Rice University professor develops inexpensive process for thiophosphate synthesis, reducing the cost of phosphorylation by up to 90%. This breakthrough opens new avenues for drug design and could lead to more efficient production of genetically targeted therapies.
A recent study found that a higher body fat percentage is linked to lower sperm counts and changes in male reproductive hormones. Men with high body fat percentages had lower semen volume, sperm concentration, and testosterone levels compared to those with normal body fat percentages.
Researchers found specific combinations of blood proteins from western diamondback rattlesnakes provided unprecedented neutralizing power against multiple dangerous snake species. Combining several FETUA proteins dramatically increased ability to neutralize venom's damaging effects.
Ectopic pregnancy hospital admissions have been increasing in England since 2021, with significant disparities between deprived and non-deprived areas. The study highlights the need for an equity-focused approach to address preventable inequalities in health and access to care.
A study published in the Journal of Clinical Oncology found that combining atezolizumab with modified FOLFOX6 chemotherapy and bevacizumab improved progression-free survival by 58% for patients with metastatic dMMR colorectal cancer. The combination also showed higher response rates and reduced primary disease progression.
Researchers at Penn State will use the funding to develop new tools for investigating the genetics underpinning relationships between mosquitoes and various microbes. The projects aim to improve scientific understanding of mosquito-borne pathogens and eventually enable new discoveries that could help inhibit disease spread.
Chika C. Okafor, a University of Tennessee Veterinary Public Health faculty member, has been named president-elect of the American College of Veterinary Preventive Medicine (ACVPM) Epidemiology Specialty. He will help lead the national specialty in Veterinary Epidemiology before assuming the presidency in 2027.
A new review published in Addiction found that controlled breathing interventions can reduce cravings in people who use substances, including alcohol and tobacco. The strongest evidence showed small but statistically significant reductions in craving.
Researchers have created microscopic oil droplets in water that can change shape in complex ways and engulf their surroundings. The droplets' behavior mimics morphogenesis, a process by which cells reshape themselves, without relying on genes or cellular machinery.
Researchers at the University of Queensland have developed ultra-wideband radar sensors to measure muscle forces in a non-invasive way. This technology has the potential to improve rehabilitation, injury prevention, and recovery for people with motor neuron disease or aging. The goal is to eventually use real-time sensor data to assist...
Researchers discovered a new mechanism by which leiomodin builds actin filaments in muscles, challenging a long-standing paradigm. This breakthrough may lead to therapies for dilated cardiomyopathy and other muscle diseases.
An international clinical trial has shown that a once-weekly oral treatment for HIV is non-inferior to one of today's leading daily therapies. The Phase 3 ISLEND-1 trial evaluated a tablet combining islatravir and lenacapavir in adults with well-controlled HIV, demonstrating over 93% viral suppression in both groups.
The University of Phoenix survey found that 60% of working learners who use AI in the workplace report improved knowledge of accessibility standards, with nearly 1 in 5 experiencing significant improvement. The survey also highlights the need for clearer organizational guidance on accessibility, with 45% of respondents unsure if it is ...
Research suggests that an overactive immune response in the brain may play a role in Dravet Syndrome, leading to frequent seizures and developmental challenges. Blocking an inflammatory pathway called cGAS-STING-interferon signaling could lead to new therapeutic strategies for epilepsy disorders.
Researchers at Hebrew University of Jerusalem identify previously unknown law of geometry that explains why growing surfaces suddenly develop complex patterns. The discovery could reshape understanding of natural structures and guide design of shape-changing materials.
A Phase III clinical trial has demonstrated that a new cell therapy called deramiocel can slow the weakening of skeletal muscles by 54% and preserve heart function, slowing progression of cardiomyopathy. The therapy, based on Marbán's discoveries, takes a different approach from other treatments for Duchenne muscular dystrophy.
A systematic review of 47 randomized trials found that oral antihistamines do not improve eczema symptoms and may cause harm. Alternative treatments like moisturizers, topical anti-inflammatory treatments, and whole-body treatments like phototherapy and biologics are recommended.
Researchers found that nanosecond laser-driven proton FLASH radiotherapy effectively kills cancer cells while minimizing damage to normal cells. The study showed that this new irradiation method preserves mitochondrial structure and function, reducing ferroptosis and stress responses in healthy tissues.
A new study published in The Journal of Archaeological Science: Reports sheds light on longstanding relationships between humans and sea turtles in the Southern Caribbean. The research reveals details of interactions between humans and turtles dating back 1,000-years and provides information needed to protect populations going forward.
Researchers developed a low-noise magnetic sensor that improves weak-field detection, leveraging spin-texture dynamics to break the sensitivity–noise limitation. The anomalous Hall magnetic sensor achieved a magnetic-field detectivity of 15.7 nT/√Hz at 1 Hz, nearly one order of magnitude better than conventional ferromagnetic materials.
Researchers found that Bofutsushosan reduced fibrosis in fat tissue and liver of mice with obesity, and identified herbal components with anti-fibrotic activity. The study suggests that Bofutsushosan may have benefits beyond weight control, providing a scientific basis for studying Kampo medicines.
Alison Derbenwick Miller brings extensive executive leadership experience to ACM, with a focus on research, education, and global partnerships. As CEO, she aims to strengthen ACM's role in advancing computing, promoting technical excellence, and supporting member growth.
The research team created 'OpenABE' base editors, which precisely edit both nuclear and mitochondrial genes while reducing off-target effects. This breakthrough enables safer treatment of genetic diseases.
Researchers discovered a signaling pathway activated by acidic tumor environments that drives resistance to PARP inhibitors. Blocking the pathway resensitizes tumors, suggesting a potential new therapeutic strategy for overcoming acquired resistance.
A new database maps building-level landslide risk for the entire US, revealing that 6.5 million people live in landslide-prone regions. The analysis shows an urban-rural divide in landslide susceptibility, with rural areas facing greater economic constraints and limited resources.
Researchers developed a highly crystalline three-dimensional graphitic carbon tube grid that improves filtering supercapacitor performance, offering potential for compact and efficient electronic devices. The new material shows faster coupled electron and ion transport and strong high mass loading capabilities.
The US has launched a new national center to help strengthen its cement and concrete supply chain at a time of rising demand and increasing imports. The ACCENT Center will accelerate the development of advanced materials and manufacturing processes, closing critical gaps between laboratory research and field performance.
A review of 47 trials involving 6,230 children and adults found that adding oral antihistamines to existing treatments showed small but clinically unimportant reductions in eczema severity. First-generation antihistamines may also increase cognitive impairment and the risk of stopping treatment due to side effects.
Researchers developed CAMI-2DNet, an AI system that measures a child's ability to imitate simple body movements using ordinary video recordings. This technology brings scalable and objective methods for evaluating motor imitation, a key behavioral marker associated with autism.
A study of over 64,000 people found that those born before and during World War II sugar rationing had a lower risk of developing dementia. Those with lower sugar levels in early life also experienced a delay in dementia development, on average by 2.6 years.
Researchers developed a quantum machine learning framework to predict which tumor mutations will trigger an immune response. The Q-CHIPP model outperformed classical computing methods and achieved a significant technical milestone by scaling to full-length peptide modeling on quantum hardware.
Three academic papers from Sage journals published in 2015 have demonstrated enduring influence over the decade, according to the 10-Year Impact Awards. The awards recognize the most-cited articles alongside policy citation data, highlighting research's broader impact on debates and decision-making.
Researchers develop SenMayo gene set to identify senescent cells across different tissues and experimental models. Several studies evaluate approaches to reduce the burden or harmful effects of senescent cells in preclinical models.
A new study reveals that avocado trees alternate between male and female flowers based on a single gene that evolved about 42 million years ago. This genetic mechanism helps prevent self-pollination and inbreeding, allowing avocado breeders to sort seedlings more efficiently.
A new study reveals that global crop models are less sensitive to heat extremes than real-world observations, particularly in the reproductive stages of rice. This discrepancy highlights the need for adaptation measures such as developing heat-tolerant varieties and adjusting planting dates to protect crops from extreme heat.
Researchers found that problematic Internet usage is associated with worse mood, more stress, and longer internet use times. The study suggests that temptation is the main driver for continued internet use, with feelings of pleasure and relief emerging as reinforcing factors.
A team of international researchers has uncovered a unique fossil from China that preserves the digestive system of an ancient marine reptile. The study provides insight into the early adaptations of long-necked marine reptiles to life in the oceans, contradicting previous assumptions about their limited aquatic capabilities.
Players who prefer cooperative, strategic, and story-driven video games are at a higher risk of extreme social withdrawal known as hikikomori. The study suggests that game-based mental health interventions may be beneficial for this population.
Elephants released from human care successfully reintegrate into the wild, exhibiting behaviors comparable to those of their wild neighbors. While some individuals show age- and sex-related differences, overall, rewilded elephants adapt well, with most stress levels within normal ranges.
A Swiss study finds that the quality of relationships between humans and animals is more important than pet ownership in determining wellbeing. The research suggests that women, people who spend more time with animals, and those who feel close to them report stronger emotional support from their pets.
Under elevated CO2 levels, trees work with microbes to 'mine' soil nutrients, increasing nitrogen availability by 30%. This 'faster but tighter' cycle supports tree growth and productivity.
A new study published in PLOS One found that healthcare preferences differ substantially by age and sex among adults over 50. Women tend to prioritize quality of life over length of life, while men prefer doctors to make treatment decisions. Older adults are more cautious about risks and less willing to try experimental treatments.
Researchers at Tulane University discovered that vesper bats have two distinct copies of genes producing antibodies, which helps them recognize and fight infections. This finding opens up new areas of study on the evolution of immunity and how animals respond to diseases.
Northwestern University chemists have developed a new approach that replaces traditional trial-and-error methods with intentional design using flexible DNA strands. The strategy enables precise control over protein connections, creating soft, flexible crystals with high structural order. This breakthrough simplifies one of structural b...
A new model, BloomNet, uses deep learning to forecast algal blooms up to 72 hours ahead, offering probabilistic forecasts and uncertainty estimates. The approach also identifies key environmental drivers and provides interpretable indicators of risk, enabling targeted interventions.
A new research project led by Dr. Jiahui Ding aims to understand how maternal viral infections shape fetal immune development, influencing susceptibility to infectious diseases throughout life. Preliminary findings suggest that placental inflammatory pathways operate differently between males and females during fetal development.
A new report from the University of Nottingham suggests that a lack of data on prisoner characteristics is contributing to preventable deaths in custody. The team recommends strengthening prisoner data to identify patterns of inequality and unmet needs, ultimately supporting evidence-based prevention of deaths and service development.
Researchers have found that hydrogen-induced embrittlement can be twice as severe in Nickel-base superalloys at elevated temperatures, posing a challenge for gas turbine safety and reliability. The study suggests that designing temperature-specific alloys with tailored microstructures could help mitigate this issue.
A new study reveals that photoreceptors possess an internal recycling system that removes damaged proteins and maintains cellular health. This discovery has important implications for inherited retinal diseases and raises questions about the safety of certain drugs in clinical testing.
A University of Michigan study finds that fungi are far more abundant deep below ground than previously thought, with over 689 unique species identified. The researchers also discovered complex underground food webs and found evidence of carbon sequestration in the Earth's crust.
A team from the University of Maryland has developed an open-access database to improve analysis, visualization, experiment design, and AI-driven research in solid-state battery science. The database captures critical data points on materials, components, fabrication methods, and testing conditions.
A new study projects that South Korea's suicide deaths may shift towards never-married men with tertiary education as higher education becomes more common. The study highlights the importance of considering demographic change in suicide prevention strategies.
Researchers will examine whether online support strengthens brain development linked to emotional and mental health in prematurely born infants. The scalable intervention could transform how families receive support after discharge from the neonatal intensive care unit, bringing evidence-based support into the home.
Research team identifies best strategies for managing native cacao trees in Peru, resulting in 59% higher yields after three years. Grafting native 'Blanco de Piura' cacao varieties onto fully grown trees increases productivity levels comparable to commercial clones.
Researchers at Emory University developed an AI system, CapuchinAI, to automate cognitive studies of capuchin monkeys in the wild using facial recognition and real-time testing. The system identifies individual capuchins with 97% accuracy and provides a scalable field method for cognitive testing.
A recent study found that most injuries linked to deaths in released coho salmon can be avoided by not using landing nets. Researchers recommend keeping the fish in the water whenever possible and avoiding tandem or treble hooks.
A new paper by Professor Robert Boatright argues that Showa period Godzilla films provide a deeper and more informative representation of Trump's political career. The films' narrative arcs parallel Trump's presidency, including his conflicts with other powerful figures and the fate of his allies. By analyzing these allegorical framewo...
In medieval Kazakhstan, people living in Dzhankent city employed diverse herding practices to ensure milk and dairy products were available year-round. The study found they bred sheep throughout the year, with most births occurring in spring months, to keep them producing milk during winters.
A Canadian research team led by Dr. Amanda Grenier is investigating how to address the growing issue of older people falling through the cracks. The AIM BIG initiative will bring together experts, community organizations, and older adults to develop evidence-based resources to support advocacy, decision-making, and service delivery.
A study found that patients with proximal humerus fractures often avoid movements due to fear of re-injury or discomfort, leading to chronic pain and impaired mobility. Early identification and targeted interventions can help boost confidence and facilitate faster recovery.