Berkeley researchers have imaged the human RISC-loading complex for the first time, proposing a model of how small RNA molecules target specific messenger RNAs for silencing and/or destruction. This work provides new insights into RNA interference mechanisms and has significant implications for gene regulation in humans.
Scripps researchers have discovered the Nbs1 component of the Mre11-Rad50-Nbs1 complex, which helps cells repair severe DNA damage. The complex is critical in preventing cancer development and can also repair diseased cells targeted by chemotherapy.
Researchers discovered molecular evidence supporting Darwin's theory of evolution, finding that complex machines evolved through a process of combination and modification of existing proteins. The study provides a blueprint for understanding the evolution of cellular machinery, contradicting Intelligent Design explanations.
A Syracuse University research team discovered a second molecular switch within the Mixed Lineage Leukemia protein complex, which could be exploited to prevent abnormal cell production. The W-RAD switching mechanism signals cells to create multiple copies of cancer cells.
Computational biologists at Carnegie Mellon University have developed a statistical method to uncover genome variations underlying complex disease syndromes. The graph-guided fused lasso (GFlasso) method showed increased power in detecting gene variants associated with complex symptoms compared to other methods.
Researchers have identified fundamental rules that determine food-web stability, with diverse predator-prey links enhancing stability in high and intermediate trophic levels. Small ecosystems follow different rules than large ones, with strong interactions between species stabilizing smaller webs, but destabilizing larger ones.
Researchers found that numerous small changes in multiple gene regions impact flowering time, reproductive ability, and other complex traits in corn. The study also identified subtle genetic variations influencing reproductive success, paving the way for more accurate predictions and breeding strategies.
A three-protein DNA repair complex called MRN is crucial for a normal gene-shuffling process to proceed properly. The study found that Mre11 plays a critical role in preventing cancer by repairing double strand breaks in B cells.
Elinor Ostrom suggests a diagnostic tool to help scholars frame the question and think through variables in complex social-ecological systems. The framework provides guidance for researchers and policymakers to analyze diversely structured markets and hierarchies.
Researchers have discovered two new structures involving the central component of an enzyme important to the complement system of the immune response. These findings may pave the way for more efficient therapeutics for diseases such as age-related macular degeneration, rheumatoid arthritis, and systemic lupus erythematosus.
A Purdue University study found that animals make complex decisions about choosing mates, considering multiple factors beyond major histocompatibility complex (MHC) genes. Tail length also plays a role in reproductive success, with larger males being more likely to be chosen as sires.
A comprehensive investigation into sea urchins' axial complex has shown that various internal organs are structurally linked. The study uses high-resolution imaging to analyze specimens from multiple orders, providing a re-evaluation of published studies spanning two centuries.
Researchers discovered how a SUMO protein guides an enzyme complex to alter chromatin structure and regulate gene expression. The interaction between SUMO and the enzyme complex prevents aberrant gene expression, which is common in cancer and neurodegenerative diseases.
Scientists have decoded the structure of a needlelike protein complex on Shigella bacteria, essential for infection, revealing new insights into the mechanism of bacterial injection systems that could lead to new drugs.
Researchers have successfully tested a method to adjust the immune system to accept transplanted cells as 'self' in mice. The complex combines IL-2 with an antibody to stimulate T regulatory cells, boosting specific populations and subduing others.
Researchers have developed a method to generate complex, multilayer oral tissues using human embryonic stem cells. The tissues mimic normal oral cavity tissues and show promise for treating oral diseases through transplantation.
The study reveals the precise orientation of the Fenna-Matthews-Olson (FMO) antenna protein on the membrane, allowing for efficient energy transfer. The 'taco shell' protein plays a crucial role in connecting the peripheral chlorosome antenna complex to the reaction center.
Beijing Institute of Technology researchers developed a unique multi-living agent concept to analyze complex information systems under SRSC environment. They found that analyzing agents' livelihood can determine system behavior well or not.
A groundbreaking study at Brandeis University has shed light on a crucial step in the complex process of genetic encoding for the first time. The researchers report that they were able to crystallize a large complex of a macromolecular machine in the human cell and determine its structure, zeroing in on the process of RNA splicing.
Researchers found that acetylation affects yeast lifespan through the NuA4 enzyme complex, which also controls sugar production in cells. This discovery may have implications for understanding aging and human diseases, as the mechanisms identified are conserved across species.
Researchers at VIB have identified a molecule that can form the basis for a new therapy for Alzheimer's disease. By targeting the Aph1B γ-secretase complex, they hope to develop a medicine that can prevent the formation of amyloid plaques and stop the progression of the disease.
The Department of Energy has awarded the University of Georgia Complex Carbohydrate Research Center a four-year, $3.1 million grant to continue supporting research on complex carbohydrates in plants and microbes. The grant renewal marks the sixth time the center has received funding since its inception in 1986.
Scientists at Stanford University School of Medicine have identified a protein complex that plays a pivotal role in controlling the ability of embryonic stem cells to become any cell type. The finding is an important advance in harnessing the unique abilities of embryonic stem cells to treat disease and generate replacement tissue.
Researchers have discovered complex organic molecules in interstellar space using powerful radio telescopes. Detailed images of protoclusters reveal a complex mix of stars in different stages of formation.
A groundbreaking study reveals how enzymes in the cell cooperate to make fat, providing insights into a potential target for developing new anti-obesity and anti-cancer drugs. The research used state-of-the-art electron microscopy to capture the complex movements of fatty acid synthase, a molecular structure that is extremely flexible.
Researchers at Brown University have successfully grown and assembled living microtissues into complex three-dimensional structures, advancing tissue engineering. The breakthrough could eventually reduce the need for certain kinds of animal research, with implications for basic cell biology, drug discovery, and tissue research.
Scientists at Burnham Institute for Medical Research have determined the structure of protein interactions responsible for triggering apoptosis. The research reveals a particular arrangement of Fas receptor and FADD proteins that act as a control switch for cell death signaling.
Researchers found no significant difference between pediatric patients who underwent cardiopulmonary bypass and those who did not, in terms of I.Q. scores and neuropsychological tests. The study provides good news for school-aged children with less complex heart defects undergoing surgery.
A new Eph receptor tyrosine kinase, EphA4, is overexpressed in gastric cancer and associated with depth of invasion, recurrence, and poor prognosis. The study also found that EphA4 forms a hetero receptor complex with FGFR1, potentiating FGFR-mediated downstream signal transduction.
Three new devices are being showcased to reduce blockages in peripheral and coronary arteries, providing cardiac support. The AngioSculpt device optimizes stenting of complex lesions with a low rate of complications.
Researchers at the GSK-IMCB Group in Singapore have made a groundbreaking discovery about how cells move, revealing a complex of three proteins that regulate the myosin network within a cell. This finding has significant implications for understanding various diseases, including cancer growth and developmental biology.
A meta-analysis found that longer psychodynamic psychotherapy lasting at least a year is effective and superior to shorter-term therapy for patients with complex mental disorders. The study suggests that short-term therapy may be insufficient for these patients, who often require more intensive treatment.
The Conaway Lab identifies a new way in which the proteasome helps regulate gene expression through its interaction with the chromatin remodeling complex INO80. This mechanism involves the deubiquitinating enzyme Uch37, which can remove protein tags from other proteins.
A new study published in the Quarterly Journal of Experimental Psychology found that conscious thinking can lead to better choices for complex decisions, debunking a controversial 2006 research result. The study suggests that unconscious thought is more susceptible to irrelevant factors and that conscious thinkers given adequate time t...
Researchers have been awarded $4 million to develop software for multithreaded supercomputers, enabling faster analysis of complex problems like power grid stability and biological networks. The new machines can handle large, random datasets more efficiently than traditional systems.
Researchers at Texas A&M University have developed a computational tool to study complex units of clustered genes called operons in bacteria. The tool allows scientists to analyze many bacterial genomes at once and is more accurate than previous methods.
Researchers from Carnegie Institution and University of Cape Town used diamonds to trace origin of platinum deposits, suggesting ancient parts of mantle beneath African continent as source. The study's findings may lead to better exploration models and strategies for similar ore deposits.
New research explores the evolutionary origins of the brain, shedding light on how complex synapse structures drove brain evolution. The study finds that sophisticated molecular processing of nerve impulses was key to developing animals with more complex behaviors.
Mathematicians Dmitry Khavinson and Genevra Neumann describe how their work on the Fundamental Theorem of Algebra led them to questions in astrophysics, specifically gravitational lensing. Their result resolves a conjecture of Sun Hong Rhie, establishing that the number of zeros of certain rational harmonic functions is 5n - 5.
Researchers used a neutral model to predict fish diversity in the Mississippi-Missouri River System, demonstrating its potential for analyzing complex systems. The approach, which assumes functional equivalence among species, provides new insights into biodiversity patterns and their relationship with environmental change.
The University of Washington is leading a $6.25M project to develop an electronic Sherlock Holmes system for complex data analysis in the military. The system will integrate various types of sensor data to predict behavior and make decisions, addressing the challenge of handling high degrees of complexity and uncertainty.
A new study by Yale and Washington University researchers challenges the idea that complex traits have a 'cost of complexity,' suggesting that many mutations only affect a small number of traits. The team identified genomic regions affecting skeleton characteristics, revealing a well-coordinated process in tuning up complex traits.
A study published in PNAS reveals that evolution drives animals to become more complex, with most branches evolving in the same direction. The researchers found that complexity increases as organisms adapt to their environments and compete for resources.
The Stowers Institute's Workman Lab has characterized a novel histone acetyltransferase protein complex called ATAC, which plays a crucial role in regulating chromosome functions. The study provides insight into the ATAC complex's functions and its potential link to human diseases such as developmental defects and cancers.
The MMB/dREAM complex, composed of Myb and E2F2-RB proteins, epigenetically regulates expression of the Polo kinase in Drosophila. Disruptions to this pathway are associated with human cancers and may lead to similar epigenetic changes.
A systematic review found that complex interventions, such as preventive home visits and community-based care, improved physical function and reduced the need for nursing home care in elderly people. The meta-analysis also showed a reduction in hospital admissions and falls, with benefits evident in studies started before 1993.
The Kansas State University researchers are analyzing data from feedlots to create decision-making tools for managing bovine respiratory disease complex. They hope to generate estimates of the effect of certain risk factors and develop a system to classify distributions of disease events within feedlot pens.
A recent study by the Hadassah-Hebrew University Medical Center found that only one out of 63 patients with complex fibroadenomas had a malignancy. The researchers concluded that these lesions can be treated similarly to simple fibroadenomas, allowing for non-surgical follow-up.
A study at Cincinnati Children's Hospital Medical Center reveals that a protein recycling system failure may be linked to the development of certain diseases, such as cancer and heart disease, as well as birth defects. The Retromer Complex plays a critical role in delivering signaling proteins to tissue-building sites.
Researchers at St. Jude Children's Research Hospital discovered a new signaling molecule IL-35 that prevents immune responses from running amok. The finding could lead to the development of new treatments for cancer, autoimmune diseases, and inflammatory diseases.
Researchers at Harvard University have developed a new technique called Brainbow that allows for the imaging of neurons in a wide range of colors, enabling scientists to better map the complex wiring diagram of the brain and nervous system. This breakthrough has significant implications for understanding brain disorders and development.
Researchers synthesized natural and social sciences to understand coupled human and natural systems, revealing complexities in environmental and socioeconomic patterns. The study emphasizes the need for specialization easing up to develop feasible policies for effective solutions to complex problems.
The Conaway Lab has discovered a critical role for the chromatin remodeling complex INO80 in activating transcription mediated by the transcription factor YY1. This finding provides new insights into how YY1 regulates gene expression, which is crucial for cell cycle control and may have implications for cancer therapy.
Researchers reveal an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. This new level of control has significant implications for multi-cellular differentiation mechanisms.
Montréal researchers have identified a novel cellular protein complex targeted by HIV-1 Vpr to stop infected cell division. This discovery may lead to the development of a new class of drugs to combat HIV.
A study found that the percentage of deaths from complex chronic conditions occurring at home increased significantly between 1989 and 2003, especially for infants and adolescents. This shift may be attributed to advances in home-based medical technology and changes in attitudes towards pediatric palliative care and hospice services.
The study reveals that a combinatorial action of multiple protein domains is required to read histone modifications, targeting the Rpd3S complex to deacetylate transcribed chromatin. This finding has significant implications for understanding and treating Huntington's disease and other neurodegenerative disorders.
Corals have been found to possess a large and complex genetic repertoire, with estimates suggesting up to 25,000 genes. This discovery has significant implications for understanding the evolution of complex features such as the nervous and immune systems in vertebrates.
A new study published in PLoS Genetics used computer simulations to trace genetic changes over thousands of generations in a simulated population, testing the effectiveness of statistical genetic methods in identifying multiple genes causing complex diseases. The researchers found that known methods are limited and identified which met...
Researchers at the Salk Institute have discovered a novel RPA-like complex that specifically targets the short single-stranded DNA tail end of yeast chromosomes. This complex helps maintain telomere integrity and prevent premature senescence or cancer development.