Researchers at IOCB Prague developed a new type of fluorescent label that provides higher-contrast and clearer images in living cells. This innovation reduces the need for repeated washing and minimizes excess dye binding, making it more cost-effective and efficient for studying cellular processes.
JMIR Publications has partnered with Norwegian Agency for Shared Services in Education and Research (Sikt) to offer a flat-fee unlimited open access publishing model to researchers in Norway. The pilot program provides full waivers of Article Processing Fees, eliminating financial and administrative burdens on researchers and librarians.
A mobile app developed by researchers from UNIGE and Agroscope helps winegrowers anticipate climate change impacts on their vineyards. The app uses climate analogues to identify regions with comparable climatic conditions in the future, allowing for the adoption of suitable viticultural practices.
The symposium brings together researchers to discuss end-of-life experiences, exploring biological processes, cultural interpretations, and spiritual approaches. It features lectures by prominent international experts, including Christof Koch, Michael Rera, Daniel Kondziella, and Jim Tucker.
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
Researchers at KAIST have developed a new surface-control technology to control, at the atomic level, the surface of indium phosphide magic-sized clusters, overcoming the limitation of luminescence efficiency below 1%. The breakthrough results in an 18-fold increase in brightness, opening up applications in next-generation displays and...
Researchers developed a novel camouflage strategy using rough surface, silver nanowires, and biometric coatings to deceive multiple detection methods simultaneously. The device effectively simulated the spectral characteristics of vegetation and reduced infrared emissivity.
Pompe disease is a rare genetic disorder caused by a deficiency in the GAA enzyme, leading to glycogen accumulation in cells. Genethon's gene therapy approach has shown preclinical efficacy in animal studies, correcting glycogen accumulation and improving cardiac hypertrophy and muscular dysfunction.
A Rutgers University study reveals that early gender stereotypes can influence how children learn math, with young learners more inclined to trust incorrect information from male teachers. The findings suggest that children are not only absorbing stereotypes but also using them to calibrate their understanding of the world.
KRISS has developed a fabrication technique that coats solid electrolyte powders with multifunctional compounds, reducing production costs by over 90% and achieving record-high density without expensive mother powder. This breakthrough enables the commercialization of oxide-based all-solid-state batteries.
Researchers at Science Tokyo have elucidated the molecular mechanism of Golgi membrane-associated degradation (GOMED), a selective protein cleanup system. They found that GOMED recognizes substrates using K33-linked ubiquitin chains and employs optineurin (OPTN) as an adaptor molecule to guide them for degradation.
Scientists have developed injectable nanorobots with ultrasensitive chemotaxis for precision cancer therapy, achieving high targeting efficiency, deep penetration, and significant cell internalization in a tumor-bearing mouse model. The nanorobots showed a 49-fold boost in tumor suppression efficacy compared to passive counterparts.
Scientists introduce a groundbreaking approach to generate significant photocurrents from perfectly symmetric materials by engineering surface electronic states. This discovery opens new pathways for designing ultrafast spintronic devices and energy harvesting systems.
A study found that hydroclimatic extremes and changes in agriculture led to the collapse of the Tang dynasty in 907 CE. The research analyzed tree ring data and concluded that increased droughts and floods took a toll on the empire's outer borders and agricultural systems.
A new study reveals that young Finnish environmental activists construct complex and contradictory identities tied to intergenerational responsibility and global climate justice. The research identified five key activist identities: the tough activist, troublemaker, planetary citizen, compulsory activist, and non-activist.
Researchers have developed a new way to produce ammonia, a common fertilizer, that is cleaner and more efficient than traditional methods. The process uses calcium nitride and hydrogen atoms to create ammonia without emitting carbon dioxide, and can be scaled up for widespread use.
The partnership will accelerate development of multivalent vaccines for pandemic and emerging infectious threats, using advanced automated organoid models. Researchers will co-develop a physiologically relevant, automated tonsillar organoid model for rapid testing of saDNA-based vaccine candidates.
Researchers at IIT develop optical microscopy technique that combines polarization and dark-field microscopy to observe cells with high contrast, preserving their natural conditions. The next step involves using AI to enrich images with molecular information related to diseases.
The review details the dual role of interferon regulatory factors (IRFs) in regulating essential antiviral responses while mitigating excessive inflammation. IRF proteins have distinct roles, with some driving interferon production and others acting as fine-tuners or negative regulators.
Researchers at UC3M have received grants from the Ramón Areces Foundation to develop projects using AI, digitization, and chronotope mapping in archaeology, history, and cinema. The projects aim to advance knowledge of the Castilian Middle Ages and the Spanish film industry.
Astronomers have captured a vivid portrait of a 'reborn' black hole, likened to the eruption of a 'cosmic volcano', in the radio galaxy J1007+3540. The black hole's newly ignited jets are being bent and distorted by the massive galaxy cluster environment.
A new study predicts train-induced environmental vibration using physics-based numerical simulations and limited field data, outperforming conventional models. The method improves existing workflows, reducing dependence on expensive field measurements.
An 18-week study found that maintaining grip strength and chair-rise performance alongside weight loss was possible without a prescribed strength-training program, alongside improvements in biomarkers linked to metabolic and cognitive aging. A plant-forward diet featuring fresh lean pork supported healthy-aging markers in older adults.
Researchers summarize itaconate biology highlighting its chemical reactivity and therapeutic potential in treating infectious diseases, sepsis, autoimmunity, neurodegenerative disorders. Itaconate exerts biological effects through post-translational modifications, altering protein activity and signaling pathways
The study reveals that low levels of CTDNEP1 drive early and deadly pancreatic tumors, highlighting its role as a tumor suppressor. Tumors with low CTDNEP1 expression showed stronger metabolic activity and immune evasion.
The 2026 Hill Prizes recognize innovators addressing pressing challenges through high-risk, high-reward ideas. Top Texas researchers receive $500,000 in direct funding to accelerate their work on AI coaching systems, biological breakthroughs and more.
Researchers developed a technology to map pre-malignant gene mutations and their effects in solid tissues, finding over half of cells contained clonal driver mutations. The study used esophageal tissue samples from six older adults, discovering NOTCH1 and TP53 driver mutations that induced clonal overgrowth and impaired cell development.
Patients who undergo unscheduled cesarean deliveries are at substantially increased risk for acute psychological stress during childbirth. Results show that over 1 in 4 patients experienced clinically significant acute stress shortly after birth.
Researchers use AI to analyze data from over 200 chemicals, predicting toxicity for hundreds more disinfection byproducts. The model highlights potential risks of trihalomethanes and haloacetic acids in tap water.
Researchers have discovered how Mycoplasma pneumoniae obtains essential lipids from the human body and targets fat-rich tissues. The bacterium uses the P116 protein to capture cholesterol and other lipids, allowing it to survive and colonize tissues beyond the lungs.
A global study reveals invasive alien species reduce terrestrial insect abundance by 31% and species richness by 21%. Insects are often overlooked victims of invasion, exacerbating population declines and ecosystem disruption.
Researchers found that adding nitrogen fertilizer to the soil increases plant protein and reduces carb content, making them unpalatable to locusts. The study showed a doubled crop yield in treated plots with fewer locusts and less damage to crops.
Obesity is a chronic health condition associated with harm to health, affecting more than one-third of the US population. A new American Heart Association scientific statement emphasizes socioeconomic and structural barriers to obesity prevention and management.
A new study by University College London researchers found that women and people with anxiety are prone to two distinct types of underconfidence. Women initially show underconfidence but confidence grows as time elapses, while those with anxiety become less confident with more reflection.
Research found that deciduous tree dominance reduces wildfire carbon losses in boreal forests, storing more carbon above ground and releasing less in deep organic soils. This shift could help slow climate warming by reducing carbon emissions per unit area burned.
Developed by Mass General Brigham researchers, the autonomous AI system achieves high accuracy in detecting cognitive impairment using routine clinical documentation. The system includes five specialized agents that critique each other and refine their reasoning, just like clinicians would in a case conference.
A new study integrates ocean damage from climate change into the social cost of carbon, doubling the global cost to society. The 'blue' social cost of carbon accounts for economic losses from fisheries impacts, coastal infrastructure damage, and other ecosystem degradation.
The COMET project AutoForst aims to increase safety, alleviate labor shortages, and improve forest logistics with digital and automated systems. Researchers will develop sensor and camera systems to recognize critical situations during loading and automate transport systems.
A research group at Osaka Metropolitan University has pioneered a technology for preparing biodegradable polymer capsules using naturally occurring molecules. The new method produces stable, shelf-life-friendly capsules that can store target molecules and undergo photodegradation upon exposure to light.
Scientists found that mosquitoes in the Atlantic Forest prefer feeding on humans due to convenience as biodiversity dwindles. This preference increases the risk of pathogen transmission and highlights the need for targeted surveillance and prevention actions.
A new study published in the Journal of Public Health found that maternity services in Northern England consistently report higher-than-average rates of perinatal mortality, including stillbirths and neonatal deaths. The study identified ten organizations with higher-than-average deaths and fifteen with lower-than-average deaths, highl...
A new study found that varenicline, a medication used to quit smoking, can help men with cannabis use disorder reduce their cannabis use. However, the same treatment showed no significant effect on female participants. Women who received varenicline reported higher withdrawal and craving scores and lower medication adherence compared t...
A new study quantifies the time spent in moderate to intense heat-related discomfort by South American beef cattle, finding they experience 280-2,800 hours of heat stress per year. Providing shade can reduce this impact by up to 85% and generate economic benefits.
Researchers have decoded the logic of microRNA strand selection using AI, revealing a conserved and programmable mechanism governing gene regulation. The study found that this decision follows conserved rules rather than chance, with mammalian microRNAs showing a strong bias towards a single dominant strand.
A team of researchers at Northern Arizona University discovered that fabricated gold, copper and iron nanocrystals exhibit pentagonal constructs resembling natural snowflakes, governed by emergence dynamics. This phenomenon holds key findings for controlling nanomaterial synthesis and advancing the field.
A team of scientists uncovered fossil evidence of a tiny ecosystem that helped revive marine life after the end-Ordovician ice age and mass extinction event. The discovery provides insights into ancient biological processes and highlights the importance of seafloor ecosystems in regulating carbon and nutrient cycles.
A major U.S. clinical trial has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced prostate cancer. Researchers found that men who carry a specific version of the gene SULT2A1 clear abiraterone from their bodies more slowly, which could affect how well it w...
A new study reveals that crystal dislocations can serve as powerful building blocks for quantum interconnects, enabling the creation of stable and coherent qubits. The researchers showed that nitrogen-vacancy centers in diamond can be attracted to dislocations and retain their quantum properties when positioned near these line defects.
A study led by Dr Varghese Peter found that infant-directed speech ( IDS ) helps babies distinguish between vowel sounds, supporting early language learning. The research suggests that 'baby talk' may be more than just cute – it plays a vital role in infants' language development.
Researchers used big-data approach to discover climate change and mantle processes had limited influence on Central Asian landscape. Instead, dynamics of distant Tethys Ocean directly correlate with short-lived mountain building in Central Asia.
Researchers at Griffith University have successfully conducted a Phase II clinical trial in China, showing promising results for a carbohydrate-based drug candidate called STC3141. The treatment aims to reduce organ damage and reverse biological responses associated with sepsis.
Electrospinning fabricates electroactive fibrous scaffolds that mimic the structure of the extracellular matrix while providing electrical activity, enabling non-invasive and self-powered tissue repair. This technology promotes diverse intelligent applications in tissue regeneration, including conductive, piezoelectric, and triboelectr...
A Curtin University-led study found that playing video games for more than 10 hours a week can lead to a decline in diet quality, obesity, and poor sleep quality. The study suggests that low and moderate gaming is generally fine, but excessive gaming may crowd out healthy habits.
A team at Texas Biomedical Research Institute found that even with effective treatments for TB and HIV, the immune system remains seriously out-of-whack following treatment. The study suggests that host-directed therapies specifically targeting the immune system could potentially restore lung immune system functionality.
A team at UC San Diego is developing functional, patient-specific livers using 3D bioprinting and stem cell technology. The goal is to create 'made-to-order' livers grown from a patient's own cells, offering a safe alternative to transplantation that eliminates the need for donor organs.
A new study provides a long-sought structural explanation for how Vibrio cholerae colonizes the human gut and produces the cholera toxin. The research reveals that ToxR and TcpP stabilize a specific part of the RNA polymerase directly onto DNA, achieving virulence gene activation without reshaping the transcription machinery.
A large study found that home fingertip oxygen monitors give higher readings for patients with darker skin tones, which can lead to missed diagnoses and delayed medical attention. The researchers suggest interpreting SpO2 readings in context and developing guidance to address these limitations.
Shadrack Byfield's autobiography offers insight into the suffering and resilience of Britain's homecoming soldiers. The new evidence shows Byfield's tenacious pursuit of veterans' benefits, struggles with pain, poverty, and police, and his determination to design a custom prosthesis after losing his arm.
A clinical trial from Finland found that wearing a cast for six weeks is comparable to surgery for healing unstable ankle fractures, with fewer treatment-related harms. The study's results support the use of conservative treatment approaches to stabilize the ankle mortise and promote fracture union.
Researchers have developed a new method for generating hydrogen using gas-atomized Ca–Mg eutectic alloys. When added to water, these powders produce hydrogen at room temperature with high efficiency and controllability, making them an attractive candidate for portable hydrogen supply devices and emergency power units.