology enhances the detection of invisible bloody prints, critical for forensic evidence analysis.
A new study by Massachusetts General Hospital researchers finds that a proposed law to regulate high-risk diagnostic tests could increase US healthcare costs by $565 million to $1.1 billion over a three-year period, depending on stringency of enforcement.