Researchers have identified a new type of brain plaque, called mitochondrial plaques, that may emerge at the earliest stages of Alzheimer's disease. These plaques contain high levels of amyloid precursor protein and can directly affect neurons, making them a potential target for new treatments.
Wearable sensors can track dynamic changes in uric acid levels, providing valuable information for assessing healing progress and adjusting treatment plans. Researchers have improved the accuracy and reliability of these sensors using new materials and technologies.
Researchers connected visible stress responses to genetic and physiological changes in plants, identifying a conserved stress signaling mechanism. A protein called DUS2 was found to regulate photosynthesis under stress by modifying RNA transcripts.
A pilot clinical trial of psilocybin-assisted therapy in veterans with severe PTSD found that 75% of participants were in remission one month after treatment, with no serious adverse events reported. The results suggest the protocol may be a game-changer for those struggling with treatment-resistant PTSD.
Researchers at University of Witwatersrand have discovered that quantum information can be kept intact even when transmitted through turbulent environments. This breakthrough enables the use of twisted light to create high-capacity communication networks and ultra-resilient quantum computers.
Scientists discovered a 100-million-year-old beetle fossil that reveals early evolution of firefly sensory and signaling systems. The fossil preserves elaborate antennae and light-emitting organs, suggesting that lampyroid beetles relied heavily on pheromonal cues for mate searching.
Researchers at University of Oxford have invented a novel potassium fluoride-based Appel fluorination method that converts alcohols into alkyl halides, including fluorides. The new technology uses simple and inexpensive fluoride sources, minimizes waste, and recycles catalysts and by-products.
The vascular system plays a critical role in mediating muscle-bone interactions, influencing both their development and health. Therapeutic strategies targeting the vascular-musculoskeletal axis hold promise for preventing and treating sarcopenia and osteoporosis.
Researchers developed a theoretical framework explaining unusual conduction behavior in magnetic materials. Quantum fluctuations affect electron transport in chiral magnets, leading to logarithmic temperature dependence at low temperatures.
Researchers at IISc have demonstrated a new way of switching materials between two fundamentally different magnetic states using an electric current. This discovery could pave the way for compact, energy-efficient electronic devices that store information and perform logic operations, with potential applications in quantum computing.
New research from Hokkaido University shows that team success or failure strongly influences how individuals learn from their mistakes. When an individual makes an error, they are less likely to correct it if their team succeeds, but more likely to adjust their behavior when the team fails.
A study analyzing 1.6 million ICE arrests found that only 34% of those arrested had a criminal conviction, with the majority having no record. Increased enforcement did not translate to more arrests of previously convicted criminals.
Researchers at Gladstone Institutes have made significant progress in understanding the causes of long COVID, focusing on changes in virus-specific immune cells. Specifically, they found that people with long COVID have distinctive changes in CD8 T cells, which are specialized to protect against specific viruses.
A new study by researchers at Johns Hopkins University highlights a significant disconnect between those who use AI health tools and those who create and fund them. The study reveals that key stakeholders have fundamentally different definitions of value, usability, and cost, creating systemic barriers to technology adoption.
A cross-sectional study examines trends in US FDA-approved cancer medicines for adult solid tumors between 2006 and 2025. The analysis reveals significant increases in approvals, particularly for original indication approvals.
New research from Memorial Sloan Kettering Cancer Center sheds light on leukemia resistance to promising new drugs and the role of bone hardness in the immune battle against metastasis. A telehealth tobacco treatment program also shows promise in helping cancer patients quit smoking.
Researchers have identified a natural protective protein called BMP3 that helps maintain healthy lung blood vessels. Increasing BMP3 levels in preclinical models of pulmonary arterial hypertension reversed key features of the disease, including damaged blood vessels and impaired heart function.
Researchers introduce a new metric W² to complement traditional measures of predictive accuracy, revealing hidden patterns of systematic bias in AI models. By combining Q² with a penalty for angular difference from the ideal line, W² provides a more comprehensive evaluation of model reliability.
Research reveals Golgi complex is involved in DNA repair control, regulating protein recruitment and localization to the nucleus. The study suggests a global process of DNA repair coordinated across the cell, with organelles like the Golgi controlling it.
A team of researchers at Rice University has created an electrochemical ion pumping platform that can desalinate wastewater while selectively recovering dissolved metals. The approach uses electrode potential as a programmable control parameter, allowing ions to move continuously through the system.
Scientists used chemical clues in microscopic fossils to find evidence that ocean acidification caused one of the largest extinction events in planktic foraminifera history. The study suggests that volcanic eruptions and rising CO2 levels led to a decrease in shell-building ability, ultimately contributing to the extinction.
A review highlights the role of culturally rooted practices in oral squamous cell carcinoma (OSCC) risk across global populations. Culturally sensitive prevention strategies combining education, harm reduction, and community engagement are crucial in reducing OSCC incidence and disparities. Dermatologists can play a key role in early c...
Pusan National University researchers have successfully developed a hybrid quantum network with indistinguishable quantum sources. The team demonstrated two-photon interference between a warm atomic ensemble and quantum dots, achieving high-visibility two-photon interference without needing spectral or temporal modifications.
Researchers discover that a two-gene supergene and gravity work together to create butterfly lily's unique left- and right-handed flowers. This coordinated arrangement promotes pollen transfer between opposite handedness flowers, maintaining the species' reproductive characteristics.
A study published in Communications Medicine found that early vitrectomy surgery can be more beneficial for patients' vision than the current antibiotic-first approach. After six months, patients who received this treatment showed a median improvement of 40 additional letters they could read compared to those receiving antibiotics.
A team of researchers has discovered a supergene controlling the development of mirror-image flowers in South African butterfly lilies. The study found that two tightly linked genes work together to ensure precise positioning of reproductive organs, promoting genetic diversity and adaptation.
The study argues that managing wildfires requires integrated risk governance systems spanning prevention, preparedness, response, and recovery. CMCC researchers identify the need for cooperation and coordination across sectors and governance levels to build resilience to climate-driven wildfire risk in Europe.
The FLEX Toolkit is a new ADHD toolkit designed specifically for use in UK primary schools. It provides teachers with strategies and regulation tools to support children with ADHD, helping to shift the narrative and promote success and celebration of individual strengths.
Neuroimaging studies reveal that systemic diseases profoundly affect brain structure and function, while brain disorders can influence peripheral organ systems. Cardiovascular diseases, metabolic disorders, autoimmune diseases, and infectious diseases are all associated with characteristic patterns of brain changes.
Traveling patients from restrictive states experience mistrust of online sources, legal concerns, and knowledge gaps regarding remote services. Health policies should address these issues to improve understanding and trust in safe, reliable options.
A nationwide real-world study investigated the incidence of HBV reactivation in Chinese IBD patients receiving infliximab, identifying key risk factors and characterizing outcomes. The study recommends universal HBV screening before biologic therapy initiation and tailored management strategies based on HBV serology and disease activity.
A study of ancient DNA from over 500 mammoth bones found that Ice Age humans selectively targeted female woolly mammoths, unlike the sex ratio among naturally occurring remains. The research sheds light on how ancient humans and mammoths interacted across the Late Pleistocene.
Recent progress in lanthanide carriers is mapped to improve biomedical imaging and diagnosis, combining optical, X-ray, and magnetic resonance imaging techniques. These carriers enable high-resolution imaging with tunability for different applications, reducing tissue damage and enhancing image clarity.
Liquid biopsy targeting viral ctDNA holds promise as a diagnostic and surveillance tool for head and neck cancer. The study aims to monitor treatment response and assess minimal residual disease (MRD) to adapt treatment via precision oncology.
A new report proposes a complementary strategy of increasing potassium intake to reduce blood pressure, alongside reducing sodium intake. The authors conclude that dietary sodium reduction is a foundational strategy, but with new evidence supporting equal emphasis on increasing potassium intake.
Researchers have developed a new technique that pinpoints areas of human DNA inherited from two unknown, ancient ancestors. The study reveals that modern humans interbred with these 'ghost' ancestors and Denisovans in Eurasia around 1.8 million years ago.
Researchers have discovered that oscillatory pressure accelerates densification and inhibits grain growth in Al2O3/TiCp composites, resulting in improved mechanical properties and near-full density. The study integrates sintering kinetics with metal hysteresis theory to elucidate the promoting mechanism of dynamic pressure.
A new wearable sticker system has been developed to simplify diagnostic sweat testing for cystic fibrosis, a genetic disorder affecting digestion and breathing. The innovative technology is reliably accurate and makes the test more accessible beyond specialized centers.
Chandrasekaran, an assistant professor at Boston University School of Medicine, has been recognized with a Faculty Early Career Development Program (CAREER) award. He will receive $400,000 over five years to support his research on multisensory integration and its applications in understanding brain function.
A global assessment found that only 63.3% of lakes worldwide meet good water quality standards, exposing nearly half of the world's population to potential health risks associated with freshwater security. Strong regional disparities were observed, with Europe and North America faring better than Asia, South America, and Africa.
Researchers propose a four-stage pathway to evaluate AI for intracranial aneurysm detection, including lesion-level testing, reader performance evaluation, and surveillance after deployment. The framework aims to assess the tool's net clinical benefit in specific care settings.
Researchers have discovered that Leishmania parasites do not move through their hosts' bodies on their own, but instead embed themselves in phagocytes and manipulate immune cell migration. This manipulation is species-specific and depends on variations in individual genes.
Researchers found that molecules in tiny gaps between gold nanoparticles can synchronize their behavior even with light escaping quickly. The study could lead to new ways to build synchronized states of matter like superfluids and potentially advance sensing, photonics, and quantum devices.
A new set of recommendations provides clinicians with evidence-based guidance on discussing smoking cessation, including the use of nicotine e-cigarettes as a treatment option. The authors emphasize that the best approach will vary from person to person and should be tailored to each patient's goals, preferences, and medical needs.
A phase 2 clinical trial found that combining two immunotherapies with standard chemotherapy prior to surgery improved pathologic complete response rates in high-risk, early-stage HER2-negative breast cancer patients. The regimen demonstrated strong activity among patients with ImPrint-positive tumors, including high pCR rates.
The American Meteorological Society recognizes individuals and organizations making a positive difference in the world through fundamental research, public engagement, teaching, and informed decision-making. This year's honorees include Rong Fu, Paola Cessi, Sharon Nicholson, Renhe Zhang, Christian Kummerow, and David Thompson.
Two studies led by Montserrat Anguera investigate the process of X chromosome inactivation in immune cells and link impaired XCI maintenance to lupus-like disease. Impaired X chromosome inactivation in B cells has been linked to lupus, offering a novel pathogenic mechanism that accounts for the strong female sex bias of SLE.
A new Perspective in Nature Sustainability proposes industry-specific net-zero blueprints to ensure corporate climate action is grounded in science. The plan aims to provide a common scientific foundation for companies to set targets and track progress, reducing the reliance on carbon credit markets and planetary limits.
A large-scale study found that even when people are exposed to less social media misinformation, their political beliefs don't change much. Researchers tested what happened when participants saw far less content from untrustworthy sources and found no measurable changes in attitudes.
Binghamton University researchers have uncovered a novel mechanism that enables the creation of two chemical changes in a single step. This breakthrough could significantly shorten the route to target molecules for pharmaceutical research.
A study found that ALS rates are higher among men who served in the US Air Force compared to Army veterans. Marine veterans had lower rates of ALS, while officers experienced more psychosocial stress, which may contribute to the increased risk.
A collaborative research group has developed an atom-holography microscope that can directly visualize three-dimensional atomic arrangements in nanoscale regions using electron-beam excitation. This breakthrough enables element-specific analysis of three-dimensional atomic structures without the need for synchrotron radiation.
Researchers found that attention networks play a crucial role in communication difficulties in children with autism, affecting verbal and non-verbal communication. Weaker connections in the Dorsal Attention Network and Salience Network led to greater difficulties with understanding gestures, facial expressions, and social signals.
Researchers identify a previously unknown mechanism linking dysfunctional mitochondria and epigenetic machinery to chronic inflammation in aging cells. The discovery reveals how senescent cells drive inflammation by switching on inflammatory genes through metabolic signals from mitochondria.
A survey of over 6,000 women aged 50+ found they value quality of life over adding extra years to their lives. Men, on the other hand, are more likely to prioritize living longer and leaving healthcare decisions to medical professionals.
The Cornell researchers have created a 'microwave brain' microchip capable of encoding information into its own language, which enables fast and secure communication. The device uses microwave token embeddings to compress data, reducing bandwidth and energy consumption.
A new holistic scoring system for dietary protein evaluates environmental impact, health, affordability, and availability. The analysis found plant-based foods dominate the highest-scoring quintile while animal-based products are in the lowest-scoring group.
Kessler Foundation has been named one of the 2026 Best Places to Work for Women, highlighting its commitment to fostering an inclusive environment where women can grow professionally and thrive as leaders. The organization's mission-driven culture values diversity and invests in the success of all employees.
Researchers at DGIST identified a novel molecular mechanism regulating the N-type voltage-gated calcium channel, which plays a critical role in neural signal transmission. This discovery provides an important clue for developing therapeutics for brain disorders such as neuropathic pain, epilepsy, and Alzheimer's disease.
A UMBC researcher is exploring the effects of two key HIV prevention drugs in colon tissue, seeking to understand why they work better for some people than others. The study aims to provide knowledge that could lead to better dosing strategies and improved formulations, making PrEP more effective.