A study found that brain immune cells undergo substantial remodeling in midlife, leading to chronic neuroinflammation and potential dementia risk. The research used advanced single-cell analysis techniques to analyze postmortem hippocampal tissue from 40 healthy adults.
Spotted hyena females show greater reproductive inequality than males due to social rank inheritance, benefiting high-ranking females' offspring. This pattern is reversed when considering grandchildren and great-grandchildren, with females demonstrating greater inequality.
Researchers develop a novel FeN4–Ru6–NiN4@PCA catalyst with atomic-level precision and multiscale electronic modulation for exceptional bifunctional oxygen electrocatalysis. The catalyst achieves high ORR half-wave potential and OER, with low bifunctional voltage gap, stability, and methanol tolerance.
Engineers create optimized interfacial energy barrier in NbSe2/WSe2 heterostructure to accelerate charge separation while suppressing dark current. This approach enables high-speed optical imaging with enhanced fidelity, opening a promising route for next-generation optoelectronic devices.
Researchers introduce 'plantymers', plastics that break down naturally in the environment, addressing traditional plastic drawbacks. Plantymers are strong enough to compete with fossil-based plastics, making them suitable for fruit packaging and other applications.
The Journal of Systematics and Evolution (JSE) is launching a special issue on deep sea biodiversity, covering taxonomy, phylogenomics, comparative genomics, and microbial ecology. Researchers worldwide can submit free-access papers with waived page and color charges until January 31, 2027.
Researchers found that even losing one copy of the TBX5 gene can drastically derail heart development due to DNA misfolding. The study reveals a new origin for genetic disease, suggesting that small drops in protein levels can scramble the 3D structure of DNA.
Exceptional points in non-linear systems follow a universal geometric order, according to a new study published in Nature Communications. The findings have implications for the design of highly sensitive sensors and could lead to a deeper understanding of non-Hermitian Physics.
A new study using remote sensing and machine learning found that mining for green technology minerals has unexpected consequences on biodiversity. The research revealed that commodities such as lithium and cobalt have the highest biodiversity risks despite lower levels of forest loss.
A multidisciplinary research framework integrating earth science and environmental engineering is proposed to mitigate the risks of waterborne pathogens. The framework emphasizes real-time detection, numerical simulation, and multi-omics approaches to track pathogens and harmful genes across various media.
Researchers at Kobe University have successfully created a subclass of T cells that can be used across patients and reproduceably turned back into those T cells. These cells attack and shrink human patient-derived colorectal cancer tumors implanted in mice, offering potential for future systemic therapy.
Research finds that one-pedal driving in electric vehicles yields narrower distributions of speed and acceleration when integrated with Adaptive Cruise Control, improving traffic flow stability. However, manual control produces pronounced speed oscillations and sharper decelerations, highlighting the need for automation.
A new US national study by Tulane University's Newcomb Institute found that Americans are reporting experiences of sexual harassment at far higher rates than they did before the #MeToo movement. The share of U.S. adults reporting sexual harassment increased from 10.7% in 2018 to 24.3% in 2024.
The study introduced an interphase activator strategy that couples both processes through one additive, converting native surface species into a reconstructed interphase and regulating the coordination environment in the polymer phase. The optimized electrolyte delivers high ionic conductivity and stability, making it suitable for soli...
Researchers demonstrate phonon focusing at room temperature in boron arsenide, a material with high thermal conductivity. This discovery could improve thermal management in electronics and enable advances in quantum computing technologies.
A new study found that PET/CT scans improved the diagnosis of fever of unknown origin (FUO) in nearly 75% of patients. The study identified predictive markers for a positive scan, including high C-reactive protein and short duration of prior antibiotic therapy.
Researchers developed a platform to move Dirac points in momentum space, allowing for free sound steering. Two fully passive devices were built: a scanning topological antenna and an angle-tunable Klein tunneling device.
The guidelines provide evidence-based recommendations for screening, diagnosis, treatment, referral, and follow-up of MAFLD in primary care. Lifestyle interventions, such as weight loss and exercise, are recommended to reduce the risk of progression and complications.
Researchers uncover new evidence about the timing and intensity of asteroid bombardment on the Moon's surface, finding it declined gradually rather than a short burst. The discovery allows scientists to reconstruct over three billion years of lunar impact history.
Researchers at Facility for Rare Isotope Beams identified magnetic transitions within the nucleus of zinc-70 as the cause of an unexpected excess of low-energy gamma rays. This discovery sheds light on a long-standing puzzle in nuclear physics and has implications for astrophysics, including the formation of heavy elements.
Direct patient or caregiver prior authorization engagement is associated with adverse outcomes, including delays and suboptimal care. This study may inform future research and intervention development to navigate PA-related administrative burden.
Researchers have demonstrated that topological insulators can withstand higher measurement currents while maintaining precise Hall resistance values, paving the way for more accurate electrical standards. This breakthrough overcomes significant technical obstacles and enables the development of universal electrical references.
A study found that the gut microbiota of Helicoverpa armigera caterpillars harbors fungi with the potential to degrade expanded polystyrene. Four fungi were isolated and demonstrated to break down polystyrene using scanning electron microscopy analysis.
A new plasma-catalysis process converts nitrogen (N2) and methane (CH4) into alkylamines, ammonia, and hydrogen under mild conditions. The study achieves high co-conversion efficiency by leveraging the synergy between plasma activation and catalyst adsorption.
Researchers developed a multi-feature fusion filtering framework to improve defect detection in heavy-haul lines, achieving accurate localization in over 90% of test cases. The method outperforms single-feature methods by reducing missed detections and large localization deviations.
A UMaine-led research team has been awarded the inaugural DOE Genesis Mission to develop AI-powered models that simulate the impact of microbes on underground chemical reactions. The project aims to improve predictions in groundwater management, environmental remediation, and energy infrastructure planning.
A new review reveals that selenium metabolism governs ferroptosis sensitivity through a broader network of selenoproteins and antioxidant defense systems. This discovery expands our understanding of ferroptosis regulation and has implications for cancer treatment and other diseases.
A landmark trial shows that children hospitalised with severe pneumonia can recover just as well from injectable to oral antibiotics, even with shorter treatment durations. This simple change could help millions of children worldwide get back to their families sooner and reduce pressure on busy hospitals.
Researchers from Pennington Biomedical will present findings on organoid models, GLP-1 therapies, and early-life nutrition. The center's broad research portfolio is represented at the annual meeting of the American Society for Nutrition.
A new study by University College London researchers found that people who experienced persistent money struggles in early and middle adulthood performed less well in cognitive tests at age 53. They also found worse brain health, including more brain shrinkage, in later life, particularly for men and those with childhood disadvantage.
Childhood lymphoid leukemia mortality rates vary significantly across Brazil due to socio-economic disparities. The study highlights the need for region-specific strategies to improve access to specialized pediatric oncology services and timely diagnosis.
Michigan State University researchers have created a new research tool to investigate the regenerative biology of zebrafish gut nerves. The tool allows for controlled removal and regeneration of neurons, revealing how neural networks are restored in about nine days. This could lead to better understanding of nerve repair in humans.
Vitiligo is an autoimmune disease where immune system attacks melanocytes, leading to skin patches. Researchers discovered dormant pigment cells that could be reactivated using pharmacological inhibitors. This finding suggests a new approach for treating vitiligo by restoring melanocyte function and pigmentation.
Researchers used Landsat thermal infrared imagery to study river temperatures over 250 dams in the US, finding temperature differences in 71% of observations and varying impacts based on dam type and season. This new approach can help better understand freshwater ecology and water resource management.
Researchers discovered widespread age-related changes in genome regulation starting in midlife, linked to neurodegenerative diseases. A single-cell study found dramatic shifts in microglia, a type of brain's immune cells, and erosion of three-dimensional genome architecture.
A new method for the controlled cleavage of carbon-carbon double bonds in alkenes has been developed using CO₂ as an oxygen donor and visible light. This process replaces traditional oxidising substances with a safer and more sustainable approach, yielding ketones and carboxylic acids.
Researchers have developed a new tool, FlatMux, that captures electrical activity from almost 200 neurons simultaneously across cortical layers and at depths up to 500 micrometers. This platform enables recordings of neurons' location and cell types, revealing how brain functions emerge from highly interconnected networks.
Researchers analyzed over 600 tumors from 544 patients and found distinct genomic signatures of DNA changes linked to different chemotherapies. These patterns appeared as early as 91 days after treatment began, allowing clinicians to track treatment-resistant tumours and potentially reduce toxic effects. The study could lead to a more ...
Researchers at Brown and U.T. Southwestern have identified a key mechanism underlying GPT2 deficiency, a rare genetic disease affecting brain development. Supplementing a metabolite called alpha-ketoglutarate may improve DNA structure and gene expression in the brain, potentially leading to new treatments.
Researchers created a virtual robot with curiosity-driven neural network and tested its performance, finding that play-like behavior and exception-handling performance helped the robot understand language faster. The study suggests a combination of curiosity and linguistic diversity is key to children's rapid language acquisition.
A modeling study reconstructs ancient language history, estimating tens of thousands of languages existed 1,000-3,000 years ago. The 'golden age' of linguistic diversity was followed by an exceptionally rapid collapse over the past two millennia.
Researchers utilized a large healthcare system biobank to identify individuals carrying rare copy number variants linked to neurodevelopmental disorders. The study found significant value in direct phenotyping, providing practical benchmarks for implementing recall-by-genotype studies in diverse healthcare systems.
A study from the University of South Alabama found Pseudomonas aeruginosa accounted for 4% of local UTI cases, exceeding national averages. The research identified previously unknown genetic strains and concerning patterns of antibiotic resistance.
Researchers from Universitat Rovira i Virgili develop a process to extract oil from coffee grounds, preserving biomass for other uses. The method recovers approximately 90% of the oil yield obtained by traditional techniques, while minimizing impurities.
A new study reveals widespread damage to Syria's archaeological sites due to looting and bulldozing, particularly in areas occupied by the Turkish military. The researchers used satellite imagery to analyze 200 sites across Syria, finding that 59% were affected since 2015.
A randomized controlled trial in Singapore found that self-sampling increased high-risk HPV detection and overall screening uptake among previously unscreened women. Screening uptake also increased among women with regular screening history, particularly those who chose self-sampling.
Researchers documented a previously undescribed orca behavior in the Gulf of California, where orcas hold and then ram sunfish to cause tissue fragmentation. The observed behavior may be a form of parental investment or simply entertainment, with potential benefits for the calf's nutrition.
The Paleocoordinates Calculator (PACA) tool simplifies paleogeographic reconstructions by providing high-quality palaeogeographic data for researchers and users. PACA facilitates access to paleogeographic data, promoting transparency and reproducibility in Earth sciences.
Diversion of U.S. food waste from landfills could significantly reduce climate impacts and nutrient pollution, with potential benefits including a 89-99% reduction in greenhouse gas emissions and a 49-54% decrease in nitrogen pollution. However, the resulting compost and organic materials may carry up to 20,000 tons of microplastics in...
Analysis of over 116,000 bird songs reveals eight fundamental acoustic motifs that underlie the diversity of passerine birdsong. Local environments play a significant role in shaping how birds communicate globally.
Researchers at Binghamton University are developing an ear probe that utilizes the unique way spiders 'hear' through their webs to detect inner-ear problems. The probe uses patented sensing technology inspired by spider silk, which can respond to sound with perfect fidelity from 1 Hz up to 50 kHz.
Researchers engineered twisted laser beams to interact with chiral molecules, distinguishing between mirror-image forms through the number of fragments produced. This simplifies detection and enhances sensitivity compared to traditional methods.
A recent study highlights the role of social relationships in knowledge sharing among farmers and proposes a new way to understand how climate-smart agricultural innovations begin. Trust, mutual support, and close relationships play a fundamental role in enabling knowledge sharing.
A Yale-led team developed a new process for removing PFAS from agricultural land at a fraction of the current remediation costs. The approach involves spreading crushed rock, which accelerates PFOS removal via plant growth, followed by biochar generation to destroy both PFAS chemicals.
A new study found that unwritten social rules in small societies play a crucial role in regulating land use and maintaining forest regeneration sustainably. The research suggests that these norms can reduce the total amount of land cleared and promote biodiversity when used in moderation.
A major international study estimates that around 43 billion days of antibiotics were needed globally in 2019 to treat bacterial infections appropriately. Many countries are using too many Watch and Reserve antibiotics, contributing to antibiotic resistance concerns.
A new study recommends reducing and reusing nappies, developing recycling technologies, and creating compostable products to tackle the plastic waste crisis. The research team identifies three system interventions that can radically reduce the environmental impact of absorbent hygiene products.
Researchers discovered a molecular link between exercise, dietary timing and liver protection against metabolic dysfunction-associated steatotic liver disease (MASLD). The study found that exercise and time-restricted feeding suppress a specific signaling axis involving miR-802, PPARγ and Psmd2.
Researchers found that sperm whales blowing bubbles while asleep release air, making them less buoyant in the process. This helps them stay underwater without popping to the surface like a cork as they sleep.
Researchers discovered 171 distinct mutations causing MET exon 14 skipping in lung cancer patients. RNA-based testing confirmed these alterations, highlighting the importance of complementary diagnostic approaches.