Researchers developed a gel that temporarily houses cytokines and CAR-T cells near tumors, enhancing their attack power. The gel enables continuous release of activated CAR-T cells, effectively treating solid tumors.
Researchers used network science to distinguish between viruses that can infect human cells and those that cannot. They identified a region on the virus spike protein critical for cell infection, which could inform vaccine development.
A study finds that Industry 4.0 technologies have largely failed to improve resource efficiency and reduce emissions, contrary to company expectations. However, companies with high digitalisation levels are better positioned to align production with demand and improve sustainability performance.
Researchers developed an AI model to predict side effects from new combination therapies by analyzing over 15 million records of adverse events. The model can recognize patterns between drugs and their side effects, enabling the prediction of adverse events for individual therapy profiles.
Researchers found that Dansgaard-Oeschger events, which occurred throughout the last ice age, were likely caused by atmospheric CO2 levels between 190-225 ppm. The study combines ice-core data with climate models to propose a new theory for these abrupt climate changes.
Researchers have deciphered the structure of the kinetochore corona, a complex protein assembly that plays a pivotal role in chromosome segregation. The study, published in The EMBO Journal, provides new insights into how this critical process is regulated and offers a framework for future studies on cell division.
Researchers at Tokyo University of Agriculture and Technology discovered that double-stranded RNA molecules can activate the immune system response leading to bone deterioration in gum disease. The study found that dsRNA triggers the differentiation of osteoclasts, cells responsible for breaking down bone, leading to increased bone ero...
Researchers used CRISPR gene editing to understand how deletions in one area of the genome affect nearby genes. They found that deleting a small region led to increased foetal globin expression and reduced adult globin levels, suggesting a key mechanism for asymptomatic patients with sickle cell disease.
Researchers revised their understanding of the relationship between Atlantic Meridional Overturning Circulation (AMOC) and freshwater from melting polar ice. A new model simulation suggests that AMOC is less sensitive to freshwater forcing than previously thought, contradicting long-held assumptions.
Researchers propose that a colossal ancient impact near the Moon's south pole created a heat plume that concentrated rare-Earth elements on the nearside, contributing to the formation of volcanic plains. This explanation sheds light on the Moon's most enduring mystery.
Wealth disparities were larger than education, occupation, and income differences in mortality rates, according to a new study involving 6,300 U.S. adults. Childhood socioeconomic status also showed significant disparities in mortality, with never and current smokers having the largest disparity.
Patients with mild to moderate kidney disease and kidney transplant recipients had a higher risk of cancer. They also faced a higher risk of dying from cancer, particularly from cancers such as bladder, kidney, and multiple myeloma, compared to those with normal kidney function.
Researchers at Peking University propose a novel structure for a slot-strip mode converter, reducing optical insertion loss and supporting both TE0 and TM0 polarizations. The converter enables advanced functions like polarization division multiplexing, with low polarization-dependent losses.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about how GI bacteria communicate with each other during gene transfers. This new understanding may lead to innovative approaches in preventing hospital infections without increasing antibiotic resistance.
A new study by Yale University researchers reveals that urbanization is constrained by infrastructure inequality, which can persist due to the durable nature of infrastructure. The findings highlight the need for policymakers to address preferential biases when allocating infrastructure to minimize inequalities.
Researchers have created a Russian-language protocol for functional magnetic resonance imaging (fMRI) to map individual language areas before neurosurgical operations. The study successfully validated the protocol in a control group, showing its ability to comprehensively map brain regions and reveal lateralisation of language function.
An interdisciplinary team studied lithium-CO2 batteries to overcome critical problems for their potential as new energy storage devices. The team identified the electrochemical mechanism's lack of understanding and efficient electrocatalysts as significant hurdles.
Researchers developed Mn-doped Ni2O3/Ni2P and Mn-doped NiXSy/Ni2P nanosheets as efficient electrocatalysts for alkaline overall water splitting. The nanostructures exhibit high intrinsic activities, abundant active sites, and excellent stability.
The new software tool, Glyco-Decipher, enables the sensitive interpretation of N-glycopeptide mass spectra at high confidence. Researchers found that the fragmentation pattern of peptide backbones is not affected by attached glycans or precursor charge states.
A new €1.5 million project led by Dr Mel Channon will investigate menstrual justice and injustice in low- and middle-income countries, focusing on Nepal and Guatemala. The research aims to improve women's experiences and reduce negative impacts of menstruation, with a focus on menstrual pain.
A new project led by Dr Rosana Pinheiro Machado will investigate the links between precarious work and authoritarian politics in Brazil, India, and the Philippines. The research aims to understand how economic growth has fueled the rise of aspirational classes and growing work precariousness.
Researchers found that industry-sponsored clinical trials neglect to cite previous trials by up to 30%, while non-industry-funded trials do so at a rate of 20%. This omission may lead to redundant or less impactful research. The authors call for complete and impartial citation of prior studies in trial protocols.
A team of scientists successfully achieved a high-quality strain-free AlN film through graphene-driving strain engineering. The strain-free AlN film grown on graphene/sapphire can be used as a reliable template layer for high-quality epitaxy of DUV-LED devices.
A new study published in JAMA Oncology finds that Medicaid expansion is associated with improved survival rates and decreased mortality rates among patients diagnosed with de novo stage 4 breast cancer. The study also reveals a significant decrease in racial disparities, with mortality rates decreasing by 5.5% among minority groups.
A study published in the Journal of Alzheimer's Disease Reports suggests that damage to the blood-brain barrier is the determining cause of Alzheimer's disease. The Lipid Invasion Model proposes that lipids entering the brain due to barrier damage lead to brain shrinkage, amyloid plaques, and tau tangles, characteristic of the disease.
A study of 415,000 US adults found that lower educational attainment and unhealthy lifestyles increased the risk of death from all causes. Lifestyle risk factors associated with higher mortality rates included smoking, physical inactivity, and obesity.
SmartScan software improves heat distribution and reduces deformations by up to 47% in laser powder bed fusion printers. The technology speeds manufacturing by optimizing scan sequences and minimizing heat-caused defects.
An AI model developed by researchers identified a subset of individuals with a 25-fold risk of developing pancreatic cancer within three to 36 months. The model used sequence of medical diagnoses from patient records to predict risk, which was validated in two independent datasets.
Researchers found that US corporate insiders with production or supply-chain activities in China sold stock ahead of the pandemic's impact, leading to significantly higher profits. These insiders were better attuned to publicly available information about COVID-19 and avoided aggregate losses of approximately $300 million.
Scientists develop models that complement simulations using reinforcement learning and numerical methods to predict climate change, turbulent flows, and morphogenesis. This approach enables faster and more energy-efficient predictions, solving complex problems in engineering and climate applications.
A study found that liberals and conservatives read dominance signals differently in the faces of men and women, with conservative biases against women's faces. The researchers suggest that this perception may be rooted in evolutionary psychology and traditional social hierarchies.
A new study published in Diabetologia found that healthy plant-based diets, including fruits, vegetables, and legumes, are linked to a lower risk of developing type 2 diabetes. The study analyzed metabolite profiles and diet indices from over 10,684 participants, revealing unique multi-metabolite profiles associated with healthy plant-...
Researchers discovered that individuals with depressive disorders have increased blood cell deformability, particularly in lymphocytes, monocytes, and neutrophils. This suggests a potential link between immune system changes and sustained immune responses.
A recent study by CityU researchers found that clothes dryers are a significant source of airborne microfibers, with some releasing up to 40 times more than washing machines. The team suggests installing filtration systems in dryer vents to mitigate this environmental concern.
Researchers from the Wyss Institute discovered that applying mechanical forces mimicking breathing motions suppresses influenza virus replication and activates protective innate immune responses. The Human Lung Chip was used to model these responses, leading to repurposed drugs for treating inflammatory lung diseases.
A 20-year study reveals how a machine manufacturer transformed its strategy to focus on ecosystem-building and preserved product revenue. The company's success relied on adapting its core product to support the new ecosystem and changing its organizational structure.
The UCF-developed real-time blood monitor uses an optical fiber to assess blood status and can be inserted directly into heart-lung machines or catheters without withdrawing blood from patients. This device has been shown to save doctors critical time during life-or-death operations, particularly in surgeries on infants.
Raising awareness about cardiac radiation exposure reduced the number of patients receiving high heart doses in lung cancer patients. The study found that standardized cardiac dose constraints improved patient care without minimizing tumor treatment or increasing dosage to other at-risk organs.
Research reveals that imbalances in the intestine's viral community may promote inflammatory bowel disease. Viruses in a normal intestine have anti-inflammatory effects, whereas those from inflamed intestines provoke inflammation. This study provides a missing functional link between the virome and human health.
The system uses multiple satellites to form an aperture-synthetic interferometer, meeting four key demands: high spatial resolution, contrast, sensitivity, and wide spectral range. Numerical simulations validate the method's efficiency, with reduced transfer times and stable orbit maintenance.
A Swedish study found that death of a parent is associated with poorer school outcomes among children, independent of family factors. Children aged 5-9 are particularly vulnerable to this effect.
High-income nations, driven by US and EU, exceed sustainable resource use thresholds by 74% globally. China ranks second in global excess material use, while low- and middle-income countries account for only 8%. Researchers call for transformative post-growth approaches to mitigate ecological breakdown.
A new study by researchers from Tsinghua University redefines the interface between liquids and solid surfaces based on intermolecular forces. The findings reveal intrinsic wetting thresholds that deviate from Young's equation, providing a new perspective on wettability and its relationship with molecular interactions.
The study analyzed over 125,000 US health care workers, finding that frontline workers were at highest risk of leaving the workforce due to burnout and stress. The researchers also identified specific factors contributing to turnover, such as inadequate staffing and lack of support from employers.
Researchers found varied diversity of gut microbiomes among brown bears at three national parks in Alaska, with Katmai showing the most diversity due to its diverse food sources. The study advances understanding of wildlife habitat, diet, and gut microbiome diversity.
Recent advances in wireless epicortical and intracortical neuronal recording systems offer promising solutions for BCIs. The development of these systems faces challenges such as high throughput, power consumption, and heat accumulation.
City of Hope researchers present new developments in cell therapy for acute myeloid leukemia and non-small cell lung cancer. A novel smoking cessation program increases patient desire to quit with personalized counseling.
Researchers at KIST have developed a 3T-OTS device that simulates the human brain's efficient information processing method. This innovation enables the creation of low-power and high-efficiency artificial sensory neurons, which can be used in life and safety fields.
The UNC Charlotte team developed a universal AI algorithm called AutoClass to clean noisy single-cell RNA sequencing (scRNA-Seq) data. The algorithm effectively removes noise and enhances downstream analysis in multiple aspects, demonstrating its robustness and scalability.
A team of astronomers led by Dr Marcin Glowacki have detected the most distant megamaser ever observed, with light traveling 58 trillion kilometers from its location at five billion light years from Earth. The megamaser is thought to be created when two galaxies collide, triggering a beam of concentrated light.
A recent study published in Genome Biology and Evolution found that ancient human remains from Bulgaria are more closely related to contemporary East Asians than Europeans. The researchers propose a scenario where an African population hub expanded into Europe and East Asia around 45,000 years ago, with the European representatives dec...
Researchers found stronger westerly jets and wave trains in early summer than late summer, gaining more energy from baroclinic conversion. This has implications for climate prediction and links between East Asia and North America.
Researchers found a steady decline in annual mammography use by breast cancer survivors between 2009 and 2016, with the largest decrease seen among younger patients. The study highlights the importance of reinforcing the significance of annual mammograms for breast cancer survivors.
A team of researchers has developed a tunable graphene-based platform to study exceptional points, which exhibit unique properties when light and matter interact. The breakthrough could lead to advancements in optoelectronic technologies and potentially contribute to the development of 'beyond-5G' wireless technology.
A randomized clinical trial found that participants treated at non-stigmatizing 'accessible care' centers were nearly three times more likely to be cured of hepatitis C than those referred out to local clinicians. The study suggests that expanding and supporting accessible care models could help eliminate the disease.
Researchers recommend expanding diagnostic workup to include cardiac arrhythmias for unexplained enuresis in adults and children. An electrocardiogram is a cost-effective and non-invasive test that can detect potentially fatal diseases.
Researchers at Mount Sinai have developed a reproducible method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes, which support heart muscle contraction. The new protocol enables efficient energy generation from both carbohydrates and fatty acids, improving disease modeling and regenerative therapies.
Researchers at Australian National University create a new experimental technique to measure the potential energy of an atom with unprecedented sensitivity. They validated quantum electrodynamics (QED) theory by achieving a precision that surpasses previous methods.
A study published in Scientific Reports found that ARS-developed Pol-line honey bees have a significantly higher winter survival rate than standard honey bees, with rates of 62.5% and 3%, respectively. Additionally, Pol-line colonies showed lower levels of three major viruses commonly transmitted by Varroa mites.
Researchers created a set of fiberglass tubes to test participants' ability to sense the location of a rolling metal ball. The study found that people could accurately determine the ball's movement without training, highlighting the role of physical cues in tactile perception.