A study by USC researchers has identified two competing proteins, DSP and DPP, that influence the strength of tooth enamel. Over-expression of DSP increases enamel hardness, while over-expression of DPP creates pitted and chalky enamel prone to fracture and wear.
Researchers analyzed the expression levels of genes in circulating white blood cells after injection with bacterial endotoxin, identifying novel pathways and associations with inflammatory processes. The findings aim to improve trauma treatment by tailoring treatments to patients' individual needs.
A study found that high-dose anticancer chemotherapy and total body irradiation can cause a lack of permanent teeth and microdontia in children. The study, conducted by Päivi Hölttä, suggests that these treatments can have long-term effects on dental development.
Researchers found that mothers with dental caries who had C-section births passed a specific bacterium to their babies, leading to an earlier onset of cavities. The study suggests that family dentists should inform patients about the potential risk if they had a C-section delivery.
A four-year multicenter study will examine why minorities face dangerous misdiagnoses for mood disorders, leading to excessive antipsychotic drug use among African-Americans. The research aims to identify underlying reasons and develop new education techniques to improve diagnosis and treatment plans.
Researchers at Michigan Medicine have found that over half of patients with rapidly progressing hearing loss had antibodies against IESCA, a protein in the inner ear. The study suggests a direct test for antibodies could predict which patients will regain hearing with steroid treatment.
A Rutgers University-led consortium found Amchitka seafood to be safe for now due to low levels of radionuclides. The study provides a baseline for future testing and aims to reassure subsistence fishermen and commercial fishing interests in the region.
A study found that psychological stress delays wound healing by up to 45% due to impaired cell differentiation and reduced oxygen levels. Hyperbaric oxygen therapy eliminated this delay, as it restored nitric oxide levels necessary for healing.
Researchers found that tumor cells use jagged1 protein to interact with endothelial cells, prompting angiogenesis and tumor growth. This discovery could lead to a two-pronged approach to treat cancer by blocking protein secretion and cell contact.
A new study has developed an oral rinse test that can detect the presence of white blood cells in patients undergoing bone marrow transplants. The test was found to be effective in predicting which patients are at risk of infection during their recovery, with a difference of less than four days being an indicator of susceptibility.
A nationwide Canadian study found that 5.5% of surveyed Canadians are very afraid of visiting the dentist, leading to over 400,000 people missing annual appointments and 1.5 million cancelled or avoided appointments at some point in their lives. Increased use of general anesthesia or sedation may be a potential remedy for this issue.
A recent survey found that 88% of nursing homes have a staff dentist, but most patients receive off-site dental care due to limited on-site equipment. Daily oral care is often assigned to nursing assistants, who are expected to prioritize other tasks.
Researchers at the University of Colorado Boulder have developed a new polymer that maintains its strength even when exposed to light, offering potential solutions for dental fillings and electronic packaging. The polymer's unique properties could also have applications in boats, automobiles, and structural materials.
The study found oleanolic acid inhibited the growth of Streptococcus mutans and Porphyromonas gingivalis, two species associated with caries and gum disease. Raisins' phytochemicals may counter a public perception that they promote cavities.
The study found that oleanolic acid and other compounds in raisins inhibited the growth of oral bacteria associated with caries and gum disease. Raisin phytochemicals were effective against Streptococcus mutans and Porphyromonas gingivalis at concentrations ranging from 200 to 1,000 micrograms per milliliter.
A study found that exposure to aircraft noise impairs reading comprehension in children, with a 5-decibel change causing delays of up to 2 months. Road traffic noise improved recall memory, but increased exposure to both types of noise led to stress and reduced quality of life.
A two-year study found that home-care patients are at a high rate of pneumonia, complications, including mortality rates 11% higher than other patients. Frailty and decreased immunity are major contributing factors.
Researchers at UCLA isolated biomarkers from saliva that accurately predicted oral squamous cell carcinoma in 90% of cases. These biomarkers, known as salivary transcriptomes, also showed promise for detecting head and neck cancers. The study's findings suggest a potential breakthrough in early disease detection.
Researchers identified two strains of lactobacillus that can trap and block HIV, potentially providing a safe and cost-efficient method for preventing its spread. The technology could be used to protect infants and women in poor countries via fermented foods or feminine products.
A study of 594 dental patients found that 71% were willing to receive information and assistance from their dentist to quit using tobacco products. The majority (71%) of patients who use tobacco are considering quitting or currently trying to quit, with overwhelming support for asking about tobacco usage and access to cessation programs.
Researchers found that short-term stress in mice enhanced their immune reaction to influenza, leading to faster and more successful recovery. This discovery has broad implications for vaccine development, suggesting new strategies could be developed to boost immunity against influenza and potentially other diseases.
A Rutgers scientist will use a new grant to investigate schizophrenia genes, with the goal of finding better treatments and reduced morbidity. The researcher aims to analyze genetic data using a new statistical analysis method and investigate a recently described class of genes involved in the central nervous system.
A recent study by NYU College of Dentistry found a significant association between high levels of oral bacteria and increased risk of low birth weight and preterm delivery. The study suggests that mother's oral health may play a crucial role in the health of her newborn.
Researchers found that higher levels of Actinomyces naeslundii gsp2 in pregnant women's saliva were linked to lower birth weights and preterm deliveries. In contrast, higher levels of Lactobacillus casei during pregnancy positively affected birth weight.
A recent study by the University of Toronto found that nearly one in five teenagers in Ontario have evidence of tooth damage. The study also revealed that youth with cavities are more likely to experience tooth injuries.
A statewide survey of coaches and students found that 40% of former tobacco users had oral lesions, with smokeless tobacco users at higher risk. Tobacco use is more prevalent among male athletes, particularly Caucasians, and increases from grade 6 to 22.7% by grade 12.
Dr. Hausen receives the IADR Distinguished Scientist Award for his pioneering work in Community Dentistry and caries risk assessment prevention. His research has inspired junior faculty members and influenced public oral health policies in Finland and beyond.
Dr. Eliades received the 2005 Wilmer Souder Award for his groundbreaking research on dental biomaterials surface analysis, including spectroscopic and electron optical methods. His work has advanced significant dental health through understanding molecular interactions and conformational changes of collagen with dentin-bonding agents.
Dr. MacDougall receives the IADR Basic Research in Biological Mineralization Award for her groundbreaking research on tooth formation and tissue-specific gene regulation. Her work has been funded continuously since 1985 by the NIH/NIDCR.
Professor Kidd's extensive research has significantly impacted the development of early caries detection methods and treatment planning. Her work has been instrumental in shaping best practices for treating dental caries, with a focus on practical clinical applications.
Dr. Rozier has made significant contributions to dental public health, developing methods and findings to improve basic public health core functions and access to dental care for disadvantaged populations. He also conducted research on effective public health interventions to promote oral health and prevent dental diseases.
The Research in Prosthodontics and Implants Award honors Dr. Naert's contributions to prosthodontics through his extensive clinical studies and biomechanical analysis. His work has significantly impacted the practice of implant dentistry.
Forensic bite-mark matching has been criticized due to its fallibility and distortion problems. A new approach using 3D imaging has shown promise in improving accuracy, but with a 15% chance of incorrect matches. The technology could be useful in courtrooms for illustrating the likelihood of a match.
Dr. Meurman's research on the role of oral infections in medically compromised patients has significant implications for geriatric populations. The 2005 Geriatric Oral Research Award recognizes his contributions to the field, including advancements in molecular biological techniques for detecting oral pathogens.
Dr. Moore's distinguished career has led to evidence-based frameworks for clinical dentistry, with notable contributions in pediatric sedation guidelines and diabetes research. His work has provided a foundation for optimal pain control and minimal adverse effects in clinical analgesics and anesthetics.
Professor Johnson is awarded the IADR Oral Medicine and Pathology Research Award for his significant contributions to dental caries, periodontal diseases, and oral cancer research. He has also made a notable impact on oral cancer prevention through his advocacy.
Dental researchers successfully grown natural tooth enamel using a protein scaffold, solving a long-standing puzzle. The discovery unlocks one mystery of enamel formation and may have long-term applications in dental science and medical-device development.
New Jersey Institute of Technology's start-up company Supertron has developed a cryogenic coil to improve Magnetic Resonance Imaging (MRI) scanners for small animal imaging. This new coil will enhance installed MRIs, enabling them to produce cleaner and clearer images at an affordable price.
Three academic centers win $225,000 IADR/GSK Oral Care Awards for innovative oral health projects. The awards aim to improve the public's oral health and quality-of-life issues associated with oral diseases.
Tissue engineering aims to regenerate human tissue through artificial means, mimicking the body's natural processes. Researchers at U-M School of Dentistry are working on combining therapies to improve tissue engineering outcomes, such as using parathyroid hormone and bone morphogenetic proteins.
The Caries Assessment and Risk Evaluation (CARE) test measures saliva's oligosaccharides to predict future cavity history with 98% confidence. The test identifies children at risk, allowing for preventive measures to be taken.
Researchers are developing saliva testing technology to detect diseases like cancer, predict cavities, and identify drug use. Preliminary results show that analyzing protein sugars in saliva can determine an individual's vulnerability to cavities.
The RAE's focus on funding has compromised training of medical students and high-quality translational research. The authors propose abolishing the RAE, recommending efficient peer-review mechanisms to recognize research excellence without compromising clinical academics.
A study led by William Giannobile at the University of Michigan showed that gene therapy involving BMP-7 can produce nearly 50% more supporting bone around dental implants. This breakthrough has potential to reduce the need for bone grafts in reconstructive surgery.
Researchers found that indirect CT venography increases the detection rate of thromboembolic disease by 20% compared to traditional CTPA. The addition of CTV improves diagnosis for patients with pulmonary embolism and deep vein thrombosis, saving lives.
Researchers at the University of Manchester are exploring the role of p63 in cleft palate development. By investigating how this protein works during normal development and how it is disrupted in cleft palate, the study aims to improve understanding of the condition and potential therapies.
The American Association for Cancer Research (AACR) has supported nine faculty members from minority-serving institutions with $16,000 awards to attend special conferences in 2004. The winners were chosen by an Advisory Committee and are engaged in meritorious cancer research.
Researchers found that women experiencing menopause have reduced estrogen sensitivity in their brains, leading to increased hot flashes and night sweats. The study suggests that this insensitivity may contribute to menopause-related symptoms.
Researchers discovered distinct patterns of mRNA in saliva that can indicate developing oral cancer. The study found that a salivary test could identify cancer patients with high accuracy, potentially replacing current diagnostic tests.
The Iowa report found that nearly one in eight children were without health insurance at some point in 2000, with 90,000 children uninsured annually. The study also revealed that many eligible children were not enrolled in Medicaid or hawk-i programs due to inadequate enrollment.
High levels of radiation from thyroid treatment can trigger homeland security detectors, which are now more common with increased sensitivity. Hospitals should develop documentation guidelines for patients undergoing nuclear medicine procedures to minimize this risk.
Researchers at UCSC have made new insights into the atomic interactions underlying zirconium tungstate's negative thermal expansion. The team found a combination of geometrical frustration and unusual atomic motions are likely important to this phenomenon.
Researchers investigated anaerobic and facultative anaerobic bacteria in a study on photodynamic therapy. The photosensitizers were able to completely suppress the anaerobic key pathogens, but facultative anaerobic bacteria tested responded less effectively to PDT.
Dr. Adele Boskey, a researcher at the Hospital for Special Surgery, has been elected as an AAAS Fellow for her significant work on biological calcification and extracellular matrix proteins. She was recognized at the 2005 AAAS Annual Meeting in Washington, DC.
Clemson University receives a $600,000 NSF grant to support biomaterials research and the growth of an advanced materials industry cluster. The grant aims to facilitate technology transfer between academia and private industry, promoting economic development in South Carolina.
A study found that intensive continuing education workshops can boost nurses' knowledge of and use of evidence-based practice. This can lead to better patient care and outcomes, with a potential improvement of up to 28%. The research highlights the importance of increasing nurses' knowledge of EBP.
Researchers have identified a specific gene, EN2, that contributes to autism spectrum disorder (ASD). Variations in this gene may affect brain development and behavior. The study also found changes in neurotransmitter systems, including acetylcholine and serotonin, which may disrupt communication between cells.
The panel found that traditional 'get tough' approaches exacerbate problems, while positive intervention programs like Functional Family Therapy and Multisystemic Therapy show promise in reducing arrests and out-of-home placements. These effective programs focus on developing social competency skills and family involvement.
Researchers have identified up to 28 proteins in saliva, including biomarkers for diseases like cancer. Saliva testing may become a life-saving alternative to blood tests in developing nations where early diagnosis is critical.
A U-M team, led by Dr. Stephen Feinberg, is engineering tissue grafts to treat mouth wounds in patients with diabetes or undergoing chemotherapy. The grafts, made from a combination of mucosal cells and AlloDerm, show promise for smaller donor sites and faster healing times.